UniProtKB - P08476 (INHBA_HUMAN)
Protein
Inhibin beta A chain
Gene
INHBA
Organism
Homo sapiens (Human)
Status
Functioni
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
GO - Molecular functioni
- cytokine activity Source: HGNC-UCL
- growth factor activity Source: UniProtKB
- hormone activity Source: UniProtKB
- identical protein binding Source: UniProtKB
- inhibin binding Source: Ensembl
- peptide hormone binding Source: UniProtKB
- protein-containing complex binding Source: Ensembl
- type II activin receptor binding Source: BHF-UCL
GO - Biological processi
- activin receptor signaling pathway Source: BHF-UCL
- cell-cell signaling Source: UniProtKB
- cell cycle arrest Source: HGNC-UCL
- cell differentiation Source: UniProtKB
- cell surface receptor signaling pathway Source: UniProtKB
- cellular response to cholesterol Source: Ensembl
- cellular response to follicle-stimulating hormone stimulus Source: Ensembl
- defense response Source: UniProtKB
- endodermal cell differentiation Source: BHF-UCL
- erythrocyte differentiation Source: UniProtKB
- extrinsic apoptotic signaling pathway Source: BHF-UCL
- eyelid development in camera-type eye Source: UniProtKB
- G1/S transition of mitotic cell cycle Source: HGNC-UCL
- GABAergic neuron differentiation Source: ParkinsonsUK-UCL
- hair follicle development Source: UniProtKB
- hematopoietic progenitor cell differentiation Source: UniProtKB
- hemoglobin biosynthetic process Source: UniProtKB
- male gonad development Source: UniProtKB
- mesodermal cell differentiation Source: Ensembl
- negative regulation of B cell differentiation Source: UniProtKB
- negative regulation of cell cycle Source: HGNC-UCL
- negative regulation of cell growth Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of follicle-stimulating hormone secretion Source: UniProtKB
- negative regulation of interferon-gamma production Source: UniProtKB
- negative regulation of macrophage differentiation Source: UniProtKB
- negative regulation of phosphorylation Source: UniProtKB
- nervous system development Source: UniProtKB
- odontogenesis Source: UniProtKB
- ovarian follicle development Source: UniProtKB
- positive regulation of cellular protein metabolic process Source: BHF-UCL
- positive regulation of erythrocyte differentiation Source: HGNC-UCL
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: UniProtKB
- positive regulation of follicle-stimulating hormone secretion Source: UniProtKB
- positive regulation of gene expression Source: BHF-UCL
- positive regulation of ovulation Source: UniProtKB
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- progesterone secretion Source: UniProtKB
- regulation of follicle-stimulating hormone secretion Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: UniProtKB
- response to drug Source: UniProtKB
- roof of mouth development Source: UniProtKB
- SMAD protein signal transduction Source: GO_Central
- striatal medium spiny neuron differentiation Source: ParkinsonsUK-UCL
Keywordsi
Molecular function | Growth factor, Hormone |
Enzyme and pathway databases
PathwayCommonsi | P08476 |
Reactomei | R-HSA-1502540, Signaling by Activin R-HSA-209822, Glycoprotein hormones R-HSA-2473224, Antagonism of Activin by Follistatin |
SignaLinki | P08476 |
SIGNORi | P08476 |
Names & Taxonomyi
Protein namesi | Recommended name: Inhibin beta A chainAlternative name(s): Activin beta-A chain Erythroid differentiation protein Short name: EDF |
Gene namesi | Name:INHBA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6066, INHBA |
MIMi | 147290, gene |
neXtProti | NX_P08476 |
VEuPathDBi | HostDB:ENSG00000122641.9 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- activin A complex Source: HGNC-UCL
- extracellular region Source: UniProtKB
- extracellular space Source: GO_Central
- inhibin A complex Source: HGNC-UCL
Other locations
- perinuclear region of cytoplasm Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 3624 |
MalaCardsi | INHBA |
OpenTargetsi | ENSG00000122641 |
Orphaneti | 213504, Adenocarcinoma of ovary |
PharmGKBi | PA29877 |
Miscellaneous databases
Pharosi | P08476, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3588735 |
Genetic variation databases
BioMutai | INHBA |
DMDMi | 124279 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | By similarityAdd BLAST | 20 | |
PropeptideiPRO_0000033708 | 21 – 310 | Add BLAST | 290 | |
ChainiPRO_0000033709 | 311 – 426 | Inhibin beta A chainAdd BLAST | 116 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 165 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 314 ↔ 322 | 1 Publication | ||
Disulfide bondi | 321 ↔ 391 | 1 Publication | ||
Disulfide bondi | 350 ↔ 423 | 1 Publication | ||
Disulfide bondi | 354 ↔ 425 | 1 Publication | ||
Disulfide bondi | 390 | Interchain1 Publication |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
EPDi | P08476 |
MassIVEi | P08476 |
MaxQBi | P08476 |
PaxDbi | P08476 |
PeptideAtlasi | P08476 |
PRIDEi | P08476 |
ProteomicsDBi | 52111 |
PTM databases
GlyGeni | P08476, 3 sites, 2 O-linked glycans (2 sites) |
iPTMneti | P08476 |
PhosphoSitePlusi | P08476 |
Expressioni
Gene expression databases
Bgeei | ENSG00000122641, Expressed in layer of synovial tissue and 202 other tissues |
ExpressionAtlasi | P08476, baseline and differential |
Genevisiblei | P08476, HS |
Organism-specific databases
HPAi | ENSG00000122641, Tissue enriched (placenta) |
Interactioni
Subunit structurei
Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B.
Interacts with FST and FSTL3.
3 PublicationsBinary interactionsi
P08476
With | #Exp. | IntAct |
---|---|---|
Fst [P21674] from Rattus norvegicus. | 2 | EBI-8077140,EBI-5746973 |
GO - Molecular functioni
- cytokine activity Source: HGNC-UCL
- growth factor activity Source: UniProtKB
- hormone activity Source: UniProtKB
- identical protein binding Source: UniProtKB
- inhibin binding Source: Ensembl
- type II activin receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 109836, 15 interactors |
DIPi | DIP-5824N |
IntActi | P08476, 1 interactor |
MINTi | P08476 |
STRINGi | 9606.ENSP00000242208 |
Miscellaneous databases
RNActi | P08476, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P08476 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08476 |
Family & Domainsi
Sequence similaritiesi
Belongs to the TGF-beta family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000157116 |
HOGENOMi | CLU_020515_5_1_1 |
InParanoidi | P08476 |
OMAi | WIFLKMS |
OrthoDBi | 1385831at2759 |
PhylomeDBi | P08476 |
TreeFami | TF351791 |
Family and domain databases
DisProti | DP02234 |
Gene3Di | 2.10.90.10, 1 hit |
IDEALi | IID00338 |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000491, Inhibin_betaA IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PRINTSi | PR00670, INHIBINBA |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P08476-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLLWLRGFL LASCWIIVRS SPTPGSEGHS AAPDCPSCAL AALPKDVPNS
60 70 80 90 100
QPEMVEAVKK HILNMLHLKK RPDVTQPVPK AALLNAIRKL HVGKVGENGY
110 120 130 140 150
VEIEDDIGRR AEMNELMEQT SEIITFAESG TARKTLHFEI SKEGSDLSVV
160 170 180 190 200
ERAEVWLFLK VPKANRTRTK VTIRLFQQQK HPQGSLDTGE EAEEVGLKGE
210 220 230 240 250
RSELLLSEKV VDARKSTWHV FPVSSSIQRL LDQGKSSLDV RIACEQCQES
260 270 280 290 300
GASLVLLGKK KKKEEEGEGK KKGGGEGGAG ADEEKEQSHR PFLMLQARQS
310 320 330 340 350
EDHPHRRRRR GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC
360 370 380 390 400
EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS
410 420
MLYYDDGQNI IKKDIQNMIV EECGCS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 377 – 379 | RMR → AC in CAA51163 (Ref. 7) Curated | 3 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072640 | 280 | G → E Found in a patient with early-onset epithelial ovarian tumor; uncertain pathological significance. 1 Publication | 1 | |
Natural variantiVAR_052566 | 299 | Q → P. Corresponds to variant dbSNP:rs41294833Ensembl. | 1 | |
Natural variantiVAR_072641 | 386 | N → S Found in a patient with early-onset epithelial ovarian tumor; alters the ratio of secreted activins and ihibins; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1361491625Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M13436 mRNA Translation: AAA59168.1 X04447 Genomic DNA Translation: CAA28041.1 X57578, X57579 Genomic DNA Translation: CAA40805.1 X57579 Genomic DNA Translation: CAA40806.1 AC005027 Genomic DNA Translation: AAQ96861.1 BC007858 mRNA Translation: AAH07858.1 J03634 mRNA Translation: AAA35787.1 X72498 mRNA Translation: CAA51163.1 |
CCDSi | CCDS5464.1 |
PIRi | S30488, B24248 |
RefSeqi | NP_002183.1, NM_002192.3 XP_016867665.1, XM_017012176.1 |
Genome annotation databases
Ensembli | ENST00000242208; ENSP00000242208; ENSG00000122641 ENST00000442711; ENSP00000397197; ENSG00000122641 ENST00000638023; ENSP00000490646; ENSG00000122641 |
GeneIDi | 3624 |
KEGGi | hsa:3624 |
UCSCi | uc003thq.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Activin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M13436 mRNA Translation: AAA59168.1 X04447 Genomic DNA Translation: CAA28041.1 X57578, X57579 Genomic DNA Translation: CAA40805.1 X57579 Genomic DNA Translation: CAA40806.1 AC005027 Genomic DNA Translation: AAQ96861.1 BC007858 mRNA Translation: AAH07858.1 J03634 mRNA Translation: AAA35787.1 X72498 mRNA Translation: CAA51163.1 |
CCDSi | CCDS5464.1 |
PIRi | S30488, B24248 |
RefSeqi | NP_002183.1, NM_002192.3 XP_016867665.1, XM_017012176.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1NYS | X-ray | 3.05 | B/D | 311-426 | [»] | |
1NYU | X-ray | 3.10 | B/D | 311-426 | [»] | |
1S4Y | X-ray | 2.30 | B/D | 311-426 | [»] | |
2ARP | X-ray | 2.00 | A | 311-426 | [»] | |
2ARV | X-ray | 2.00 | A/B | 311-426 | [»] | |
2B0U | X-ray | 2.80 | A/B | 311-426 | [»] | |
2P6A | X-ray | 3.40 | A/B | 311-426 | [»] | |
3B4V | X-ray | 2.48 | A/B/E/F | 311-426 | [»] | |
4MID | X-ray | 2.14 | A | 334-426 | [»] | |
5HLY | X-ray | 2.30 | A | 30-426 | [»] | |
5HLZ | X-ray | 2.85 | A/C/E/G | 30-305 | [»] | |
B/D/F/H | 311-426 | [»] | ||||
SMRi | P08476 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109836, 15 interactors |
DIPi | DIP-5824N |
IntActi | P08476, 1 interactor |
MINTi | P08476 |
STRINGi | 9606.ENSP00000242208 |
Chemistry databases
ChEMBLi | CHEMBL3588735 |
PTM databases
GlyGeni | P08476, 3 sites, 2 O-linked glycans (2 sites) |
iPTMneti | P08476 |
PhosphoSitePlusi | P08476 |
Genetic variation databases
BioMutai | INHBA |
DMDMi | 124279 |
Proteomic databases
EPDi | P08476 |
MassIVEi | P08476 |
MaxQBi | P08476 |
PaxDbi | P08476 |
PeptideAtlasi | P08476 |
PRIDEi | P08476 |
ProteomicsDBi | 52111 |
Protocols and materials databases
ABCDi | P08476, 22 sequenced antibodies |
Antibodypediai | 13122, 540 antibodies |
DNASUi | 3624 |
Genome annotation databases
Ensembli | ENST00000242208; ENSP00000242208; ENSG00000122641 ENST00000442711; ENSP00000397197; ENSG00000122641 ENST00000638023; ENSP00000490646; ENSG00000122641 |
GeneIDi | 3624 |
KEGGi | hsa:3624 |
UCSCi | uc003thq.4, human |
Organism-specific databases
CTDi | 3624 |
DisGeNETi | 3624 |
GeneCardsi | INHBA |
HGNCi | HGNC:6066, INHBA |
HPAi | ENSG00000122641, Tissue enriched (placenta) |
MalaCardsi | INHBA |
MIMi | 147290, gene |
neXtProti | NX_P08476 |
OpenTargetsi | ENSG00000122641 |
Orphaneti | 213504, Adenocarcinoma of ovary |
PharmGKBi | PA29877 |
VEuPathDBi | HostDB:ENSG00000122641.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000157116 |
HOGENOMi | CLU_020515_5_1_1 |
InParanoidi | P08476 |
OMAi | WIFLKMS |
OrthoDBi | 1385831at2759 |
PhylomeDBi | P08476 |
TreeFami | TF351791 |
Enzyme and pathway databases
PathwayCommonsi | P08476 |
Reactomei | R-HSA-1502540, Signaling by Activin R-HSA-209822, Glycoprotein hormones R-HSA-2473224, Antagonism of Activin by Follistatin |
SignaLinki | P08476 |
SIGNORi | P08476 |
Miscellaneous databases
BioGRID-ORCSi | 3624, 7 hits in 876 CRISPR screens |
ChiTaRSi | INHBA, human |
EvolutionaryTracei | P08476 |
GenomeRNAii | 3624 |
Pharosi | P08476, Tbio |
PROi | PR:P08476 |
RNActi | P08476, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122641, Expressed in layer of synovial tissue and 202 other tissues |
ExpressionAtlasi | P08476, baseline and differential |
Genevisiblei | P08476, HS |
Family and domain databases
DisProti | DP02234 |
Gene3Di | 2.10.90.10, 1 hit |
IDEALi | IID00338 |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000491, Inhibin_betaA IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PRINTSi | PR00670, INHIBINBA |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INHBA_HUMAN | |
Accessioni | P08476Primary (citable) accession number: P08476 Secondary accession number(s): Q14599 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | July 1, 1989 | |
Last modified: | February 10, 2021 | |
This is version 220 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants