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UniProtKB - P08493 (MGP_HUMAN)
Protein
Matrix Gla protein
Gene
MGP
Organism
Homo sapiens (Human)
Status
Functioni
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
GO - Molecular functioni
- calcium ion binding Source: InterPro
- extracellular matrix structural constituent Source: ProtInc
- structural constituent of bone Source: ProtInc
GO - Biological processi
- cartilage condensation Source: ProtInc
- cell differentiation Source: UniProtKB-KW
- ossification Source: ProtInc
- regulation of bone mineralization Source: InterPro
Keywordsi
Molecular function | Developmental protein |
Biological process | Chondrogenesis, Differentiation, Osteogenesis |
Enzyme and pathway databases
PathwayCommonsi | P08493 |
SignaLinki | P08493 |
Names & Taxonomyi
Protein namesi | Recommended name: Matrix Gla proteinShort name: MGP Alternative name(s): Cell growth-inhibiting gene 36 protein |
Gene namesi | Name:MGP Synonyms:MGLAP ORF Names:GIG36 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7060, MGP |
MIMi | 154870, gene |
neXtProti | NX_P08493 |
VEuPathDBi | HostDB:ENSG00000111341 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular matrix Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Keutel syndrome (KTLS)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
Related information in OMIMKeywords - Diseasei
DeafnessOrganism-specific databases
DisGeNETi | 4256 |
MalaCardsi | MGP |
MIMi | 245150, phenotype |
OpenTargetsi | ENSG00000111341 |
Orphaneti | 85202, Keutel syndrome |
PharmGKBi | PA30790 |
Miscellaneous databases
Pharosi | P08493, Tbio |
Chemistry databases
DrugBanki | DB01373, Calcium |
Genetic variation databases
BioMutai | MGP |
DMDMi | 118572668 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Add BLAST | 19 | |
ChainiPRO_0000011109 | 20 – 96 | Matrix Gla proteinAdd BLAST | 77 | |
PropeptideiPRO_0000011110 | 97 – 103 | Removed in mature form; probably by carboxypeptidase N | 7 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 21 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 22 | Phosphoserine1 Publication | 1 | |
Modified residuei | 25 | Phosphoserine1 Publication | 1 | |
Modified residuei | 28 | Phosphoserine1 Publication | 1 | |
Modified residuei | 56 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 60 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 67 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 71 | 4-carboxyglutamatePROSITE-ProRule annotationBy similarity | 1 | |
Disulfide bondi | 73 ↔ 79 | PROSITE-ProRule annotation |
Post-translational modificationi
Requires vitamin K-dependent gamma-carboxylation for its function.
Keywords - PTMi
Disulfide bond, Gamma-carboxyglutamic acid, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-1141 |
jPOSTi | P08493 |
MassIVEi | P08493 |
MaxQBi | P08493 |
PeptideAtlasi | P08493 |
PRIDEi | P08493 |
ProteomicsDBi | 52112 [P08493-1] |
PTM databases
iPTMneti | P08493 |
PhosphoSitePlusi | P08493 |
Expressioni
Gene expression databases
Bgeei | ENSG00000111341, Expressed in descending thoracic aorta and 218 other tissues |
ExpressionAtlasi | P08493, baseline and differential |
Genevisiblei | P08493, HS |
Organism-specific databases
HPAi | ENSG00000111341, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 110412, 4 interactors |
IntActi | P08493, 1 interactor |
Miscellaneous databases
RNActi | P08493, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 97 | GlaPROSITE-ProRule annotationAdd BLAST | 47 |
Sequence similaritiesi
Belongs to the osteocalcin/matrix Gla protein family.Curated
Keywords - Domaini
SignalPhylogenomic databases
GeneTreei | ENSGT00390000003753 |
HOGENOMi | CLU_177119_1_0_1 |
InParanoidi | P08493 |
OMAi | MESYEIN |
OrthoDBi | 1512503at2759 |
PhylomeDBi | P08493 |
TreeFami | TF330920 |
Family and domain databases
InterProi | View protein in InterPro IPR035972, GLA-like_dom_SF IPR000294, GLA_domain IPR027118, MGP IPR002384, Osteocalcin/MGP |
PANTHERi | PTHR10109, PTHR10109, 1 hit |
PRINTSi | PR00002, GLABONE |
SMARTi | View protein in SMART SM00069, GLA, 1 hit |
SUPFAMi | SSF57630, SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00011, GLA_1, 1 hit PS50998, GLA_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P08493-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKSLILLAIL AALAVVTLCY ESHESMESYE LNPFINRRNA NTFISPQQRW
60 70 80 90 100
RAKVQERIRE RSKPVHELNR EACDDYRLCE RYAMVYGYNA AYNRYFRKRR
GTK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YGZ6 | H0YGZ6_HUMAN | Matrix Gla protein | MGP | 74 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 20 | Y → C in AAH93078 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 51 | R → G in CAG29354 (Ref. 6) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016177 | 53 | K → E. Corresponds to variant dbSNP:rs1801716EnsemblClinVar. | 1 | |
Natural variantiVAR_016178 | 102 | T → A7 PublicationsCorresponds to variant dbSNP:rs4236EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046999 | 20 | Y → YGEWQKEENFGFDIVSVLSL NWHRAQ in isoform 2. Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58549 mRNA Translation: AAB53766.1 M55270 Genomic DNA Translation: AAB53765.1 X07362 mRNA Translation: CAA30287.1 X53331 mRNA Translation: CAA37418.1 AY542304 mRNA Translation: AAT08173.1 BT006733 mRNA Translation: AAP35379.1 CR450358 mRNA Translation: CAG29354.1 AK312029 mRNA Translation: BAG34966.1 DQ004248 Genomic DNA Translation: AAY16978.1 AC007655 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96333.1 BC005272 mRNA Translation: AAH05272.1 BC070314 mRNA Translation: AAH70314.1 BC093078 mRNA Translation: AAH93078.1 |
CCDSi | CCDS53752.1 [P08493-2] CCDS8669.1 [P08493-1] |
PIRi | A35811, GEHUM |
RefSeqi | NP_000891.2, NM_000900.4 [P08493-1] NP_001177768.1, NM_001190839.2 [P08493-2] |
Genome annotation databases
Ensembli | ENST00000228938.5; ENSP00000228938.5; ENSG00000111341.10 [P08493-2] ENST00000539261.6; ENSP00000445907.1; ENSG00000111341.10 |
GeneIDi | 4256 |
KEGGi | hsa:4256 |
MANE-Selecti | ENST00000539261.6; ENSP00000445907.1; NM_000900.5; NP_000891.2 |
UCSCi | uc001rcn.3, human [P08493-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M58549 mRNA Translation: AAB53766.1 M55270 Genomic DNA Translation: AAB53765.1 X07362 mRNA Translation: CAA30287.1 X53331 mRNA Translation: CAA37418.1 AY542304 mRNA Translation: AAT08173.1 BT006733 mRNA Translation: AAP35379.1 CR450358 mRNA Translation: CAG29354.1 AK312029 mRNA Translation: BAG34966.1 DQ004248 Genomic DNA Translation: AAY16978.1 AC007655 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96333.1 BC005272 mRNA Translation: AAH05272.1 BC070314 mRNA Translation: AAH70314.1 BC093078 mRNA Translation: AAH93078.1 |
CCDSi | CCDS53752.1 [P08493-2] CCDS8669.1 [P08493-1] |
PIRi | A35811, GEHUM |
RefSeqi | NP_000891.2, NM_000900.4 [P08493-1] NP_001177768.1, NM_001190839.2 [P08493-2] |
3D structure databases
AlphaFoldDBi | P08493 |
SMRi | P08493 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110412, 4 interactors |
IntActi | P08493, 1 interactor |
Chemistry databases
DrugBanki | DB01373, Calcium |
PTM databases
iPTMneti | P08493 |
PhosphoSitePlusi | P08493 |
Genetic variation databases
BioMutai | MGP |
DMDMi | 118572668 |
Proteomic databases
CPTACi | non-CPTAC-1141 |
jPOSTi | P08493 |
MassIVEi | P08493 |
MaxQBi | P08493 |
PeptideAtlasi | P08493 |
PRIDEi | P08493 |
ProteomicsDBi | 52112 [P08493-1] |
Protocols and materials databases
Antibodypediai | 2842, 295 antibodies from 30 providers |
DNASUi | 4256 |
Genome annotation databases
Ensembli | ENST00000228938.5; ENSP00000228938.5; ENSG00000111341.10 [P08493-2] ENST00000539261.6; ENSP00000445907.1; ENSG00000111341.10 |
GeneIDi | 4256 |
KEGGi | hsa:4256 |
MANE-Selecti | ENST00000539261.6; ENSP00000445907.1; NM_000900.5; NP_000891.2 |
UCSCi | uc001rcn.3, human [P08493-1] |
Organism-specific databases
CTDi | 4256 |
DisGeNETi | 4256 |
GeneCardsi | MGP |
HGNCi | HGNC:7060, MGP |
HPAi | ENSG00000111341, Low tissue specificity |
MalaCardsi | MGP |
MIMi | 154870, gene 245150, phenotype |
neXtProti | NX_P08493 |
OpenTargetsi | ENSG00000111341 |
Orphaneti | 85202, Keutel syndrome |
PharmGKBi | PA30790 |
VEuPathDBi | HostDB:ENSG00000111341 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000003753 |
HOGENOMi | CLU_177119_1_0_1 |
InParanoidi | P08493 |
OMAi | MESYEIN |
OrthoDBi | 1512503at2759 |
PhylomeDBi | P08493 |
TreeFami | TF330920 |
Enzyme and pathway databases
PathwayCommonsi | P08493 |
SignaLinki | P08493 |
Miscellaneous databases
BioGRID-ORCSi | 4256, 12 hits in 1073 CRISPR screens |
ChiTaRSi | MGP, human |
GeneWikii | Matrix_gla_protein |
GenomeRNAii | 4256 |
Pharosi | P08493, Tbio |
PROi | PR:P08493 |
RNActi | P08493, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111341, Expressed in descending thoracic aorta and 218 other tissues |
ExpressionAtlasi | P08493, baseline and differential |
Genevisiblei | P08493, HS |
Family and domain databases
InterProi | View protein in InterPro IPR035972, GLA-like_dom_SF IPR000294, GLA_domain IPR027118, MGP IPR002384, Osteocalcin/MGP |
PANTHERi | PTHR10109, PTHR10109, 1 hit |
PRINTSi | PR00002, GLABONE |
SMARTi | View protein in SMART SM00069, GLA, 1 hit |
SUPFAMi | SSF57630, SSF57630, 1 hit |
PROSITEi | View protein in PROSITE PS00011, GLA_1, 1 hit PS50998, GLA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MGP_HUMAN | |
Accessioni | P08493Primary (citable) accession number: P08493 Secondary accession number(s): A0M8W5 Q6ICN5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | November 28, 2006 | |
Last modified: | May 25, 2022 | |
This is version 200 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families