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Protein

GTPase NRas

Gene

Nras

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Activity regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTP8
Nucleotide bindingi57 – 61GTP5
Nucleotide bindingi116 – 119GTP4

GO - Molecular functioni

  • GTPase activity Source: MGI
  • GTP binding Source: UniProtKB-KW
  • protein-containing complex binding Source: MGI

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase NRas
Alternative name(s):
Transforming protein N-Ras
Gene namesi
Name:Nras
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97376 Nras

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000430101 – 186GTPase NRasAdd BLAST186
PropeptideiPRO_0000043011187 – 189Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi181S-palmitoyl cysteineBy similarity1
Modified residuei186Cysteine methyl esterBy similarity1
Lipidationi186S-farnesyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.By similarity
Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

EPDiP08556
MaxQBiP08556
PaxDbiP08556
PeptideAtlasiP08556
PRIDEiP08556

PTM databases

iPTMnetiP08556
PhosphoSitePlusiP08556
SwissPalmiP08556

Expressioni

Gene expression databases

CleanExiMM_NRAS

Interactioni

Subunit structurei

Interacts (active GTP-bound form preferentially) with RGS14. Interacts (active GTP-bound form) with RASSF7 (By similarity).By similarity

Protein-protein interaction databases

IntActiP08556, 1 interactor
STRINGi10090.ENSMUSP00000029445

Structurei

3D structure databases

ProteinModelPortaliP08556
SMRiP08556
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 185Hypervariable regionAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
HOVERGENiHBG009351
InParanoidiP08556

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P08556-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI
110 120 130 140 150
KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP FIETSAKTRQ
160 170 180
GVEDAFYTLV REIRQYRLKK LNSSDDGTQG CMGSPCVLM
Length:189
Mass (Da):21,199
Last modified:August 1, 1988 - v1
Checksum:i688D33F6814855B7
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9D091Q9D091_MOUSE
GTPase NRas
Nras mCG_6411
189Annotation score:
A0A0G2JGP4A0A0G2JGP4_MOUSE
GTPase NRas
Nras
183Annotation score:
A0A0G2JE25A0A0G2JE25_MOUSE
GTPase NRas
Nras
150Annotation score:
A0A0G2JGM2A0A0G2JGM2_MOUSE
GTPase NRas
Nras
74Annotation score:
E9PVD5E9PVD5_MOUSE
GTPase NRas
Nras
46Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti189M → MCKTL in CAA31958 (PubMed:2835730).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12124
, M12121, M12122, M12123 Genomic DNA Translation: AAA39839.1
X13664 mRNA Translation: CAA31958.1
X06909 Genomic DNA Translation: CAA30010.1
PIRiA23560 TVMSNS
UniGeneiMm.400954

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12124
, M12121, M12122, M12123 Genomic DNA Translation: AAA39839.1
X13664 mRNA Translation: CAA31958.1
X06909 Genomic DNA Translation: CAA30010.1
PIRiA23560 TVMSNS
UniGeneiMm.400954

3D structure databases

ProteinModelPortaliP08556
SMRiP08556
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP08556, 1 interactor
STRINGi10090.ENSMUSP00000029445

PTM databases

iPTMnetiP08556
PhosphoSitePlusiP08556
SwissPalmiP08556

Proteomic databases

EPDiP08556
MaxQBiP08556
PaxDbiP08556
PeptideAtlasiP08556
PRIDEiP08556

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97376 Nras

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
HOVERGENiHBG009351
InParanoidiP08556

Miscellaneous databases

ChiTaRSiNras mouse
PROiPR:P08556
SOURCEiSearch...

Gene expression databases

CleanExiMM_NRAS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRASN_MOUSE
AccessioniPrimary (citable) accession number: P08556
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 12, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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