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Protein

Tegument protein UL46

Gene

UL46

Organism
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays a role in the activation of the host PI3K/AKT pathway to promote cell survival. Interacts with and activates host LCK and thereby recruits downstream partners SHC1, GRB2 and PI3KR1 in order to activate the PI3K pathway by phosphorylating host AKT on its activating residues. This mechanism is inhibited by the viral protein US3 that instead promotes incorporation of UL46 into virions.By similarity

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Tegument protein UL46
Alternative name(s):
Tegument protein VP11/12
Gene namesi
ORF Names:UL46
OrganismiHuman herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10304 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157931 – 715Tegument protein UL46Add BLAST715

Post-translational modificationi

Phosphorylated by host LCK. The phosphorylation seems to be lymphocyte-specific.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP08314

Interactioni

Subunit structurei

Interacts with VP16. Interacts with host LCK, PIK3R1, SHC1 AND GRB2; these interactions promote the activation of the PI3K/AKT pathway. Interacts with host YWHAB. Interacts with ICP0; this interaction targets UL46 for degradation by the proteasome.By similarity

Structurei

3D structure databases

SMRiP08314
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi582 – 586Poly-Asp5
Compositional biasi665 – 674Poly-Pro10

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR005051 Herpes_UL46
PfamiView protein in Pfam
PF03387 Herpes_UL46, 1 hit

Sequencei

Sequence statusi: Complete.

P08314-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRRTRGASS LRLARCLTPA NLIRGDNAGV PERRIFGGCL LPTPEGLLSA
60 70 80 90 100
AVGALRQRSD DAQPAFLTCT DRSVRLAARQ HNTVPESLIV DGLASDPHYE
110 120 130 140 150
YIRHYASAAT QALGEVELTG GQLSRAILTQ YWKYLQTVVP SGLDVPEDPV
160 170 180 190 200
GDCDPSLHVL LRPTLAPKLL ARTPFKSGAA AAKYAATVAG LRDALHRIQQ
210 220 230 240 250
YMFFMRPADP SRPSTDTALR LNELLAYVSV LYRWASWMLW TTDKHVCHRL
260 270 280 290 300
SPSNRRFLPL GGSPEAPAET FARHLDRGPS GTTGSMQCMA LRAAVSDVLG
310 320 330 340 350
HLTRLANLWQ TGKRSGGTYG TVDTVVSTVE VLSIVHHHAQ YIINATLTGY
360 370 380 390 400
GVWATDSLNN EYLRAAVDSQ ERFCRTTAPL FPTMTAPSWA RMELSIKAWF
410 420 430 440 450
GAALAADLLR SGAPSLHYES ILRLVASRRT TWSAGPPPDD MARGPGGHRA
460 470 480 490 500
GGGTVGKRFS GPARQRAPAP PPTSPTLDPR GHPAVPEAPR GRPAPPLPDA
510 520 530 540 550
DDPVAEPPGC AAQPATYYTH MGEVPPRLPA RNVAGPDRRP PAATCPLLVR
560 570 580 590 600
RASLGSLDRP RGWGPAPEGE PDQMEATYLT ADDDDDARRK ATHAASARER
610 620 630 640 650
HAPYEDDESI YETVSEDGGR VYEEIPWMRV YENVCANTAN AAPASPYIEA
660 670 680 690 700
ENPLYDWGGS ALFSPPPRPP PPPPLSPSPV LARHRANALT NDGPTNVAAL
710
SALLTKLKRE GRRSR
Length:715
Mass (Da):77,357
Last modified:August 1, 1988 - v1
Checksum:i9490E875ADD88155
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15621 Genomic DNA Translation: AAA45768.1
PIRiB26133 TNBE77

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15621 Genomic DNA Translation: AAA45768.1
PIRiB26133 TNBE77

3D structure databases

SMRiP08314
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP08314

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR005051 Herpes_UL46
PfamiView protein in Pfam
PF03387 Herpes_UL46, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTEG1_HHV1F
AccessioniPrimary (citable) accession number: P08314
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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