Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Low affinity immunoglobulin gamma Fc region receptor III

Gene

Fcgr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor which binds to IgG1, IgG2a and IgG2b (PubMed:17558411). Mediates neutrophil activation by IgG complexes redundantly with Fcgr4 (PubMed:18097064).2 Publications

GO - Molecular functioni

  • IgG binding Source: MGI
  • IgG receptor activity Source: UniProtKB
  • immunoglobulin receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionIgG-binding protein, Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor III
Short name:
IgG Fc receptor III
Alternative name(s):
Fc-gamma RIII
Short name:
FcRIII
CD_antigen: CD16
Gene namesi
Name:Fcgr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:95500 Fcgr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 215ExtracellularSequence analysisAdd BLAST185
Transmembranei216 – 235HelicalSequence analysisAdd BLAST20
Topological domaini236 – 261CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000001515431 – 261Low affinity immunoglobulin gamma Fc region receptor IIIAdd BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 98PROSITE-ProRule annotation
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi137 ↔ 181PROSITE-ProRule annotation
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP08508
PaxDbiP08508
PeptideAtlasiP08508
PRIDEiP08508

PTM databases

PhosphoSitePlusiP08508

Expressioni

Gene expression databases

CleanExiMM_FCGR3

Interactioni

Subunit structurei

Interacts with INPP5D/SHIP1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131938

Structurei

3D structure databases

ProteinModelPortaliP08508
SMRiP08508
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 110Ig-like C2-type 1Add BLAST78
Domaini116 – 198Ig-like C2-type 2Add BLAST83

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9AP Eukaryota
ENOG410YXNK LUCA
HOGENOMiHOG000251632
HOVERGENiHBG051602
InParanoidiP08508

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P08508-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFQNAHSGSQ WLLPPLTILL LFAFADRQSA ALPKAVVKLD PPWIQVLKED
60 70 80 90 100
MVTLMCEGTH NPGNSSTQWF HNGRSIRSQV QASYTFKATV NDSGEYRCQM
110 120 130 140 150
EQTRLSDPVD LGVISDWLLL QTPQRVFLEG ETITLRCHSW RNKLLNRISF
160 170 180 190 200
FHNEKSVRYH HYKSNFSIPK ANHSHSGDYY CKGSLGSTQH QSKPVTITVQ
210 220 230 240 250
DPATTSSISL VWYHTAFSLV MCLLFAVDTG LYFYVRRNLQ TPREYWRKSL
260
SIRKHQAPQD K
Length:261
Mass (Da):30,036
Last modified:August 1, 1988 - v1
Checksum:i757FB83668E41069
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PUV2E9PUV2_MOUSE
Low affinity immunoglobulin gamma F...
Fcgr3
266Annotation score:
A0A0B4J1M6A0A0B4J1M6_MOUSE
Low affinity immunoglobulin gamma F...
Fcgr3
267Annotation score:
E9PVR4E9PVR4_MOUSE
Low affinity immunoglobulin gamma F...
Fcgr3
74Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14215 mRNA Translation: AAA37604.1
X60929 Genomic DNA Translation: CAA43266.1
PIRiS29360
UniGeneiMm.22119

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14215 mRNA Translation: AAA37604.1
X60929 Genomic DNA Translation: CAA43266.1
PIRiS29360
UniGeneiMm.22119

3D structure databases

ProteinModelPortaliP08508
SMRiP08508
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131938

PTM databases

PhosphoSitePlusiP08508

Proteomic databases

MaxQBiP08508
PaxDbiP08508
PeptideAtlasiP08508
PRIDEiP08508

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95500 Fcgr3

Phylogenomic databases

eggNOGiENOG410J9AP Eukaryota
ENOG410YXNK LUCA
HOGENOMiHOG000251632
HOVERGENiHBG051602
InParanoidiP08508

Miscellaneous databases

PROiPR:P08508
SOURCEiSearch...

Gene expression databases

CleanExiMM_FCGR3

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFCGR3_MOUSE
AccessioniPrimary (citable) accession number: P08508
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: June 20, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again