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UniProtKB - P08515 (GST26_SCHJA)
Protein
Glutathione S-transferase class-mu 26 kDa isozyme
Gene
N/A
Organism
Schistosoma japonicum (Blood fluke)
Status
Functioni
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
Miscellaneous
There are at least two isoenzymes of GST in S.japonicum.
Catalytic activityi
- EC:2.5.1.18
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 111 | SubstrateCurated | 1 |
GO - Molecular functioni
- glutathione transferase activity Source: UniProtKB-EC
GO - Biological processi
- glutathione metabolic process Source: InterPro
Keywordsi
Molecular function | Transferase |
Enzyme and pathway databases
BRENDAi | 2.5.1.18, 5607 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione S-transferase class-mu 26 kDa isozyme (EC:2.5.1.18)Short name: GST 26 Alternative name(s): Sj26 antigen SjGST |
Organismi | Schistosoma japonicum (Blood fluke) |
Taxonomic identifieri | 6182 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Trematoda › Digenea › Strigeidida › Schistosomatoidea › Schistosomatidae › Schistosoma |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000185805 | 2 – 218 | Glutathione S-transferase class-mu 26 kDa isozymeAdd BLAST | 217 |
Proteomic databases
PRIDEi | P08515 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationStructurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SASBDBi | P08515 |
SMRi | P08515 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08515 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 83 | GST N-terminalAdd BLAST | 82 | |
Domaini | 85 – 203 | GST C-terminalAdd BLAST | 119 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 7 – 8 | Glutathione binding1 Publication1 Publication | 2 | |
Regioni | 41 – 45 | Glutathione binding1 Publication1 Publication | 5 | |
Regioni | 54 – 55 | Glutathione binding1 Publication1 Publication | 2 | |
Regioni | 67 – 68 | Glutathione binding1 Publication1 Publication | 2 |
Sequence similaritiesi
Family and domain databases
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF14497, GST_C_3, 1 hit PF02798, GST_N, 1 hit |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P08515-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL
60 70 80 90 100
EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL
110 120 130 140 150
DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH
160 170 180 190 200
PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA
210
WPLQGWQATF GGGDHPPK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14654 mRNA Translation: AAB59203.1 |
PIRi | A61514 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14654 mRNA Translation: AAB59203.1 |
PIRi | A61514 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B8X | X-ray | 2.70 | A | 2-218 | [»] | |
1BG5 | X-ray | 2.60 | A | 1-218 | [»] | |
1DUG | X-ray | 1.80 | A/B | 2-218 | [»] | |
1GNE | X-ray | 2.50 | A | 2-218 | [»] | |
1GTA | X-ray | 2.40 | A | 1-218 | [»] | |
1GTB | X-ray | 2.60 | A | 1-218 | [»] | |
1M99 | X-ray | 2.30 | A | 1-218 | [»] | |
1M9A | X-ray | 2.10 | A | 1-218 | [»] | |
1M9B | X-ray | 2.60 | A | 1-218 | [»] | |
1U87 | X-ray | 3.50 | A | 1-218 | [»] | |
1U88 | X-ray | 3.50 | A/B | 1-218 | [»] | |
1UA5 | X-ray | 2.50 | A | 1-218 | [»] | |
1Y6E | X-ray | 3.00 | A/B | 2-218 | [»] | |
3CRT | X-ray | 1.90 | A | 1-214 | [»] | |
3CRU | X-ray | 2.30 | A | 1-214 | [»] | |
3D0Z | X-ray | 2.50 | A | 1-214 | [»] | |
3QMZ | X-ray | 6.00 | S/T | 2-218 | [»] | |
4AI6 | X-ray | 3.40 | A/B | 2-218 | [»] | |
4AKG | X-ray | 3.30 | A/B | 2-218 | [»] | |
4AKH | X-ray | 3.60 | A/B | 2-218 | [»] | |
4AKI | X-ray | 3.70 | A/B | 2-218 | [»] | |
4ECB | X-ray | 2.20 | A/B | 1-218 | [»] | |
4ECC | X-ray | 2.20 | A | 1-215 | [»] | |
4WR4 | X-ray | 1.60 | A | 2-218 | [»] | |
4WR5 | X-ray | 1.93 | A | 2-218 | [»] | |
5GZZ | X-ray | 2.39 | B/C/D/E/F/G | 1-218 | [»] | |
6JI6 | X-ray | 1.50 | A | 1-218 | [»] | |
6N8U | X-ray | 1.96 | A/B | 1-218 | [»] | |
6RWD | X-ray | 1.53 | A/B | 1-218 | [»] | |
7NT8 | X-ray | 2.22 | A/B | 1-218 | [»] | |
SASBDBi | P08515 | |||||
SMRi | P08515 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
DrugCentrali | P08515 |
Proteomic databases
PRIDEi | P08515 |
Protocols and materials databases
ABCDi | P08515, 23 sequenced antibodies |
Enzyme and pathway databases
BRENDAi | 2.5.1.18, 5607 |
Miscellaneous databases
EvolutionaryTracei | P08515 |
Family and domain databases
InterProi | View protein in InterPro IPR010987, Glutathione-S-Trfase_C-like IPR036282, Glutathione-S-Trfase_C_sf IPR040079, Glutathione_S-Trfase IPR004045, Glutathione_S-Trfase_N IPR004046, GST_C IPR036249, Thioredoxin-like_sf |
Pfami | View protein in Pfam PF14497, GST_C_3, 1 hit PF02798, GST_N, 1 hit |
SFLDi | SFLDS00019, Glutathione_Transferase_(cytos, 1 hit |
SUPFAMi | SSF47616, SSF47616, 1 hit SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS50405, GST_CTER, 1 hit PS50404, GST_NTER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GST26_SCHJA | |
Accessioni | P08515Primary (citable) accession number: P08515 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 137 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families