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UniProtKB - P08493 (MGP_HUMAN)

Entry version 200 (25 May 2022)
Sequence version 2 (28 Nov 2006)
Previous versions | rss
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Protein

Matrix Gla protein

Gene

MGP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processChondrogenesis, Differentiation, Osteogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P08493

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P08493

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Matrix Gla protein
Short name:
MGP
Alternative name(s):
Cell growth-inhibiting gene 36 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MGP
Synonyms:MGLAP
ORF Names:GIG36
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7060, MGP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		154870, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P08493

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000111341

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Keutel syndrome (KTLS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
Related information in OMIM

Keywords - Diseasei

Deafness

Organism-specific databases

DisGeNET

More...DisGeNETi		4256

MalaCards human disease database

More...MalaCardsi		MGP
MIMi245150, phenotype

Open Targets

More...OpenTargetsi		ENSG00000111341

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		85202, Keutel syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30790

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P08493, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01373, Calcium

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MGP

Domain mapping of disease mutations (DMDM)

More...DMDMi		118572668

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Add BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001110920 – 96Matrix Gla proteinAdd BLAST77
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001111097 – 103Removed in mature form; probably by carboxypeptidase N7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei214-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei22Phosphoserine1 Publication1
Modified residuei25Phosphoserine1 Publication1
Modified residuei28Phosphoserine1 Publication1
Modified residuei564-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei604-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei674-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei714-carboxyglutamatePROSITE-ProRule annotationBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi73 ↔ 79PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Requires vitamin K-dependent gamma-carboxylation for its function.

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-1141

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P08493

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P08493

MaxQB - The MaxQuant DataBase

More...MaxQBi		P08493

PeptideAtlas

More...PeptideAtlasi		P08493

PRoteomics IDEntifications database

More...PRIDEi		P08493

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52112 [P08493-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08493

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P08493

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000111341, Expressed in descending thoracic aorta and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P08493, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P08493, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000111341, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110412, 4 interactors

Protein interaction database and analysis system

More...IntActi		P08493, 1 interactor

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P08493, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P08493

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P08493

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 97GlaPROSITE-ProRule annotationAdd BLAST47

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the osteocalcin/matrix Gla protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003753

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_177119_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08493

Identification of Orthologs from Complete Genome Data

More...OMAi		MESYEIN

Database of Orthologous Groups

More...OrthoDBi		1512503at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P08493

TreeFam database of animal gene trees

More...TreeFami		TF330920

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035972, GLA-like_dom_SF
IPR000294, GLA_domain
IPR027118, MGP
IPR002384, Osteocalcin/MGP

The PANTHER Classification System

More...PANTHERi		PTHR10109, PTHR10109, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00002, GLABONE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00069, GLA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57630, SSF57630, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00011, GLA_1, 1 hit
PS50998, GLA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P08493-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSLILLAIL AALAVVTLCY ESHESMESYE LNPFINRRNA NTFISPQQRW 
        60         70         80         90        100
RAKVQERIRE RSKPVHELNR EACDDYRLCE RYAMVYGYNA AYNRYFRKRR 

GTK
Length:103
Mass (Da):12,353
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i243968D715D54549
GO
Isoform 2 (identifier: P08493-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Y → YGEWQKEENFGFDIVSVLSLNWHRAQ

Show »
Length:128
Mass (Da):15,325
Checksum:iEC1C9523BC0836E6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGZ6H0YGZ6_HUMAN
Matrix Gla protein
MGP
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20Y → C in AAH93078 (PubMed:15489334).Curated1
Sequence conflicti51R → G in CAG29354 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01617753K → E. Corresponds to variant dbSNP:rs1801716EnsemblClinVar.1
Natural variantiVAR_016178102T → A7 PublicationsCorresponds to variant dbSNP:rs4236EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04699920Y → YGEWQKEENFGFDIVSVLSL NWHRAQ in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M58549 mRNA Translation: AAB53766.1
M55270 Genomic DNA Translation: AAB53765.1
X07362 mRNA Translation: CAA30287.1
X53331 mRNA Translation: CAA37418.1
AY542304 mRNA Translation: AAT08173.1
BT006733 mRNA Translation: AAP35379.1
CR450358 mRNA Translation: CAG29354.1
AK312029 mRNA Translation: BAG34966.1
DQ004248 Genomic DNA Translation: AAY16978.1
AC007655 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96333.1
BC005272 mRNA Translation: AAH05272.1
BC070314 mRNA Translation: AAH70314.1
BC093078 mRNA Translation: AAH93078.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53752.1 [P08493-2]
CCDS8669.1 [P08493-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A35811, GEHUM

NCBI Reference Sequences

More...RefSeqi		NP_000891.2, NM_000900.4 [P08493-1]
NP_001177768.1, NM_001190839.2 [P08493-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000228938.5; ENSP00000228938.5; ENSG00000111341.10 [P08493-2]
ENST00000539261.6; ENSP00000445907.1; ENSG00000111341.10

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4256

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4256

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000539261.6; ENSP00000445907.1; NM_000900.5; NP_000891.2

UCSC genome browser

More...UCSCi		uc001rcn.3, human [P08493-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58549 mRNA Translation: AAB53766.1
M55270 Genomic DNA Translation: AAB53765.1
X07362 mRNA Translation: CAA30287.1
X53331 mRNA Translation: CAA37418.1
AY542304 mRNA Translation: AAT08173.1
BT006733 mRNA Translation: AAP35379.1
CR450358 mRNA Translation: CAG29354.1
AK312029 mRNA Translation: BAG34966.1
DQ004248 Genomic DNA Translation: AAY16978.1
AC007655 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96333.1
BC005272 mRNA Translation: AAH05272.1
BC070314 mRNA Translation: AAH70314.1
BC093078 mRNA Translation: AAH93078.1
CCDSiCCDS53752.1 [P08493-2]
CCDS8669.1 [P08493-1]
PIRiA35811, GEHUM
RefSeqiNP_000891.2, NM_000900.4 [P08493-1]
NP_001177768.1, NM_001190839.2 [P08493-2]

3D structure databases

AlphaFoldDBiP08493
SMRiP08493
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi110412, 4 interactors
IntActiP08493, 1 interactor

Chemistry databases

DrugBankiDB01373, Calcium

PTM databases

iPTMnetiP08493
PhosphoSitePlusiP08493

Genetic variation databases

BioMutaiMGP
DMDMi118572668

Proteomic databases

CPTACinon-CPTAC-1141
jPOSTiP08493
MassIVEiP08493
MaxQBiP08493
PeptideAtlasiP08493
PRIDEiP08493
ProteomicsDBi52112 [P08493-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2842, 295 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		4256

Genome annotation databases

EnsembliENST00000228938.5; ENSP00000228938.5; ENSG00000111341.10 [P08493-2]
ENST00000539261.6; ENSP00000445907.1; ENSG00000111341.10
GeneIDi4256
KEGGihsa:4256
MANE-SelectiENST00000539261.6; ENSP00000445907.1; NM_000900.5; NP_000891.2
UCSCiuc001rcn.3, human [P08493-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4256
DisGeNETi4256

GeneCards: human genes, protein and diseases

More...GeneCardsi		MGP
HGNCiHGNC:7060, MGP
HPAiENSG00000111341, Low tissue specificity
MalaCardsiMGP
MIMi154870, gene
245150, phenotype
neXtProtiNX_P08493
OpenTargetsiENSG00000111341
Orphaneti85202, Keutel syndrome
PharmGKBiPA30790
VEuPathDBiHostDB:ENSG00000111341

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00390000003753
HOGENOMiCLU_177119_1_0_1
InParanoidiP08493
OMAiMESYEIN
OrthoDBi1512503at2759
PhylomeDBiP08493
TreeFamiTF330920

Enzyme and pathway databases

PathwayCommonsiP08493
SignaLinkiP08493

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4256, 12 hits in 1073 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MGP, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Matrix_gla_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4256
PharosiP08493, Tbio

Protein Ontology

More...PROi		PR:P08493
RNActiP08493, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000111341, Expressed in descending thoracic aorta and 218 other tissues
ExpressionAtlasiP08493, baseline and differential
GenevisibleiP08493, HS

Family and domain databases

InterProiView protein in InterPro
IPR035972, GLA-like_dom_SF
IPR000294, GLA_domain
IPR027118, MGP
IPR002384, Osteocalcin/MGP
PANTHERiPTHR10109, PTHR10109, 1 hit
PRINTSiPR00002, GLABONE
SMARTiView protein in SMART
SM00069, GLA, 1 hit
SUPFAMiSSF57630, SSF57630, 1 hit
PROSITEiView protein in PROSITE
PS00011, GLA_1, 1 hit
PS50998, GLA_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08493
Secondary accession number(s): A0M8W5
, B2R519, J3KMX7, Q2TU41, Q567P9, Q6ICN5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 28, 2006
Last modified: May 25, 2022
This is version 200 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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