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Protein

Inhibin beta A chain

Gene

INHBA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functioni

  • cytokine activity Source: HGNC
  • growth factor activity Source: UniProtKB
  • hormone activity Source: UniProtKB
  • identical protein binding Source: UniProtKB
  • inhibin binding Source: Ensembl
  • peptide hormone binding Source: UniProtKB
  • protein heterodimerization activity Source: Ensembl
  • transforming growth factor beta receptor binding Source: GO_Central
  • type II activin receptor binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Hormone

Enzyme and pathway databases

ReactomeiR-HSA-1502540 Signaling by Activin
R-HSA-209822 Glycoprotein hormones
R-HSA-2473224 Antagonism of Activin by Follistatin
SignaLinkiP08476
SIGNORiP08476

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta A chain
Alternative name(s):
Activin beta-A chain
Erythroid differentiation protein
Short name:
EDF
Gene namesi
Name:INHBA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000122641.9
HGNCiHGNC:6066 INHBA
MIMi147290 gene
neXtProtiNX_P08476

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3624
MalaCardsiINHBA
OpenTargetsiENSG00000122641
Orphaneti213504 Adenocarcinoma of ovary
PharmGKBiPA29877

Chemistry databases

ChEMBLiCHEMBL3588735

Polymorphism and mutation databases

BioMutaiINHBA
DMDMi124279

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
PropeptideiPRO_000003370821 – 310Add BLAST290
ChainiPRO_0000033709311 – 426Inhibin beta A chainAdd BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi314 ↔ 3221 Publication
Disulfide bondi321 ↔ 3911 Publication
Disulfide bondi350 ↔ 4231 Publication
Disulfide bondi354 ↔ 4251 Publication
Disulfide bondi390Interchain1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDiP08476
MaxQBiP08476
PaxDbiP08476
PeptideAtlasiP08476
PRIDEiP08476
ProteomicsDBi52111

PTM databases

iPTMnetiP08476
PhosphoSitePlusiP08476

Expressioni

Gene expression databases

BgeeiENSG00000122641 Expressed in 187 organ(s), highest expression level in placenta
CleanExiHS_INHBA
ExpressionAtlasiP08476 baseline and differential
GenevisibleiP08476 HS

Interactioni

Subunit structurei

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FstP216742EBI-8077140,EBI-5746973From Rattus norvegicus.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109836, 9 interactors
DIPiDIP-5824N
IntActiP08476, 1 interactor
MINTiP08476
STRINGi9606.ENSP00000242208

Structurei

Secondary structure

1426
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08476
SMRiP08476
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08476

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000220890
HOVERGENiHBG105613
InParanoidiP08476
KOiK04667
OMAiLRPHPKH
OrthoDBiEOG091G09LW
PhylomeDBiP08476
TreeFamiTF351791

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000491 Inhibin_betaA
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PRINTSiPR00670 INHIBINBA
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08476-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLLWLRGFL LASCWIIVRS SPTPGSEGHS AAPDCPSCAL AALPKDVPNS
60 70 80 90 100
QPEMVEAVKK HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY
110 120 130 140 150
VEIEDDIGRR AEMNELMEQT SEIITFAESG TARKTLHFEI SKEGSDLSVV
160 170 180 190 200
ERAEVWLFLK VPKANRTRTK VTIRLFQQQK HPQGSLDTGE EAEEVGLKGE
210 220 230 240 250
RSELLLSEKV VDARKSTWHV FPVSSSIQRL LDQGKSSLDV RIACEQCQES
260 270 280 290 300
GASLVLLGKK KKKEEEGEGK KKGGGEGGAG ADEEKEQSHR PFLMLQARQS
310 320 330 340 350
EDHPHRRRRR GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC
360 370 380 390 400
EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS
410 420
MLYYDDGQNI IKKDIQNMIV EECGCS
Length:426
Mass (Da):47,442
Last modified:July 1, 1989 - v2
Checksum:i201CDEDF99CB6919
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti377 – 379RMR → AC in CAA51163 (Ref. 7) Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_072640280G → E Found in a patient with early-onset epithelial ovarian tumor; uncertain pathological significance. 1 Publication1
Natural variantiVAR_052566299Q → P. Corresponds to variant dbSNP:rs41294833Ensembl.1
Natural variantiVAR_072641386N → S Found in a patient with early-onset epithelial ovarian tumor; alters the ratio of secreted activins and ihibins; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1361491625Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13436 mRNA Translation: AAA59168.1
X04447 Genomic DNA Translation: CAA28041.1
X57578, X57579 Genomic DNA Translation: CAA40805.1
X57579 Genomic DNA Translation: CAA40806.1
AC005027 Genomic DNA Translation: AAQ96861.1
BC007858 mRNA Translation: AAH07858.1
J03634 mRNA Translation: AAA35787.1
X72498 mRNA Translation: CAA51163.1
CCDSiCCDS5464.1
PIRiS30488 B24248
RefSeqiNP_002183.1, NM_002192.3
XP_016867665.1, XM_017012176.1
UniGeneiHs.28792
Hs.583348

Genome annotation databases

EnsembliENST00000242208; ENSP00000242208; ENSG00000122641
ENST00000442711; ENSP00000397197; ENSG00000122641
ENST00000638023; ENSP00000490646; ENSG00000122641
GeneIDi3624
KEGGihsa:3624
UCSCiuc003thq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Activin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13436 mRNA Translation: AAA59168.1
X04447 Genomic DNA Translation: CAA28041.1
X57578, X57579 Genomic DNA Translation: CAA40805.1
X57579 Genomic DNA Translation: CAA40806.1
AC005027 Genomic DNA Translation: AAQ96861.1
BC007858 mRNA Translation: AAH07858.1
J03634 mRNA Translation: AAA35787.1
X72498 mRNA Translation: CAA51163.1
CCDSiCCDS5464.1
PIRiS30488 B24248
RefSeqiNP_002183.1, NM_002192.3
XP_016867665.1, XM_017012176.1
UniGeneiHs.28792
Hs.583348

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NYSX-ray3.05B/D311-426[»]
1NYUX-ray3.10B/D311-426[»]
1S4YX-ray2.30B/D311-426[»]
2ARPX-ray2.00A311-426[»]
2ARVX-ray2.00A/B311-426[»]
2B0UX-ray2.80A/B311-426[»]
2P6AX-ray3.40A/B311-426[»]
3B4VX-ray2.48A/B/E/F311-426[»]
4MIDX-ray2.14A334-426[»]
5HLYX-ray2.30A30-426[»]
5HLZX-ray2.85A/C/E/G30-305[»]
B/D/F/H311-426[»]
ProteinModelPortaliP08476
SMRiP08476
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109836, 9 interactors
DIPiDIP-5824N
IntActiP08476, 1 interactor
MINTiP08476
STRINGi9606.ENSP00000242208

Chemistry databases

ChEMBLiCHEMBL3588735

PTM databases

iPTMnetiP08476
PhosphoSitePlusiP08476

Polymorphism and mutation databases

BioMutaiINHBA
DMDMi124279

Proteomic databases

EPDiP08476
MaxQBiP08476
PaxDbiP08476
PeptideAtlasiP08476
PRIDEiP08476
ProteomicsDBi52111

Protocols and materials databases

DNASUi3624
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242208; ENSP00000242208; ENSG00000122641
ENST00000442711; ENSP00000397197; ENSG00000122641
ENST00000638023; ENSP00000490646; ENSG00000122641
GeneIDi3624
KEGGihsa:3624
UCSCiuc003thq.4 human

Organism-specific databases

CTDi3624
DisGeNETi3624
EuPathDBiHostDB:ENSG00000122641.9
GeneCardsiINHBA
HGNCiHGNC:6066 INHBA
MalaCardsiINHBA
MIMi147290 gene
neXtProtiNX_P08476
OpenTargetsiENSG00000122641
Orphaneti213504 Adenocarcinoma of ovary
PharmGKBiPA29877
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000220890
HOVERGENiHBG105613
InParanoidiP08476
KOiK04667
OMAiLRPHPKH
OrthoDBiEOG091G09LW
PhylomeDBiP08476
TreeFamiTF351791

Enzyme and pathway databases

ReactomeiR-HSA-1502540 Signaling by Activin
R-HSA-209822 Glycoprotein hormones
R-HSA-2473224 Antagonism of Activin by Follistatin
SignaLinkiP08476
SIGNORiP08476

Miscellaneous databases

EvolutionaryTraceiP08476
GenomeRNAii3624
PROiPR:P08476
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122641 Expressed in 187 organ(s), highest expression level in placenta
CleanExiHS_INHBA
ExpressionAtlasiP08476 baseline and differential
GenevisibleiP08476 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000491 Inhibin_betaA
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PRINTSiPR00670 INHIBINBA
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINHBA_HUMAN
AccessioniPrimary (citable) accession number: P08476
Secondary accession number(s): Q14599
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 1, 1989
Last modified: October 10, 2018
This is version 204 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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