INHBA

Functionⁱ

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

GO - Molecular functionⁱ

cytokine activity
Source: HGNC
Inferred from direct assayⁱ
- 9884026
growth factor activity
Source: UniProtKB
Traceable author statementⁱ
- 12324653
hormone activity
Source: UniProtKB
Traceable author statementⁱ
- 12456957
identical protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 2575216
inhibin binding Source: Ensembl
peptide hormone binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16198295
protein heterodimerization activity Source: Ensembl
transforming growth factor beta receptor binding Source: GO_Central
type II activin receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7890768

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activin receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 9884026
cell-cell signaling
Source: UniProtKB
Traceable author statementⁱ
- 12456957
cell cycle arrest
Source: HGNC
Inferred from direct assayⁱ
- 9884026
cell development Source: GO_Central
cell differentiation
Source: UniProtKB
Traceable author statementⁱ
- 12456957
cell surface receptor signaling pathway
Source: UniProtKB
Traceable author statementⁱ
- 12456957
cellular response to cholesterol Source: Ensembl
cellular response to follicle-stimulating hormone stimulus Source: Ensembl
defense response
Source: UniProtKB
Traceable author statementⁱ
- 12456957
endodermal cell differentiation
Source: BHF-UCL
Inferred from direct assayⁱ
- 21828274
erythrocyte differentiation
Source: UniProtKB
Non-traceable author statementⁱ
- 1310063
extrinsic apoptotic signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 9884026
eyelid development in camera-type eye Source: UniProtKB
G1/S transition of mitotic cell cycle
Source: HGNC
Inferred from direct assayⁱ
- 9884026
GABAergic neuron differentiation
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 25804741
hair follicle development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 10932194
hematopoietic progenitor cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 15451575
hemoglobin biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 1310063
male gonad development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 10932194
mesodermal cell differentiation Source: Ensembl
negative regulation of B cell differentiation
Source: UniProtKB
Traceable author statementⁱ
- 12456957
negative regulation of cell cycle
Source: HGNC
Inferred from direct assayⁱ
- 9884026
negative regulation of cell growth
Source: UniProtKB
Inferred from direct assayⁱ
- 20573232
negative regulation of cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 11948405
negative regulation of follicle-stimulating hormone secretion
Source: UniProtKB
Non-traceable author statementⁱ
- 3267209
negative regulation of interferon-gamma biosynthetic process
Source: UniProtKB
Traceable author statementⁱ
- 12456957
negative regulation of macrophage differentiation
Source: UniProtKB
Traceable author statementⁱ
- 12456957
negative regulation of phosphorylation
Source: UniProtKB
Traceable author statementⁱ
- 12456957
nervous system development
Source: UniProtKB
Non-traceable author statementⁱ
- 10320815
odontogenesis
Source: UniProtKB
Inferred from genetic interactionⁱ
- 10932194
ovarian follicle development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 10932194
positive regulation of cellular protein metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 21828274
positive regulation of erythrocyte differentiation
Source: HGNC
Inferred from direct assayⁱ
- 9032295
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Source: UniProtKB
Inferred from direct assayⁱ
- 8267637
positive regulation of follicle-stimulating hormone secretion
Source: UniProtKB
Traceable author statementⁱ
- 12456957
positive regulation of gene expression
Source: BHF-UCL
Inferred from direct assayⁱ
- 23812417
positive regulation of ovulation Source: UniProtKB
positive regulation of pathway-restricted SMAD protein phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 19736306
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 21281489
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 12702211
- 21281489
progesterone secretion
Source: UniProtKB
Inferred from genetic interactionⁱ
- 10932194
regulation of follicle-stimulating hormone secretion
Source: UniProtKB
Inferred from genetic interactionⁱ
- 10932194
regulation of MAPK cascade Source: GO_Central
regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 11948405
response to drug
Source: UniProtKB
Inferred from direct assayⁱ
- 20573232
roof of mouth development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 10932194
SMAD protein signal transduction Source: GO_Central
striatal medium spiny neuron differentiation
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 25804741

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor, Hormone

Molecular function

Growth factor, Hormone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1502540 Signaling by Activin R-HSA-209822 Glycoprotein hormones R-HSA-2473224 Antagonism of Activin by Follistatin
SignaLinkⁱ	P08476
SIGNORⁱ	P08476

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Inhibin beta A chain Alternative name(s): Activin beta-A chain Erythroid differentiation protein Short name: EDF
Gene namesⁱ	Name:INHBA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000122641.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6066 INHBA
MIMⁱ	147290 gene
neXtProtⁱ	NX_P08476

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3624
MalaCards human disease database More...MalaCardsⁱ	INHBA
Open Targets More...OpenTargetsⁱ	ENSG00000122641
Orphanetⁱ	213504 Adenocarcinoma of ovary
PharmGKBⁱ	PA29877

Chemistry databases

ChEMBLⁱ	CHEMBL3588735

ChEMBLⁱ

CHEMBL3588735

Polymorphism and mutation databases

BioMutaⁱ	INHBA
DMDMⁱ	124279

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 20	By similarityAdd BLAST	20
PropeptideⁱPRO_0000033708	21 – 310	Add BLAST	290
ChainⁱPRO_0000033709	311 – 426	Inhibin beta A chainAdd BLAST	116

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	165	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	314 ↔ 322	1 Publication
Disulfide bondⁱ	321 ↔ 391	1 Publication
Disulfide bondⁱ	350 ↔ 423	1 Publication
Disulfide bondⁱ	354 ↔ 425	1 Publication
Disulfide bondⁱ	390	Interchain1 Publication

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P08476
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P08476
PaxDbⁱ	P08476
PeptideAtlas More...PeptideAtlasⁱ	P08476
PRIDEⁱ	P08476
ProteomicsDBⁱ	52111

PTM databases

iPTMnetⁱ	P08476
PhosphoSitePlusⁱ	P08476

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000122641 Expressed in 187 organ(s), highest expression level in placenta
CleanExⁱ	HS_INHBA
ExpressionAtlasⁱ	P08476 baseline and differential
Genevisibleⁱ	P08476 HS

Interactionⁱ

Subunit structureⁱ

Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B. Interacts with FST and FSTL3.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Fst	P21674	2	EBI-8077140,EBI-5746973	From Rattus norvegicus.

With

Entry

#Exp.

IntAct

Notes

Fst

P21674

2

EBI-8077140,EBI-5746973

From Rattus norvegicus.

GO - Molecular functionⁱ

cytokine activity
Source: HGNC
Inferred from direct assayⁱ
- 9884026
growth factor activity
Source: UniProtKB
Traceable author statementⁱ
- 12324653
hormone activity
Source: UniProtKB
Traceable author statementⁱ
- 12456957
identical protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 2575216
inhibin binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
transforming growth factor beta receptor binding Source: GO_Central
type II activin receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 7890768

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109836, 9 interactors
Database of interacting proteins More...DIPⁱ	DIP-5824N
IntActⁱ	P08476, 1 interactor
Molecular INTeraction database More...MINTⁱ	P08476
STRINGⁱ	9606.ENSP00000242208

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	52 – 65	Combined sources	14
Helixⁱ	80 – 89	Combined sources	10
Beta strandⁱ	92 – 95	Combined sources	4
Helixⁱ	97 – 99	Combined sources	3
Beta strandⁱ	101 – 103	Combined sources	3
Helixⁱ	107 – 118	Combined sources	12
Beta strandⁱ	120 – 126	Combined sources	7
Beta strandⁱ	135 – 139	Combined sources	5
Helixⁱ	143 – 146	Combined sources	4
Beta strandⁱ	149 – 160	Combined sources	12
Beta strandⁱ	170 – 180	Combined sources	11
Beta strandⁱ	201 – 212	Combined sources	12
Beta strandⁱ	217 – 222	Combined sources	6
Helixⁱ	224 – 232	Combined sources	9
Beta strandⁱ	237 – 243	Combined sources	7
Turnⁱ	245 – 251	Combined sources	7
Beta strandⁱ	253 – 255	Combined sources	3
Helixⁱ	284 – 289	Combined sources	6
Beta strandⁱ	292 – 298	Combined sources	7
Beta strandⁱ	318 – 320	Combined sources	3
Beta strandⁱ	321 – 324	Combined sources	4
Beta strandⁱ	327 – 329	Combined sources	3
Helixⁱ	330 – 333	Combined sources	4
Turnⁱ	336 – 338	Combined sources	3
Beta strandⁱ	339 – 341	Combined sources	3
Beta strandⁱ	343 – 346	Combined sources	4
Beta strandⁱ	349 – 352	Combined sources	4
Helixⁱ	356 – 358	Combined sources	3
Beta strandⁱ	362 – 364	Combined sources	3
Helixⁱ	368 – 375	Combined sources	8
Turnⁱ	378 – 380	Combined sources	3
Turnⁱ	382 – 386	Combined sources	5
Beta strandⁱ	391 – 404	Combined sources	14
Turnⁱ	406 – 408	Combined sources	3
Beta strandⁱ	410 – 425	Combined sources	16

Show more details

3D structure databases

ProteinModelPortalⁱ	P08476
SMRⁱ	P08476
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P08476

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TGF-beta family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3900 Eukaryota ENOG410XT8Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143982
HOGENOMⁱ	HOG000220890
HOVERGENⁱ	HBG105613
InParanoidⁱ	P08476
KEGG Orthology (KO) More...KOⁱ	K04667
OMAⁱ	LRPHPKH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09LW
PhylomeDBⁱ	P08476
TreeFamⁱ	TF351791

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR000491 Inhibin_betaA IPR001839 TGF-b_C IPR001111 TGF-b_propeptide IPR015615 TGF-beta-rel IPR017948 TGFb_CS
PANTHERⁱ	PTHR11848 PTHR11848, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00019 TGF_beta, 1 hit PF00688 TGFb_propeptide, 1 hit
PRINTSⁱ	PR00670 INHIBINBA
SMARTⁱ	View protein in SMART SM00204 TGFB, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00250 TGF_BETA_1, 1 hit PS51362 TGF_BETA_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P08476-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPLLWLRGFL LASCWIIVRS SPTPGSEGHS AAPDCPSCAL AALPKDVPNS 
        60         70         80         90        100
QPEMVEAVKK HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY 
       110        120        130        140        150
VEIEDDIGRR AEMNELMEQT SEIITFAESG TARKTLHFEI SKEGSDLSVV 
       160        170        180        190        200
ERAEVWLFLK VPKANRTRTK VTIRLFQQQK HPQGSLDTGE EAEEVGLKGE 
       210        220        230        240        250
RSELLLSEKV VDARKSTWHV FPVSSSIQRL LDQGKSSLDV RIACEQCQES 
       260        270        280        290        300
GASLVLLGKK KKKEEEGEGK KKGGGEGGAG ADEEKEQSHR PFLMLQARQS 
       310        320        330        340        350
EDHPHRRRRR GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC 
       360        370        380        390        400
EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS 
       410        420 
MLYYDDGQNI IKKDIQNMIV EECGCS

Length:426

Mass (Da):47,442

Last modified:July 1, 1989 - v2

Checksum:ⁱ201CDEDF99CB6919

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	377 – 379	RMR → AC in CAA51163 (Ref. 7) Curated		3

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_072640	280	G → E Found in a patient with early-onset epithelial ovarian tumor; uncertain pathological significance. 1 Publication	1
Natural variantⁱVAR_052566	299	Q → P. Corresponds to variant dbSNP:rs41294833Ensembl.	1
Natural variantⁱVAR_072641	386	N → S Found in a patient with early-onset epithelial ovarian tumor; alters the ratio of secreted activins and ihibins; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1361491625Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M13436 mRNA Translation: AAA59168.1 X04447 Genomic DNA Translation: CAA28041.1 X57578, X57579 Genomic DNA Translation: CAA40805.1 X57579 Genomic DNA Translation: CAA40806.1 AC005027 Genomic DNA Translation: AAQ96861.1 BC007858 mRNA Translation: AAH07858.1 J03634 mRNA Translation: AAA35787.1 X72498 mRNA Translation: CAA51163.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5464.1
PIRⁱ	S30488 B24248
NCBI Reference Sequences More...RefSeqⁱ	NP_002183.1, NM_002192.3 XP_016867665.1, XM_017012176.1
UniGeneⁱ	Hs.28792 Hs.583348

Genome annotation databases

Ensemblⁱ	ENST00000242208; ENSP00000242208; ENSG00000122641 ENST00000442711; ENSP00000397197; ENSG00000122641 ENST00000638023; ENSP00000490646; ENSG00000122641
GeneIDⁱ	3624
KEGGⁱ	hsa:3624
UCSC genome browser More...UCSCⁱ	uc003thq.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08476	Uncharacterized protein		MACMU		133	UniRef100_P08476
Inhibin, beta A (Fragment)		MUSPF		114
Uncharacterized protein		CAVPO		133
Uncharacterized protein		ICTTR		133
Inhibin, beta A (Activin A, activin AB alpha polypeptide)		HUMAN		426
+9

Protein	Similar proteins		Species	Score	Length	Source
P08476	Uncharacterized protein		MACMU		133	UniRef90_P08476
Inhibin, beta A (Fragment)		MUSPF		114
Uncharacterized protein		CAVPO		133
Uncharacterized protein		ICTTR		133
Inhibin, beta A (Activin A, activin AB alpha polypeptide)		HUMAN		426
+21

Protein	Similar proteins		Species	Score	Length	Source
P08476	Uncharacterized protein		MACMU		133	UniRef50_P08476
Inhibin, beta A (Fragment)		MUSPF		114
Uncharacterized protein		CAVPO		133
Uncharacterized protein		ICTTR		133
Inhibin, beta A (Activin A, activin AB alpha polypeptide)		HUMAN		426
+40

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Activin entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M13436 mRNA Translation: AAA59168.1 X04447 Genomic DNA Translation: CAA28041.1 X57578, X57579 Genomic DNA Translation: CAA40805.1 X57579 Genomic DNA Translation: CAA40806.1 AC005027 Genomic DNA Translation: AAQ96861.1 BC007858 mRNA Translation: AAH07858.1 J03634 mRNA Translation: AAA35787.1 X72498 mRNA Translation: CAA51163.1
CCDSⁱ	CCDS5464.1
PIRⁱ	S30488 B24248
RefSeqⁱ	NP_002183.1, NM_002192.3 XP_016867665.1, XM_017012176.1
UniGeneⁱ	Hs.28792 Hs.583348

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1NYS	X-ray	3.05	B/D	311-426	[»]
	1NYU	X-ray	3.10	B/D	311-426	[»]
	1S4Y	X-ray	2.30	B/D	311-426	[»]
	2ARP	X-ray	2.00	A	311-426	[»]
	2ARV	X-ray	2.00	A/B	311-426	[»]
	2B0U	X-ray	2.80	A/B	311-426	[»]
	2P6A	X-ray	3.40	A/B	311-426	[»]
	3B4V	X-ray	2.48	A/B/E/F	311-426	[»]
	4MID	X-ray	2.14	A	334-426	[»]
	5HLY	X-ray	2.30	A	30-426	[»]
	5HLZ	X-ray	2.85	A/C/E/G	30-305	[»]
				B/D/F/H	311-426	[»]
ProteinModelPortalⁱ	P08476
SMRⁱ	P08476
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109836, 9 interactors
DIPⁱ	DIP-5824N
IntActⁱ	P08476, 1 interactor
MINTⁱ	P08476
STRINGⁱ	9606.ENSP00000242208

Chemistry databases

ChEMBLⁱ	CHEMBL3588735

ChEMBLⁱ

CHEMBL3588735

PTM databases

iPTMnetⁱ	P08476
PhosphoSitePlusⁱ	P08476

Polymorphism and mutation databases

BioMutaⁱ	INHBA
DMDMⁱ	124279

Proteomic databases

EPDⁱ	P08476
MaxQBⁱ	P08476
PaxDbⁱ	P08476
PeptideAtlasⁱ	P08476
PRIDEⁱ	P08476
ProteomicsDBⁱ	52111

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3624
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000242208; ENSP00000242208; ENSG00000122641 ENST00000442711; ENSP00000397197; ENSG00000122641 ENST00000638023; ENSP00000490646; ENSG00000122641
GeneIDⁱ	3624
KEGGⁱ	hsa:3624
UCSCⁱ	uc003thq.4 human

Organism-specific databases

CTDⁱ	3624
DisGeNETⁱ	3624
EuPathDBⁱ	HostDB:ENSG00000122641.9
GeneCardsⁱ	INHBA
HGNCⁱ	HGNC:6066 INHBA
MalaCardsⁱ	INHBA
MIMⁱ	147290 gene
neXtProtⁱ	NX_P08476
OpenTargetsⁱ	ENSG00000122641
Orphanetⁱ	213504 Adenocarcinoma of ovary
PharmGKBⁱ	PA29877
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3900 Eukaryota ENOG410XT8Z LUCA
GeneTreeⁱ	ENSGT00910000143982
HOGENOMⁱ	HOG000220890
HOVERGENⁱ	HBG105613
InParanoidⁱ	P08476
KOⁱ	K04667
OMAⁱ	LRPHPKH
OrthoDBⁱ	EOG091G09LW
PhylomeDBⁱ	P08476
TreeFamⁱ	TF351791

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1502540 Signaling by Activin R-HSA-209822 Glycoprotein hormones R-HSA-2473224 Antagonism of Activin by Follistatin
SignaLinkⁱ	P08476
SIGNORⁱ	P08476

Miscellaneous databases

EvolutionaryTraceⁱ	P08476
GenomeRNAiⁱ	3624
Protein Ontology More...PROⁱ	PR:P08476
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000122641 Expressed in 187 organ(s), highest expression level in placenta
CleanExⁱ	HS_INHBA
ExpressionAtlasⁱ	P08476 baseline and differential
Genevisibleⁱ	P08476 HS

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR000491 Inhibin_betaA IPR001839 TGF-b_C IPR001111 TGF-b_propeptide IPR015615 TGF-beta-rel IPR017948 TGFb_CS
PANTHERⁱ	PTHR11848 PTHR11848, 1 hit
Pfamⁱ	View protein in Pfam PF00019 TGF_beta, 1 hit PF00688 TGFb_propeptide, 1 hit
PRINTSⁱ	PR00670 INHIBINBA
SMARTⁱ	View protein in SMART SM00204 TGFB, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00250 TGF_BETA_1, 1 hit PS51362 TGF_BETA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	INHBA_HUMAN
Accessionⁱ	P08476Primary (citable) accession number: P08476 Secondary accession number(s): Q14599
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	July 1, 1989
	Last modified:	October 10, 2018
	This is version 204 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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UniRef

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Supporting data

UniProtKB - P08476 (INHBA_HUMAN)

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Inhibin beta A chain

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ