Chrm3

Functionⁱ

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.3 Publications

GO - Molecular functionⁱ

acetylcholine binding
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.7
  "Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants."
  Wess J., Maggio R., Palmer J.R., Vogel Z.
  J. Biol. Chem. 267:19313-19319(1992) [PubMed] [Europe PMC] [Abstract]
  Cited for: MUTAGENESIS OF THR-234 AND TYR-506, FUNCTION, SUBCELLULAR LOCATION.
drug binding
Source: RGD
Inferred from direct assayⁱ
- "Mediation by M3-muscarinic receptors of both endothelium-dependent contraction and relaxation to acetylcholine in the aorta of the spontaneously hypertensive rat."
  Boulanger C.M., Morrison K.J., Vanhoutte P.M.
  Br. J. Pharmacol. 112:519-524(1994) [PubMed] [Europe PMC] [Abstract]
- "Differentiation of muscarinic receptors mediating negative chronotropic and vasoconstrictor responses to acetylcholine in isolated rat hearts."
  Hoover D.B., Neely D.A.
  J. Pharmacol. Exp. Ther. 282:1337-1344(1997) [PubMed] [Europe PMC] [Abstract]
G protein-coupled acetylcholine receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- Ref.7
  "Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants."
  Wess J., Maggio R., Palmer J.R., Vogel Z.
  J. Biol. Chem. 267:19313-19319(1992) [PubMed] [Europe PMC] [Abstract]
  Cited for: MUTAGENESIS OF THR-234 AND TYR-506, FUNCTION, SUBCELLULAR LOCATION.
G protein-coupled receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
G protein-coupled serotonin receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
neurotransmitter receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-RNO-390648 Muscarinic acetylcholine receptors R-RNO-416476 G alpha (q) signalling events

Reactomeⁱ

R-RNO-390648 Muscarinic acetylcholine receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Muscarinic acetylcholine receptor M3
Gene namesⁱ	Name:Chrm3 Synonyms:Chrm-3
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 17

Organism-specific databases

Rat genome database More...RGDⁱ	2343 Chrm3

RGDⁱ

2343 Chrm3

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 66	Extracellular1 PublicationAdd BLAST	66
Transmembraneⁱ	67 – 90	Helical; Name=1Add BLAST	24
Topological domainⁱ	91 – 103	Cytoplasmic1 PublicationAdd BLAST	13
Transmembraneⁱ	104 – 129	Helical; Name=2Add BLAST	26
Topological domainⁱ	130 – 141	Extracellular1 PublicationAdd BLAST	12
Transmembraneⁱ	142 – 163	Helical; Name=3Add BLAST	22
Topological domainⁱ	164 – 183	Cytoplasmic1 PublicationAdd BLAST	20
Transmembraneⁱ	184 – 205	Helical; Name=4Add BLAST	22
Topological domainⁱ	206 – 228	Extracellular1 PublicationAdd BLAST	23
Transmembraneⁱ	229 – 251	Helical; Name=5Add BLAST	23
Topological domainⁱ	252 – 490	Cytoplasmic1 PublicationAdd BLAST	239
Transmembraneⁱ	491 – 513	Helical; Name=6Add BLAST	23
Topological domainⁱ	514 – 525	Extracellular1 PublicationAdd BLAST	12
Transmembraneⁱ	526 – 545	Helical; Name=7Add BLAST	20
Topological domainⁱ	546 – 589	Cytoplasmic1 PublicationAdd BLAST	44

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Endoplasmic reticulum, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	148	Y → A: Decreased affinity for acetylcholine. 1 Publication	1
Mutagenesisⁱ	231	T → A: Decreased affinity for acetylcholine. 1 Publication	1
Mutagenesisⁱ	234	T → A: Strongly decreased affinity for acetylcholine. 2 Publications	1
Mutagenesisⁱ	506	Y → F: Decreased affinity for acetylcholine. 2 Publications	1
Mutagenesisⁱ	529	Y → F: Decreased affinity for acetylcholine. 1 Publication	1
Mutagenesisⁱ	533	Y → F: Decreased affinity for acetylcholine. 1 Publication	1

Chemistry databases

ChEMBLⁱ	CHEMBL320
DrugCentral More...DrugCentralⁱ	P08483
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	15

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069034	1 – 589	Muscarinic acetylcholine receptor M3Add BLAST		589

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	6	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	15	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	41	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	48	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	52	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	140 ↔ 220	PROSITE-ProRule annotation1 Publication
Modified residueⁱ	384	PhosphoserineBy similarity	1
Disulfide bondⁱ	516 ↔ 519	PROSITE-ProRule annotation1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P08483
PRIDEⁱ	P08483

PTM databases

PhosphoSitePlusⁱ	P08483

PhosphoSitePlusⁱ

P08483

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000049410 Expressed in brain and 8 other tissues
Genevisibleⁱ	P08483 RN

Interactionⁱ

Subunit structureⁱ

Homodimer; the dimers can form tetramers (By similarity).

Interacts with NALCN (By similarity).

Interacts with TMEM147 (By similarity).

By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	P11275	2	EBI-7946407,EBI-2640645

With

Entry

#Exp.

IntAct

Notes

P11275

2

EBI-7946407,EBI-2640645

Protein-protein interaction databases

IntActⁱ	P08483, 1 interactor
Molecular INTeraction database More...MINTⁱ	P08483
STRINGⁱ	10116.ENSRNOP00000067435

Chemistry databases

BindingDBⁱ

P08483

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	65 – 94	Combined sources	30
Beta strandⁱ	96 – 98	Combined sources	3
Helixⁱ	102 – 118	Combined sources	17
Helixⁱ	120 – 129	Combined sources	10
Beta strandⁱ	130 – 132	Combined sources	3
Helixⁱ	137 – 170	Combined sources	34
Beta strandⁱ	173 – 175	Combined sources	3
Turnⁱ	176 – 178	Combined sources	3
Helixⁱ	181 – 210	Combined sources	30
Helixⁱ	224 – 226	Combined sources	3
Helixⁱ	228 – 238	Combined sources	11
Helixⁱ	240 – 253	Combined sources	14
Helixⁱ	255 – 257	Combined sources	3
Helixⁱ	291 – 295	Combined sources	5
Helixⁱ	304 – 307	Combined sources	4
Helixⁱ	483 – 502	Combined sources	20
Helixⁱ	504 – 513	Combined sources	10
Beta strandⁱ	517 – 519	Combined sources	3
Helixⁱ	522 – 533	Combined sources	12
Helixⁱ	535 – 544	Combined sources	10
Helixⁱ	548 – 556	Combined sources	9

Show more details

3D structure databases

SMRⁱ	P08483
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	147 – 151	Agonist bindingCurated		5
Regionⁱ	506 – 529	Agonist bindingCuratedAdd BLAST		24

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	274 – 280	Basolateral sorting signalBy similarity		7

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4220 Eukaryota ENOG410YCQR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000160084
HOGENOMⁱ	CLU_009579_11_2_1
InParanoidⁱ	P08483
KEGG Orthology (KO) More...KOⁱ	K04131
OMAⁱ	VIFHKRV
Database of Orthologous Groups More...OrthoDBⁱ	1245472at2759
PhylomeDBⁱ	P08483
TreeFamⁱ	TF320495

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001183 Musac_Ach_M3_rcpt IPR000995 Musac_Ach_rcpt
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00243 MUSCARINICR PR00540 MUSCRINICM3R
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P08483-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTLHSNSTTS PLFPNISSSW VHSPSEAGLP LGTVTQLGSY NISQETGNFS 
        60         70         80         90        100
SNDTSSDPLG GHTIWQVVFI AFLTGFLALV TIIGNILVIV AFKVNKQLKT 
       110        120        130        140        150
VNNYFLLSLA CADLIIGVIS MNLFTTYIIM NRWALGNLAC DLWLSIDYVA 
       160        170        180        190        200
SNASVMNLLV ISFDRYFSIT RPLTYRAKRT TKRAGVMIGL AWVISFVLWA 
       210        220        230        240        250
PAILFWQYFV GKRTVPPGEC FIQFLSEPTI TFGTAIAAFY MPVTIMTILY 
       260        270        280        290        300
WRIYKETEKR TKELAGLQAS GTEAEAENFV HPTGSSRSCS SYELQQQGVK 
       310        320        330        340        350
RSSRRKYGRC HFWFTTKSWK PSAEQMDQDH SSSDSWNNND AAASLENSAS 
       360        370        380        390        400
SDEEDIGSET RAIYSIVLKL PGHSSILNST KLPSSDNLQV SNEDLGTVDV 
       410        420        430        440        450
ERNAHKLQAQ KSMGDGDNCQ KDFTKLPIQL ESAVDTGKTS DTNSSADKTT 
       460        470        480        490        500
ATLPLSFKEA TLAKRFALKT RSQITKRKRM SLIKEKKAAQ TLSAILLAFI 
       510        520        530        540        550
ITWTPYNIMV LVNTFCDSCI PKTYWNLGYW LCYINSTVNP VCYALCNKTF 
       560        570        580 
RTTFKTLLLC QCDKRKRRKQ QYQQRQSVIF HKRVPEQAL

Length:589

Mass (Da):66,066

Last modified:November 1, 1988 - v1

Checksum:ⁱ9A5EF2FA653C830A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	184	A → R in AAA40661 (PubMed:3037705).Curated	1
Sequence conflictⁱ	184	A → R in AAA40662 (PubMed:3037705).Curated	1
Sequence conflictⁱ	184	A → R in BAA36839 (PubMed:9972520).Curated	1
Sequence conflictⁱ	516	C → R in AAA40659 (PubMed:3120722).Curated	1
Sequence conflictⁱ	556	T → M in AAA40659 (PubMed:3120722).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M16407 mRNA Translation: AAA40661.1 M16408 Genomic DNA Translation: AAA40662.1 M18088 mRNA Translation: AAA40659.1 M62826 Genomic DNA Translation: AAA41553.1 AB017656 mRNA Translation: BAA36839.1
PIRⁱ	A29476 B94518 B29514
NCBI Reference Sequences More...RefSeqⁱ	NP_036659.2, NM_012527.2 XP_017455938.1, XM_017600449.1 XP_017455939.1, XM_017600450.1 XP_017455940.1, XM_017600451.1 XP_017455941.1, XM_017600452.1

Genome annotation databases

Ensemblⁱ	ENSRNOT00000075651; ENSRNOP00000067435; ENSRNOG00000049410
GeneIDⁱ	24260
KEGGⁱ	rno:24260
UCSC genome browser More...UCSCⁱ	RGD:2343 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08483	Muscarinic acetylcholine receptor M3		GORGO		590	UniRef90_P08483
Muscarinic acetylcholine receptor M3		BOVIN		590
Muscarinic acetylcholine receptor M3		PIG		590
Muscarinic acetylcholine receptor M3		PANTR		590
Muscarinic acetylcholine receptor M3	)	HUMAN		590
+129

Protein	Similar proteins		Species	Score	Length	Source
P08483	Muscarinic acetylcholine receptor M3		PIG		590	UniRef50_P08483
Muscarinic acetylcholine receptor M3		BOVIN		590
Muscarinic acetylcholine receptor M3	)	HUMAN		590
Muscarinic acetylcholine receptor M3		GORGO		590
Muscarinic acetylcholine receptor M3		PONPY		590
+327

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M16407 mRNA Translation: AAA40661.1 M16408 Genomic DNA Translation: AAA40662.1 M18088 mRNA Translation: AAA40659.1 M62826 Genomic DNA Translation: AAA41553.1 AB017656 mRNA Translation: BAA36839.1
PIRⁱ	A29476 B94518 B29514
RefSeqⁱ	NP_036659.2, NM_012527.2 XP_017455938.1, XM_017600449.1 XP_017455939.1, XM_017600450.1 XP_017455940.1, XM_017600451.1 XP_017455941.1, XM_017600452.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2AMK	model	-	A	56-560	[»]
	4DAJ	X-ray	3.40	A/B/C/D	57-259	[»]
				A/B/C/D	482-589	[»]
	4U14	X-ray	3.57	A	57-259	[»]
				A	482-563	[»]
	4U15	X-ray	2.80	A/B	57-259	[»]
				A/B	482-563	[»]
	4U16	X-ray	3.70	A/B	57-259	[»]
				A/B	482-563	[»]
	5ZHP	X-ray	3.10	A/B	57-308	[»]
				A/B	482-569	[»]
SMRⁱ	P08483
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P08483, 1 interactor
MINTⁱ	P08483
STRINGⁱ	10116.ENSRNOP00000067435

Chemistry databases

BindingDBⁱ	P08483
ChEMBLⁱ	CHEMBL320
DrugCentralⁱ	P08483
GuidetoPHARMACOLOGYⁱ	15

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

PhosphoSitePlusⁱ	P08483

PhosphoSitePlusⁱ

P08483

Proteomic databases

PaxDbⁱ	P08483
PRIDEⁱ	P08483

Genome annotation databases

Ensemblⁱ	ENSRNOT00000075651; ENSRNOP00000067435; ENSRNOG00000049410
GeneIDⁱ	24260
KEGGⁱ	rno:24260
UCSCⁱ	RGD:2343 rat

Organism-specific databases

CTDⁱ	1131
RGDⁱ	2343 Chrm3

Phylogenomic databases

eggNOGⁱ	KOG4220 Eukaryota ENOG410YCQR LUCA
GeneTreeⁱ	ENSGT00940000160084
HOGENOMⁱ	CLU_009579_11_2_1
InParanoidⁱ	P08483
KOⁱ	K04131
OMAⁱ	VIFHKRV
OrthoDBⁱ	1245472at2759
PhylomeDBⁱ	P08483
TreeFamⁱ	TF320495

Enzyme and pathway databases

Reactomeⁱ	R-RNO-390648 Muscarinic acetylcholine receptors R-RNO-416476 G alpha (q) signalling events

Reactomeⁱ

R-RNO-390648 Muscarinic acetylcholine receptors
R-RNO-416476 G alpha (q) signalling events

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P08483

PROⁱ

PR:P08483

Gene expression databases

Bgeeⁱ	ENSRNOG00000049410 Expressed in brain and 8 other tissues
Genevisibleⁱ	P08483 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR001183 Musac_Ach_M3_rcpt IPR000995 Musac_Ach_rcpt
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00237 GPCRRHODOPSN PR00243 MUSCARINICR PR00540 MUSCRINICM3R
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACM3_RAT
Accessionⁱ	P08483Primary (citable) accession number: P08483 Secondary accession number(s): Q9QWK9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	November 1, 1988
	Last modified:	February 26, 2020
	This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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Help

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Supporting data

UniProtKB - P08483 (ACM3_RAT)

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Muscarinic acetylcholine receptor M3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ