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UniProtKB - P08473 (NEP_HUMAN)

Protein

Neprilysin

Gene

MME

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).6 Publications

Miscellaneous

Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.

Catalytic activityi

Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.3 Publications

Cofactori

Zn2+2 PublicationsNote: Binds 1 zinc ion per subunit.2 Publications

Activity regulationi

Inhibited in a dose dependent manner by opiorphin.1 Publication

Kineticsi

  1. KM=55.1 µM for angiotensin-11 Publication
  2. KM=179 µM for angiotensin-21 Publication
  3. KM=111.4 µM for angiotensin 1-91 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Binding sitei103Substrate carboxylBy similarity1
    Metal bindingi584Zinc; catalytic1
    Active sitei5851
    Metal bindingi588Zinc; catalytic1
    Metal bindingi647Zinc; catalytic1
    Active sitei651Proton donorPROSITE-ProRule annotation1 Publication1

    GO - Molecular functioni

    View the complete GO annotation on QuickGO ...

    GO - Biological processi

    View the complete GO annotation on QuickGO ...

    Keywordsi

    Molecular functionHydrolase, Metalloprotease, Protease
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    BRENDAi3.4.24.11 2681
    ReactomeiR-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
    R-HSA-6798695 Neutrophil degranulation
    SIGNORiP08473

    Protein family/group databases

    MEROPSiM13.001

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neprilysin (EC:3.4.24.113 Publications)
    Alternative name(s):
    Atriopeptidase
    Common acute lymphocytic leukemia antigen
    Short name:
    CALLA
    Enkephalinase
    Neutral endopeptidase 24.11
    Short name:
    NEP
    Short name:
    Neutral endopeptidase
    Skin fibroblast elastase
    Short name:
    SFE
    CD_antigen: CD10
    Gene namesi
    Name:MME
    Synonyms:EPN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    Proteomesi
    • UP000005640 Componenti: Chromosome 3

    Organism-specific databases

    EuPathDBiHostDB:ENSG00000196549.10
    HGNCiHGNC:7154 MME
    MIMi120520 gene
    neXtProtiNX_P08473

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Topological domaini2 – 28CytoplasmicSequence analysisAdd BLAST27
    Transmembranei29 – 51Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
    Topological domaini52 – 750ExtracellularSequence analysisAdd BLAST699

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Charcot-Marie-Tooth disease 2T (CMT2T)2 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionAn axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.
    See also OMIM:617017
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_07768412D → A in CMT2T; unknown pathological significance. 1 Publication1
    Natural variantiVAR_077686347Y → C in CMT2T; results in reduction of neprilysin activity. 1 PublicationCorresponds to variant dbSNP:rs138218277Ensembl.1
    Natural variantiVAR_077687348A → P in CMT2T; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199567914Ensembl.1
    Natural variantiVAR_077688411Missing in CMT2T; unknown pathological significance. 1 Publication1
    Natural variantiVAR_077689422A → D in CMT2T; late-onset form; results in reduction of neprilysin activity. 1 PublicationCorresponds to variant dbSNP:rs777476150EnsemblClinVar.1
    Natural variantiVAR_077691621C → R in CMT2T; decrease of protein expression. 1 PublicationCorresponds to variant dbSNP:rs879253752EnsemblClinVar.1
    Spinocerebellar ataxia 43 (SCA43)1 Publication
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA43 is a slowly progressive, autosomal dominant form.
    See also OMIM:617018
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_077685143C → Y in SCA43. 1 PublicationCorresponds to variant dbSNP:rs879255651EnsemblClinVar.1

    Keywords - Diseasei

    Charcot-Marie-Tooth disease, Disease mutation, Neurodegeneration, Neuropathy, Spinocerebellar ataxia

    Organism-specific databases

    DisGeNETi4311
    MalaCardsiMME
    MIMi617017 phenotype
    617018 phenotype
    OpenTargetsiENSG00000196549
    Orphaneti495274 Charcot-Marie-Tooth disease type 2T
    497757 MME-related autosomal dominant Charcot Marie Tooth disease type 2
    497764 Spinocerebellar ataxia type 43
    PharmGKBiPA30864

    Chemistry databases

    ChEMBLiCHEMBL1944
    DrugBankiDB00616 Candoxatril
    DB11623 Candoxatrilat
    DB06655 Liraglutide
    DB02558 N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine
    DB00886 Omapatrilat
    DB02557 Phosphoramidon
    DB09292 Sacubitril
    DB05796 SLV 306
    DB08626 Thiorphan
    GuidetoPHARMACOLOGYi1611

    Polymorphism and mutation databases

    BioMutaiMME
    DMDMi128062

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Initiator methionineiRemoved
    ChainiPRO_00000782132 – 750NeprilysinAdd BLAST749

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Lipidationi2N-myristoyl glycine1 Publication1
    Modified residuei4PhosphoserineCombined sources1
    Modified residuei6PhosphoserineCombined sources1
    Disulfide bondi57 ↔ 62
    Disulfide bondi80 ↔ 735
    Disulfide bondi88 ↔ 695
    Disulfide bondi143 ↔ 411
    Glycosylationi145N-linked (GlcNAc...) asparagine4 Publications1
    Disulfide bondi234 ↔ 242
    Glycosylationi285N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi325N-linked (GlcNAc...) asparagine3 Publications1
    Disulfide bondi621 ↔ 747
    Glycosylationi628N-linked (GlcNAc...) asparagine4 Publications1

    Post-translational modificationi

    Myristoylation is a determinant of membrane targeting.1 Publication
    Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.5 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Myristate, Phosphoprotein

    Proteomic databases

    EPDiP08473
    MaxQBiP08473
    PaxDbiP08473
    PeptideAtlasiP08473
    PRIDEiP08473
    ProteomicsDBi52110

    PTM databases

    CarbonylDBiP08473
    GlyConnecti1541
    iPTMnetiP08473
    PhosphoSitePlusiP08473

    Expressioni

    Gene expression databases

    BgeeiENSG00000196549 Expressed in 156 organ(s), highest expression level in metanephric glomerulus
    CleanExiHS_MME
    ExpressionAtlasiP08473 baseline and differential
    GenevisibleiP08473 HS

    Organism-specific databases

    HPAiCAB000013
    HPA052583
    HPA056072

    Interactioni

    Binary interactionsi

    Protein-protein interaction databases

    BioGridi110455, 102 interactors
    IntActiP08473, 80 interactors
    MINTiP08473
    STRINGi9606.ENSP00000353679

    Chemistry databases

    BindingDBiP08473

    Structurei

    Secondary structure

    1750
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    ProteinModelPortaliP08473
    SMRiP08473
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP08473

    Family & Domainsi

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Motifi16 – 23Stop-transfer sequenceSequence analysis8

    Sequence similaritiesi

    Belongs to the peptidase M13 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG3624 Eukaryota
    COG3590 LUCA
    GeneTreeiENSGT00760000119162
    HOGENOMiHOG000245574
    HOVERGENiHBG005554
    InParanoidiP08473
    KOiK01389
    OMAiAPRNHDA
    OrthoDBiEOG091G025Y
    PhylomeDBiP08473
    TreeFamiTF315192

    Family and domain databases

    CDDicd08662 M13, 1 hit
    Gene3Di3.40.390.10, 1 hit
    InterProiView protein in InterPro
    IPR024079 MetalloPept_cat_dom_sf
    IPR029727 MME/CD10/NEP
    IPR000718 Peptidase_M13
    IPR018497 Peptidase_M13_C
    IPR008753 Peptidase_M13_N
    PANTHERiPTHR11733 PTHR11733, 1 hit
    PTHR11733:SF114 PTHR11733:SF114, 1 hit
    PfamiView protein in Pfam
    PF01431 Peptidase_M13, 1 hit
    PF05649 Peptidase_M13_N, 1 hit
    PRINTSiPR00786 NEPRILYSIN
    PROSITEiView protein in PROSITE
    PS00142 ZINC_PROTEASE, 1 hit

    Sequence (1+)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

    P08473-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MGKSESQMDI TDINTPKPKK KQRWTPLEIS LSVLVLLLTI IAVTMIALYA 
            60         70         80         90        100
    TYDDGICKSS DCIKSAARLI QNMDATTEPC TDFFKYACGG WLKRNVIPET 
           110        120        130        140        150
    SSRYGNFDIL RDELEVVLKD VLQEPKTEDI VAVQKAKALY RSCINESAID 
           160        170        180        190        200
    SRGGEPLLKL LPDIYGWPVA TENWEQKYGA SWTAEKAIAQ LNSKYGKKVL 
           210        220        230        240        250
    INLFVGTDDK NSVNHVIHID QPRLGLPSRD YYECTGIYKE ACTAYVDFMI 
           260        270        280        290        300
    SVARLIRQEE RLPIDENQLA LEMNKVMELE KEIANATAKP EDRNDPMLLY 
           310        320        330        340        350
    NKMTLAQIQN NFSLEINGKP FSWLNFTNEI MSTVNISITN EEDVVVYAPE 
           360        370        380        390        400
    YLTKLKPILT KYSARDLQNL MSWRFIMDLV SSLSRTYKES RNAFRKALYG 
           410        420        430        440        450
    TTSETATWRR CANYVNGNME NAVGRLYVEA AFAGESKHVV EDLIAQIREV 
           460        470        480        490        500
    FIQTLDDLTW MDAETKKRAE EKALAIKERI GYPDDIVSND NKLNNEYLEL 
           510        520        530        540        550
    NYKEDEYFEN IIQNLKFSQS KQLKKLREKV DKDEWISGAA VVNAFYSSGR 
           560        570        580        590        600
    NQIVFPAGIL QPPFFSAQQS NSLNYGGIGM VIGHEITHGF DDNGRNFNKD 
           610        620        630        640        650
    GDLVDWWTQQ SASNFKEQSQ CMVYQYGNFS WDLAGGQHLN GINTLGENIA 
           660        670        680        690        700
    DNGGLGQAYR AYQNYIKKNG EEKLLPGLDL NHKQLFFLNF AQVWCGTYRP 
           710        720        730        740        750
    EYAVNSIKTD VHSPGNFRII GTLQNSAEFS EAFHCRKNSY MNPEKKCRVW
    Length:750
    Mass (Da):85,514
    Last modified:January 23, 2007 - v2
    Checksum:iBCF3827C39898630
    GO

    Computationally mapped potential isoform sequencesi

    There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    C9IYX7C9IYX7_HUMAN
    Neprilysin
    MME
    		119Annotation score:
    C9JR96C9JR96_HUMAN
    Neprilysin
    MME
    		233Annotation score:
    C9J9X7C9J9X7_HUMAN
    Neprilysin
    MME
    		161Annotation score:
    C9JDZ3C9JDZ3_HUMAN
    Neprilysin
    MME
    		93Annotation score:
    Q3KQS6Q3KQS6_HUMAN
    MME protein
    MME
    		80Annotation score:
    A0A087WWM7A0A087WWM7_HUMAN
    Neprilysin
    MME
    		79Annotation score:
    C9J7X4C9J7X4_HUMAN
    Neprilysin
    MME
    		15Annotation score:

    Sequence cautioni

    The sequence CAA30157 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti26P → R in AAA51915 (PubMed:14702039).Curated1
    Sequence conflicti44T → R in AAA51915 (PubMed:14702039).Curated1
    Sequence conflicti81T → R in AAA51915 (PubMed:14702039).Curated1
    Sequence conflicti304T → R in AAA51915 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_07768412D → A in CMT2T; unknown pathological significance. 1 Publication1
    Natural variantiVAR_077685143C → Y in SCA43. 1 PublicationCorresponds to variant dbSNP:rs879255651EnsemblClinVar.1
    Natural variantiVAR_077686347Y → C in CMT2T; results in reduction of neprilysin activity. 1 PublicationCorresponds to variant dbSNP:rs138218277Ensembl.1
    Natural variantiVAR_077687348A → P in CMT2T; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199567914Ensembl.1
    Natural variantiVAR_077688411Missing in CMT2T; unknown pathological significance. 1 Publication1
    Natural variantiVAR_077689422A → D in CMT2T; late-onset form; results in reduction of neprilysin activity. 1 PublicationCorresponds to variant dbSNP:rs777476150EnsemblClinVar.1
    Natural variantiVAR_077690497Y → H1 PublicationCorresponds to variant dbSNP:rs200308207Ensembl.1
    Natural variantiVAR_077691621C → R in CMT2T; decrease of protein expression. 1 PublicationCorresponds to variant dbSNP:rs879253752EnsemblClinVar.1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		Y00811 mRNA Translation: CAA68752.1
    J03779 mRNA Translation: AAA51915.1
    M26628
    , M26607, M26608, M26609, M26610, M26611, M26612, M26613, M26614, M26615, M26616, M26617, M26618, M26619, M26620, M26621, M26622, M26623, M26624, M26625, M26626, M26627 Genomic DNA Translation: AAA52294.1
    AK291761 mRNA Translation: BAF84450.1
    EU326307 Genomic DNA Translation: ACA05913.1
    CH471052 Genomic DNA Translation: EAW78754.1
    CH471052 Genomic DNA Translation: EAW78755.1
    CH471052 Genomic DNA Translation: EAW78756.1
    CH471052 Genomic DNA Translation: EAW78757.1
    CH471052 Genomic DNA Translation: EAW78758.1
    BC101632 mRNA Translation: AAI01633.1
    BC101658 mRNA Translation: AAI01659.1
    X07166 mRNA Translation: CAA30157.1 Different initiation.
    CCDSiCCDS3172.1
    PIRiA41387 HYHUN
    RefSeqiNP_000893.2, NM_000902.3
    NP_009218.2, NM_007287.2
    NP_009219.2, NM_007288.2
    NP_009220.2, NM_007289.2
    XP_006713709.1, XM_006713646.3
    XP_006713710.1, XM_006713647.3
    XP_011511157.1, XM_011512855.2
    XP_011511158.1, XM_011512856.2
    XP_011511159.1, XM_011512857.2
    UniGeneiHs.307734

    Genome annotation databases

    EnsembliENST00000360490; ENSP00000353679; ENSG00000196549
    ENST00000460393; ENSP00000418525; ENSG00000196549
    ENST00000462745; ENSP00000419653; ENSG00000196549
    ENST00000492661; ENSP00000420389; ENSG00000196549
    ENST00000493237; ENSP00000417079; ENSG00000196549
    ENST00000615825; ENSP00000478173; ENSG00000196549
    GeneIDi4311
    KEGGihsa:4311
    UCSCiuc003fab.2 human

    Similar proteinsi

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		Y00811 mRNA Translation: CAA68752.1
    J03779 mRNA Translation: AAA51915.1
    M26628
    , M26607, M26608, M26609, M26610, M26611, M26612, M26613, M26614, M26615, M26616, M26617, M26618, M26619, M26620, M26621, M26622, M26623, M26624, M26625, M26626, M26627 Genomic DNA Translation: AAA52294.1
    AK291761 mRNA Translation: BAF84450.1
    EU326307 Genomic DNA Translation: ACA05913.1
    CH471052 Genomic DNA Translation: EAW78754.1
    CH471052 Genomic DNA Translation: EAW78755.1
    CH471052 Genomic DNA Translation: EAW78756.1
    CH471052 Genomic DNA Translation: EAW78757.1
    CH471052 Genomic DNA Translation: EAW78758.1
    BC101632 mRNA Translation: AAI01633.1
    BC101658 mRNA Translation: AAI01659.1
    X07166 mRNA Translation: CAA30157.1 Different initiation.
    CCDSiCCDS3172.1
    PIRiA41387 HYHUN
    RefSeqiNP_000893.2, NM_000902.3
    NP_009218.2, NM_007287.2
    NP_009219.2, NM_007288.2
    NP_009220.2, NM_007289.2
    XP_006713709.1, XM_006713646.3
    XP_006713710.1, XM_006713647.3
    XP_011511157.1, XM_011512855.2
    XP_011511158.1, XM_011512856.2
    XP_011511159.1, XM_011512857.2
    UniGeneiHs.307734

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1DL9model-A508-750[»]
    1DMTX-ray2.10A55-750[»]
    1QVDmodel-A55-750[»]
    1R1HX-ray1.95A55-750[»]
    1R1IX-ray2.60A55-750[»]
    1R1JX-ray2.35A55-750[»]
    1Y8JX-ray2.25A55-750[»]
    2QPJX-ray2.05A55-750[»]
    2YB9X-ray2.40A55-750[»]
    4CTHX-ray2.15A52-750[»]
    5JMYX-ray2.00A/B53-750[»]
    6GIDX-ray1.90A55-750[»]
    ProteinModelPortaliP08473
    SMRiP08473
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi110455, 102 interactors
    IntActiP08473, 80 interactors
    MINTiP08473
    STRINGi9606.ENSP00000353679

    Chemistry databases

    BindingDBiP08473
    ChEMBLiCHEMBL1944
    DrugBankiDB00616 Candoxatril
    DB11623 Candoxatrilat
    DB06655 Liraglutide
    DB02558 N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine
    DB00886 Omapatrilat
    DB02557 Phosphoramidon
    DB09292 Sacubitril
    DB05796 SLV 306
    DB08626 Thiorphan
    GuidetoPHARMACOLOGYi1611

    Protein family/group databases

    MEROPSiM13.001

    PTM databases

    CarbonylDBiP08473
    GlyConnecti1541
    iPTMnetiP08473
    PhosphoSitePlusiP08473

    Polymorphism and mutation databases

    BioMutaiMME
    DMDMi128062

    Proteomic databases

    EPDiP08473
    MaxQBiP08473
    PaxDbiP08473
    PeptideAtlasiP08473
    PRIDEiP08473
    ProteomicsDBi52110

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000360490; ENSP00000353679; ENSG00000196549
    ENST00000460393; ENSP00000418525; ENSG00000196549
    ENST00000462745; ENSP00000419653; ENSG00000196549
    ENST00000492661; ENSP00000420389; ENSG00000196549
    ENST00000493237; ENSP00000417079; ENSG00000196549
    ENST00000615825; ENSP00000478173; ENSG00000196549
    GeneIDi4311
    KEGGihsa:4311
    UCSCiuc003fab.2 human

    Organism-specific databases

    CTDi4311
    DisGeNETi4311
    EuPathDBiHostDB:ENSG00000196549.10
    GeneCardsiMME
    HGNCiHGNC:7154 MME
    HPAiCAB000013
    HPA052583
    HPA056072
    MalaCardsiMME
    MIMi120520 gene
    617017 phenotype
    617018 phenotype
    neXtProtiNX_P08473
    OpenTargetsiENSG00000196549
    Orphaneti495274 Charcot-Marie-Tooth disease type 2T
    497757 MME-related autosomal dominant Charcot Marie Tooth disease type 2
    497764 Spinocerebellar ataxia type 43
    PharmGKBiPA30864
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG3624 Eukaryota
    COG3590 LUCA
    GeneTreeiENSGT00760000119162
    HOGENOMiHOG000245574
    HOVERGENiHBG005554
    InParanoidiP08473
    KOiK01389
    OMAiAPRNHDA
    OrthoDBiEOG091G025Y
    PhylomeDBiP08473
    TreeFamiTF315192

    Enzyme and pathway databases

    BRENDAi3.4.24.11 2681
    ReactomeiR-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins
    R-HSA-6798695 Neutrophil degranulation
    SIGNORiP08473

    Miscellaneous databases

    ChiTaRSiMME human
    EvolutionaryTraceiP08473
    GeneWikiiNeprilysin
    GenomeRNAii4311
    PROiPR:P08473
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000196549 Expressed in 156 organ(s), highest expression level in metanephric glomerulus
    CleanExiHS_MME
    ExpressionAtlasiP08473 baseline and differential
    GenevisibleiP08473 HS

    Family and domain databases

    CDDicd08662 M13, 1 hit
    Gene3Di3.40.390.10, 1 hit
    InterProiView protein in InterPro
    IPR024079 MetalloPept_cat_dom_sf
    IPR029727 MME/CD10/NEP
    IPR000718 Peptidase_M13
    IPR018497 Peptidase_M13_C
    IPR008753 Peptidase_M13_N
    PANTHERiPTHR11733 PTHR11733, 1 hit
    PTHR11733:SF114 PTHR11733:SF114, 1 hit
    PfamiView protein in Pfam
    PF01431 Peptidase_M13, 1 hit
    PF05649 Peptidase_M13_N, 1 hit
    PRINTSiPR00786 NEPRILYSIN
    PROSITEiView protein in PROSITE
    PS00142 ZINC_PROTEASE, 1 hit
    ProtoNetiSearch...

    Entry informationi

    Entry nameiNEP_HUMAN
    AccessioniPrimary (citable) accession number: P08473
    Secondary accession number(s): A8K6U6, D3DNJ9, Q3MIX4
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: January 23, 2007
    Last modified: November 7, 2018
    This is version 218 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    7. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    8. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
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