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Protein

Interleukin-6

Gene

Il6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAcute phase

Enzyme and pathway databases

ReactomeiR-MMU-1059683 Interleukin-6 signaling
R-MMU-110056 MAPK3 (ERK1) activation
R-MMU-112411 MAPK1 (ERK2) activation
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
IL-6
Alternative name(s):
B-cell hybridoma growth factor
Interleukin HP-1
Gene namesi
Name:Il6
Synonyms:Il-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:96559 Il6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Animals have normal T-cell numbers in the lamina propria but the T(H)17 cells are reduced by about 10-fold.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 242 PublicationsAdd BLAST24
ChainiPRO_000001558825 – 211Interleukin-6Add BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi70 ↔ 761 Publication
Disulfide bondi99 ↔ 1091 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP08505
PaxDbiP08505
PRIDEiP08505

PTM databases

PhosphoSitePlusiP08505

Expressioni

Gene expression databases

BgeeiENSMUSG00000025746 Expressed in 27 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiMM_IL6
ExpressionAtlasiP08505 baseline and differential
GenevisibleiP08505 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200641, 2 interactors
IntActiP08505, 1 interactor
STRINGi10090.ENSMUSP00000026845

Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08505
SMRiP08505
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08505

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW11 Eukaryota
ENOG4112BXV LUCA
GeneTreeiENSGT00390000000878
HOGENOMiHOG000236330
HOVERGENiHBG000471
InParanoidiP08505
KOiK05405
OMAiLQAQNQW
OrthoDBiEOG091G0NW5
PhylomeDBiP08505
TreeFamiTF335984

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003574 IL-6
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PANTHERiPTHR45110 PTHR45110, 1 hit
PfamiView protein in Pfam
PF00489 IL6, 1 hit
PIRSFiPIRSF001935 IL6_MGF_GCSF, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

P08505-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFLSARDFH PVAFLGLMLV TTTAFPTSQV RRGDFTEDTT PNRPVYTTSQ
60 70 80 90 100
VGGLITHVLW EIVEMRKELC NGNSDCMNND DALAENNLKL PEIQRNDGCY
110 120 130 140 150
QTGYNQEICL LKISSGLLEY HSYLEYMKNN LKDNKKDKAR VLQRDTETLI
160 170 180 190 200
HIFNQEVKDL HKIVLPTPIS NALLTDKLES QKEWLRTKTI QFILKSLEEF
210
LKVTLRSTRQ T
Length:211
Mass (Da):24,384
Last modified:August 1, 1988 - v1
Checksum:iBBB47DDA9E86787A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGF4A0A0G2JGF4_MOUSE
Interleukin-6
Il6
165Annotation score:
A0A0G2JFT1A0A0G2JFT1_MOUSE
Interleukin-6
Il6
208Annotation score:
A0A0G2JFG1A0A0G2JFG1_MOUSE
Interleukin-6
Il6
194Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06203 mRNA Translation: CAA29560.1
M20572 Genomic DNA Translation: AAA39302.1
J03783 mRNA Translation: AAA39301.1
X54542 mRNA Translation: CAA38411.1
AK150440 mRNA Translation: BAE29562.1
X51457 Genomic DNA Translation: CAA35824.1
M24221 Genomic DNA Translation: AAA68814.1
CCDSiCCDS19153.1
PIRiA30531 ICMS6
RefSeqiNP_001300983.1, NM_001314054.1
NP_112445.1, NM_031168.2
UniGeneiMm.1019

Genome annotation databases

EnsembliENSMUST00000026845; ENSMUSP00000026845; ENSMUSG00000025746
GeneIDi16193
KEGGimmu:16193
UCSCiuc008wuu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06203 mRNA Translation: CAA29560.1
M20572 Genomic DNA Translation: AAA39302.1
J03783 mRNA Translation: AAA39301.1
X54542 mRNA Translation: CAA38411.1
AK150440 mRNA Translation: BAE29562.1
X51457 Genomic DNA Translation: CAA35824.1
M24221 Genomic DNA Translation: AAA68814.1
CCDSiCCDS19153.1
PIRiA30531 ICMS6
RefSeqiNP_001300983.1, NM_001314054.1
NP_112445.1, NM_031168.2
UniGeneiMm.1019

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L3YNMR-A27-211[»]
ProteinModelPortaliP08505
SMRiP08505
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200641, 2 interactors
IntActiP08505, 1 interactor
STRINGi10090.ENSMUSP00000026845

PTM databases

PhosphoSitePlusiP08505

Proteomic databases

MaxQBiP08505
PaxDbiP08505
PRIDEiP08505

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026845; ENSMUSP00000026845; ENSMUSG00000025746
GeneIDi16193
KEGGimmu:16193
UCSCiuc008wuu.1 mouse

Organism-specific databases

CTDi3569
MGIiMGI:96559 Il6

Phylogenomic databases

eggNOGiENOG410IW11 Eukaryota
ENOG4112BXV LUCA
GeneTreeiENSGT00390000000878
HOGENOMiHOG000236330
HOVERGENiHBG000471
InParanoidiP08505
KOiK05405
OMAiLQAQNQW
OrthoDBiEOG091G0NW5
PhylomeDBiP08505
TreeFamiTF335984

Enzyme and pathway databases

ReactomeiR-MMU-1059683 Interleukin-6 signaling
R-MMU-110056 MAPK3 (ERK1) activation
R-MMU-112411 MAPK1 (ERK2) activation
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

EvolutionaryTraceiP08505
PROiPR:P08505
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025746 Expressed in 27 organ(s), highest expression level in subcutaneous adipose tissue
CleanExiMM_IL6
ExpressionAtlasiP08505 baseline and differential
GenevisibleiP08505 MM

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003574 IL-6
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PANTHERiPTHR45110 PTHR45110, 1 hit
PfamiView protein in Pfam
PF00489 IL6, 1 hit
PIRSFiPIRSF001935 IL6_MGF_GCSF, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL6_MOUSE
AccessioniPrimary (citable) accession number: P08505
Secondary accession number(s): Q3UCQ0, Q8BN26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 12, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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