GSTA1

Functionⁱ

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.1 Publication

Catalytic activityⁱ

RX + glutathione = HX + R-S-glutathione.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	9	Glutathione2 Publications		1
Binding siteⁱ	45	Glutathione2 Publications		1

GO - Molecular functionⁱ

glutathione peroxidase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 16624487
glutathione transferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 20606271

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

epithelial cell differentiation
Source: UniProtKB
Inferred from expression patternⁱ
- 21492153
glutathione derivative biosynthetic process Source: Reactome
glutathione metabolic process
Source: UniProtKB
Inferred from direct assayⁱ
- 20606271
linoleic acid metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 16624487

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase

Molecular function

Transferase

Enzyme and pathway databases

BioCycⁱ	MetaCyc:G66-32542-MONOMER
BRENDAⁱ	2.5.1.18 2681
Reactomeⁱ	R-HSA-156590 Glutathione conjugation
SABIO-RKⁱ	P08263
SIGNORⁱ	P08263

Chemistry databases

SwissLipidsⁱ	SLP:000001476

SwissLipidsⁱ

SLP:000001476

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutathione S-transferase A1 (EC:2.5.1.18) Alternative name(s): GST HA subunit 1 GST class-alpha member 1 GST-epsilon GSTA1-1 GTH1 Cleaved into the following chain: Glutathione S-transferase A1, N-terminally processed
Gene namesⁱ	Name:GSTA1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000243955.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4626 GSTA1
MIMⁱ	138359 gene
neXtProtⁱ	NX_P08263

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	71	I → A or V: No significant effect on enzyme activity. Reduces protein stability. 1 Publication		1
Mutagenesisⁱ	216	A → H: Confers ability to hydrolyze S-glutathionyl benzoate to glutathione and benzoic acid. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2938
Open Targets More...OpenTargetsⁱ	ENSG00000243955
PharmGKBⁱ	PA29016

Chemistry databases

ChEMBLⁱ	CHEMBL3409
Drug and drug target database More...DrugBankⁱ	DB02486 2-Hydroxyethyl Disulfide DB00993 Azathioprine DB01008 Busulfan DB00143 Glutathione DB03003 Glutathione Sulfonic Acid DB02943 N-(4-Aminobutanoyl)-S-(4-Methoxybenzyl)-L-Cysteinylglycine DB03602 S-Benzyl-Glutathione DB04132 S-Hexylglutathione DB01915 S-Hydroxycysteine

Polymorphism and mutation databases

BioMutaⁱ	GSTA1
DMDMⁱ	121730

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000423203	1 – 222	Glutathione S-transferase A1Add BLAST	222
Initiator methionineⁱ		Removed; alternateBy similarity1 Publication
ChainⁱPRO_0000185783	2 – 222	Glutathione S-transferase A1, N-terminally processedAdd BLAST	221

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	2	N-acetylalanine; in Glutathione S-transferase A1, N-terminally processedBy similarity	1
Modified residueⁱ	4	N6-succinyllysineBy similarity	1

Keywords - PTMⁱ

Acetylation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P08263
PaxDbⁱ	P08263
PeptideAtlas More...PeptideAtlasⁱ	P08263
PRIDEⁱ	P08263
ProteomicsDBⁱ	12637 52103

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00657682

REPRODUCTION-2DPAGEⁱ

IPI00657682

PTM databases

iPTMnetⁱ	P08263
PhosphoSitePlusⁱ	P08263

Expressionⁱ

Tissue specificityⁱ

Liver.

Gene expression databases

Bgeeⁱ	ENSG00000243955
CleanExⁱ	HS_GSTA1
ExpressionAtlasⁱ	P08263 baseline and differential
Genevisibleⁱ	P08263 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA004342 HPA048934 HPA053817

HPAⁱ

HPA004342
HPA048934
HPA053817

Interactionⁱ

Subunit structureⁱ

Homodimer or heterodimer of GSTA1 and GSTA2.8 Publications

Protein-protein interaction databases

BioGridⁱ	109193, 15 interactors
IntActⁱ	P08263, 6 interactors
STRINGⁱ	9606.ENSP00000335620

Chemistry databases

BindingDBⁱ

P08263

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	6 – 13	Combined sources	8
Turnⁱ	14 – 16	Combined sources	3
Helixⁱ	17 – 26	Combined sources	10
Beta strandⁱ	31 – 35	Combined sources	5
Helixⁱ	38 – 46	Combined sources	9
Beta strandⁱ	57 – 60	Combined sources	4
Beta strandⁱ	63 – 67	Combined sources	5
Helixⁱ	68 – 78	Combined sources	11
Helixⁱ	86 – 108	Combined sources	23
Helixⁱ	109 – 111	Combined sources	3
Helixⁱ	114 – 130	Combined sources	17
Helixⁱ	132 – 143	Combined sources	12
Beta strandⁱ	146 – 149	Combined sources	4
Helixⁱ	155 – 170	Combined sources	16
Turnⁱ	172 – 177	Combined sources	6
Helixⁱ	179 – 190	Combined sources	12
Helixⁱ	192 – 198	Combined sources	7
Helixⁱ	210 – 220	Combined sources	11

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1GSD	X-ray	2.50	A/B/C/D	2-222	[»]
	1GSE	X-ray	2.00	A/B	2-222	[»]
	1GSF	X-ray	2.70	A/B/C/D	2-222	[»]
	1GUH	X-ray	2.60	A/B/C/D	2-222	[»]
	1K3L	X-ray	1.50	A/B	2-222	[»]
	1K3O	X-ray	1.80	A/B	2-222	[»]
	1K3Y	X-ray	1.30	A/B	2-222	[»]
	1LBK	X-ray	1.86	A/B	208-213	[»]
	1PKW	X-ray	2.00	A/B	1-222	[»]
	1PKZ	X-ray	2.10	A/B	1-222	[»]
	1PL1	X-ray	1.75	A/B	1-222	[»]
	1PL2	X-ray	1.80	A/B	1-222	[»]
	1USB	X-ray	2.07	A/B	2-222	[»]
	1XWG	X-ray	1.85	A/B	2-222	[»]
	1YDK	X-ray	1.95	A/B	1-222	[»]
	2R3X	X-ray	1.80	A/B	1-222	[»]
	2R6K	X-ray	2.51	A/B	1-222	[»]
	3I69	X-ray	2.38	A/B/C/D/E/F/G/H	1-222	[»]
	3I6A	X-ray	1.98	A/B/C/D/E/F/G/H	1-222	[»]
	3IK9	X-ray	2.20	A/B/C/D/E/F/G/H	1-222	[»]
	3KTL	X-ray	1.75	A/B	2-222	[»]
	3L0H	X-ray	2.13	A/B	1-222	[»]
	3Q74	X-ray	1.79	A/B	2-222	[»]
	3U6V	X-ray	2.20	A/B	1-222	[»]
	3ZFB	X-ray	1.86	A/B	1-222	[»]
	3ZFL	X-ray	1.88	A/B	1-222	[»]
	4HJ2	X-ray	2.10	A/B	4-220	[»]
	5JCU	X-ray	1.93	A/B/C/D	2-222	[»]
	5LCZ	X-ray	2.33	A/B	1-100	[»]
				A/B	201-222	[»]
	5LD0	X-ray	1.60	A	1-85	[»]
				A	214-222	[»]
ProteinModelPortalⁱ	P08263
SMRⁱ	P08263
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P08263

EvolutionaryTraceⁱ

P08263

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	3 – 83	GST N-terminalAdd BLAST		81
Domainⁱ	85 – 207	GST C-terminalAdd BLAST		123

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	54 – 55	Glutathione binding2 Publications		2
Regionⁱ	67 – 68	Glutathione binding2 Publications		2

Domainⁱ

The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity.

Sequence similaritiesⁱ

Belongs to the GST superfamily. Alpha family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1695 Eukaryota ENOG4111VAU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00670000097856
HOGENOMⁱ	HOG000115734
HOVERGENⁱ	HBG053749
InParanoidⁱ	P08263
KEGG Orthology (KO) More...KOⁱ	K00799
OMAⁱ	NEMIIVL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O3D
PhylomeDBⁱ	P08263
TreeFamⁱ	TF105321

Family and domain databases

InterProⁱ	View protein in InterPro IPR010987 Glutathione-S-Trfase_C-like IPR036282 Glutathione-S-Trfase_C_sf IPR004045 Glutathione_S-Trfase_N IPR003080 GST_alpha IPR004046 GST_C IPR036249 Thioredoxin-like_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00043 GST_C, 1 hit PF02798 GST_N, 1 hit
PRINTSⁱ	PR01266 GSTRNSFRASEA
SUPFAMⁱ	SSF47616 SSF47616, 1 hit SSF52833 SSF52833, 1 hit
PROSITEⁱ	View protein in PROSITE PS50405 GST_CTER, 1 hit PS50404 GST_NTER, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P08263-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEKPKLHYF NARGRMESTR WLLAAAGVEF EEKFIKSAED LDKLRNDGYL 
        60         70         80         90        100
MFQQVPMVEI DGMKLVQTRA ILNYIASKYN LYGKDIKERA LIDMYIEGIA 
       110        120        130        140        150
DLGEMILLLP VCPPEEKDAK LALIKEKIKN RYFPAFEKVL KSHGQDYLVG 
       160        170        180        190        200
NKLSRADIHL VELLYYVEEL DSSLISSFPL LKALKTRISN LPTVKKFLQP 
       210        220 
GSPRKPPMDE KSLEEARKIF RF

Length:222

Mass (Da):25,631

Last modified:January 23, 2007 - v3

Checksum:ⁱC8B6786DCD761350

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	18	S → C in AAA36174 (PubMed:3678589).Curated	1
Sequence conflictⁱ	51	M → T in AAT06769 (Ref. 7) Curated	1
Sequence conflictⁱ	56 – 58	PMV → AML in AAA36174 (PubMed:3678589).Curated	3
Sequence conflictⁱ	212	S → L AA sequence (PubMed:2604726).Curated	1
Sequence conflictⁱ	216	A → S AA sequence (PubMed:8431482).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_033978	19	T → I. Corresponds to variant dbSNP:rs1051578Ensembl.	1
Natural variantⁱVAR_049482	113	P → Q. Corresponds to variant dbSNP:rs1051745Ensembl.	1
Natural variantⁱVAR_049483	117	K → Q. Corresponds to variant dbSNP:rs1051757Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M15872 mRNA Translation: AAA70226.1 M21758 mRNA Translation: AAA52615.1 M25627 mRNA Translation: AAA36174.1 M14777 mRNA Translation: AAA52618.1 S76235 S76232 Genomic DNA Translation: AAB20973.1 S49975 mRNA Translation: AAB24012.1 AY532928 mRNA Translation: AAT06769.1 CR407656 mRNA Translation: CAG28584.1 AL590363 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04385.1 BC053578 mRNA Translation: AAH53578.1 BC110891 mRNA Translation: AAI10892.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4945.1
PIRⁱ	A25909 A56666 S29657
NCBI Reference Sequences More...RefSeqⁱ	NP_665683.1, NM_145740.4
UniGeneⁱ	Hs.446309

Genome annotation databases

Ensemblⁱ	ENST00000334575; ENSP00000335620; ENSG00000243955
GeneIDⁱ	2938
KEGGⁱ	hsa:2938
UCSC genome browser More...UCSCⁱ	uc003paz.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P08263	Glutathione S-transferase		HUMAN		222
GSTA5 isoform 2		PANTR		222
Glutathione S-transferase A1		CALJA		222
Glutathione S-transferase A3		MACMU		222
Glutathione S-transferase A3		MACFA		222
+89

Protein	Similar proteins		Species	Score	Length
P08263	Glutathione S-transferase		HUMAN		222
Uncharacterized protein		PAPAN		222
Uncharacterized protein		CERAT		222
Uncharacterized protein		MANLE		222
UPI000C29EF39		Ugandan red Colobus		74
+240

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M15872 mRNA Translation: AAA70226.1 M21758 mRNA Translation: AAA52615.1 M25627 mRNA Translation: AAA36174.1 M14777 mRNA Translation: AAA52618.1 S76235 S76232 Genomic DNA Translation: AAB20973.1 S49975 mRNA Translation: AAB24012.1 AY532928 mRNA Translation: AAT06769.1 CR407656 mRNA Translation: CAG28584.1 AL590363 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04385.1 BC053578 mRNA Translation: AAH53578.1 BC110891 mRNA Translation: AAI10892.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4945.1
PIRⁱ	A25909 A56666 S29657
NCBI Reference Sequences More...RefSeqⁱ	NP_665683.1, NM_145740.4
UniGeneⁱ	Hs.446309

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1GSD	X-ray	2.50	A/B/C/D	2-222	[»]
	1GSE	X-ray	2.00	A/B	2-222	[»]
	1GSF	X-ray	2.70	A/B/C/D	2-222	[»]
	1GUH	X-ray	2.60	A/B/C/D	2-222	[»]
	1K3L	X-ray	1.50	A/B	2-222	[»]
	1K3O	X-ray	1.80	A/B	2-222	[»]
	1K3Y	X-ray	1.30	A/B	2-222	[»]
	1LBK	X-ray	1.86	A/B	208-213	[»]
	1PKW	X-ray	2.00	A/B	1-222	[»]
	1PKZ	X-ray	2.10	A/B	1-222	[»]
	1PL1	X-ray	1.75	A/B	1-222	[»]
	1PL2	X-ray	1.80	A/B	1-222	[»]
	1USB	X-ray	2.07	A/B	2-222	[»]
	1XWG	X-ray	1.85	A/B	2-222	[»]
	1YDK	X-ray	1.95	A/B	1-222	[»]
	2R3X	X-ray	1.80	A/B	1-222	[»]
	2R6K	X-ray	2.51	A/B	1-222	[»]
	3I69	X-ray	2.38	A/B/C/D/E/F/G/H	1-222	[»]
	3I6A	X-ray	1.98	A/B/C/D/E/F/G/H	1-222	[»]
	3IK9	X-ray	2.20	A/B/C/D/E/F/G/H	1-222	[»]
	3KTL	X-ray	1.75	A/B	2-222	[»]
	3L0H	X-ray	2.13	A/B	1-222	[»]
	3Q74	X-ray	1.79	A/B	2-222	[»]
	3U6V	X-ray	2.20	A/B	1-222	[»]
	3ZFB	X-ray	1.86	A/B	1-222	[»]
	3ZFL	X-ray	1.88	A/B	1-222	[»]
	4HJ2	X-ray	2.10	A/B	4-220	[»]
	5JCU	X-ray	1.93	A/B/C/D	2-222	[»]
	5LCZ	X-ray	2.33	A/B	1-100	[»]
				A/B	201-222	[»]
	5LD0	X-ray	1.60	A	1-85	[»]
				A	214-222	[»]
ProteinModelPortalⁱ	P08263
SMRⁱ	P08263
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109193, 15 interactors
IntActⁱ	P08263, 6 interactors
STRINGⁱ	9606.ENSP00000335620

Chemistry databases

BindingDBⁱ	P08263
ChEMBLⁱ	CHEMBL3409
Drug and drug target database More...DrugBankⁱ	DB02486 2-Hydroxyethyl Disulfide DB00993 Azathioprine DB01008 Busulfan DB00143 Glutathione DB03003 Glutathione Sulfonic Acid DB02943 N-(4-Aminobutanoyl)-S-(4-Methoxybenzyl)-L-Cysteinylglycine DB03602 S-Benzyl-Glutathione DB04132 S-Hexylglutathione DB01915 S-Hydroxycysteine
SwissLipidsⁱ	SLP:000001476

PTM databases

iPTMnetⁱ	P08263
PhosphoSitePlusⁱ	P08263

Polymorphism and mutation databases

BioMutaⁱ	GSTA1
DMDMⁱ	121730

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00657682

REPRODUCTION-2DPAGEⁱ

IPI00657682

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P08263
PaxDbⁱ	P08263
PeptideAtlas More...PeptideAtlasⁱ	P08263
PRIDEⁱ	P08263
ProteomicsDBⁱ	12637 52103

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2938
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000334575; ENSP00000335620; ENSG00000243955
GeneIDⁱ	2938
KEGGⁱ	hsa:2938
UCSC genome browser More...UCSCⁱ	uc003paz.4 human

Organism-specific databases

CTDⁱ	2938
DisGeNET More...DisGeNETⁱ	2938
EuPathDBⁱ	HostDB:ENSG00000243955.5
GeneCardsⁱ	GSTA1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4626 GSTA1
Human Protein Atlas More...HPAⁱ	HPA004342 HPA048934 HPA053817
MIMⁱ	138359 gene
neXtProtⁱ	NX_P08263
Open Targets More...OpenTargetsⁱ	ENSG00000243955
PharmGKBⁱ	PA29016
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1695 Eukaryota ENOG4111VAU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00670000097856
HOGENOMⁱ	HOG000115734
HOVERGENⁱ	HBG053749
InParanoidⁱ	P08263
KEGG Orthology (KO) More...KOⁱ	K00799
OMAⁱ	NEMIIVL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O3D
PhylomeDBⁱ	P08263
TreeFamⁱ	TF105321

Enzyme and pathway databases

BioCycⁱ	MetaCyc:G66-32542-MONOMER
BRENDAⁱ	2.5.1.18 2681
Reactomeⁱ	R-HSA-156590 Glutathione conjugation
SABIO-RKⁱ	P08263
SIGNORⁱ	P08263

Miscellaneous databases

ChiTaRSⁱ	GSTA1 human
EvolutionaryTraceⁱ	P08263
GeneWikiⁱ	Glutathione_S-transferase_A1
GenomeRNAiⁱ	2938
Protein Ontology More...PROⁱ	PR:P08263
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000243955
CleanExⁱ	HS_GSTA1
ExpressionAtlasⁱ	P08263 baseline and differential
Genevisibleⁱ	P08263 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR010987 Glutathione-S-Trfase_C-like IPR036282 Glutathione-S-Trfase_C_sf IPR004045 Glutathione_S-Trfase_N IPR003080 GST_alpha IPR004046 GST_C IPR036249 Thioredoxin-like_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00043 GST_C, 1 hit PF02798 GST_N, 1 hit
PRINTSⁱ	PR01266 GSTRNSFRASEA
SUPFAMⁱ	SSF47616 SSF47616, 1 hit SSF52833 SSF52833, 1 hit
PROSITEⁱ	View protein in PROSITE PS50405 GST_CTER, 1 hit PS50404 GST_NTER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GSTA1_HUMAN
Accessionⁱ	P08263Primary (citable) accession number: P08263 Secondary accession number(s): Q14750, Q5GHF8, Q5SZC1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	January 23, 2007
	Last modified:	June 20, 2018
	This is version 199 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniParc

Help

UniRef

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Supporting data

UniProtKB - P08263 (GSTA1_HUMAN)

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Glutathione S-transferase A1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ