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Protein

Hemagglutinin glycoprotein

Gene

H

Organism
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.1 Publication

Caution

Morbiliviruses hemagglutinins have no neuraminidase activity.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHemagglutinin
Biological processHost-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

UniLectiniP08362

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin glycoprotein
Gene namesi
Name:H
OrganismiMeasles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
Taxonomic identifieri11235 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeMorbillivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000833 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37IntravirionSequence analysisAdd BLAST37
Transmembranei38 – 58Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini59 – 617Virion surfaceSequence analysisAdd BLAST559

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001425991 – 617Hemagglutinin glycoproteinAdd BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi168N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi200N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi238N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with human NECTIN4; this interaction allows virus infection of the respiratory epithelium (By similarity). Interacts with human MCP/CD46 antigen and SLAMF1.By similarity2 Publications

Protein-protein interaction databases

DIPiDIP-59049N
IntActiP08362, 2 interactors

Structurei

Secondary structure

1617
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08362
SMRiP08362
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08362

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG0900004D

Family and domain databases

InterProiView protein in InterPro
IPR000665 Hemagglutn/HN
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00423 HN, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

P08362-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPQRDRINA FYKDNPHPKG SRIVINREHL MIDRPYVLLA VLFVMFLSLI
60 70 80 90 100
GLLAIAGIRL HRAAIYTAEI HKSLSTNLDV TNSIEHQVKD VLTPLFKIIG
110 120 130 140 150
DEVGLRTPQR FTDLVKFISD KIKFLNPDRE YDFRDLTWCI NPPERIKLDY
160 170 180 190 200
DQYCADVAAE ELMNALVNST LLETRTTNQF LAVSKGNCSG PTTIRGQFSN
210 220 230 240 250
MSLSLLDLYL GRGYNVSSIV TMTSQGMYGG TYLVEKPNLS SKRSELSQLS
260 270 280 290 300
MYRVFEVGVI RNPGLGAPVF HMTNYLEQPV SNDLSNCMVA LGELKLAALC
310 320 330 340 350
HGEDSITIPY QGSGKGVSFQ LVKLGVWKSP TDMQSWVPLS TDDPVIDRLY
360 370 380 390 400
LSSHRGVIAD NQAKWAVPTT RTDDKLRMET CFQQACKGKI QALCENPEWA
410 420 430 440 450
PLKDNRIPSY GVLSVDLSLT VELKIKIASG FGPLITHGSG MDLYKSNHNN
460 470 480 490 500
VYWLTIPPMK NLALGVINTL EWIPRFKVSP YLFNVPIKEA GEDCHAPTYL
510 520 530 540 550
PAEVDGDVKL SSNLVILPGQ DLQYVLATYD TSRVEHAVVY YVYSPSRSFS
560 570 580 590 600
YFYPFRLPIK GVPIELQVEC FTWDQKLWCR HFCVLADSES GGHITHSGME
610
GMGVSCTVTR EDGTNRR
Length:617
Mass (Da):69,250
Last modified:August 1, 1988 - v1
Checksum:i0E5A05AEDA43D9C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14877 Genomic RNA Translation: AAA46424.1
K01711 Genomic RNA Translation: AAA75500.1
PIRiA27006 HMNZED

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14877 Genomic RNA Translation: AAA46424.1
K01711 Genomic RNA Translation: AAA75500.1
PIRiA27006 HMNZED

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RKCX-ray2.70A156-617[»]
2ZB5X-ray3.00A149-617[»]
2ZB6X-ray2.60A149-617[»]
3ALWX-ray3.55A184-607[»]
3ALXX-ray3.15A/B/C/D184-607[»]
3ALZX-ray4.52A149-617[»]
3INBX-ray3.10A/B179-617[»]
ProteinModelPortaliP08362
SMRiP08362
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59049N
IntActiP08362, 2 interactors

Protein family/group databases

UniLectiniP08362

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG0900004D

Miscellaneous databases

EvolutionaryTraceiP08362

Family and domain databases

InterProiView protein in InterPro
IPR000665 Hemagglutn/HN
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00423 HN, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHEMA_MEASE
AccessioniPrimary (citable) accession number: P08362
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: July 18, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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