UniProtKB - P08555 (DSDX_ECOLI)
Protein
D-serine transporter DsdX
Gene
dsdX
Organism
Escherichia coli (strain K12)
Status
Functioni
A D-serine-specific transporter, may function as a H+ symporter.By similarity
Caution
An ORF called dsdC was originally (PubMed:3275618) assigned to the wrong DNA strand and thought to be a D-serine deaminase activator, it was then resequenced by Ref. 2 and still thought to be 'dsdC', but this time to function as a D-serine permease. It is PubMed:7592420 that showed that dsdC is another gene and that this sequence should be called dsdX. It should also be noted that the C-terminal part of dsdX (from 338 onward) was also sequenced (PubMed:3029015 and PubMed:1659648) and was thought to be a separate ORF (don't worry, we also had difficulties understanding what happened!).1 Publication
GO - Molecular functioni
- D-serine transmembrane transporter activity Source: EcoCyc
- gluconate transmembrane transporter activity Source: GO_Central
GO - Biological processi
- cellular response to DNA damage stimulus Source: EcoliWiki
- D-serine transport Source: EcoCyc
- gluconate transmembrane transport Source: GO_Central
Keywordsi
Biological process | Amino-acid transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:DSDX-MONOMER |
Protein family/group databases
TCDBi | 2.A.8.1.5, the gluconate:h(+) symporter (gntp) family |
Names & Taxonomyi
Protein namesi | Recommended name: D-serine transporter DsdX |
Gene namesi | Name:dsdX1 Publication Synonyms:orf4451 Publication, yfdA, yfdD Ordered Locus Names:b2365, JW2362 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Multi-pass membrane protein Curated
Plasma Membrane
- integral component of plasma membrane Source: EcoliWiki
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 4 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 5 – 25 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 26 – 28 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 29 – 49 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 50 – 56 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 57 – 77 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 78 – 105 | PeriplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 106 – 126 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 127 – 139 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 140 – 160 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 161 – 177 | PeriplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 178 – 198 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 199 – 223 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 224 – 244 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 245 – 257 | PeriplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 258 – 278 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 279 – 301 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 302 – 322 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 323 – 342 | PeriplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 343 – 363 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 364 – 384 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 385 – 405 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 406 – 424 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 425 – 445 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000061937 | 1 – 445 | D-serine transporter DsdXAdd BLAST | 445 |
Proteomic databases
PaxDbi | P08555 |
PRIDEi | P08555 |
Expressioni
Inductioni
By growth in D-serine, controlled by DsdC.1 Publication
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260554, 2 interactors |
DIPi | DIP-9481N |
IntActi | P08555, 1 interactor |
STRINGi | 511145.b2365 |
Family & Domainsi
Sequence similaritiesi
Belongs to the GntP permease family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2610, Bacteria |
HOGENOMi | CLU_027949_0_0_6 |
InParanoidi | P08555 |
PhylomeDBi | P08555 |
Family and domain databases
InterProi | View protein in InterPro IPR003474, Glcn_transporter |
PANTHERi | PTHR30354, PTHR30354, 1 hit |
Pfami | View protein in Pfam PF02447, GntP_permease, 1 hit |
PIRSFi | PIRSF002746, Gluconate_transporter, 1 hit |
TIGRFAMsi | TIGR00791, gntP, 1 hit |
i Sequence
Sequence statusi: Complete.
P08555-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHSQIWVVST LLISIVLIVL TIVKFKFHPF LALLLASFFV GTMMGMGPLD
60 70 80 90 100
MVNAIESGIG GTLGFLAAVI GLGTILGKMM EVSGAAERIG LTLQRCRWLS
110 120 130 140 150
VDVIMVLVGL ICGITLFVEV GVVLLIPLAF SIAKKTNTSL LKLAIPLCTA
160 170 180 190 200
LMAVHCVVPP HPAALYVANK LGADIGSVIV YGLLVGLMAS LIGGPLFLKF
210 220 230 240 250
LGQRLPFKPV PTEFADLKVR DEKTLPSLGA TLFTILLPIA LMLVKTIAEL
260 270 280 290 300
NMARESGLYI LVEFIGNPIT AMFIAVFVAY YVLGIRQHMS MGTMLTHTEN
310 320 330 340 350
GFGSIANILL IIGAGGAFNA ILKSSSLADT LAVILSNMHM HPILLAWLVA
360 370 380 390 400
LILHAAVGSA TVAMMGATAI VAPMLPLYPD ISPEIIAIAI GSGAIGCTIV
410 420 430 440
TDSLFWLVKQ YCGATLNETF KYYTTATFIA SVVALAGTFL LSFII
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X91821 Genomic DNA Translation: CAA62932.1 X86379 Genomic DNA Translation: CAA60138.1 J01603 Genomic DNA Translation: AAA87974.1 U00096 Genomic DNA Translation: AAC75424.1 AP009048 Genomic DNA Translation: BAA16225.1 M19035 Genomic DNA No translation available. X81461 Genomic DNA Translation: CAA57221.2 |
PIRi | S54140 |
RefSeqi | NP_416866.1, NC_000913.3 WP_000556048.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75424; AAC75424; b2365 BAA16225; BAA16225; BAA16225 |
GeneIDi | 57728151 949103 |
KEGGi | ecj:JW2362 eco:b2365 |
PATRICi | fig|1411691.4.peg.4364 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X91821 Genomic DNA Translation: CAA62932.1 X86379 Genomic DNA Translation: CAA60138.1 J01603 Genomic DNA Translation: AAA87974.1 U00096 Genomic DNA Translation: AAC75424.1 AP009048 Genomic DNA Translation: BAA16225.1 M19035 Genomic DNA No translation available. X81461 Genomic DNA Translation: CAA57221.2 |
PIRi | S54140 |
RefSeqi | NP_416866.1, NC_000913.3 WP_000556048.1, NZ_LN832404.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260554, 2 interactors |
DIPi | DIP-9481N |
IntActi | P08555, 1 interactor |
STRINGi | 511145.b2365 |
Protein family/group databases
TCDBi | 2.A.8.1.5, the gluconate:h(+) symporter (gntp) family |
Proteomic databases
PaxDbi | P08555 |
PRIDEi | P08555 |
Genome annotation databases
EnsemblBacteriai | AAC75424; AAC75424; b2365 BAA16225; BAA16225; BAA16225 |
GeneIDi | 57728151 949103 |
KEGGi | ecj:JW2362 eco:b2365 |
PATRICi | fig|1411691.4.peg.4364 |
Organism-specific databases
EchoBASEi | EB0246 |
Phylogenomic databases
eggNOGi | COG2610, Bacteria |
HOGENOMi | CLU_027949_0_0_6 |
InParanoidi | P08555 |
PhylomeDBi | P08555 |
Enzyme and pathway databases
BioCyci | EcoCyc:DSDX-MONOMER |
Miscellaneous databases
PROi | PR:P08555 |
Family and domain databases
InterProi | View protein in InterPro IPR003474, Glcn_transporter |
PANTHERi | PTHR30354, PTHR30354, 1 hit |
Pfami | View protein in Pfam PF02447, GntP_permease, 1 hit |
PIRSFi | PIRSF002746, Gluconate_transporter, 1 hit |
TIGRFAMsi | TIGR00791, gntP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DSDX_ECOLI | |
Accessioni | P08555Primary (citable) accession number: P08555 Secondary accession number(s): P11693 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families