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UniProtKB - P08263 (GSTA1_HUMAN)

Entry version 215 (02 Dec 2020)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
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Protein

Glutathione S-transferase A1

Gene

GSTA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487).1 Publication3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The isomerase activity is inhibited by S-methylglutathione (GSMe).1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 29.3 sec(-1) for the isomerization of androst-5-ene-3,17-dione.1 Publication
  1. KM=160 µM for prostaglandin A2 (at pH 7.0 and 37 degrees Celsius)1 Publication
  2. KM=160 µM for glutathione (at pH 8.0)1 Publication
  3. KM=58 µM for androst-5-ene-3,17-dione (at pH 8.0)1 Publication
  1. Vmax=121 nmol/min/mg enzyme for the formation of the glutathione-S-conjugate of prostaglandin A2 (at pH 7.0 and 37 degrees Celsius)1 Publication
  2. Vmax=40 µmol/min/mg enzyme for the isomerization of androst-5-ene-3,17-dione (at pH 8.0)1 Publication

pH dependencei

Optimum pH is 8.0 for the isomerization of androst-5-ene-3,17-dione.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei9Glutathione2 Publications1
Binding sitei45Glutathione2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Oxidoreductase, Peroxidase, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:G66-32542-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.5.1.18, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P08263

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-156590, Glutathione conjugation
R-HSA-189483, Heme degradation

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P08263

SIGNOR Signaling Network Open Resource

More...SIGNORi		P08263

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001476

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutathione S-transferase A12 Publications (EC:2.5.1.181 Publication)
Alternative name(s):
13-hydroperoxyoctadecadienoate peroxidase1 Publication (EC:1.11.1.-1 Publication)
Androst-5-ene-3,17-dione isomerase1 Publication (EC:5.3.3.-1 Publication)
GST HA subunit 1
GST class-alpha member 1
GST-epsilon
GSTA1-1
GTH1
Cleaved into the following chain:
Glutathione S-transferase A1, N-terminally processed
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GSTA1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000243955.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:4626, GSTA1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		138359, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P08263

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi9Y → F: Decreased isomerase activity. 1 Publication1
Mutagenesisi71I → A or V: No significant effect on enzyme activity. Reduces protein stability. 1 Publication1
Mutagenesisi216A → H: Confers ability to hydrolyze S-glutathionyl benzoate to glutathione and benzoic acid. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		2938

Open Targets

More...OpenTargetsi		ENSG00000243955

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29016

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P08263, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3409

Drug and drug target database

More...DrugBanki		DB02486, 2-Hydroxyethyl Disulfide
DB00993, Azathioprine
DB01008, Busulfan
DB11672, Curcumin
DB00143, Glutathione
DB03310, Glutathione disulfide
DB03003, Glutathione sulfonic acid
DB13014, Hypericin
DB02943, N-(4-Aminobutanoyl)-S-(4-methoxybenzyl)-L-cysteinylglycine
DB03602, S-benzylglutathione
DB04132, S-Hexylglutathione
DB01915, S-Hydroxycysteine

DrugCentral

More...DrugCentrali		P08263

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GSTA1

Domain mapping of disease mutations (DMDM)

More...DMDMi		121730

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004232031 – 222Glutathione S-transferase A1Add BLAST222
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved; alternateBy similarity1 Publication
ChainiPRO_00001857832 – 222Glutathione S-transferase A1, N-terminally processedAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylalanine; in Glutathione S-transferase A1, N-terminally processedBy similarity1
Modified residuei4N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P08263

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P08263

MaxQB - The MaxQuant DataBase

More...MaxQBi		P08263

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08263

PeptideAtlas

More...PeptideAtlasi		P08263

PRoteomics IDEntifications database

More...PRIDEi		P08263

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		12637
52103

2D gel databases

REPRODUCTION-2DPAGE

More...REPRODUCTION-2DPAGEi		IPI00657682

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08263

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P08263

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000243955, Expressed in nephron tubule and 163 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P08263, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P08263, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000243955, Group enriched (adrenal gland, intestine, kidney, liver, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer or heterodimer of GSTA1 and GSTA2.

8 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109193, 15 interactors

Protein interaction database and analysis system

More...IntActi		P08263, 12 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000335620

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P08263

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P08263, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P08263

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P08263

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 83GST N-terminalAdd BLAST81
Domaini85 – 207GST C-terminalAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni54 – 55Glutathione binding2 Publications2
Regioni67 – 68Glutathione binding2 Publications2

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1695, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000164034

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_039475_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08263

Identification of Orthologs from Complete Genome Data

More...OMAi		FIEQPED

Database for complete collections of gene phylogenies

More...PhylomeDBi		P08263

TreeFam database of animal gene trees

More...TreeFami		TF105321

Family and domain databases

Database of protein disorder

More...DisProti		DP01506

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010987, Glutathione-S-Trfase_C-like
IPR036282, Glutathione-S-Trfase_C_sf
IPR040079, Glutathione_S-Trfase
IPR004045, Glutathione_S-Trfase_N
IPR003080, GST_alpha
IPR004046, GST_C
IPR036249, Thioredoxin-like_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00043, GST_C, 1 hit
PF02798, GST_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01266, GSTRNSFRASEA

Structure-Function Linkage Database

More...SFLDi		SFLDS00019, Glutathione_Transferase_(cytos, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47616, SSF47616, 1 hit
SSF52833, SSF52833, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50405, GST_CTER, 1 hit
PS50404, GST_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P08263-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEKPKLHYF NARGRMESTR WLLAAAGVEF EEKFIKSAED LDKLRNDGYL 
        60         70         80         90        100
MFQQVPMVEI DGMKLVQTRA ILNYIASKYN LYGKDIKERA LIDMYIEGIA 
       110        120        130        140        150
DLGEMILLLP VCPPEEKDAK LALIKEKIKN RYFPAFEKVL KSHGQDYLVG 
       160        170        180        190        200
NKLSRADIHL VELLYYVEEL DSSLISSFPL LKALKTRISN LPTVKKFLQP 
       210        220 
GSPRKPPMDE KSLEEARKIF RF
Length:222
Mass (Da):25,631
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8B6786DCD761350
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18S → C in AAA36174 (PubMed:3678589).Curated1
Sequence conflicti51M → T in AAT06769 (Ref. 7) Curated1
Sequence conflicti56 – 58PMV → AML in AAA36174 (PubMed:3678589).Curated3
Sequence conflicti212S → L AA sequence (PubMed:2604726).Curated1
Sequence conflicti216A → S AA sequence (PubMed:8431482).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03397819T → I. Corresponds to variant dbSNP:rs1051578Ensembl.1
Natural variantiVAR_049482113P → Q. Corresponds to variant dbSNP:rs1051745Ensembl.1
Natural variantiVAR_049483117K → Q. Corresponds to variant dbSNP:rs1051757Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M15872 mRNA Translation: AAA70226.1
M21758 mRNA Translation: AAA52615.1
M25627 mRNA Translation: AAA36174.1
M14777 mRNA Translation: AAA52618.1
S76235 S76232 Genomic DNA Translation: AAB20973.1
S49975 mRNA Translation: AAB24012.1
AY532928 mRNA Translation: AAT06769.1
CR407656 mRNA Translation: CAG28584.1
AL590363 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04385.1
BC053578 mRNA Translation: AAH53578.1
BC110891 mRNA Translation: AAI10892.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4945.1

Protein sequence database of the Protein Information Resource

More...PIRi		A25909, A56666
S29657

NCBI Reference Sequences

More...RefSeqi		NP_665683.1, NM_145740.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000334575; ENSP00000335620; ENSG00000243955

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2938

UCSC genome browser

More...UCSCi		uc003paz.4, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15872 mRNA Translation: AAA70226.1
M21758 mRNA Translation: AAA52615.1
M25627 mRNA Translation: AAA36174.1
M14777 mRNA Translation: AAA52618.1
S76235 S76232 Genomic DNA Translation: AAB20973.1
S49975 mRNA Translation: AAB24012.1
AY532928 mRNA Translation: AAT06769.1
CR407656 mRNA Translation: CAG28584.1
AL590363 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04385.1
BC053578 mRNA Translation: AAH53578.1
BC110891 mRNA Translation: AAI10892.1
CCDSiCCDS4945.1
PIRiA25909, A56666
S29657
RefSeqiNP_665683.1, NM_145740.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GSDX-ray2.50A/B/C/D2-222[»]
1GSEX-ray2.00A/B2-222[»]
1GSFX-ray2.70A/B/C/D2-222[»]
1GUHX-ray2.60A/B/C/D2-222[»]
1K3LX-ray1.50A/B2-222[»]
1K3OX-ray1.80A/B2-222[»]
1K3YX-ray1.30A/B2-222[»]
1LBKX-ray1.86A/B208-213[»]
1PKWX-ray2.00A/B1-222[»]
1PKZX-ray2.10A/B1-222[»]
1PL1X-ray1.75A/B1-222[»]
1PL2X-ray1.80A/B1-222[»]
1USBX-ray2.07A/B2-222[»]
1XWGX-ray1.85A/B2-222[»]
1YDKX-ray1.95A/B1-222[»]
2R3XX-ray1.80A/B1-222[»]
2R6KX-ray2.51A/B1-222[»]
3I69X-ray2.38A/B/C/D/E/F/G/H1-222[»]
3I6AX-ray1.98A/B/C/D/E/F/G/H1-222[»]
3IK9X-ray2.20A/B/C/D/E/F/G/H1-222[»]
3KTLX-ray1.75A/B2-222[»]
3L0HX-ray2.13A/B1-222[»]
3Q74X-ray1.79A/B2-222[»]
3U6VX-ray2.20A/B1-222[»]
3ZFBX-ray1.86A/B1-222[»]
3ZFLX-ray1.88A/B1-222[»]
4HJ2X-ray2.10A/B4-220[»]
5JCUX-ray1.93A/B/C/D2-222[»]
5LCZX-ray2.33A/B1-100[»]
A/B201-222[»]
5LD0X-ray1.60A1-85[»]
A214-222[»]
6ATOX-ray1.55A/B2-222[»]
6ATPX-ray1.70A/B2-222[»]
6ATQX-ray2.00A/B2-222[»]
6ATRX-ray1.29A/B2-222[»]
6YAWX-ray2.19A/B1-222[»]
SMRiP08263
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109193, 15 interactors
IntActiP08263, 12 interactors
STRINGi9606.ENSP00000335620

Chemistry databases

BindingDBiP08263
ChEMBLiCHEMBL3409
DrugBankiDB02486, 2-Hydroxyethyl Disulfide
DB00993, Azathioprine
DB01008, Busulfan
DB11672, Curcumin
DB00143, Glutathione
DB03310, Glutathione disulfide
DB03003, Glutathione sulfonic acid
DB13014, Hypericin
DB02943, N-(4-Aminobutanoyl)-S-(4-methoxybenzyl)-L-cysteinylglycine
DB03602, S-benzylglutathione
DB04132, S-Hexylglutathione
DB01915, S-Hydroxycysteine
DrugCentraliP08263
SwissLipidsiSLP:000001476

PTM databases

iPTMnetiP08263
PhosphoSitePlusiP08263

Polymorphism and mutation databases

BioMutaiGSTA1
DMDMi121730

2D gel databases

REPRODUCTION-2DPAGEiIPI00657682

Proteomic databases

jPOSTiP08263
MassIVEiP08263
MaxQBiP08263
PaxDbiP08263
PeptideAtlasiP08263
PRIDEiP08263
ProteomicsDBi12637
52103

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30937, 472 antibodies

The DNASU plasmid repository

More...DNASUi		2938

Genome annotation databases

EnsembliENST00000334575; ENSP00000335620; ENSG00000243955
GeneIDi2938
KEGGihsa:2938
UCSCiuc003paz.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2938
DisGeNETi2938
EuPathDBiHostDB:ENSG00000243955.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		GSTA1
HGNCiHGNC:4626, GSTA1
HPAiENSG00000243955, Group enriched (adrenal gland, intestine, kidney, liver, testis)
MIMi138359, gene
neXtProtiNX_P08263
OpenTargetsiENSG00000243955
PharmGKBiPA29016

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1695, Eukaryota
GeneTreeiENSGT00940000164034
HOGENOMiCLU_039475_4_0_1
InParanoidiP08263
OMAiFIEQPED
PhylomeDBiP08263
TreeFamiTF105321

Enzyme and pathway databases

BioCyciMetaCyc:G66-32542-MONOMER
BRENDAi2.5.1.18, 2681
PathwayCommonsiP08263
ReactomeiR-HSA-156590, Glutathione conjugation
R-HSA-189483, Heme degradation
SABIO-RKiP08263
SIGNORiP08263

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2938, 5 hits in 817 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GSTA1, human
EvolutionaryTraceiP08263

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Glutathione_S-transferase_A1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2938
PharosiP08263, Tchem

Protein Ontology

More...PROi		PR:P08263
RNActiP08263, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000243955, Expressed in nephron tubule and 163 other tissues
ExpressionAtlasiP08263, baseline and differential
GenevisibleiP08263, HS

Family and domain databases

DisProtiDP01506
Gene3Di3.40.30.10, 1 hit
InterProiView protein in InterPro
IPR010987, Glutathione-S-Trfase_C-like
IPR036282, Glutathione-S-Trfase_C_sf
IPR040079, Glutathione_S-Trfase
IPR004045, Glutathione_S-Trfase_N
IPR003080, GST_alpha
IPR004046, GST_C
IPR036249, Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043, GST_C, 1 hit
PF02798, GST_N, 1 hit
PRINTSiPR01266, GSTRNSFRASEA
SFLDiSFLDS00019, Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616, SSF47616, 1 hit
SSF52833, SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405, GST_CTER, 1 hit
PS50404, GST_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGSTA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08263
Secondary accession number(s): Q14750, Q5GHF8, Q5SZC1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: December 2, 2020
This is version 215 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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