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Protein

Cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Paracoccus denitrificans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

binuclear copper center (CuA)Note: Binds a binuclear copper A center per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi210Copper A11
Metal bindingi245Copper A11
Metal bindingi245Copper A21
Metal bindingi247Copper A2; via carbonyl oxygen1
Metal bindingi249Copper A11
Metal bindingi249Copper A21
Metal bindingi253Copper A21
Metal bindingi256Copper A11

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Enzyme and pathway databases

BRENDAi1.9.3.1 3341

Protein family/group databases

TCDBi3.D.4.6.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Oxidase aa(3) subunit 2
Gene namesi
Name:ctaC
Synonyms:coiI, ctaB
OrganismiParacoccus denitrificans
Taxonomic identifieri266 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeParacoccus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 55PeriplasmicAdd BLAST26
Transmembranei56 – 88HelicalAdd BLAST33
Topological domaini89 – 103CytoplasmicAdd BLAST15
Transmembranei104 – 134HelicalAdd BLAST31
Topological domaini135 – 280PeriplasmicAdd BLAST146

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

DrugBankiDB04147 Lauryl Dimethylamine-N-Oxide

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
ChainiPRO_000000605930 – 280Cytochrome c oxidase subunit 2Add BLAST251
PropeptideiPRO_0000006060281 – 298C-terminal propeptideAdd BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30Pyrrolidone carboxylic acid1 Publication1

Keywords - PTMi

Pyrrolidone carboxylic acid

Interactioni

Protein-protein interaction databases

DIPiDIP-6089N

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08306
SMRiP08306
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08306

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CV4 Bacteria
COG1622 LUCA

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08306-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMAIATKRRG VAAVMSLGVA TMTAVPALAQ DVLGDLPVIG KPVNGGMNFQ
60 70 80 90 100
PASSPLAHDQ QWLDHFVLYI ITAVTIFVCL LLLICIVRFN RRANPVPARF
110 120 130 140 150
THNTPIEVIW TLVPVLILVA IGAFSLPILF RSQEMPNDPD LVIKAIGHQW
160 170 180 190 200
YWSYEYPNDG VAFDALMLEK EALADAGYSE DEYLLATDNP VVVPVGKKVL
210 220 230 240 250
VQVTATDVIH AWTIPAFAVK QDAVPGRIAQ LWFSVDQEGV YFGQCSELCG
260 270 280 290
INHAYMPIVV KAVSQEKYEA WLAGAKEEFA ADASDYLPAS PVKLASAE
Length:298
Mass (Da):32,539
Last modified:August 1, 1988 - v1
Checksum:i918A64A9E3B93366
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160 – 161GV → AF AA sequence (PubMed:2820725).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05828 Genomic DNA Translation: CAA29268.1
RefSeqiWP_011750547.1, NZ_PPGA01000006.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05828 Genomic DNA Translation: CAA29268.1
RefSeqiWP_011750547.1, NZ_PPGA01000006.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AR1X-ray2.70B1-298[»]
1QLEX-ray3.00B30-281[»]
1ZYYmodel-B30-281[»]
3EHBX-ray2.32B1-298[»]
3HB3X-ray2.25B1-298[»]
ProteinModelPortaliP08306
SMRiP08306
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6089N

Chemistry databases

DrugBankiDB04147 Lauryl Dimethylamine-N-Oxide

Protein family/group databases

TCDBi3.D.4.6.1 the proton-translocating cytochrome oxidase (cox) superfamily

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CV4 Bacteria
COG1622 LUCA

Enzyme and pathway databases

BRENDAi1.9.3.1 3341

Miscellaneous databases

EvolutionaryTraceiP08306

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX2_PARDE
AccessioniPrimary (citable) accession number: P08306
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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