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Protein

Potassium voltage-gated channel protein Shaker

Gene

Sh

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Forms rapidly inactivating tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient and may contribute to A-type currents (PubMed:2448636). Plays a role in the regulation of sleep need or efficiency (PubMed:15858564).2 Publications

GO - Molecular functioni

  • voltage-gated cation channel activity Source: FlyBase
  • voltage-gated potassium channel activity Source: FlyBase

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-DME-1296072 Voltage gated Potassium channels

Protein family/group databases

TCDBi1.A.1.2.6 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel protein Shaker
Alternative name(s):
Protein minisleep
Gene namesi
Name:Sh
Synonyms:mns
ORF Names:CG12348
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0003380 Sh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 224CytoplasmicBy similarityAdd BLAST224
Transmembranei225 – 246Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini247 – 278ExtracellularBy similarityAdd BLAST32
Transmembranei279 – 300Helical; Name=Segment S2By similarityAdd BLAST22
Topological domaini301 – 311CytoplasmicBy similarityAdd BLAST11
Transmembranei312 – 332Helical; Name=Segment S3By similarityAdd BLAST21
Topological domaini333 – 357ExtracellularBy similarityAdd BLAST25
Transmembranei358 – 378Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini379 – 393CytoplasmicBy similarityAdd BLAST15
Transmembranei394 – 415Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini416 – 429ExtracellularBy similarityAdd BLAST14
Intramembranei430 – 441Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei442 – 449By similarity8
Topological domaini450 – 456ExtracellularBy similarity7
Transmembranei457 – 485Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini486 – 655CytoplasmicBy similarityAdd BLAST170

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Reduced sleep. Flies sleep for one-third of the wild-type amount. They perform normally in a number of tasks, have preserved sleep homeostasis, but are not impaired by sleep deprivation. They also have a reduced lifespan.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi248T → I in mns; flies display reduced sleep. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000539631 – 655Potassium voltage-gated channel protein ShakerAdd BLAST655

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi259N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi263N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP08510
PRIDEiP08510

PTM databases

iPTMnetiP08510

Expressioni

Gene expression databases

BgeeiFBgn0003380 Expressed in 15 organ(s), highest expression level in brain
ExpressionAtlasiP08510 baseline and differential
GenevisibleiP08510 DM

Interactioni

Subunit structurei

Homotetramer or heterotetramer of potassium channel proteins.Curated

Binary interactionsi

WithEntry#Exp.IntActNotes
dlg1P310073EBI-85074,EBI-389374

Protein-protein interaction databases

BioGridi59101, 16 interactors
DIPiDIP-41151N
IntActiP08510, 5 interactors
MINTiP08510
STRINGi7227.FBpp0088599

Structurei

Secondary structure

1655
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08510
SMRiP08510
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08510

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 188Tetramerization domainBy similarityAdd BLAST188
Regioni380 – 393S4-S5 linkerBy similarityAdd BLAST14

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi442 – 447Selectivity filterBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 53Gln-richAdd BLAST39
Compositional biasi558 – 619Gln-richAdd BLAST62
Compositional biasi625 – 630Poly-Ala6

Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1545 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118846
InParanoidiP08510
KOiK04874
OMAiPEPDHEC
OrthoDBiEOG091G10NU
PhylomeDBiP08510

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform E (identifier: P08510-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVAGLYGL GEDRQHRKKQ QQQQQHQKEQ LEQKEEQKKI AERKLQLREQ
60 70 80 90 100
QLQRNSLDGY GSLPKLSSQD EEGGAGHGFG GGPQHFEPIP HDHDFCERVV
110 120 130 140 150
INVSGLRFET QLRTLNQFPD TLLGDPARRL RYFDPLRNEY FFDRSRPSFD
160 170 180 190 200
AILYYYQSGG RLRRPVNVPL DVFSEEIKFY ELGDQAINKF REDEGFIKEE
210 220 230 240 250
ERPLPDNEKQ RKVWLLFEYP ESSQAARVVA IISVFVILLS IVIFCLETLP
260 270 280 290 300
EFKHYKVFNT TTNGTKIEED EVPDITDPFF LIETLCIIWF TFELTVRFLA
310 320 330 340 350
CPNKLNFCRD VMNVIDIIAI IPYFITLATV VAEEEDTLNL PKAPVSPQDK
360 370 380 390 400
SSNQAMSLAI LRVIRLVRVF RIFKLSRHSK GLQILGRTLK ASMRELGLLI
410 420 430 440 450
FFLFIGVVLF SSAVYFAEAG SENSFFKSIP DAFWWAVVTM TTVGYGDMTP
460 470 480 490 500
VGVWGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETD QEEMQSQNFN
510 520 530 540 550
HVTSCPYLPG TLGQHMKKSS LSESSSDMMD LDDGVESTPG LTETHPGRSA
560 570 580 590 600
VAPFLGAQQQ QQQPVASSLS MSIDKQLQHP LQQLTQTQLY QQQQQQQQQQ
610 620 630 640 650
QNGFKQQQQQ TQQQLQQQQS HTINASAAAA TSGSGSSGLT MRHNNALAVS

IETDV
Length:655
Mass (Da):74,193
Last modified:April 4, 2006 - v3
Checksum:i5833E3052C9D19B3
GO
Isoform Alpha (identifier: P08510-2) [UniParc]FASTAAdd to basket
Also known as: B, Adult

The sequence of this isoform differs from the canonical sequence as follows:
     453-463: VWGKIVGSLCA → FWGKIVGSLCV
     506-655: PYLPGTLGQH...ALAVSIETDV → SYLPGALGQH...AMAVSIETDV

Show »
Length:616
Mass (Da):70,281
Checksum:iB6453435442CB513
GO
Isoform Beta (identifier: P08510-3) [UniParc]FASTAAdd to basket
Also known as: C, I, J, Late population

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MAAVAGLYGL...LQRNSLDGYG → MTMWQSGGMG...SGSNERNLNQ

Show »
Length:643
Mass (Da):72,501
Checksum:iE1F358B5555496D2
GO
Isoform Delta (identifier: P08510-5) [UniParc]FASTAAdd to basket
Also known as: Larval, A, H

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MAAVAGLYGL...LQRNSLDGYG → MAHITTTHGSLSQATR
     349-349: D → V
     350-655: Missing.

Show »
Length:304
Mass (Da):34,946
Checksum:i05898ADD605604B5
GO
Isoform Epsilon (identifier: P08510-6) [UniParc]FASTAAdd to basket
Also known as: Larval, F

The sequence of this isoform differs from the canonical sequence as follows:
     349-349: D → V
     350-655: Missing.

Show »
Length:349
Mass (Da):40,493
Checksum:iB509504C2D3EE550
GO
Isoform D (identifier: P08510-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MAAVAGLYGL...LQRNSLDGYG → MAHITTTHGSLSQATR
     453-463: VWGKIVGSLCA → FWGKIVGSLCV
     506-655: PYLPGTLGQH...ALAVSIETDV → SYLPGALGQH...AMAVSIETDV

Note: No experimental confirmation available.
Show »
Length:571
Mass (Da):64,734
Checksum:i7CFF19956D54D599
GO
Isoform N (identifier: P08510-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-655: VVLFSSAVYF...ALAVSIETDV → KFHTVNKKKK...IKTTTKDTYI

Note: No experimental confirmation available.
Show »
Length:505
Mass (Da):58,751
Checksum:i5F0D4BCB5FA4F23D
GO
Isoform L (identifier: P08510-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MAAVAGLYGL...LQRNSLDGYG → MTMWQSGGMG...SGSNERNLNQ
     512-512: L → LV

Note: No experimental confirmation available.
Show »
Length:644
Mass (Da):72,600
Checksum:iA9B6FD52794B82C3
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0S0X7Z4A0A0S0X7Z4_DROME
Shaker, isoform T
Sh BcDNA:GH03046, CG12348, CG17860, CG7640, Dmel\CG12348 Sh BcDNA:GH03046, CG12348, CG17860, CG7640, Dmel\CG12348, EKO, Eko, F-c, K[[v]]1, Kv1, minisleep, SH, sh, Sha, sha, Shw, V-I, CG12348, Dmel_CG12348
655Annotation score:
E1JJQ5E1JJQ5_DROME
Shaker, isoform H
Sh BcDNA:GH03046, CG12348, CG17860, CG7640, Dmel\CG12348 Sh BcDNA:GH03046, CG12348, CG17860, CG7640, Dmel\CG12348, EKO, Eko, F-c, K[[v]]1, Kv1, minisleep, SH, sh, Sha, sha, Shw, V-I, CG12348, Dmel_CG12348
304Annotation score:
M9PHG6M9PHG6_DROME
Shaker, isoform S
Sh BcDNA:GH03046, CG12348, CG17860, CG7640, Dmel\CG12348 Sh BcDNA:GH03046, CG12348, CG17860, CG7640, Dmel\CG12348, EKO, Eko, F-c, K[[v]]1, Kv1, minisleep, SH, sh, Sha, sha, Shw, V-I, CG12348, Dmel_CG12348
604Annotation score:
M9PJQ4M9PJQ4_DROME
Shaker, isoform M
Sh BcDNA:GH03046, CG12348, CG17860, CG7640, Dmel\CG12348 Sh BcDNA:GH03046, CG12348, CG17860, CG7640, Dmel\CG12348, EKO, Eko, F-c, K[[v]]1, Kv1, minisleep, SH, sh, Sha, sha, Shw, V-I, CG12348, Dmel_CG12348
337Annotation score:
M9NGK2M9NGK2_DROME
Shaker, isoform K
Sh BcDNA:GH03046, CG12348, CG17860, CG7640, Dmel\CG12348 Sh BcDNA:GH03046, CG12348, CG17860, CG7640, Dmel\CG12348, EKO, Eko, F-c, K[[v]]1, Kv1, minisleep, SH, sh, Sha, sha, Shw, V-I, CG12348, Dmel_CG12348
297Annotation score:

Sequence cautioni

The sequence AAA70217 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti563Q → QQ in CAA29917 (PubMed:2448635).Curated1
Sequence conflicti583 – 584QL → HV in CAA29917 (PubMed:2448635).Curated2

RNA editingi

Edited at positions 178, 360, 464, 489 and 491.1 Publication
Partially edited.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti178K → E in RNA edited version. 1
Natural varianti178K → G in RNA edited version. 1
Natural varianti178K → R in RNA edited version. 1
Natural varianti360I → M in RNA edited version. 1
Natural varianti464I → V in RNA edited version. 1
Natural varianti489T → A in RNA edited version. 1
Natural varianti491Q → R in RNA edited version. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0009541 – 61MAAVA…LDGYG → MTMWQSGGMGGHGSQNNPWM KLMGIVHKERRHTENVQSQS GSNERNLNQ in isoform Beta and isoform L. 3 PublicationsAdd BLAST61
Alternative sequenceiVSP_0009561 – 61MAAVA…LDGYG → MAHITTTHGSLSQATR in isoform Delta and isoform D. 4 PublicationsAdd BLAST61
Alternative sequenceiVSP_000957349D → V in isoform Delta and isoform Epsilon. 2 Publications1
Alternative sequenceiVSP_000958350 – 655Missing in isoform Delta and isoform Epsilon. 2 PublicationsAdd BLAST306
Alternative sequenceiVSP_054719407 – 655VVLFS…IETDV → KFHTVNKKKKNNIPHLLIDL RVLFKQHQKQKRNTAKRLRP SRQTYPRYPAPSKDIFSTTS HCPKVLIHILTVNRSKTTYN YSGIVQRSRIKTTTKDTYI in isoform N. CuratedAdd BLAST249
Alternative sequenceiVSP_017889453 – 463VWGKIVGSLCA → FWGKIVGSLCV in isoform Alpha and isoform D. 5 PublicationsAdd BLAST11
Alternative sequenceiVSP_000959506 – 655PYLPG…IETDV → SYLPGALGQHLKKSSLSESS SDIMDLDDGIDATTPGLTDH TGRHMVPFLRTQQSFEKQQL QLQLQLQQQSQSPHGQQMTQ QQQLGQNGLRSTNSLQLRHN NAMAVSIETDV in isoform Alpha and isoform D. 5 PublicationsAdd BLAST150
Alternative sequenceiVSP_054720512L → LV in isoform L. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17211 mRNA Translation: AAA28417.1
X06184 mRNA Translation: CAA29549.1
X07131 mRNA Translation: CAA30143.1
X07132 mRNA Translation: CAA30144.1
X07133 mRNA Translation: CAA30145.1
X07134 mRNA Translation: CAA30146.1
X06742 mRNA Translation: CAA29917.1
AE014298 Genomic DNA Translation: AAF48785.3
AE014298 Genomic DNA Translation: AAF48786.3
AE014298 Genomic DNA Translation: AAF48790.2
AE014298 Genomic DNA Translation: AAN09451.1
AE014298 Genomic DNA Translation: AAN09452.1
AE014298 Genomic DNA Translation: AAS65395.2
AE014298 Genomic DNA Translation: AAS65396.1
AE014298 Genomic DNA Translation: ADV37750.1
AE014298 Genomic DNA Translation: AFH07440.1
AE014298 Genomic DNA Translation: AGB95507.1
AY118398 mRNA Translation: AAM48427.1
BT050432 mRNA Translation: ACJ13139.1
M17155 mRNA Translation: AAA70217.1 Frameshift.
X78908 Genomic DNA Translation: CAA55519.1
PIRiA27159
JH0193
S00480
S02284
RefSeqiNP_001162788.1, NM_001169317.1 [P08510-5]
NP_001188668.1, NM_001201739.2 [P08510-3]
NP_001245727.1, NM_001258798.2 [P08510-9]
NP_001259665.2, NM_001272736.2 [P08510-2]
NP_523393.3, NM_078669.5 [P08510-2]
NP_728120.1, NM_167592.4 [P08510-7]
NP_728122.1, NM_167594.4 [P08510-3]
NP_728123.1, NM_167595.4 [P08510-1]
NP_728124.1, NM_167596.5 [P08510-5]
NP_996497.1, NM_206774.2 [P08510-6]
NP_996498.2, NM_206775.5 [P08510-3]
UniGeneiDm.7088

Genome annotation databases

EnsemblMetazoaiFBtr0089657; FBpp0088599; FBgn0003380 [P08510-1]
FBtr0089658; FBpp0088600; FBgn0003380 [P08510-2]
FBtr0089659; FBpp0088601; FBgn0003380 [P08510-5]
FBtr0089660; FBpp0088602; FBgn0003380 [P08510-7]
FBtr0089661; FBpp0088603; FBgn0003380 [P08510-3]
FBtr0089663; FBpp0088605; FBgn0003380 [P08510-6]
FBtr0301955; FBpp0291167; FBgn0003380 [P08510-5]
FBtr0302902; FBpp0292033; FBgn0003380 [P08510-3]
FBtr0302903; FBpp0292034; FBgn0003380 [P08510-3]
FBtr0308200; FBpp0300520; FBgn0003380 [P08510-9]
FBtr0346703; FBpp0312316; FBgn0003380 [P08510-2]
GeneIDi32780
KEGGidme:Dmel_CG12348
UCSCiCG12348-RG d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing, RNA editing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17211 mRNA Translation: AAA28417.1
X06184 mRNA Translation: CAA29549.1
X07131 mRNA Translation: CAA30143.1
X07132 mRNA Translation: CAA30144.1
X07133 mRNA Translation: CAA30145.1
X07134 mRNA Translation: CAA30146.1
X06742 mRNA Translation: CAA29917.1
AE014298 Genomic DNA Translation: AAF48785.3
AE014298 Genomic DNA Translation: AAF48786.3
AE014298 Genomic DNA Translation: AAF48790.2
AE014298 Genomic DNA Translation: AAN09451.1
AE014298 Genomic DNA Translation: AAN09452.1
AE014298 Genomic DNA Translation: AAS65395.2
AE014298 Genomic DNA Translation: AAS65396.1
AE014298 Genomic DNA Translation: ADV37750.1
AE014298 Genomic DNA Translation: AFH07440.1
AE014298 Genomic DNA Translation: AGB95507.1
AY118398 mRNA Translation: AAM48427.1
BT050432 mRNA Translation: ACJ13139.1
M17155 mRNA Translation: AAA70217.1 Frameshift.
X78908 Genomic DNA Translation: CAA55519.1
PIRiA27159
JH0193
S00480
S02284
RefSeqiNP_001162788.1, NM_001169317.1 [P08510-5]
NP_001188668.1, NM_001201739.2 [P08510-3]
NP_001245727.1, NM_001258798.2 [P08510-9]
NP_001259665.2, NM_001272736.2 [P08510-2]
NP_523393.3, NM_078669.5 [P08510-2]
NP_728120.1, NM_167592.4 [P08510-7]
NP_728122.1, NM_167594.4 [P08510-3]
NP_728123.1, NM_167595.4 [P08510-1]
NP_728124.1, NM_167596.5 [P08510-5]
NP_996497.1, NM_206774.2 [P08510-6]
NP_996498.2, NM_206775.5 [P08510-3]
UniGeneiDm.7088

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HO2NMR-A378-397[»]
1HO7NMR-A378-397[»]
ProteinModelPortaliP08510
SMRiP08510
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59101, 16 interactors
DIPiDIP-41151N
IntActiP08510, 5 interactors
MINTiP08510
STRINGi7227.FBpp0088599

Protein family/group databases

TCDBi1.A.1.2.6 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiP08510

Proteomic databases

PaxDbiP08510
PRIDEiP08510

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089657; FBpp0088599; FBgn0003380 [P08510-1]
FBtr0089658; FBpp0088600; FBgn0003380 [P08510-2]
FBtr0089659; FBpp0088601; FBgn0003380 [P08510-5]
FBtr0089660; FBpp0088602; FBgn0003380 [P08510-7]
FBtr0089661; FBpp0088603; FBgn0003380 [P08510-3]
FBtr0089663; FBpp0088605; FBgn0003380 [P08510-6]
FBtr0301955; FBpp0291167; FBgn0003380 [P08510-5]
FBtr0302902; FBpp0292033; FBgn0003380 [P08510-3]
FBtr0302903; FBpp0292034; FBgn0003380 [P08510-3]
FBtr0308200; FBpp0300520; FBgn0003380 [P08510-9]
FBtr0346703; FBpp0312316; FBgn0003380 [P08510-2]
GeneIDi32780
KEGGidme:Dmel_CG12348
UCSCiCG12348-RG d. melanogaster

Organism-specific databases

CTDi32780
FlyBaseiFBgn0003380 Sh

Phylogenomic databases

eggNOGiKOG1545 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118846
InParanoidiP08510
KOiK04874
OMAiPEPDHEC
OrthoDBiEOG091G10NU
PhylomeDBiP08510

Enzyme and pathway databases

ReactomeiR-DME-1296072 Voltage gated Potassium channels

Miscellaneous databases

ChiTaRSiSh fly
EvolutionaryTraceiP08510
GenomeRNAii32780
PROiPR:P08510

Gene expression databases

BgeeiFBgn0003380 Expressed in 15 organ(s), highest expression level in brain
ExpressionAtlasiP08510 baseline and differential
GenevisibleiP08510 DM

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCNAS_DROME
AccessioniPrimary (citable) accession number: P08510
Secondary accession number(s): A4V4Q2
, B6IDJ2, M9MSC0, M9NEM4, M9PF21, P08511, P08512, P08513, Q24277, Q24521, Q7KUW5, Q8IQY9, Q8MT41, Q9VWZ5, Q9VWZ9, Q9VX00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: April 4, 2006
Last modified: September 12, 2018
This is version 210 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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