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Entry version 134 (02 Dec 2020)
Sequence version 1 (01 Aug 1988)
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Protein

Inner membrane protein CreD

Gene

creD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Mutations of this gene leads to an enhanced transcription of the gene cause tolerance to colicin E2.

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG10145-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inner membrane protein CreD
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:creD
Synonyms:cet
Ordered Locus Names:b4400, JW4363
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 297PeriplasmicSequence analysisAdd BLAST270
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 322CytoplasmicSequence analysis4
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 347PeriplasmicSequence analysis4
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Topological domaini369 – 378CytoplasmicSequence analysis10
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400PeriplasmicSequence analysis1
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Topological domaini422 – 450CytoplasmicSequence analysisAdd BLAST29

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000793451 – 450Inner membrane protein CreDAdd BLAST450

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P08369

PRoteomics IDEntifications database

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PRIDEi
P08369

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
4262782, 8 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b4400

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P08369

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
COG4452, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_036281_1_0_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08369

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P08369

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR010364, Uncharacterised_IM_CreD

The PANTHER Classification System

More...
PANTHERi
PTHR30092, PTHR30092, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06123, CreD, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF004548, CreD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P08369-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKSPLFWKM TSLFGAVLLL LIPIMLIRQV IVERADYRSD VEDAIRQSTS
60 70 80 90 100
GPQKLVGPLI AIPVTELYTV QEEDKTVERK RSFIHFWLPE SLMVDGNQNV
110 120 130 140 150
EERKIGIYTG QVWHSDLTLK ADFDVSRLSE LNAPNITLGK PFIVISVGDA
160 170 180 190 200
RGIGVVKAPE VNGTALTIEP GTGLEQGGQG VHIPLPEGDW RKQNLKLNMA
210 220 230 240 250
LNLSGTGDLS VVPGGRNSEM TLTSNWPHPS FLGDFLPAKR EVSESGFQAH
260 270 280 290 300
WQSSWFANNL GERFASGNDT GWENFPAFSV AVTTPADQYQ LTDRATKYAI
310 320 330 340 350
LLIALTFMAF FVFETLTAQR LHPMQYLLVG LSLVMFYLLL LALSEHTGFT
360 370 380 390 400
VAWIIASLIG AIMNGIYLQA VLKGWCNSML FTLALLLLDG VMWGLLNSAD
410 420 430 440 450
SALLLGTSVL VVALAGMMFV TRNIDWYAFS LPKMKASKEV TTDDELRIWK
Length:450
Mass (Da):49,830
Last modified:August 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2D9F63197EB1B13
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M13608 Genomic DNA Translation: AAA24376.1
Y00538 Genomic DNA Translation: CAA68602.1
U14003 Genomic DNA Translation: AAA97296.1
U00096 Genomic DNA Translation: AAC77353.1
AP009048 Genomic DNA Translation: BAE78389.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D25038, BVECCT

NCBI Reference Sequences

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RefSeqi
NP_418817.1, NC_000913.3
WP_000920294.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC77353; AAC77353; b4400
BAE78389; BAE78389; BAE78389

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
948868

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ecj:JW4363
eco:b4400

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.2284

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13608 Genomic DNA Translation: AAA24376.1
Y00538 Genomic DNA Translation: CAA68602.1
U14003 Genomic DNA Translation: AAA97296.1
U00096 Genomic DNA Translation: AAC77353.1
AP009048 Genomic DNA Translation: BAE78389.1
PIRiD25038, BVECCT
RefSeqiNP_418817.1, NC_000913.3
WP_000920294.1, NZ_LN832404.1

3D structure databases

SMRiP08369
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4262782, 8 interactors
STRINGi511145.b4400

Proteomic databases

PaxDbiP08369
PRIDEiP08369

Genome annotation databases

EnsemblBacteriaiAAC77353; AAC77353; b4400
BAE78389; BAE78389; BAE78389
GeneIDi948868
KEGGiecj:JW4363
eco:b4400
PATRICifig|1411691.4.peg.2284

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0143

Phylogenomic databases

eggNOGiCOG4452, Bacteria
HOGENOMiCLU_036281_1_0_6
InParanoidiP08369
PhylomeDBiP08369

Enzyme and pathway databases

BioCyciEcoCyc:EG10145-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P08369

Family and domain databases

InterProiView protein in InterPro
IPR010364, Uncharacterised_IM_CreD
PANTHERiPTHR30092, PTHR30092, 1 hit
PfamiView protein in Pfam
PF06123, CreD, 1 hit
PIRSFiPIRSF004548, CreD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRED_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08369
Secondary accession number(s): Q2M5R7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: December 2, 2020
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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