UniProtKB - P08558 (BP44_BPMU)
Baseplate hub protein gp44
P
Functioni
Forms the central cylindrical hub of the baseplate and plays an important role in baseplate and tail assembly (Probable). Core component of the initiator complex that triggers the tail tube polymerization during tail assembly (Probable). Forms a conduit that probably functions as an extension of the tail tube allowing viral DNA release during ejection. Might facilitate the interaction of the virus with the host cell surface through electrostatic interactions during virus entry into host cell.
CuratedRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 209 – 228 | H-T-H motifSequence analysisAdd BLAST | 20 |
GO - Biological processi
- viral genome ejection through host cell envelope, contractile tail mechanism Source: UniProtKB-KW
- viral tail assembly Source: UniProtKB-KW
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Baseplate hub protein gp44Alternative name(s): 43 kDa tail protein Gene product 44 Short name: gp44 Gene product P Short name: gpP |
Gene namesi | Name:P Ordered Locus Names:Mup44 |
Organismi | Escherichia phage Mu (Bacteriophage Mu) |
Taxonomic identifieri | 10677 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Uroviricota › Caudoviricetes › Caudovirales › Myoviridae › Muvirus |
Virus hosti | Enterobacteriaceae [TaxID: 543] |
Proteomesi |
|
Subcellular locationi
- Virion 2 Publications
- Host cytoplasm 1 Publication Note: Baseplate protein.1 Publication
Keywords - Cellular componenti
Host cytoplasm, Viral baseplate protein, Viral tail protein, VirionPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000077692 | 1 – 379 | Baseplate hub protein gp44Add BLAST | 379 |
Post-translational modificationi
Expressioni
Inductioni
Keywords - Developmental stagei
Late proteinInteractioni
Subunit structurei
Heterotrimer of one uncleaved (42 kDa) and two cleaved (40 kDa) forms.
Forms a hub-like structure with an inner diameter of 25 Angstroms through which DNA can presumably pass during infection.
Part of a complex composed of three DNA circularization protein N, three baseplate hub protein gp44 and three sub-complex wedge (made of two copies of each baseplate protein gp46, gp47 and gp48) that forms the baseplate (PubMed:27555589).
3 PublicationsStructurei
Secondary structure
3D structure databases
SMRi | P08558 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08558 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 344 – 379 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 363 – 379 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Domaini
Family and domain databases
Gene3Di | 3.30.1920.10, 1 hit |
InterProi | View protein in InterPro IPR023399, Baseplate-like_2-layer_sand IPR026276, Baseplate_GpP |
PIRSFi | PIRSF004440, GpP, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSNTVTLRAD GRLFTGWTSV SVTRSIESVA GYFELGVNVP PGTDLSGLAP
60 70 80 90 100
GKKFTLEIGG QIVCTGYIDS RRRQMTADSM KITVAGRDKT ADLIDCAAVY
110 120 130 140 150
SGGQWKNRTL EQIARDLCAP YGVTVRWELS DKESSAAFPG FTLDHSETVY
160 170 180 190 200
EALVRASRAR GVLMTSNAAG ELVFSRAAST ATDELVLGEN LLTLDFEEDF
210 220 230 240 250
RDRFSEYTVK GYARANGAEG DDIDAKSIVS RKGTATDSDV TRYRPMIIIA
260 270 280 290 300
DSKITAKDAQ ARALREQRRR LAKSITFEAE IDGWTRKDGQ LWMPNLLVTI
310 320 330 340 350
DASKYAIKTT ELLVSKVTLI LNDQDGLKTR VSLAPREGFL VPVESDRKNR
360 370
KGGDSNGGID ALVEDYYRRH PEKTPPWKE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06796 Genomic DNA Translation: CAA29956.1 AF083977 Genomic DNA Translation: AAF01122.1 |
PIRi | S01891, ZPBPMU |
RefSeqi | NP_050648.1, NC_000929.1 |
Genome annotation databases
GeneIDi | 2636285 |
KEGGi | vg:2636285 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X06796 Genomic DNA Translation: CAA29956.1 AF083977 Genomic DNA Translation: AAF01122.1 |
PIRi | S01891, ZPBPMU |
RefSeqi | NP_050648.1, NC_000929.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WRU | X-ray | 2.10 | A | 1-379 | [»] | |
SMRi | P08558 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Genome annotation databases
GeneIDi | 2636285 |
KEGGi | vg:2636285 |
Miscellaneous databases
EvolutionaryTracei | P08558 |
Family and domain databases
Gene3Di | 3.30.1920.10, 1 hit |
InterProi | View protein in InterPro IPR023399, Baseplate-like_2-layer_sand IPR026276, Baseplate_GpP |
PIRSFi | PIRSF004440, GpP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BP44_BPMU | |
Accessioni | P08558Primary (citable) accession number: P08558 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | August 1, 1988 | |
Last modified: | February 23, 2022 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references