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Protein

Potassium voltage-gated channel protein Shaker

Gene

Sh

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Forms rapidly inactivating tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient and may contribute to A-type currents (PubMed:2448636). Plays a role in the regulation of sleep need or efficiency (PubMed:15858564).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • delayed rectifier potassium channel activity Source: GO_Central
  • voltage-gated cation channel activity Source: FlyBase
  • voltage-gated potassium channel activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1296072 Voltage gated Potassium channels

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.1.2.6 the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium voltage-gated channel protein Shaker
Alternative name(s):
Protein minisleep
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sh
Synonyms:mns
ORF Names:CG12348
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003380 Sh

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 224CytoplasmicBy similarityAdd BLAST224
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei225 – 246Helical; Name=Segment S1By similarityAdd BLAST22
Topological domaini247 – 278ExtracellularBy similarityAdd BLAST32
Transmembranei279 – 300Helical; Name=Segment S2By similarityAdd BLAST22
Topological domaini301 – 311CytoplasmicBy similarityAdd BLAST11
Transmembranei312 – 332Helical; Name=Segment S3By similarityAdd BLAST21
Topological domaini333 – 357ExtracellularBy similarityAdd BLAST25
Transmembranei358 – 378Helical; Voltage-sensor; Name=Segment S4By similarityAdd BLAST21
Topological domaini379 – 393CytoplasmicBy similarityAdd BLAST15
Transmembranei394 – 415Helical; Name=Segment S5By similarityAdd BLAST22
Topological domaini416 – 429ExtracellularBy similarityAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei430 – 441Helical; Name=Pore helixBy similarityAdd BLAST12
Intramembranei442 – 449By similarity8
Topological domaini450 – 456ExtracellularBy similarity7
Transmembranei457 – 485Helical; Name=Segment S6By similarityAdd BLAST29
Topological domaini486 – 655CytoplasmicBy similarityAdd BLAST170

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Reduced sleep. Flies sleep for one-third of the wild-type amount. They perform normally in a number of tasks, have preserved sleep homeostasis, but are not impaired by sleep deprivation. They also have a reduced lifespan.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi248T → I in mns; flies display reduced sleep. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000539631 – 655Potassium voltage-gated channel protein ShakerAdd BLAST655

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi259N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi263N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P08510

PRoteomics IDEntifications database

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PRIDEi
P08510

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P08510

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0003380 Expressed in 15 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P08510 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P08510 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer or heterotetramer of potassium channel proteins.Curated

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
dlg1P310073EBI-85074,EBI-389374

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
59101, 16 interactors

Database of interacting proteins

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DIPi
DIP-41151N

Protein interaction database and analysis system

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IntActi
P08510, 5 interactors

Molecular INTeraction database

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MINTi
P08510

STRING: functional protein association networks

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STRINGi
7227.FBpp0088599

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1655
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HO2NMR-A378-397[»]
1HO7NMR-A378-397[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P08510

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P08510

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P08510

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 188Tetramerization domainBy similarityAdd BLAST188
Regioni380 – 393S4-S5 linkerBy similarityAdd BLAST14

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi442 – 447Selectivity filterBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 53Gln-richAdd BLAST39
Compositional biasi558 – 619Gln-richAdd BLAST62
Compositional biasi625 – 630Poly-Ala6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1545 Eukaryota
COG1226 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000170670

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P08510

KEGG Orthology (KO)

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KOi
K04874

Identification of Orthologs from Complete Genome Data

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OMAi
GMTFHTY

Database for complete collections of gene phylogenies

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PhylomeDBi
P08510

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.120.350, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR11537 PTHR11537, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00169 KCHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform E (identifier: P08510-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVAGLYGL GEDRQHRKKQ QQQQQHQKEQ LEQKEEQKKI AERKLQLREQ
60 70 80 90 100
QLQRNSLDGY GSLPKLSSQD EEGGAGHGFG GGPQHFEPIP HDHDFCERVV
110 120 130 140 150
INVSGLRFET QLRTLNQFPD TLLGDPARRL RYFDPLRNEY FFDRSRPSFD
160 170 180 190 200
AILYYYQSGG RLRRPVNVPL DVFSEEIKFY ELGDQAINKF REDEGFIKEE
210 220 230 240 250
ERPLPDNEKQ RKVWLLFEYP ESSQAARVVA IISVFVILLS IVIFCLETLP
260 270 280 290 300
EFKHYKVFNT TTNGTKIEED EVPDITDPFF LIETLCIIWF TFELTVRFLA
310 320 330 340 350
CPNKLNFCRD VMNVIDIIAI IPYFITLATV VAEEEDTLNL PKAPVSPQDK
360 370 380 390 400
SSNQAMSLAI LRVIRLVRVF RIFKLSRHSK GLQILGRTLK ASMRELGLLI
410 420 430 440 450
FFLFIGVVLF SSAVYFAEAG SENSFFKSIP DAFWWAVVTM TTVGYGDMTP
460 470 480 490 500
VGVWGKIVGS LCAIAGVLTI ALPVPVIVSN FNYFYHRETD QEEMQSQNFN
510 520 530 540 550
HVTSCPYLPG TLGQHMKKSS LSESSSDMMD LDDGVESTPG LTETHPGRSA
560 570 580 590 600
VAPFLGAQQQ QQQPVASSLS MSIDKQLQHP LQQLTQTQLY QQQQQQQQQQ
610 620 630 640 650
QNGFKQQQQQ TQQQLQQQQS HTINASAAAA TSGSGSSGLT MRHNNALAVS

IETDV
Length:655
Mass (Da):74,193
Last modified:April 4, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5833E3052C9D19B3
GO
Isoform Alpha (identifier: P08510-2) [UniParc]FASTAAdd to basket
Also known as: B, Adult

The sequence of this isoform differs from the canonical sequence as follows:
     453-463: VWGKIVGSLCA → FWGKIVGSLCV
     506-655: PYLPGTLGQH...ALAVSIETDV → SYLPGALGQH...AMAVSIETDV

Show »
Length:616
Mass (Da):70,281
Checksum:iB6453435442CB513
GO
Isoform Beta (identifier: P08510-3) [UniParc]FASTAAdd to basket
Also known as: C, I, J, Late population

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MAAVAGLYGL...LQRNSLDGYG → MTMWQSGGMG...SGSNERNLNQ

Show »
Length:643
Mass (Da):72,501
Checksum:iE1F358B5555496D2
GO
Isoform Delta (identifier: P08510-5) [UniParc]FASTAAdd to basket
Also known as: Larval, A, H

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MAAVAGLYGL...LQRNSLDGYG → MAHITTTHGSLSQATR
     349-349: D → V
     350-655: Missing.

Show »
Length:304
Mass (Da):34,946
Checksum:i05898ADD605604B5
GO
Isoform Epsilon (identifier: P08510-6) [UniParc]FASTAAdd to basket
Also known as: Larval, F

The sequence of this isoform differs from the canonical sequence as follows:
     349-349: D → V
     350-655: Missing.

Show »
Length:349
Mass (Da):40,493
Checksum:iB509504C2D3EE550
GO
Isoform D (identifier: P08510-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MAAVAGLYGL...LQRNSLDGYG → MAHITTTHGSLSQATR
     453-463: VWGKIVGSLCA → FWGKIVGSLCV
     506-655: PYLPGTLGQH...ALAVSIETDV → SYLPGALGQH...AMAVSIETDV

Note: No experimental confirmation available.
Show »
Length:571
Mass (Da):64,734
Checksum:i7CFF19956D54D599
GO
Isoform N (identifier: P08510-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     407-655: VVLFSSAVYF...ALAVSIETDV → KFHTVNKKKK...IKTTTKDTYI

Note: No experimental confirmation available.
Show »
Length:505
Mass (Da):58,751
Checksum:i5F0D4BCB5FA4F23D
GO
Isoform L (identifier: P08510-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: MAAVAGLYGL...LQRNSLDGYG → MTMWQSGGMG...SGSNERNLNQ
     512-512: L → LV

Note: No experimental confirmation available.
Show »
Length:644
Mass (Da):72,600
Checksum:iA9B6FD52794B82C3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0S0X7Z4A0A0S0X7Z4_DROME
Shaker, isoform T
Sh BcDNA:GH03046, CG17860, CG7640, Dmel\CG12348, EKO
655Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JJQ5E1JJQ5_DROME
Shaker, isoform H
Sh BcDNA:GH03046, CG17860, CG7640, Dmel\CG12348, EKO
304Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PHG6M9PHG6_DROME
Shaker, isoform S
Sh BcDNA:GH03046, CG17860, CG7640, Dmel\CG12348, EKO
604Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PJQ4M9PJQ4_DROME
Shaker, isoform M
Sh BcDNA:GH03046, CG17860, CG7640, Dmel\CG12348, EKO
337Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9NGK2M9NGK2_DROME
Shaker, isoform K
Sh BcDNA:GH03046, CG17860, CG7640, Dmel\CG12348, EKO
297Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA70217 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti563Q → QQ in CAA29917 (PubMed:2448635).Curated1
Sequence conflicti583 – 584QL → HV in CAA29917 (PubMed:2448635).Curated2

<p>This subsection of the ‘Sequence’ section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Edited at positions 178, 360, 464, 489 and 491.1 Publication
Partially edited.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti178K → E in RNA edited version. 1
Natural varianti178K → G in RNA edited version. 1
Natural varianti178K → R in RNA edited version. 1
Natural varianti360I → M in RNA edited version. 1
Natural varianti464I → V in RNA edited version. 1
Natural varianti489T → A in RNA edited version. 1
Natural varianti491Q → R in RNA edited version. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0009541 – 61MAAVA…LDGYG → MTMWQSGGMGGHGSQNNPWM KLMGIVHKERRHTENVQSQS GSNERNLNQ in isoform Beta and isoform L. 3 PublicationsAdd BLAST61
Alternative sequenceiVSP_0009561 – 61MAAVA…LDGYG → MAHITTTHGSLSQATR in isoform Delta and isoform D. 4 PublicationsAdd BLAST61
Alternative sequenceiVSP_000957349D → V in isoform Delta and isoform Epsilon. 2 Publications1
Alternative sequenceiVSP_000958350 – 655Missing in isoform Delta and isoform Epsilon. 2 PublicationsAdd BLAST306
Alternative sequenceiVSP_054719407 – 655VVLFS…IETDV → KFHTVNKKKKNNIPHLLIDL RVLFKQHQKQKRNTAKRLRP SRQTYPRYPAPSKDIFSTTS HCPKVLIHILTVNRSKTTYN YSGIVQRSRIKTTTKDTYI in isoform N. CuratedAdd BLAST249
Alternative sequenceiVSP_017889453 – 463VWGKIVGSLCA → FWGKIVGSLCV in isoform Alpha and isoform D. 5 PublicationsAdd BLAST11
Alternative sequenceiVSP_000959506 – 655PYLPG…IETDV → SYLPGALGQHLKKSSLSESS SDIMDLDDGIDATTPGLTDH TGRHMVPFLRTQQSFEKQQL QLQLQLQQQSQSPHGQQMTQ QQQLGQNGLRSTNSLQLRHN NAMAVSIETDV in isoform Alpha and isoform D. 5 PublicationsAdd BLAST150
Alternative sequenceiVSP_054720512L → LV in isoform L. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M17211 mRNA Translation: AAA28417.1
X06184 mRNA Translation: CAA29549.1
X07131 mRNA Translation: CAA30143.1
X07132 mRNA Translation: CAA30144.1
X07133 mRNA Translation: CAA30145.1
X07134 mRNA Translation: CAA30146.1
X06742 mRNA Translation: CAA29917.1
AE014298 Genomic DNA Translation: AAF48785.3
AE014298 Genomic DNA Translation: AAF48786.3
AE014298 Genomic DNA Translation: AAF48790.2
AE014298 Genomic DNA Translation: AAN09451.1
AE014298 Genomic DNA Translation: AAN09452.1
AE014298 Genomic DNA Translation: AAS65395.2
AE014298 Genomic DNA Translation: AAS65396.1
AE014298 Genomic DNA Translation: ADV37750.1
AE014298 Genomic DNA Translation: AFH07440.1
AE014298 Genomic DNA Translation: AGB95507.1
AY118398 mRNA Translation: AAM48427.1
BT050432 mRNA Translation: ACJ13139.1
M17155 mRNA Translation: AAA70217.1 Frameshift.
X78908 Genomic DNA Translation: CAA55519.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A27159
JH0193
S00480
S02284

NCBI Reference Sequences

More...
RefSeqi
NP_001162788.1, NM_001169317.1 [P08510-5]
NP_001188668.1, NM_001201739.2 [P08510-3]
NP_001245727.1, NM_001258798.2 [P08510-9]
NP_001259665.2, NM_001272736.2 [P08510-2]
NP_523393.3, NM_078669.5 [P08510-2]
NP_728120.1, NM_167592.4 [P08510-7]
NP_728122.1, NM_167594.4 [P08510-3]
NP_728123.1, NM_167595.4 [P08510-1]
NP_728124.1, NM_167596.5 [P08510-5]
NP_996497.1, NM_206774.2 [P08510-6]
NP_996498.2, NM_206775.5 [P08510-3]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.7088

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0089657; FBpp0088599; FBgn0003380 [P08510-1]
FBtr0089658; FBpp0088600; FBgn0003380 [P08510-2]
FBtr0089659; FBpp0088601; FBgn0003380 [P08510-5]
FBtr0089660; FBpp0088602; FBgn0003380 [P08510-7]
FBtr0089661; FBpp0088603; FBgn0003380 [P08510-3]
FBtr0089663; FBpp0088605; FBgn0003380 [P08510-6]
FBtr0301955; FBpp0291167; FBgn0003380 [P08510-5]
FBtr0302902; FBpp0292033; FBgn0003380 [P08510-3]
FBtr0302903; FBpp0292034; FBgn0003380 [P08510-3]
FBtr0308200; FBpp0300520; FBgn0003380 [P08510-9]
FBtr0346703; FBpp0312316; FBgn0003380 [P08510-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
32780

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG12348

UCSC genome browser

More...
UCSCi
CG12348-RG d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing, RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17211 mRNA Translation: AAA28417.1
X06184 mRNA Translation: CAA29549.1
X07131 mRNA Translation: CAA30143.1
X07132 mRNA Translation: CAA30144.1
X07133 mRNA Translation: CAA30145.1
X07134 mRNA Translation: CAA30146.1
X06742 mRNA Translation: CAA29917.1
AE014298 Genomic DNA Translation: AAF48785.3
AE014298 Genomic DNA Translation: AAF48786.3
AE014298 Genomic DNA Translation: AAF48790.2
AE014298 Genomic DNA Translation: AAN09451.1
AE014298 Genomic DNA Translation: AAN09452.1
AE014298 Genomic DNA Translation: AAS65395.2
AE014298 Genomic DNA Translation: AAS65396.1
AE014298 Genomic DNA Translation: ADV37750.1
AE014298 Genomic DNA Translation: AFH07440.1
AE014298 Genomic DNA Translation: AGB95507.1
AY118398 mRNA Translation: AAM48427.1
BT050432 mRNA Translation: ACJ13139.1
M17155 mRNA Translation: AAA70217.1 Frameshift.
X78908 Genomic DNA Translation: CAA55519.1
PIRiA27159
JH0193
S00480
S02284
RefSeqiNP_001162788.1, NM_001169317.1 [P08510-5]
NP_001188668.1, NM_001201739.2 [P08510-3]
NP_001245727.1, NM_001258798.2 [P08510-9]
NP_001259665.2, NM_001272736.2 [P08510-2]
NP_523393.3, NM_078669.5 [P08510-2]
NP_728120.1, NM_167592.4 [P08510-7]
NP_728122.1, NM_167594.4 [P08510-3]
NP_728123.1, NM_167595.4 [P08510-1]
NP_728124.1, NM_167596.5 [P08510-5]
NP_996497.1, NM_206774.2 [P08510-6]
NP_996498.2, NM_206775.5 [P08510-3]
UniGeneiDm.7088

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HO2NMR-A378-397[»]
1HO7NMR-A378-397[»]
ProteinModelPortaliP08510
SMRiP08510
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59101, 16 interactors
DIPiDIP-41151N
IntActiP08510, 5 interactors
MINTiP08510
STRINGi7227.FBpp0088599

Protein family/group databases

TCDBi1.A.1.2.6 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiP08510

Proteomic databases

PaxDbiP08510
PRIDEiP08510

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089657; FBpp0088599; FBgn0003380 [P08510-1]
FBtr0089658; FBpp0088600; FBgn0003380 [P08510-2]
FBtr0089659; FBpp0088601; FBgn0003380 [P08510-5]
FBtr0089660; FBpp0088602; FBgn0003380 [P08510-7]
FBtr0089661; FBpp0088603; FBgn0003380 [P08510-3]
FBtr0089663; FBpp0088605; FBgn0003380 [P08510-6]
FBtr0301955; FBpp0291167; FBgn0003380 [P08510-5]
FBtr0302902; FBpp0292033; FBgn0003380 [P08510-3]
FBtr0302903; FBpp0292034; FBgn0003380 [P08510-3]
FBtr0308200; FBpp0300520; FBgn0003380 [P08510-9]
FBtr0346703; FBpp0312316; FBgn0003380 [P08510-2]
GeneIDi32780
KEGGidme:Dmel_CG12348
UCSCiCG12348-RG d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
32780
FlyBaseiFBgn0003380 Sh

Phylogenomic databases

eggNOGiKOG1545 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00940000170670
InParanoidiP08510
KOiK04874
OMAiGMTFHTY
PhylomeDBiP08510

Enzyme and pathway databases

ReactomeiR-DME-1296072 Voltage gated Potassium channels

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sh fly
EvolutionaryTraceiP08510

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
32780

Protein Ontology

More...
PROi
PR:P08510

Gene expression databases

BgeeiFBgn0003380 Expressed in 15 organ(s), highest expression level in brain
ExpressionAtlasiP08510 baseline and differential
GenevisibleiP08510 DM

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003972 K_chnl_volt-dep_Kv1
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR00169 KCHANNEL
PR01491 KVCHANNEL
PR01496 SHAKERCHANEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNAS_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08510
Secondary accession number(s): A4V4Q2
, B6IDJ2, M9MSC0, M9NEM4, M9PF21, P08511, P08512, P08513, Q24277, Q24521, Q7KUW5, Q8IQY9, Q8MT41, Q9VWZ5, Q9VWZ9, Q9VX00
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: April 4, 2006
Last modified: January 16, 2019
This is version 213 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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