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Protein

Inhibin beta A chain

Gene

INHBA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine activity Source: HGNC
  • growth factor activity Source: UniProtKB
  • hormone activity Source: UniProtKB
  • identical protein binding Source: UniProtKB
  • inhibin binding Source: Ensembl
  • peptide hormone binding Source: UniProtKB
  • protein heterodimerization activity Source: Ensembl
  • transforming growth factor beta receptor binding Source: GO_Central
  • type II activin receptor binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor, Hormone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1502540 Signaling by Activin
R-HSA-209822 Glycoprotein hormones
R-HSA-2473224 Antagonism of Activin by Follistatin

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P08476

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P08476

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inhibin beta A chain
Alternative name(s):
Activin beta-A chain
Erythroid differentiation protein
Short name:
EDF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INHBA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000122641.9

Human Gene Nomenclature Database

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HGNCi
HGNC:6066 INHBA

Online Mendelian Inheritance in Man (OMIM)

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MIMi
147290 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08476

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3624

MalaCards human disease database

More...
MalaCardsi
INHBA

Open Targets

More...
OpenTargetsi
ENSG00000122641

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
213504 Adenocarcinoma of ovary

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29877

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3588735

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
INHBA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124279

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20By similarityAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000003370821 – 310Add BLAST290
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000033709311 – 426Inhibin beta A chainAdd BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi314 ↔ 3221 Publication
Disulfide bondi321 ↔ 3911 Publication
Disulfide bondi350 ↔ 4231 Publication
Disulfide bondi354 ↔ 4251 Publication
Disulfide bondi390Interchain1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P08476

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P08476

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08476

PeptideAtlas

More...
PeptideAtlasi
P08476

PRoteomics IDEntifications database

More...
PRIDEi
P08476

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52111

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08476

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P08476

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000122641 Expressed in 187 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

More...
CleanExi
HS_INHBA

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P08476 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P08476 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
FstP216742EBI-8077140,EBI-5746973From Rattus norvegicus.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109836, 9 interactors

Database of interacting proteins

More...
DIPi
DIP-5824N

Protein interaction database and analysis system

More...
IntActi
P08476, 1 interactor

Molecular INTeraction database

More...
MINTi
P08476

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000242208

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1426
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P08476

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P08476

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P08476

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3900 Eukaryota
ENOG410XT8Z LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157116

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000220890

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG105613

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08476

KEGG Orthology (KO)

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KOi
K04667

Identification of Orthologs from Complete Genome Data

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OMAi
LRPHPKH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G09LW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P08476

TreeFam database of animal gene trees

More...
TreeFami
TF351791

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000491 Inhibin_betaA
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11848 PTHR11848, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00670 INHIBINBA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00204 TGFB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57501 SSF57501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P08476-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLLWLRGFL LASCWIIVRS SPTPGSEGHS AAPDCPSCAL AALPKDVPNS
60 70 80 90 100
QPEMVEAVKK HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY
110 120 130 140 150
VEIEDDIGRR AEMNELMEQT SEIITFAESG TARKTLHFEI SKEGSDLSVV
160 170 180 190 200
ERAEVWLFLK VPKANRTRTK VTIRLFQQQK HPQGSLDTGE EAEEVGLKGE
210 220 230 240 250
RSELLLSEKV VDARKSTWHV FPVSSSIQRL LDQGKSSLDV RIACEQCQES
260 270 280 290 300
GASLVLLGKK KKKEEEGEGK KKGGGEGGAG ADEEKEQSHR PFLMLQARQS
310 320 330 340 350
EDHPHRRRRR GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC
360 370 380 390 400
EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS
410 420
MLYYDDGQNI IKKDIQNMIV EECGCS
Length:426
Mass (Da):47,442
Last modified:July 1, 1989 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i201CDEDF99CB6919
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti377 – 379RMR → AC in CAA51163 (Ref. 7) Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072640280G → E Found in a patient with early-onset epithelial ovarian tumor; uncertain pathological significance. 1 Publication1
Natural variantiVAR_052566299Q → P. Corresponds to variant dbSNP:rs41294833Ensembl.1
Natural variantiVAR_072641386N → S Found in a patient with early-onset epithelial ovarian tumor; alters the ratio of secreted activins and ihibins; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1361491625Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M13436 mRNA Translation: AAA59168.1
X04447 Genomic DNA Translation: CAA28041.1
X57578, X57579 Genomic DNA Translation: CAA40805.1
X57579 Genomic DNA Translation: CAA40806.1
AC005027 Genomic DNA Translation: AAQ96861.1
BC007858 mRNA Translation: AAH07858.1
J03634 mRNA Translation: AAA35787.1
X72498 mRNA Translation: CAA51163.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5464.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S30488 B24248

NCBI Reference Sequences

More...
RefSeqi
NP_002183.1, NM_002192.3
XP_016867665.1, XM_017012176.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.28792
Hs.583348

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000242208; ENSP00000242208; ENSG00000122641
ENST00000442711; ENSP00000397197; ENSG00000122641
ENST00000638023; ENSP00000490646; ENSG00000122641

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3624

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3624

UCSC genome browser

More...
UCSCi
uc003thq.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Activin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13436 mRNA Translation: AAA59168.1
X04447 Genomic DNA Translation: CAA28041.1
X57578, X57579 Genomic DNA Translation: CAA40805.1
X57579 Genomic DNA Translation: CAA40806.1
AC005027 Genomic DNA Translation: AAQ96861.1
BC007858 mRNA Translation: AAH07858.1
J03634 mRNA Translation: AAA35787.1
X72498 mRNA Translation: CAA51163.1
CCDSiCCDS5464.1
PIRiS30488 B24248
RefSeqiNP_002183.1, NM_002192.3
XP_016867665.1, XM_017012176.1
UniGeneiHs.28792
Hs.583348

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NYSX-ray3.05B/D311-426[»]
1NYUX-ray3.10B/D311-426[»]
1S4YX-ray2.30B/D311-426[»]
2ARPX-ray2.00A311-426[»]
2ARVX-ray2.00A/B311-426[»]
2B0UX-ray2.80A/B311-426[»]
2P6AX-ray3.40A/B311-426[»]
3B4VX-ray2.48A/B/E/F311-426[»]
4MIDX-ray2.14A334-426[»]
5HLYX-ray2.30A30-426[»]
5HLZX-ray2.85A/C/E/G30-305[»]
B/D/F/H311-426[»]
ProteinModelPortaliP08476
SMRiP08476
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109836, 9 interactors
DIPiDIP-5824N
IntActiP08476, 1 interactor
MINTiP08476
STRINGi9606.ENSP00000242208

Chemistry databases

ChEMBLiCHEMBL3588735

PTM databases

iPTMnetiP08476
PhosphoSitePlusiP08476

Polymorphism and mutation databases

BioMutaiINHBA
DMDMi124279

Proteomic databases

EPDiP08476
MaxQBiP08476
PaxDbiP08476
PeptideAtlasiP08476
PRIDEiP08476
ProteomicsDBi52111

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3624
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242208; ENSP00000242208; ENSG00000122641
ENST00000442711; ENSP00000397197; ENSG00000122641
ENST00000638023; ENSP00000490646; ENSG00000122641
GeneIDi3624
KEGGihsa:3624
UCSCiuc003thq.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3624
DisGeNETi3624
EuPathDBiHostDB:ENSG00000122641.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
INHBA
HGNCiHGNC:6066 INHBA
MalaCardsiINHBA
MIMi147290 gene
neXtProtiNX_P08476
OpenTargetsiENSG00000122641
Orphaneti213504 Adenocarcinoma of ovary
PharmGKBiPA29877

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00940000157116
HOGENOMiHOG000220890
HOVERGENiHBG105613
InParanoidiP08476
KOiK04667
OMAiLRPHPKH
OrthoDBiEOG091G09LW
PhylomeDBiP08476
TreeFamiTF351791

Enzyme and pathway databases

ReactomeiR-HSA-1502540 Signaling by Activin
R-HSA-209822 Glycoprotein hormones
R-HSA-2473224 Antagonism of Activin by Follistatin
SignaLinkiP08476
SIGNORiP08476

Miscellaneous databases

EvolutionaryTraceiP08476

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3624

Protein Ontology

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PROi
PR:P08476

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000122641 Expressed in 187 organ(s), highest expression level in placenta
CleanExiHS_INHBA
ExpressionAtlasiP08476 baseline and differential
GenevisibleiP08476 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR000491 Inhibin_betaA
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
PRINTSiPR00670 INHIBINBA
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINHBA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08476
Secondary accession number(s): Q14599
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 1, 1989
Last modified: December 5, 2018
This is version 206 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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