Inhibin beta A chain

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: HGNC <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 9884026
• growth factor activity Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 12324653
• hormone activity Source: UniProtKBTraceable author statementⁱ
  • 12456957
• identical protein binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 2575216
• inhibin binding Source: Ensembl
• peptide hormone binding Source: UniProtKBInferred from physical interactionⁱ
  • 16198295
• protein heterodimerization activity Source: Ensembl
• transforming growth factor beta receptor binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• type II activin receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • 7890768

GO - Biological processⁱ

• activin receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • 9884026
• cell-cell signaling Source: UniProtKBTraceable author statementⁱ
  • 12456957
• cell cycle arrest Source: HGNCInferred from direct assayⁱ
  • 9884026
• cell development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cell differentiation Source: UniProtKBTraceable author statementⁱ
  • 12456957
• cell surface receptor signaling pathway Source: UniProtKBTraceable author statementⁱ
  • 12456957
• cellular response to cholesterol Source: Ensembl
• cellular response to follicle-stimulating hormone stimulus Source: Ensembl
• defense response Source: UniProtKBTraceable author statementⁱ
  • 12456957
• endodermal cell differentiation Source: BHF-UCLInferred from direct assayⁱ
  • 21828274
• erythrocyte differentiation Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 1310063
• extrinsic apoptotic signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • 9884026
• eyelid development in camera-type eye Source: UniProtKB
• G1/S transition of mitotic cell cycle Source: HGNCInferred from direct assayⁱ
  • 9884026
• GABAergic neuron differentiation Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • 25804741
• hair follicle development Source: UniProtKB <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 10932194
• hematopoietic progenitor cell differentiation Source: UniProtKBInferred from direct assayⁱ
  • 15451575
• hemoglobin biosynthetic process Source: UniProtKBInferred from direct assayⁱ
  • 1310063
• male gonad development Source: UniProtKBInferred from genetic interactionⁱ
  • 10932194
• mesodermal cell differentiation Source: Ensembl
• negative regulation of B cell differentiation Source: UniProtKBTraceable author statementⁱ
  • 12456957
• negative regulation of cell cycle Source: HGNCInferred from direct assayⁱ
  • 9884026
• negative regulation of cell growth Source: UniProtKBInferred from direct assayⁱ
  • 20573232
• negative regulation of cell proliferation Source: UniProtKBInferred from direct assayⁱ
  • 11948405
• negative regulation of follicle-stimulating hormone secretion Source: UniProtKBNon-traceable author statementⁱ
  • 3267209
• negative regulation of interferon-gamma biosynthetic process Source: UniProtKBTraceable author statementⁱ
  • 12456957
• negative regulation of macrophage differentiation Source: UniProtKBTraceable author statementⁱ
  • 12456957
• negative regulation of phosphorylation Source: UniProtKBTraceable author statementⁱ
  • 12456957
• nervous system development Source: UniProtKBNon-traceable author statementⁱ
  • 10320815
• odontogenesis Source: UniProtKBInferred from genetic interactionⁱ
  • 10932194
• ovarian follicle development Source: UniProtKBInferred from genetic interactionⁱ
  • 10932194
• positive regulation of cellular protein metabolic process Source: BHF-UCLInferred from direct assayⁱ
  • 21828274
• positive regulation of erythrocyte differentiation Source: HGNCInferred from direct assayⁱ
  • 9032295
• positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKBInferred from direct assayⁱ
  • 8267637
• positive regulation of follicle-stimulating hormone secretion Source: UniProtKBTraceable author statementⁱ
  • 12456957
• positive regulation of gene expression Source: BHF-UCLInferred from direct assayⁱ
  • 23812417
• positive regulation of ovulation Source: UniProtKB
• positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • 19736306
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • 21281489
• positive regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • 12702211
  • 21281489
• progesterone secretion Source: UniProtKBInferred from genetic interactionⁱ
  • 10932194
• regulation of apoptotic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• regulation of follicle-stimulating hormone secretion Source: UniProtKBInferred from genetic interactionⁱ
  • 10932194
• regulation of MAPK cascade Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • 11948405
• response to drug Source: UniProtKBInferred from direct assayⁱ
  • 20573232
• roof of mouth development Source: UniProtKBInferred from genetic interactionⁱ
  • 10932194
• SMAD protein signal transduction Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• striatal medium spiny neuron differentiation Source: ParkinsonsUK-UCLInferred from direct assayⁱ
  • 25804741

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• cytokine activity Source: HGNCInferred from direct assayⁱ
  • 9884026
• growth factor activity Source: UniProtKBTraceable author statementⁱ
  • 12324653
• hormone activity Source: UniProtKBTraceable author statementⁱ
  • 12456957
• identical protein binding Source: UniProtKBInferred from physical interactionⁱ
  • 2575216
• inhibin binding Source: Ensembl
• protein heterodimerization activity Source: Ensembl
• transforming growth factor beta receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• type II activin receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • 7890768

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MPLLWLRGFL LASCWIIVRS SPTPGSEGHS AAPDCPSCAL AALPKDVPNS 
        60         70         80         90        100
QPEMVEAVKK HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY 
       110        120        130        140        150
VEIEDDIGRR AEMNELMEQT SEIITFAESG TARKTLHFEI SKEGSDLSVV 
       160        170        180        190        200
ERAEVWLFLK VPKANRTRTK VTIRLFQQQK HPQGSLDTGE EAEEVGLKGE 
       210        220        230        240        250
RSELLLSEKV VDARKSTWHV FPVSSSIQRL LDQGKSSLDV RIACEQCQES 
       260        270        280        290        300
GASLVLLGKK KKKEEEGEGK KKGGGEGGAG ADEEKEQSHR PFLMLQARQS 
       310        320        330        340        350
EDHPHRRRRR GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC 
       360        370        380        390        400
EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS 
       410        420 
MLYYDDGQNI IKKDIQNMIV EECGCS                           

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 7
   Human chromosome 7: entries, gene names and cross-references to MIM
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families
4. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
5. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
6. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot