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UniProtKB - P08254 (MMP3_HUMAN)
Protein
Stromelysin-1
Gene
MMP3
Organism
Homo sapiens (Human)
Status
Functioni
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.
Catalytic activityi
- Preferential cleavage where P1', P2' and P3' are hydrophobic residues. EC:3.4.24.17
Cofactori
Protein has several cofactor binding sites:Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 92 | Zinc 2; in inhibited form | 1 | |
Metal bindingi | 124 | Calcium 1 | 1 | |
Metal bindingi | 158 | Calcium 2 | 1 | |
Metal bindingi | 168 | Zinc 1 | 1 | |
Metal bindingi | 170 | Zinc 1 | 1 | |
Metal bindingi | 175 | Calcium 3 | 1 | |
Metal bindingi | 176 | Calcium 3; via carbonyl oxygen | 1 | |
Metal bindingi | 178 | Calcium 3; via carbonyl oxygen | 1 | |
Metal bindingi | 180 | Calcium 3; via carbonyl oxygen | 1 | |
Metal bindingi | 183 | Zinc 1 | 1 | |
Metal bindingi | 190 | Calcium 2; via carbonyl oxygen | 1 | |
Metal bindingi | 192 | Calcium 2; via carbonyl oxygen | 1 | |
Metal bindingi | 194 | Calcium 2 | 1 | |
Metal bindingi | 196 | Zinc 1 | 1 | |
Metal bindingi | 198 | Calcium 3 | 1 | |
Metal bindingi | 199 | Calcium 1 | 1 | |
Metal bindingi | 201 | Calcium 1 | 1 | |
Metal bindingi | 201 | Calcium 3 | 1 | |
Metal bindingi | 218 | Zinc 2; catalytic1 Publication | 1 | |
Active sitei | 219 | 1 | ||
Metal bindingi | 222 | Zinc 2; catalytic1 Publication | 1 | |
Metal bindingi | 228 | Zinc 2; catalytic1 Publication | 1 | |
Metal bindingi | 297 | Calcium 4; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 389 | Calcium 4; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 438 | Calcium 4; via carbonyl oxygenBy similarity | 1 |
GO - Molecular functioni
- endopeptidase activity Source: ParkinsonsUK-UCL
- metalloendopeptidase activity Source: GO_Central
- metallopeptidase activity Source: UniProtKB
- peptidase activity Source: UniProtKB
- serine-type endopeptidase activity Source: Reactome
- zinc ion binding Source: InterPro
GO - Biological processi
- cellular response to nitric oxide Source: ParkinsonsUK-UCL
- cellular response to UV-A Source: UniProtKB
- collagen catabolic process Source: GO_Central
- extracellular matrix disassembly Source: Reactome
- extracellular matrix organization Source: GO_Central
- negative regulation of hydrogen peroxide metabolic process Source: ParkinsonsUK-UCL
- positive regulation of oxidative stress-induced cell death Source: ParkinsonsUK-UCL
- positive regulation of protein-containing complex assembly Source: ParkinsonsUK-UCL
- proteolysis Source: UniProtKB
- regulation of neuroinflammatory response Source: ARUK-UCL
- response to amyloid-beta Source: ARUK-UCL
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Biological process | Collagen degradation |
Ligand | Calcium, Metal-binding, Zinc |
Enzyme and pathway databases
BRENDAi | 3.4.24.17, 2681 |
PathwayCommonsi | P08254 |
Reactomei | R-HSA-1442490, Collagen degradation R-HSA-1474228, Degradation of the extracellular matrix R-HSA-1592389, Activation of Matrix Metalloproteinases R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures R-HSA-2179392, EGFR Transactivation by Gastrin R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9009391, Extra-nuclear estrogen signaling |
SignaLinki | P08254 |
SIGNORi | P08254 |
Protein family/group databases
MEROPSi | M10.005 |
Names & Taxonomyi
Protein namesi | Recommended name: Stromelysin-1 (EC:3.4.24.17)Short name: SL-1 Alternative name(s): Matrix metalloproteinase-3 Short name: MMP-3 Transin-1 |
Gene namesi | Name:MMP3 Synonyms:STMY1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7173, MMP3 |
MIMi | 185250, gene |
neXtProti | NX_P08254 |
VEuPathDBi | HostDB:ENSG00000149968 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix Curated
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: ProtInc
Other locations
- extracellular matrix Source: InterPro
Keywords - Cellular componenti
Extracellular matrix, SecretedPathology & Biotechi
Involvement in diseasei
Coronary heart disease 6 (CHDS6)2 Publications
Disease susceptibility is associated with variants affecting the gene represented in this entry. A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.
Disease descriptionA multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries.
Related information in OMIMOrganism-specific databases
DisGeNETi | 4314 |
MalaCardsi | MMP3 |
MIMi | 614466, phenotype |
OpenTargetsi | ENSG00000149968 |
PharmGKBi | PA30886 |
Miscellaneous databases
Pharosi | P08254, Tchem |
Chemistry databases
ChEMBLi | CHEMBL283 |
DrugBanki | DB02367, (1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-Pyrrolidine DB04140, 1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6-Oxo-Hexahydro-Pyrimidine-4-Carboxylic Acid Hydroxyamide DB08643, 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER DB07390, 2-[3-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-ureido]-N-methyl-3-phenyl-propionamide DB07988, 2-[3-(5-Mercapto-[1,3,4]thiadiazol-2yl)-ureido]-N-methyl-3-pentafluorophenyl-propionamide DB02449, 3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperidin-1-Yl)-Benzenesulfonylamino]-Propionic Acid DB08030, 3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide DB01996, 3-Methylpyridine DB03033, 4-methoxybenzenesulfinate DB03368, 5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione DB07987, [2-(5-Mercapto-[1,3,4]thiadiazol-2-ylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester DB07986, [4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-ACETIC ACID DB02090, A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor DB02697, Hydroxyaminovaline DB00786, Marimastat DB08507, N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID DB01877, N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4-(Z,E-N-Methoxyimino)Pyrrolidine-2r-Carboxamide DB04232, N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4-Benzyloxycarbonyl-Piperazine-2-Carboxamide DB02350, N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide DB08271, N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID DB08029, N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide DB04416, R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid |
DrugCentrali | P08254 |
GuidetoPHARMACOLOGYi | 1630 |
Genetic variation databases
BioMutai | MMP3 |
DMDMi | 116857 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | 1 PublicationAdd BLAST | 17 | |
PropeptideiPRO_0000028728 | 18 – 99 | Activation peptideAdd BLAST | 82 | |
ChainiPRO_0000028729 | 100 – 477 | Stromelysin-1Add BLAST | 378 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 290 ↔ 477 | By similarity |
Keywords - PTMi
Disulfide bond, ZymogenProteomic databases
EPDi | P08254 |
jPOSTi | P08254 |
MassIVEi | P08254 |
PaxDbi | P08254 |
PeptideAtlasi | P08254 |
PRIDEi | P08254 |
ProteomicsDBi | 52102 |
PTM databases
GlyGeni | P08254, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | P08254 |
PhosphoSitePlusi | P08254 |
Expressioni
Gene expression databases
Bgeei | ENSG00000149968, Expressed in calcaneal tendon and 127 other tissues |
ExpressionAtlasi | P08254, baseline and differential |
Genevisiblei | P08254, HS |
Organism-specific databases
HPAi | ENSG00000149968, Tissue enriched (salivary) |
Interactioni
Binary interactionsi
P08254
With | #Exp. | IntAct |
---|---|---|
MEOX2 [P50222] | 3 | EBI-6957351,EBI-748397 |
Protein-protein interaction databases
BioGRIDi | 110458, 19 interactors |
IntActi | P08254, 8 interactors |
MINTi | P08254 |
STRINGi | 9606.ENSP00000299855 |
Chemistry databases
BindingDBi | P08254 |
Miscellaneous databases
RNActi | P08254, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P08254 |
BMRBi | P08254 |
SMRi | P08254 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08254 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 287 – 336 | Hemopexin 1Add BLAST | 50 | |
Repeati | 337 – 383 | Hemopexin 2Add BLAST | 47 | |
Repeati | 385 – 433 | Hemopexin 3Add BLAST | 49 | |
Repeati | 434 – 477 | Hemopexin 4Add BLAST | 44 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 262 – 287 | DisorderedSequence analysisAdd BLAST | 26 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 90 – 97 | Cysteine switchBy similarity | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 266 – 287 | Pro residuesSequence analysisAdd BLAST | 22 |
Domaini
The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Sequence similaritiesi
Belongs to the peptidase M10A family.Curated
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG1565, Eukaryota |
GeneTreei | ENSGT00940000159759 |
HOGENOMi | CLU_015489_6_0_1 |
InParanoidi | P08254 |
OMAi | NFVQQYL |
OrthoDBi | 1075463at2759 |
PhylomeDBi | P08254 |
TreeFami | TF315428 |
Family and domain databases
CDDi | cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 2.110.10.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR021158, Pept_M10A_Zn_BS IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf |
Pfami | View protein in Pfam PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit |
PROSITEi | View protein in PROSITE PS00546, CYSTEINE_SWITCH, 1 hit PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits PS00142, ZINC_PROTEASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P08254-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKSLPILLLL CVAVCSAYPL DGAARGEDTS MNLVQKYLEN YYDLKKDVKQ
60 70 80 90 100
FVRRKDSGPV VKKIREMQKF LGLEVTGKLD SDTLEVMRKP RCGVPDVGHF
110 120 130 140 150
RTFPGIPKWR KTHLTYRIVN YTPDLPKDAV DSAVEKALKV WEEVTPLTFS
160 170 180 190 200
RLYEGEADIM ISFAVREHGD FYPFDGPGNV LAHAYAPGPG INGDAHFDDD
210 220 230 240 250
EQWTKDTTGT NLFLVAAHEI GHSLGLFHSA NTEALMYPLY HSLTDLTRFR
260 270 280 290 300
LSQDDINGIQ SLYGPPPDSP ETPLVPTEPV PPEPGTPANC DPALSFDAVS
310 320 330 340 350
TLRGEILIFK DRHFWRKSLR KLEPELHLIS SFWPSLPSGV DAAYEVTSKD
360 370 380 390 400
LVFIFKGNQF WAIRGNEVRA GYPRGIHTLG FPPTVRKIDA AISDKEKNKT
410 420 430 440 450
YFFVEDKYWR FDEKRNSMEP GFPKQIAEDF PGIDSKIDAV FEEFGFFYFF
460 470
TGSSQLEFDP NAKKVTHTLK SNSWLNC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PKX2 | E9PKX2_HUMAN | Stromelysin-1 | MMP3 | 42 | Annotation score: | ||
H7C139 | H7C139_HUMAN | Stromelysin-1 | MMP3 | 99 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 420 | P → L (PubMed:3477804).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013090 | 45 | K → E3 PublicationsCorresponds to variant dbSNP:rs679620EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X05232 mRNA Translation: CAA28859.1 J03209 mRNA Translation: AAA36321.1 U78045 Genomic DNA Translation: AAB36942.1 AK223283 mRNA Translation: BAD97003.1 AK223291 mRNA Translation: BAD97011.1 AK313310 mRNA Translation: BAG36115.1 AF405705 Genomic DNA Translation: AAK95247.1 CH471065 Genomic DNA Translation: EAW67032.1 BC069676 mRNA Translation: AAH69676.1 BC069716 mRNA Translation: AAH69716.1 BC074815 mRNA Translation: AAH74815.1 BC074869 mRNA Translation: AAH74869.1 BC105954 mRNA Translation: AAI05955.1 BC107490 mRNA Translation: AAI07491.1 BC107491 mRNA Translation: AAI07492.1 |
CCDSi | CCDS8323.1 |
PIRi | A28156, KCHUS1 |
RefSeqi | NP_002413.1, NM_002422.4 |
Genome annotation databases
Ensembli | ENST00000299855.10; ENSP00000299855.5; ENSG00000149968.12 |
GeneIDi | 4314 |
KEGGi | hsa:4314 |
MANE-Selecti | ENST00000299855.10; ENSP00000299855.5; NM_002422.5; NP_002413.1 |
UCSCi | uc001phj.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X05232 mRNA Translation: CAA28859.1 J03209 mRNA Translation: AAA36321.1 U78045 Genomic DNA Translation: AAB36942.1 AK223283 mRNA Translation: BAD97003.1 AK223291 mRNA Translation: BAD97011.1 AK313310 mRNA Translation: BAG36115.1 AF405705 Genomic DNA Translation: AAK95247.1 CH471065 Genomic DNA Translation: EAW67032.1 BC069676 mRNA Translation: AAH69676.1 BC069716 mRNA Translation: AAH69716.1 BC074815 mRNA Translation: AAH74815.1 BC074869 mRNA Translation: AAH74869.1 BC105954 mRNA Translation: AAI05955.1 BC107490 mRNA Translation: AAI07491.1 BC107491 mRNA Translation: AAI07492.1 |
CCDSi | CCDS8323.1 |
PIRi | A28156, KCHUS1 |
RefSeqi | NP_002413.1, NM_002422.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1B3D | X-ray | 2.30 | A/B | 100-272 | [»] | |
1B8Y | X-ray | 2.00 | A | 100-266 | [»] | |
1BIW | X-ray | 2.50 | A/B | 100-272 | [»] | |
1BM6 | NMR | - | A | 100-272 | [»] | |
1BQO | X-ray | 2.30 | A/B | 100-272 | [»] | |
1C3I | X-ray | 1.83 | A/B | 100-272 | [»] | |
1C8T | X-ray | 2.60 | A/B | 103-268 | [»] | |
1CAQ | X-ray | 1.80 | A | 100-267 | [»] | |
1CIZ | X-ray | 1.64 | A | 100-267 | [»] | |
1CQR | X-ray | 2.00 | A/B | 100-272 | [»] | |
1D5J | X-ray | 2.60 | A/B | 100-272 | [»] | |
1D7X | X-ray | 2.00 | A/B | 100-272 | [»] | |
1D8F | X-ray | 2.40 | A/B | 100-272 | [»] | |
1D8M | X-ray | 2.44 | A/B | 100-272 | [»] | |
1G05 | X-ray | 2.45 | A/B | 100-272 | [»] | |
1G49 | X-ray | 1.90 | A/B | 100-272 | [»] | |
1G4K | X-ray | 2.00 | A/B/C | 100-267 | [»] | |
1HFS | X-ray | 1.70 | A | 105-264 | [»] | |
1HY7 | X-ray | 1.50 | A/B | 100-272 | [»] | |
1OO9 | NMR | - | A | 100-267 | [»] | |
1QIA | X-ray | 2.00 | A/B/C/D | 106-267 | [»] | |
1QIC | X-ray | 2.00 | A/B/C/D | 106-266 | [»] | |
1SLM | X-ray | 1.90 | A | 18-272 | [»] | |
1SLN | X-ray | 2.27 | A | 100-272 | [»] | |
1UEA | X-ray | 2.80 | A/C | 100-272 | [»] | |
1UMS | NMR | - | A | 100-273 | [»] | |
1UMT | NMR | - | A | 100-273 | [»] | |
1USN | X-ray | 1.80 | A | 100-264 | [»] | |
2D1O | X-ray | 2.02 | A/B | 100-270 | [»] | |
2JNP | NMR | - | A | 105-265 | [»] | |
2JT5 | NMR | - | A | 105-265 | [»] | |
2JT6 | NMR | - | A | 105-265 | [»] | |
2SRT | NMR | - | A | 100-272 | [»] | |
2USN | X-ray | 2.20 | A | 100-264 | [»] | |
3OHL | X-ray | 2.36 | A | 100-266 | [»] | |
3OHO | X-ray | 2.50 | A | 100-268 | [»] | |
3USN | NMR | - | A | 100-267 | [»] | |
4DPE | X-ray | 1.96 | A/B | 100-272 | [»] | |
4G9L | X-ray | 1.88 | A/B | 100-272 | [»] | |
4JA1 | X-ray | 1.96 | A/B | 100-272 | [»] | |
6MAV | X-ray | 2.37 | A | 100-267 | [»] | |
6N9D | X-ray | 2.67 | A | 100-264 | [»] | |
AlphaFoldDBi | P08254 | |||||
BMRBi | P08254 | |||||
SMRi | P08254 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110458, 19 interactors |
IntActi | P08254, 8 interactors |
MINTi | P08254 |
STRINGi | 9606.ENSP00000299855 |
Chemistry databases
BindingDBi | P08254 |
ChEMBLi | CHEMBL283 |
DrugBanki | DB02367, (1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-Pyrrolidine DB04140, 1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6-Oxo-Hexahydro-Pyrimidine-4-Carboxylic Acid Hydroxyamide DB08643, 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER DB07390, 2-[3-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-ureido]-N-methyl-3-phenyl-propionamide DB07988, 2-[3-(5-Mercapto-[1,3,4]thiadiazol-2yl)-ureido]-N-methyl-3-pentafluorophenyl-propionamide DB02449, 3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperidin-1-Yl)-Benzenesulfonylamino]-Propionic Acid DB08030, 3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide DB01996, 3-Methylpyridine DB03033, 4-methoxybenzenesulfinate DB03368, 5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione DB07987, [2-(5-Mercapto-[1,3,4]thiadiazol-2-ylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester DB07986, [4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-ACETIC ACID DB02090, A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor DB02697, Hydroxyaminovaline DB00786, Marimastat DB08507, N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID DB01877, N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4-(Z,E-N-Methoxyimino)Pyrrolidine-2r-Carboxamide DB04232, N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4-Benzyloxycarbonyl-Piperazine-2-Carboxamide DB02350, N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide DB08271, N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID DB08029, N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide DB04416, R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid |
DrugCentrali | P08254 |
GuidetoPHARMACOLOGYi | 1630 |
Protein family/group databases
MEROPSi | M10.005 |
PTM databases
GlyGeni | P08254, 2 sites, 1 O-linked glycan (2 sites) |
iPTMneti | P08254 |
PhosphoSitePlusi | P08254 |
Genetic variation databases
BioMutai | MMP3 |
DMDMi | 116857 |
Proteomic databases
EPDi | P08254 |
jPOSTi | P08254 |
MassIVEi | P08254 |
PaxDbi | P08254 |
PeptideAtlasi | P08254 |
PRIDEi | P08254 |
ProteomicsDBi | 52102 |
Protocols and materials databases
ABCDi | P08254, 1 sequenced antibody |
Antibodypediai | 1509, 1359 antibodies from 50 providers |
DNASUi | 4314 |
Genome annotation databases
Ensembli | ENST00000299855.10; ENSP00000299855.5; ENSG00000149968.12 |
GeneIDi | 4314 |
KEGGi | hsa:4314 |
MANE-Selecti | ENST00000299855.10; ENSP00000299855.5; NM_002422.5; NP_002413.1 |
UCSCi | uc001phj.2, human |
Organism-specific databases
CTDi | 4314 |
DisGeNETi | 4314 |
GeneCardsi | MMP3 |
HGNCi | HGNC:7173, MMP3 |
HPAi | ENSG00000149968, Tissue enriched (salivary) |
MalaCardsi | MMP3 |
MIMi | 185250, gene 614466, phenotype |
neXtProti | NX_P08254 |
OpenTargetsi | ENSG00000149968 |
PharmGKBi | PA30886 |
VEuPathDBi | HostDB:ENSG00000149968 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1565, Eukaryota |
GeneTreei | ENSGT00940000159759 |
HOGENOMi | CLU_015489_6_0_1 |
InParanoidi | P08254 |
OMAi | NFVQQYL |
OrthoDBi | 1075463at2759 |
PhylomeDBi | P08254 |
TreeFami | TF315428 |
Enzyme and pathway databases
BRENDAi | 3.4.24.17, 2681 |
PathwayCommonsi | P08254 |
Reactomei | R-HSA-1442490, Collagen degradation R-HSA-1474228, Degradation of the extracellular matrix R-HSA-1592389, Activation of Matrix Metalloproteinases R-HSA-2022090, Assembly of collagen fibrils and other multimeric structures R-HSA-2179392, EGFR Transactivation by Gastrin R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9009391, Extra-nuclear estrogen signaling |
SignaLinki | P08254 |
SIGNORi | P08254 |
Miscellaneous databases
BioGRID-ORCSi | 4314, 11 hits in 1076 CRISPR screens |
ChiTaRSi | MMP3, human |
EvolutionaryTracei | P08254 |
GeneWikii | MMP3 |
GenomeRNAii | 4314 |
Pharosi | P08254, Tchem |
PROi | PR:P08254 |
RNActi | P08254, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000149968, Expressed in calcaneal tendon and 127 other tissues |
ExpressionAtlasi | P08254, baseline and differential |
Genevisiblei | P08254, HS |
Family and domain databases
CDDi | cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 2.110.10.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR021158, Pept_M10A_Zn_BS IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf |
Pfami | View protein in Pfam PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit |
PROSITEi | View protein in PROSITE PS00546, CYSTEINE_SWITCH, 1 hit PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits PS00142, ZINC_PROTEASE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MMP3_HUMAN | |
Accessioni | P08254Primary (citable) accession number: P08254 Secondary accession number(s): B2R8B8, Q3B7S0, Q6GRF8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | February 1, 1991 | |
Last modified: | May 25, 2022 | |
This is version 228 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families