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Protein

Muscarinic acetylcholine receptor M1

Gene

Chrm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105Antagonist1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-390648 Muscarinic acetylcholine receptors
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M1
Gene namesi
Name:Chrm1
Synonyms:Chrm-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2342 Chrm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 47Helical; Name=1By similarityAdd BLAST23
Topological domaini48 – 61CytoplasmicSequence analysisAdd BLAST14
Transmembranei62 – 82Helical; Name=2By similarityAdd BLAST21
Topological domaini83 – 99ExtracellularSequence analysisAdd BLAST17
Transmembranei100 – 121Helical; Name=3By similarityAdd BLAST22
Topological domaini122 – 141CytoplasmicSequence analysisAdd BLAST20
Transmembranei142 – 164Helical; Name=4By similarityAdd BLAST23
Topological domaini165 – 186ExtracellularSequence analysisAdd BLAST22
Transmembranei187 – 209Helical; Name=5By similarityAdd BLAST23
Topological domaini210 – 366CytoplasmicSequence analysisAdd BLAST157
Transmembranei367 – 387Helical; Name=6By similarityAdd BLAST21
Topological domaini388 – 401ExtracellularSequence analysisAdd BLAST14
Transmembranei402 – 421Helical; Name=7By similarityAdd BLAST20
Topological domaini422 – 460CytoplasmicSequence analysisAdd BLAST39

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL276
GuidetoPHARMACOLOGYi13

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690191 – 460Muscarinic acetylcholine receptor M1Add BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineCurated1
Glycosylationi12N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi98 ↔ 178Curated
Modified residuei230PhosphothreonineBy similarity1
Modified residuei254PhosphoserineCombined sources1
Modified residuei428PhosphothreonineSequence analysis1
Modified residuei451PhosphoserineSequence analysis1
Modified residuei455PhosphothreonineSequence analysis1
Modified residuei457PhosphoserineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP08482
PRIDEiP08482

PTM databases

iPTMnetiP08482
PhosphoSitePlusiP08482

Expressioni

Gene expression databases

BgeeiENSRNOG00000018385 Expressed in 4 organ(s), highest expression level in brain
GenevisibleiP08482 RN

Interactioni

Subunit structurei

Interacts with GPRASP2.By similarity

Protein-protein interaction databases

BioGridi247270, 1 interactor
CORUMiP08482
STRINGi10116.ENSRNOP00000024785

Chemistry databases

BindingDBiP08482

Structurei

3D structure databases

ProteinModelPortaliP08482
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM1 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4220 Eukaryota
ENOG410YCQR LUCA
GeneTreeiENSGT00780000121874
HOGENOMiHOG000231484
HOVERGENiHBG105720
InParanoidiP08482
KOiK04129
OMAiRCCRTPR
OrthoDBiEOG091G06VI
PhylomeDBiP08482
TreeFamiTF320495

Family and domain databases

CDDicd15049 7tmA_mAChR, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002228 Musac_Ach_M1_rcpt
IPR000995 Musac_Ach_rcpt
PANTHERiPTHR43914:SF7 PTHR43914:SF7, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00243 MUSCARINICR
PR00538 MUSCRINICM1R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P08482-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNTSVPPAVS PNITVLAPGK GPWQVAFIGI TTGLLSLATV TGNLLVLISF
60 70 80 90 100
KVNTELKTVN NYFLLSLACA DLIIGTFSMN LYTTYLLMGH WALGTLACDL
110 120 130 140 150
WLALDYVASN ASVMNLLLIS FDRYFSVTRP LSYRAKRTPR RAALMIGLAW
160 170 180 190 200
LVSFVLWAPA ILFWQYLVGE RTVLAGQCYI QFLSQPIITF GTAMAAFYLP
210 220 230 240 250
VTVMCTLYWR IYRETENRAR ELAALQGSET PGKGGGSSSS SERSQPGAEG
260 270 280 290 300
SPESPPGRCC RCCRAPRLLQ AYSWKEEEEE DEGSMESLTS SEGEEPGSEV
310 320 330 340 350
VIKMPMVDSE AQAPTKQPPK SSPNTVKRPT KKGRDRGGKG QKPRGKEQLA
360 370 380 390 400
KRKTFSLVKE KKAARTLSAI LLAFILTWTP YNIMVLVSTF CKDCVPETLW
410 420 430 440 450
ELGYWLCYVN STVNPMCYAL CNKAFRDTFR LLLLCRWDKR RWRKIPKRPG
460
SVHRTPSRQC
Length:460
Mass (Da):51,369
Last modified:August 1, 1988 - v1
Checksum:i527573ED8FF7C317
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16406 Genomic DNA Translation: AAA40660.1
S73971 Genomic DNA Translation: AAB20705.1
PIRiA94518 A29514
RefSeqiNP_542951.1, NM_080773.1
XP_006231036.1, XM_006230974.3
XP_008758437.1, XM_008760215.2
UniGeneiRn.119395

Genome annotation databases

EnsembliENSRNOT00000024785; ENSRNOP00000024785; ENSRNOG00000018385
GeneIDi25229
KEGGirno:25229
UCSCiRGD:2342 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16406 Genomic DNA Translation: AAA40660.1
S73971 Genomic DNA Translation: AAB20705.1
PIRiA94518 A29514
RefSeqiNP_542951.1, NM_080773.1
XP_006231036.1, XM_006230974.3
XP_008758437.1, XM_008760215.2
UniGeneiRn.119395

3D structure databases

ProteinModelPortaliP08482
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247270, 1 interactor
CORUMiP08482
STRINGi10116.ENSRNOP00000024785

Chemistry databases

BindingDBiP08482
ChEMBLiCHEMBL276
GuidetoPHARMACOLOGYi13

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP08482
PhosphoSitePlusiP08482

Proteomic databases

PaxDbiP08482
PRIDEiP08482

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024785; ENSRNOP00000024785; ENSRNOG00000018385
GeneIDi25229
KEGGirno:25229
UCSCiRGD:2342 rat

Organism-specific databases

CTDi1128
RGDi2342 Chrm1

Phylogenomic databases

eggNOGiKOG4220 Eukaryota
ENOG410YCQR LUCA
GeneTreeiENSGT00780000121874
HOGENOMiHOG000231484
HOVERGENiHBG105720
InParanoidiP08482
KOiK04129
OMAiRCCRTPR
OrthoDBiEOG091G06VI
PhylomeDBiP08482
TreeFamiTF320495

Enzyme and pathway databases

ReactomeiR-RNO-390648 Muscarinic acetylcholine receptors
R-RNO-416476 G alpha (q) signalling events

Miscellaneous databases

PROiPR:P08482

Gene expression databases

BgeeiENSRNOG00000018385 Expressed in 4 organ(s), highest expression level in brain
GenevisibleiP08482 RN

Family and domain databases

CDDicd15049 7tmA_mAChR, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002228 Musac_Ach_M1_rcpt
IPR000995 Musac_Ach_rcpt
PANTHERiPTHR43914:SF7 PTHR43914:SF7, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00243 MUSCARINICR
PR00538 MUSCRINICM1R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACM1_RAT
AccessioniPrimary (citable) accession number: P08482
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 7, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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