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Protein

Non-structural protein P8

Gene

Segment-10

Organism
Bluetongue virus 10 (isolate USA) (BTV 10)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the inhibition of host innate immune response. Interacts with host OPTN and thus inhibits the recruitment of TBK1 to the host Golgi apparatus. In turn, downstream partner IRF3 cannot be activated and IFN-beta production is impaired.2 Publications
Facilitates viral particle release either by increasing plasma membrane permeability through a viroporin-like activity (PubMed:15292261) or by viral budding.2 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein P8
Alternative name(s):
Non-structural protein NS3
Cleaved into the following chain:
Gene namesi
Name:Segment-10
OrganismiBluetongue virus 10 (isolate USA) (BTV 10)
Taxonomic identifieri10900 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeOrbivirus
Virus hostiAntilocapra americana (Pronghorn) [TaxID: 9891]
Bos taurus (Bovine) [TaxID: 9913]
Capra hircus (Goat) [TaxID: 9925]
Culicoides variipennis (Biting midge) [TaxID: 46212]
Ovis aries (Sheep) [TaxID: 9940]
Proteomesi
  • UP000007662 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host Golgi apparatus, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000406281 – 229Non-structural protein P8Add BLAST229
ChainiPRO_000004062914 – 229Non-structural protein NS3AAdd BLAST216

Interactioni

Subunit structurei

Forms homooligomers via coiled-coil motif (PubMed:15292261, PubMed:26318174). Interacts with host OPTN; this interaction inhibits innate immune response (PubMed:27538435).3 Publications

Protein-protein interaction databases

ELMiP08363

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 26CCM-I1 PublicationAdd BLAST13
Regioni94 – 116CCM-III1 PublicationAdd BLAST23
Regioni185 – 198CCM-II1 PublicationAdd BLAST14

Sequence similaritiesi

Belongs to the orbivirus NS3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR002565 Orbi_NS3
PfamiView protein in Pfam
PF01616 Orbi_NS3, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003183 Orbi_NS3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08363-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSGLIQRFE EEKMKHNQDR VEELSLVRVD DTISQPPRYA PSAPMPSSMP
60 70 80 90 100
TVALEILDKA MSNTTGATQT QKAEKAAFAS YAEAFRDDVR LRQIKRHVNE
110 120 130 140 150
QILPKLKSDL SELKKKRAII HTTLLVAAVV ALLTSVCTLS SDMSVAFKIN
160 170 180 190 200
GTKTEVPSWF KSLNPMLGVV NLGATFLMMV CAKSERALNQ QIDMIKKEVM
210 220
KKQSYNDAVR MSFTEFSSIP LDGFEMPLT
Length:229
Mass (Da):25,602
Last modified:August 1, 1988 - v1
Checksum:i1A23B53198ECB684
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28981 Genomic RNA Translation: AAA42840.1
PIRiA29153 P8XR10
RefSeqiYP_052960.1, NC_006015.1

Genome annotation databases

GeneIDi2943154
KEGGivg:2943154

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28981 Genomic RNA Translation: AAA42840.1
PIRiA29153 P8XR10
RefSeqiYP_052960.1, NC_006015.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP08363

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2943154
KEGGivg:2943154

Family and domain databases

InterProiView protein in InterPro
IPR002565 Orbi_NS3
PfamiView protein in Pfam
PF01616 Orbi_NS3, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003183 Orbi_NS3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVP8_BTV10
AccessioniPrimary (citable) accession number: P08363
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 10, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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