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Protein

Fructose-bisphosphate aldolase, cytoplasmic isozyme

Gene
N/A
Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (100281592), Glucose-6-phosphate isomerase (100281592), Glucose-6-phosphate isomerase (100281592), Glucose-6-phosphate isomerase (100281592), Glucose-6-phosphate isomerase (100382805), Glucose-6-phosphate isomerase (100382805), Glucose-6-phosphate isomerase (100382805), Glucose-6-phosphate isomerase (ZEAMMB73_Zm00001d014644), Glucose-6-phosphate isomerase (ZEAMMB73_Zm00001d034256), Glucose-6-phosphate isomerase, Glucose-6-phosphate isomerase (542313), Glucose-6-phosphate isomerase (542313), Glucose-6-phosphate isomerase, cytosolic (PHI1)
  3. ATP-dependent 6-phosphofructokinase (PFK), ATP-dependent 6-phosphofructokinase (100281464), ATP-dependent 6-phosphofructokinase (100281464), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (100280449), ATP-dependent 6-phosphofructokinase (PFK), ATP-dependent 6-phosphofructokinase (100192478), ATP-dependent 6-phosphofructokinase (PFK), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (100280449), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (PFP-ALPHA), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (PFP-ALPHA), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta (100282190), ATP-dependent 6-phosphofructokinase (100280694), ATP-dependent 6-phosphofructokinase (PFK), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (PFP-ALPHA), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (100280449), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (PFP-ALPHA), ATP-dependent 6-phosphofructokinase (PFK), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (PFP-ALPHA), ATP-dependent 6-phosphofructokinase (PFK), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta (100382182), ATP-dependent 6-phosphofructokinase (103629493), ATP-dependent 6-phosphofructokinase (103629493), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (PFPalpha retrogene), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit alpha (PFP-ALPHA), ATP-dependent 6-phosphofructokinase (100279231), ATP-dependent 6-phosphofructokinase (100857010), ATP-dependent 6-phosphofructokinase (PFK), ATP-dependent 6-phosphofructokinase (PFK), Pyrophosphate--fructose 6-phosphate 1-phosphotransferase subunit beta (100282190), ATP-dependent 6-phosphofructokinase (103647427), ATP-dependent 6-phosphofructokinase (100281464), ATP-dependent 6-phosphofructokinase (PFK), ATP-dependent 6-phosphofructokinase (103647427), ATP-dependent 6-phosphofructokinase (103630144), ATP-dependent 6-phosphofructokinase (103630633), ATP-dependent 6-phosphofructokinase (103647427), ATP-dependent 6-phosphofructokinase (100191982)
  4. Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (542261), Fructose-bisphosphate aldolase (100273196), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, cytoplasmic isozyme, Fructose-bisphosphate aldolase (100272845), Fructose-bisphosphate aldolase (100502020), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (100272913), Multifunctional fusion protein (ZEAMMB73_Zm00001d028270), Multifunctional fusion protein (ZEAMMB73_Zm00001d028270), Fructose-bisphosphate aldolase (ZEAMMB73_Zm00001d040084), Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase, Fructose-bisphosphate aldolase (100502020), Fructose-bisphosphate aldolase
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52Substrate1
Binding sitei142Substrate1
Active sitei183Proton acceptorBy similarity1
Active sitei225Schiff-base intermediate with dihydroxyacetone-P1
Sitei355Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

GO - Molecular functioni

  • fructose-bisphosphate aldolase activity Source: AgBase

GO - Biological processi

  • glycolytic process Source: UniProtKB-UniPathway
  • response to anoxia Source: AgBase
  • sucrose biosynthetic process Source: AgBase

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandSchiff base

Enzyme and pathway databases

SABIO-RKiP08440
UniPathwayiUPA00109; UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase, cytoplasmic isozyme (EC:4.1.2.13)
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Organism-specific databases

MaizeGDBi24903

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002169211 – 355Fructose-bisphosphate aldolase, cytoplasmic isozymeAdd BLAST355

Proteomic databases

PaxDbiP08440
PRIDEiP08440
ProMEXiP08440

Expressioni

Gene expression databases

ExpressionAtlasiP08440 differential

Interactioni

Protein-protein interaction databases

STRINGi4577.GRMZM2G057823_P01

Structurei

3D structure databases

ProteinModelPortaliP08440
SMRiP08440
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557 Eukaryota
COG3588 LUCA
HOGENOMiHOG000220876
KOiK01623

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR029768 Aldolase_I_AS
IPR013785 Aldolase_TIM
IPR000741 FBA_I
PfamiView protein in Pfam
PF00274 Glycolytic, 1 hit
PROSITEiView protein in PROSITE
PS00158 ALDOLASE_CLASS_I, 1 hit

Sequencei

Sequence statusi: Complete.

P08440-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAYCGKYKD ELIKNAAYIG TPGKGILAAD ESTGTIGKRL SSINVENVEE
60 70 80 90 100
NRRALRELLF CCPGALQYIS GVILFEETLY QKTKDGKPFV DVLKEGGVLP
110 120 130 140 150
GIKVDKGTIE VVGTDKETTT QGHDDLGKRC AKYYEAGARF AKWRAVLKIG
160 170 180 190 200
PNEPSQLAID LNAQGLARYA IICQENGLVP IVEPEILVDG PHDIDRCAYV
210 220 230 240 250
TETVLAACYK ALNEHHVLLE GTLLKPNMVT PGSDSKKVTP EVIAEYTVRT
260 270 280 290 300
LQRTVPAAVP AVLFLSGGQS EEEATRNLNA MNKLSTKKPW SLSFSFGRAL
310 320 330 340 350
QASTLKAWAG KVENLEKARA AFLARCKANS EATLGTYKGD AAADTESLHV

KDYKY
Length:355
Mass (Da):38,604
Last modified:August 1, 1988 - v1
Checksum:i54B480978ECD1470
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12872 Genomic DNA Translation: CAA31366.1
M16220 mRNA Translation: AAA33435.1
PIRiS07789 ADZM
RefSeqiNP_001105336.1, NM_001111866.1
UniGeneiZm.72659

Genome annotation databases

GeneIDi542261
KEGGizma:542261

Similar proteinsi

Entry informationi

Entry nameiALF_MAIZE
AccessioniPrimary (citable) accession number: P08440
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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