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Protein

Extracellular superoxide dismutase [Cu-Zn]

Gene

SOD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds 1 copper ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi114Copper; catalytic1
Metal bindingi116Copper; catalytic1
Metal bindingi131Copper; catalytic1
Metal bindingi131Zinc; structural1
Metal bindingi139Zinc; structural1
Metal bindingi142Zinc; structural1
Metal bindingi145Zinc; structural1
Metal bindingi181Copper; catalytic1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntioxidant, Heparin-binding, Oxidoreductase
LigandCopper, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS03242-MONOMER
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Short name:
EC-SOD
Gene namesi
Name:SOD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000109610.5
HGNCiHGNC:11181 SOD3
MIMi185490 gene
neXtProtiNX_P08294

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6649
OpenTargetsiENSG00000109610
PharmGKBiPA36018

Chemistry databases

ChEMBLiCHEMBL2069159

Polymorphism and mutation databases

BioMutaiSOD3
DMDMi108885292

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000003285519 – 240Extracellular superoxide dismutase [Cu-Zn]Add BLAST222

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 2081 Publication
Glycosylationi107N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi125 ↔ 2071 Publication
Glycosylationi229N-linked (Glc) (glycation) lysine; in vitro1 Publication1
Glycosylationi230N-linked (Glc) (glycation) lysine; in vitro1 Publication1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei41Not glycated1
Sitei92Not glycated1
Sitei238Not glycated1

Keywords - PTMi

Disulfide bond, Glycation, Glycoprotein

Proteomic databases

EPDiP08294
MaxQBiP08294
PaxDbiP08294
PeptideAtlasiP08294
PRIDEiP08294
ProteomicsDBi52104

PTM databases

GlyConnecti1233
iPTMnetiP08294
PhosphoSitePlusiP08294

Miscellaneous databases

PMAP-CutDBiP08294

Expressioni

Tissue specificityi

Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.

Gene expression databases

BgeeiENSG00000109610 Expressed in 186 organ(s), highest expression level in thoracic aorta
CleanExiHS_SOD3
ExpressionAtlasiP08294 baseline and differential
GenevisibleiP08294 HS

Organism-specific databases

HPAiHPA042110

Interactioni

Subunit structurei

Homotetramer.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi112532, 1 interactor
IntActiP08294, 9 interactors
STRINGi9606.ENSP00000371554

Chemistry databases

BindingDBiP08294

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08294
SMRiP08294
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08294

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0441 Eukaryota
COG2032 LUCA
GeneTreeiENSGT00530000063226
HOGENOMiHOG000263447
HOVERGENiHBG000062
InParanoidiP08294
KOiK16627
OMAiEQEDDMG
OrthoDBiEOG091G13ID
PhylomeDBiP08294
TreeFamiTF105133

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
PRINTSiPR00068 CUZNDISMTASE
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00087 SOD_CU_ZN_1, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P08294-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLALLCSCLL LAAGASDAWT GEDSAEPNSD SAEWIRDMYA KVTEIWQEVM
60 70 80 90 100
QRRDDDGALH AACQVQPSAT LDAAQPRVTG VVLFRQLAPR AKLDAFFALE
110 120 130 140 150
GFPTEPNSSS RAIHVHQFGD LSQGCESTGP HYNPLAVPHP QHPGDFGNFA
160 170 180 190 200
VRDGSLWRYR AGLAASLAGP HSIVGRAVVV HAGEDDLGRG GNQASVENGN
210 220 230 240
AGRRLACCVV GVCGPGLWER QAREHSERKK RRRESECKAA
Length:240
Mass (Da):25,851
Last modified:May 30, 2006 - v2
Checksum:i585B8DEBFC506CF4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R1V4M0R1V4_HUMAN
Extracellular superoxide dismutase ...
SOD3
54Annotation score:

Polymorphismi

The variant Gly-231 which is found in about 2.2% of individual displays a 10-fold increased plasma EC-SOD content due to reduced heparin-binding affinity and thus the impairment of its binding ability to endothelial cell surface.3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02077658A → T5 PublicationsCorresponds to variant dbSNP:rs2536512Ensembl.1
Natural variantiVAR_02077791A → T1 PublicationCorresponds to variant dbSNP:rs17879876Ensembl.1
Natural variantiVAR_014705231R → G5 PublicationsCorresponds to variant dbSNP:rs1799895EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02947 mRNA Translation: AAA66000.1
U10116 Genomic DNA Translation: AAA62278.1
CR541853 mRNA Translation: CAG46651.1
AY787834 Genomic DNA Translation: AAV40827.1
BC014418 mRNA Translation: AAH14418.1
CCDSiCCDS3430.1
PIRiA28301 DSHUEC
RefSeqiNP_003093.2, NM_003102.2
UniGeneiHs.2420

Genome annotation databases

EnsembliENST00000382120; ENSP00000371554; ENSG00000109610
GeneIDi6649
KEGGihsa:6649
UCSCiuc003gqz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Superoxide dismutase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02947 mRNA Translation: AAA66000.1
U10116 Genomic DNA Translation: AAA62278.1
CR541853 mRNA Translation: CAG46651.1
AY787834 Genomic DNA Translation: AAV40827.1
BC014418 mRNA Translation: AAH14418.1
CCDSiCCDS3430.1
PIRiA28301 DSHUEC
RefSeqiNP_003093.2, NM_003102.2
UniGeneiHs.2420

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JLPX-ray1.70A/B/C/D19-240[»]
ProteinModelPortaliP08294
SMRiP08294
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112532, 1 interactor
IntActiP08294, 9 interactors
STRINGi9606.ENSP00000371554

Chemistry databases

BindingDBiP08294
ChEMBLiCHEMBL2069159

PTM databases

GlyConnecti1233
iPTMnetiP08294
PhosphoSitePlusiP08294

Polymorphism and mutation databases

BioMutaiSOD3
DMDMi108885292

Proteomic databases

EPDiP08294
MaxQBiP08294
PaxDbiP08294
PeptideAtlasiP08294
PRIDEiP08294
ProteomicsDBi52104

Protocols and materials databases

DNASUi6649
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382120; ENSP00000371554; ENSG00000109610
GeneIDi6649
KEGGihsa:6649
UCSCiuc003gqz.4 human

Organism-specific databases

CTDi6649
DisGeNETi6649
EuPathDBiHostDB:ENSG00000109610.5
GeneCardsiSOD3
HGNCiHGNC:11181 SOD3
HPAiHPA042110
MIMi185490 gene
neXtProtiNX_P08294
OpenTargetsiENSG00000109610
PharmGKBiPA36018
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0441 Eukaryota
COG2032 LUCA
GeneTreeiENSGT00530000063226
HOGENOMiHOG000263447
HOVERGENiHBG000062
InParanoidiP08294
KOiK16627
OMAiEQEDDMG
OrthoDBiEOG091G13ID
PhylomeDBiP08294
TreeFamiTF105133

Enzyme and pathway databases

BioCyciMetaCyc:HS03242-MONOMER
ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species

Miscellaneous databases

ChiTaRSiSOD3 human
EvolutionaryTraceiP08294
GeneWikiiSOD3
GenomeRNAii6649
PMAP-CutDBiP08294
PROiPR:P08294
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109610 Expressed in 186 organ(s), highest expression level in thoracic aorta
CleanExiHS_SOD3
ExpressionAtlasiP08294 baseline and differential
GenevisibleiP08294 HS

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
PRINTSiPR00068 CUZNDISMTASE
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00087 SOD_CU_ZN_1, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSODE_HUMAN
AccessioniPrimary (citable) accession number: P08294
Secondary accession number(s): Q5U781, Q6FHA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 30, 2006
Last modified: October 10, 2018
This is version 197 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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