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Protein

UDP-glucuronosyltransferase 2B17

Gene

Ugt2b17

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. 2B17 is active on testosterone.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  • glucuronosyltransferase activity Source: RGD

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.17 5301

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Chemistry databases

SwissLipidsiSLP:000001700

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 2B17 (EC:2.4.1.17)
Short name:
UDPGT 2B17
Alternative name(s):
17-beta-hydroxysteroid-specific UDPGT
RLUG38
Testosterone, dihydrotestosterone, and beta-estradiol-specific UDPGT
UDP-glucuronosyltransferase 2B5
Short name:
UDPGT 2B5
UDPGTr-3
Gene namesi
Name:Ugt2b17
Synonyms:Ugt2b3, Ugt2b5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628623 Ugt2b5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei494 – 510HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000003602724 – 530UDP-glucuronosyltransferase 2B17Add BLAST507

Proteomic databases

PaxDbiP08542
PRIDEiP08542

PTM databases

iPTMnetiP08542
PhosphoSitePlusiP08542

Expressioni

Inductioni

Constitutively expressed.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000034723

Structurei

3D structure databases

ProteinModelPortaliP08542
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004033
InParanoidiP08542
KOiK00699

Family and domain databases

InterProiView protein in InterPro
IPR002213 UDP_glucos_trans
IPR035595 UDP_glycos_trans_CS
PfamiView protein in Pfam
PF00201 UDPGT, 1 hit
PROSITEiView protein in PROSITE
PS00375 UDPGT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.iShow all

P08542-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGKWISALL LLQISCCFQS GNCGKVLVWP MEFSHWMNIK TILDELVQRG
60 70 80 90 100
HEVTVLKPSA YYVLDPKKSP DLKFETFPTS VSKDELENYF IKLVDVWTYE
110 120 130 140 150
LQRDTCLSYS PLLQNMIDGF SDYYLSLCKD TVSNKQLMAK LQESKFDVLL
160 170 180 190 200
SDPVAACGEL IAEVLHIPFL YSLRFSPGYK IEKSSGRFIL PPSYVPVILS
210 220 230 240 250
GMGGPMTFID RVKNMICTLY FDFWFHMFNA KKWDPFYSEI LGRPTTLAET
260 270 280 290 300
MGKAEMWLIR SYWDLEFPHP TLPNVDYIGG LQCRPPKPLP KDMEDFVQSS
310 320 330 340 350
GEHGVVVFSL GSMVSSMTEE KANAIAWALA QIPQKVLWKF DGKTPATLGP
360 370 380 390 400
NTRVYKWLPQ NDLLGHPKTK AFVTHSGANG VYEAIYHGIP MVGIPMFGEQ
410 420 430 440 450
HDNIAHMVAK GAAVTLNIRT MSKSDLFNAL KEIINNPFYK KNAVWLSTIH
460 470 480 490 500
HDQPMKPLDK AVFWIEFVMR HKGAKHLRPL GHDLPWYQYH SLDVIGFLLT
510 520 530
CSAVIAVLTV KCFLFIYRLF VKKEKKMKNE
Length:530
Mass (Da):60,525
Last modified:February 1, 1991 - v2
Checksum:iBB633D70DBF8A7E4
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P36511UDB15_RAT
UDP-glucuronosyltransferase 2B15
Ugt2b15 Ugt2b12, Ugt2b36, Ugt2b4
530Annotation score:
P09875UD2B1_RAT
UDP-glucuronosyltransferase 2B1
Ugt2b1 Udpgtr2
529Annotation score:
P08541UD2B2_RAT
UDP-glucuronosyltransferase 2B2
Ugt2b Ugt2b2
530Annotation score:
P19488UDB37_RAT
UDP-glucuronosyltransferase 2B37
Ugt2b37 Ugt2b5, Ugt2b6
530Annotation score:
Q68G19Q68G19_RAT
UDP-glucuronosyltransferase
Ugt2b35 Ugt2b15, Ugt2b36, Ugt2b4, rCG_57123
530Annotation score:
F1LM22F1LM22_RAT
UDP-glucuronosyltransferase
Ugt2b Ugt2b15, Ugt2b37
530Annotation score:
F1M7N8F1M7N8_RAT
UDP-glucuronosyltransferase
Ugt2b37 LOC102550717, Ugt2b15
530Annotation score:
D4A132D4A132_RAT
UDP-glucuronosyltransferase
Ugt2b10 Ugt2b17
532Annotation score:
F1M3E3F1M3E3_RAT
UDP-glucuronosyltransferase
Ugt2b15 Ugt2b37
530Annotation score:
D3ZLR6D3ZLR6_RAT
UDP-glucuronosyltransferase
Ugt2b15 Ugt2b37
530Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54T → S in CAA68351 (PubMed:3108864).Curated1
Sequence conflicti119G → E in CAA68351 (PubMed:3108864).Curated1
Sequence conflicti376S → G in CAA68351 (PubMed:3108864).Curated1
Sequence conflicti424S → T in CAA68351 (PubMed:3108864).Curated1
Sequence conflicti500T → S in CAA68351 (PubMed:3108864).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31109 mRNA Translation: AAA41280.1
Y00156 mRNA Translation: CAA68351.1
PIRiS07390
RefSeqiNP_695226.2, NM_153314.2
UniGeneiRn.24945

Genome annotation databases

GeneIDi266685
KEGGirno:266685
UCSCiRGD:628623 rat

Similar proteinsi

Entry informationi

Entry nameiUDB17_RAT
AccessioniPrimary (citable) accession number: P08542
Secondary accession number(s): P16915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 1, 1991
Last modified: February 28, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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