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UniProtKB - P08525 (QCR8_YEAST)

Entry version 176 (08 May 2019)
Sequence version 2 (01 Oct 1993)
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Protein

Cytochrome b-c1 complex subunit 8

Gene

QCR8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The complex couples electron transfer from ubiquinol to cytochrome c. QCR8, together with cytochrome b, binds to ubiquinone.

Miscellaneous

Present with 6140 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		YEAST:YJL166W-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-SCE-611105 Respiratory electron transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 8
Alternative name(s):
Complex III subunit 8
Complex III subunit VII
Ubiquinol-cytochrome c reductase complex 11 kDa protein
Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:QCR8
Ordered Locus Names:YJL166W
ORF Names:J0526
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		FungiDB:YJL166W

Saccharomyces Genome Database

More...SGDi		S000003702 QCR8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001935511 – 94Cytochrome b-c1 complex subunit 8Add BLAST94

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		P08525

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08525

PRoteomics IDEntifications database

More...PRIDEi		P08525

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P08525

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		33593, 317 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-567 Mitochondrial electron transport complex III

Database of interacting proteins

More...DIPi		DIP-4706N

Protein interaction database and analysis system

More...IntActi		P08525, 4 interactors

Molecular INTeraction database

More...MINTi		P08525

STRING: functional protein association networks

More...STRINGi		4932.YJL166W

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30G2-94[»]
1KB9X-ray2.30H2-94[»]
1KYOX-ray2.97H/S2-94[»]
1P84X-ray2.50H2-94[»]
2IBZX-ray2.30G1-94[»]
3CX5X-ray1.90H/S2-94[»]
3CXHX-ray2.50H/S2-94[»]
4PD4X-ray3.04H2-94[»]
6GIQelectron microscopy3.23H/S1-94[»]
6HU9electron microscopy3.35H/S2-94[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P08525

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P08525

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UQCRQ/QCR8 family.Curated

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004029

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000205681

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08525

KEGG Orthology (KO)

More...KOi		K00418

Identification of Orthologs from Complete Genome Data

More...OMAi		IFNTWRR

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.5.210, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004205 Cyt_bc1_su8
IPR036642 Cyt_bc1_su8_sf

The PANTHER Classification System

More...PANTHERi		PTHR12119 PTHR12119, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02939 UcrQ, 1 hit

ProDom; a protein domain database

More...ProDomi		View protein in ProDom or Entries sharing at least one domain
PD331499 UcrQ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81508 SSF81508, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P08525-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPPSGKTYM GWWGHMGGPK QKGITSYAVS PYAQKPLQGI FHNAVFNSFR 
        60         70         80         90 
RFKSQFLYVL IPAGIYWYWW KNGNEYNEFL YSKAGREELE RVNV
Length:94
Mass (Da):10,975
Last modified:October 1, 1993 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9CB828E495F6ED9E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X05550 Genomic DNA Translation: CAA29065.1
Z49441 Genomic DNA Translation: CAA89461.1
AY558554 Genomic DNA Translation: AAS56880.1
BK006943 Genomic DNA Translation: DAA08637.1

Protein sequence database of the Protein Information Resource

More...PIRi		S48138

NCBI Reference Sequences

More...RefSeqi		NP_012369.1, NM_001181599.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YJL166W_mRNA; YJL166W_mRNA; YJL166W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		853273

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YJL166W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05550 Genomic DNA Translation: CAA29065.1
Z49441 Genomic DNA Translation: CAA89461.1
AY558554 Genomic DNA Translation: AAS56880.1
BK006943 Genomic DNA Translation: DAA08637.1
PIRiS48138
RefSeqiNP_012369.1, NM_001181599.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EZVX-ray2.30G2-94[»]
1KB9X-ray2.30H2-94[»]
1KYOX-ray2.97H/S2-94[»]
1P84X-ray2.50H2-94[»]
2IBZX-ray2.30G1-94[»]
3CX5X-ray1.90H/S2-94[»]
3CXHX-ray2.50H/S2-94[»]
4PD4X-ray3.04H2-94[»]
6GIQelectron microscopy3.23H/S1-94[»]
6HU9electron microscopy3.35H/S2-94[»]
SMRiP08525
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33593, 317 interactors
ComplexPortaliCPX-567 Mitochondrial electron transport complex III
DIPiDIP-4706N
IntActiP08525, 4 interactors
MINTiP08525
STRINGi4932.YJL166W

Proteomic databases

MaxQBiP08525
PaxDbiP08525
PRIDEiP08525
TopDownProteomicsiP08525

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL166W_mRNA; YJL166W_mRNA; YJL166W
GeneIDi853273
KEGGisce:YJL166W

Organism-specific databases

EuPathDBiFungiDB:YJL166W
SGDiS000003702 QCR8

Phylogenomic databases

GeneTreeiENSGT00390000004029
HOGENOMiHOG000205681
InParanoidiP08525
KOiK00418
OMAiIFNTWRR

Enzyme and pathway databases

BioCyciYEAST:YJL166W-MONOMER
ReactomeiR-SCE-611105 Respiratory electron transport

Miscellaneous databases

EvolutionaryTraceiP08525

Protein Ontology

More...PROi		PR:P08525

Family and domain databases

Gene3Di1.20.5.210, 1 hit
InterProiView protein in InterPro
IPR004205 Cyt_bc1_su8
IPR036642 Cyt_bc1_su8_sf
PANTHERiPTHR12119 PTHR12119, 1 hit
PfamiView protein in Pfam
PF02939 UcrQ, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD331499 UcrQ, 1 hit
SUPFAMiSSF81508 SSF81508, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQCR8_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08525
Secondary accession number(s): D6VW21
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 1, 1993
Last modified: May 8, 2019
This is version 176 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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