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Protein

Matrix Gla protein

Gene

MGP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processChondrogenesis, Differentiation, Osteogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Matrix Gla protein
Short name:
MGP
Alternative name(s):
Cell growth-inhibiting gene 36 protein
Gene namesi
Name:MGP
Synonyms:MGLAP
ORF Names:GIG36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111341.9
HGNCiHGNC:7060 MGP
MIMi154870 gene
neXtProtiNX_P08493

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Keutel syndrome (KTLS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
See also OMIM:245150

Keywords - Diseasei

Deafness

Organism-specific databases

DisGeNETi4256
MalaCardsiMGP
MIMi245150 phenotype
OpenTargetsiENSG00000111341
Orphaneti85202 Keutel syndrome
PharmGKBiPA30790

Polymorphism and mutation databases

BioMutaiMGP
DMDMi118572668

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001110920 – 96Matrix Gla proteinAdd BLAST77
PropeptideiPRO_000001111097 – 103Removed in mature form; probably by carboxypeptidase N7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei214-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei22Phosphoserine1 Publication1
Modified residuei25Phosphoserine1 Publication1
Modified residuei28Phosphoserine1 Publication1
Modified residuei564-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei604-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei674-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei714-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Disulfide bondi73 ↔ 79PROSITE-ProRule annotation

Post-translational modificationi

Requires vitamin K-dependent gamma-carboxylation for its function.

Keywords - PTMi

Disulfide bond, Gamma-carboxyglutamic acid, Phosphoprotein

Proteomic databases

MaxQBiP08493
PeptideAtlasiP08493
PRIDEiP08493
ProteomicsDBi52112

PTM databases

iPTMnetiP08493
PhosphoSitePlusiP08493

Expressioni

Gene expression databases

BgeeiENSG00000111341 Expressed in 206 organ(s), highest expression level in descending thoracic aorta
CleanExiHS_MGP
ExpressionAtlasiP08493 baseline and differential
GenevisibleiP08493 HS

Organism-specific databases

HPAiHPA013949

Interactioni

Protein-protein interaction databases

BioGridi110412, 2 interactors
IntActiP08493, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP08493
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 97GlaPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000003753
HOGENOMiHOG000113581
HOVERGENiHBG006353
InParanoidiP08493
KOiK19481
OMAiPFLNRRN
OrthoDBiEOG091G0XPC
PhylomeDBiP08493
TreeFamiTF330920

Family and domain databases

InterProiView protein in InterPro
IPR035972 GLA-like_dom_SF
IPR000294 GLA_domain
IPR027118 MGP
IPR002384 Osteocalcin/MGP
PANTHERiPTHR10109 PTHR10109, 1 hit
PRINTSiPR00002 GLABONE
SMARTiView protein in SMART
SM00069 GLA, 1 hit
SUPFAMiSSF57630 SSF57630, 1 hit
PROSITEiView protein in PROSITE
PS00011 GLA_1, 1 hit
PS50998 GLA_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P08493-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKSLILLAIL AALAVVTLCY ESHESMESYE LNPFINRRNA NTFISPQQRW
60 70 80 90 100
RAKVQERIRE RSKPVHELNR EACDDYRLCE RYAMVYGYNA AYNRYFRKRR

GTK
Length:103
Mass (Da):12,353
Last modified:November 28, 2006 - v2
Checksum:i243968D715D54549
GO
Isoform 2 (identifier: P08493-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Y → YGEWQKEENFGFDIVSVLSLNWHRAQ

Note: Gene prediction based on EST data.
Show »
Length:128
Mass (Da):15,325
Checksum:iEC1C9523BC0836E6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YGZ6H0YGZ6_HUMAN
Matrix Gla protein
MGP
74Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20Y → C in AAH93078 (PubMed:15489334).Curated1
Sequence conflicti51R → G in CAG29354 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01617753K → E. Corresponds to variant dbSNP:rs1801716Ensembl.1
Natural variantiVAR_016178102T → A7 PublicationsCorresponds to variant dbSNP:rs4236EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04699920Y → YGEWQKEENFGFDIVSVLSL NWHRAQ in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58549 mRNA Translation: AAB53766.1
M55270 Genomic DNA Translation: AAB53765.1
X07362 mRNA Translation: CAA30287.1
X53331 mRNA Translation: CAA37418.1
AY542304 mRNA Translation: AAT08173.1
BT006733 mRNA Translation: AAP35379.1
CR450358 mRNA Translation: CAG29354.1
AK312029 mRNA Translation: BAG34966.1
DQ004248 Genomic DNA Translation: AAY16978.1
AC007655 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96333.1
BC005272 mRNA Translation: AAH05272.1
BC070314 mRNA Translation: AAH70314.1
BC093078 mRNA Translation: AAH93078.1
CCDSiCCDS53752.1 [P08493-2]
CCDS8669.1 [P08493-1]
PIRiA35811 GEHUM
RefSeqiNP_000891.2, NM_000900.4 [P08493-1]
NP_001177768.1, NM_001190839.2 [P08493-2]
UniGeneiHs.365706

Genome annotation databases

EnsembliENST00000228938; ENSP00000228938; ENSG00000111341 [P08493-2]
ENST00000539261; ENSP00000445907; ENSG00000111341 [P08493-1]
GeneIDi4256
KEGGihsa:4256
UCSCiuc001rcn.3 human [P08493-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58549 mRNA Translation: AAB53766.1
M55270 Genomic DNA Translation: AAB53765.1
X07362 mRNA Translation: CAA30287.1
X53331 mRNA Translation: CAA37418.1
AY542304 mRNA Translation: AAT08173.1
BT006733 mRNA Translation: AAP35379.1
CR450358 mRNA Translation: CAG29354.1
AK312029 mRNA Translation: BAG34966.1
DQ004248 Genomic DNA Translation: AAY16978.1
AC007655 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96333.1
BC005272 mRNA Translation: AAH05272.1
BC070314 mRNA Translation: AAH70314.1
BC093078 mRNA Translation: AAH93078.1
CCDSiCCDS53752.1 [P08493-2]
CCDS8669.1 [P08493-1]
PIRiA35811 GEHUM
RefSeqiNP_000891.2, NM_000900.4 [P08493-1]
NP_001177768.1, NM_001190839.2 [P08493-2]
UniGeneiHs.365706

3D structure databases

ProteinModelPortaliP08493
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110412, 2 interactors
IntActiP08493, 1 interactor

PTM databases

iPTMnetiP08493
PhosphoSitePlusiP08493

Polymorphism and mutation databases

BioMutaiMGP
DMDMi118572668

Proteomic databases

MaxQBiP08493
PeptideAtlasiP08493
PRIDEiP08493
ProteomicsDBi52112

Protocols and materials databases

DNASUi4256
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228938; ENSP00000228938; ENSG00000111341 [P08493-2]
ENST00000539261; ENSP00000445907; ENSG00000111341 [P08493-1]
GeneIDi4256
KEGGihsa:4256
UCSCiuc001rcn.3 human [P08493-1]

Organism-specific databases

CTDi4256
DisGeNETi4256
EuPathDBiHostDB:ENSG00000111341.9
GeneCardsiMGP
HGNCiHGNC:7060 MGP
HPAiHPA013949
MalaCardsiMGP
MIMi154870 gene
245150 phenotype
neXtProtiNX_P08493
OpenTargetsiENSG00000111341
Orphaneti85202 Keutel syndrome
PharmGKBiPA30790
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000003753
HOGENOMiHOG000113581
HOVERGENiHBG006353
InParanoidiP08493
KOiK19481
OMAiPFLNRRN
OrthoDBiEOG091G0XPC
PhylomeDBiP08493
TreeFamiTF330920

Miscellaneous databases

ChiTaRSiMGP human
GeneWikiiMatrix_gla_protein
GenomeRNAii4256
PROiPR:P08493
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111341 Expressed in 206 organ(s), highest expression level in descending thoracic aorta
CleanExiHS_MGP
ExpressionAtlasiP08493 baseline and differential
GenevisibleiP08493 HS

Family and domain databases

InterProiView protein in InterPro
IPR035972 GLA-like_dom_SF
IPR000294 GLA_domain
IPR027118 MGP
IPR002384 Osteocalcin/MGP
PANTHERiPTHR10109 PTHR10109, 1 hit
PRINTSiPR00002 GLABONE
SMARTiView protein in SMART
SM00069 GLA, 1 hit
SUPFAMiSSF57630 SSF57630, 1 hit
PROSITEiView protein in PROSITE
PS00011 GLA_1, 1 hit
PS50998 GLA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMGP_HUMAN
AccessioniPrimary (citable) accession number: P08493
Secondary accession number(s): A0M8W5
, B2R519, J3KMX7, Q2TU41, Q567P9, Q6ICN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 28, 2006
Last modified: October 10, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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