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UniProtKB - P08253 (MMP2_HUMAN)

Protein

72 kDa type IV collagenase

Gene

MMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.
PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.
Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Catalytic activityi

Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.

Cofactori

Protein has several cofactor binding sites:
  • Ca2+Note: Binds 4 Ca2+ ions per subunit.
  • Zn2+Note: Binds 2 Zn2+ ions per subunit.

Activity regulationi

Inhibited by histatin-3 1/24 (histatin-5).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi102Zinc 2; in inhibited formBy similarity1
Metal bindingi134Calcium 1By similarity1
Metal bindingi168Calcium 2By similarity1
Metal bindingi178Zinc 1By similarity1
Metal bindingi180Zinc 1By similarity1
Metal bindingi185Calcium 3By similarity1
Metal bindingi186Calcium 3; via carbonyl oxygenBy similarity1
Metal bindingi193Zinc 1By similarity1
Metal bindingi200Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi202Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi204Calcium 2By similarity1
Metal bindingi206Zinc 1By similarity1
Metal bindingi208Calcium 3By similarity1
Metal bindingi209Calcium 1By similarity1
Metal bindingi211Calcium 3By similarity1
Metal bindingi403Zinc 2; catalyticBy similarity1
Active sitei404PROSITE-ProRule annotation1
Metal bindingi407Zinc 2; catalyticBy similarity1
Metal bindingi413Zinc 2; catalyticBy similarity1
Metal bindingi476Calcium 4; via carbonyl oxygen1
Metal bindingi521Calcium 4; via carbonyl oxygen1
Metal bindingi569Calcium 4; via carbonyl oxygen1
Metal bindingi618Calcium 4; via carbonyl oxygen1

GO - Molecular functioni

  • metalloendopeptidase activity Source: Reactome
  • metallopeptidase activity Source: UniProtKB
  • serine-type endopeptidase activity Source: Reactome
  • zinc ion binding Source: ProtInc
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
Biological processAngiogenesis, Collagen degradation
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS01565-MONOMER
BRENDAi3.4.24.24 2681
ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SIGNORiP08253

Protein family/group databases

MEROPSiM10.003

Names & Taxonomyi

Protein namesi
Recommended name:
72 kDa type IV collagenase (EC:3.4.24.24)
Alternative name(s):
72 kDa gelatinase
Gelatinase A
Matrix metalloproteinase-2
Short name:
MMP-2
TBE-1
Cleaved into the following chain:
PEX
Gene namesi
Name:MMP2
Synonyms:CLG4A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000087245.12
HGNCiHGNC:7166 MMP2
MIMi120360 gene
neXtProtiNX_P08253

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Extracellular matrix, Membrane, Mitochondrion, Nucleus, Secreted

Pathology & Biotechi

Involvement in diseasei

Multicentric osteolysis, nodulosis, and arthropathy (MONA)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive syndrome characterized by severe multicentric osteolysis with predominant involvement of the hands and feet. Additional features include coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy.
See also OMIM:259600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032423101R → H in MONA. 1 PublicationCorresponds to variant dbSNP:rs121912953EnsemblClinVar.1
Natural variantiVAR_054996400Missing in MONA. 1 Publication1
Natural variantiVAR_032425404E → K in MONA. 1 PublicationCorresponds to variant dbSNP:rs121912955EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi4313
MalaCardsiMMP2
MIMi259600 phenotype
OpenTargetsiENSG00000087245
Orphaneti85196 Nodulosis-arthropathy-osteolysis syndrome
3460 Torg-Winchester syndrome
PharmGKBiPA30877

Chemistry databases

ChEMBLiCHEMBL333
DrugBankiDB05387 AE-941
DB01197 Captopril
DB04866 Halofuginone
DB00786 Marimastat
DB01630 SC-74020
GuidetoPHARMACOLOGYi1629

Polymorphism and mutation databases

BioMutaiMMP2
DMDMi116856

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
PropeptideiPRO_000002871430 – 109Activation peptideAdd BLAST80
ChainiPRO_0000028715110 – 66072 kDa type IV collagenaseAdd BLAST551
ChainiPRO_0000391626445 – 660PEXAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi233 ↔ 259PROSITE-ProRule annotation
Disulfide bondi247 ↔ 274PROSITE-ProRule annotation
Disulfide bondi291 ↔ 317PROSITE-ProRule annotation
Disulfide bondi305 ↔ 332PROSITE-ProRule annotation
Disulfide bondi349 ↔ 375PROSITE-ProRule annotation
Disulfide bondi363 ↔ 390PROSITE-ProRule annotation
Disulfide bondi469 ↔ 660PROSITE-ProRule annotation1 Publication
Glycosylationi573N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi642N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro.1 Publication
The propeptide is processed by MMP14 (MT-MMP1) and MMP16 (MT-MMP3). Autocatalytic cleavage in the C-terminal produces the anti-angiogenic peptide, PEX. This processing appears to be facilitated by binding integrinv/beta3.2 Publications

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Phosphoprotein, Zymogen

Proteomic databases

EPDiP08253
MaxQBiP08253
PaxDbiP08253
PeptideAtlasiP08253
PRIDEiP08253
ProteomicsDBi52101

PTM databases

CarbonylDBiP08253
iPTMnetiP08253
PhosphoSitePlusiP08253

Miscellaneous databases

PMAP-CutDBiP08253

Expressioni

Tissue specificityi

Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.1 Publication

Inductioni

Aspirin appears to inhibit expression.1 Publication

Gene expression databases

BgeeiENSG00000087245 Expressed in 208 organ(s), highest expression level in mucosa of stomach
CleanExiHS_MMP2
ExpressionAtlasiP08253 baseline and differential
GenevisibleiP08253 HS

Organism-specific databases

HPAiCAB002788
HPA001939

Interactioni

Subunit structurei

Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.8 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi110457, 38 interactors
CORUMiP08253
IntActiP08253, 21 interactors
MINTiP08253
STRINGi9606.ENSP00000219070

Chemistry databases

BindingDBiP08253

Structurei

Secondary structure

1660
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08253
SMRiP08253
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08253

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini228 – 276Fibronectin type-II 1PROSITE-ProRule annotationAdd BLAST49
Domaini286 – 334Fibronectin type-II 2PROSITE-ProRule annotationAdd BLAST49
Domaini344 – 392Fibronectin type-II 3PROSITE-ProRule annotationAdd BLAST49
Repeati472 – 516Hemopexin 1Add BLAST45
Repeati517 – 563Hemopexin 2Add BLAST47
Repeati565 – 613Hemopexin 3Add BLAST49
Repeati614 – 660Hemopexin 4Add BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 221Collagenase-like 1Add BLAST112
Regioni222 – 396Collagen-bindingAdd BLAST175
Regioni397 – 465Collagenase-like 2Add BLAST69
Regioni414 – 660Required for inhibitor TIMP2 bindingAdd BLAST247

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi100 – 107Cysteine switchBy similarity8

Domaini

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Sequence similaritiesi

Belongs to the peptidase M10A family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00910000144034
HOGENOMiHOG000217926
HOVERGENiHBG052484
InParanoidiP08253
KOiK01398
OMAiHESCTSA
OrthoDBiEOG091G03DP
PhylomeDBiP08253
TreeFamiTF315428

Family and domain databases

CDDicd00062 FN2, 3 hits
cd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di1.10.101.10, 1 hit
2.10.10.10, 3 hits
2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR028708 72kDa_collagenase
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR013806 Kringle-like
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
IPR036366 PGBDSf
PANTHERiPTHR10201:SF29 PTHR10201:SF29, 4 hits
PfamiView protein in Pfam
PF00040 fn2, 3 hits
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00059 FN2, 3 hits
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
SSF57440 SSF57440, 3 hits
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00023 FN2_1, 3 hits
PS51092 FN2_2, 3 hits
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits
PS00142 ZINC_PROTEASE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P08253-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEALMARGAL TGPLRALCLL GCLLSHAAAA PSPIIKFPGD VAPKTDKELA 
        60         70         80         90        100
VQYLNTFYGC PKESCNLFVL KDTLKKMQKF FGLPQTGDLD QNTIETMRKP 
       110        120        130        140        150
RCGNPDVANY NFFPRKPKWD KNQITYRIIG YTPDLDPETV DDAFARAFQV 
       160        170        180        190        200
WSDVTPLRFS RIHDGEADIM INFGRWEHGD GYPFDGKDGL LAHAFAPGTG 
       210        220        230        240        250
VGGDSHFDDD ELWTLGEGQV VRVKYGNADG EYCKFPFLFN GKEYNSCTDT 
       260        270        280        290        300
GRSDGFLWCS TTYNFEKDGK YGFCPHEALF TMGGNAEGQP CKFPFRFQGT 
       310        320        330        340        350
SYDSCTTEGR TDGYRWCGTT EDYDRDKKYG FCPETAMSTV GGNSEGAPCV 
       360        370        380        390        400
FPFTFLGNKY ESCTSAGRSD GKMWCATTAN YDDDRKWGFC PDQGYSLFLV 
       410        420        430        440        450
AAHEFGHAMG LEHSQDPGAL MAPIYTYTKN FRLSQDDIKG IQELYGASPD 
       460        470        480        490        500
IDLGTGPTPT LGPVTPEICK QDIVFDGIAQ IRGEIFFFKD RFIWRTVTPR 
       510        520        530        540        550
DKPMGPLLVA TFWPELPEKI DAVYEAPQEE KAVFFAGNEY WIYSASTLER 
       560        570        580        590        600
GYPKPLTSLG LPPDVQRVDA AFNWSKNKKT YIFAGDKFWR YNEVKKKMDP 
       610        620        630        640        650
GFPKLIADAW NAIPDNLDAV VDLQGGGHSY FFKGAYYLKL ENQSLKSVKF 
       660
GSIKSDWLGC
Length:660
Mass (Da):73,882
Last modified:February 1, 1991 - v2
Checksum:iBC7147DC8B49F289
GO
Isoform 2 (identifier: P08253-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: Induced by oxidative stress.
Show »
Length:584
Mass (Da):65,765
Checksum:iEC1C16C91ECBC26C
GO
Isoform 3 (identifier: P08253-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAV → M

Note: No experimental confirmation available.
Show »
Length:610
Mass (Da):68,831
Checksum:iFB214CA4334DC5FC
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BR66H3BR66_HUMAN
72 kDa type IV collagenase
MMP2
201Annotation score:
H3BV48H3BV48_HUMAN
72 kDa type IV collagenase
MMP2
118Annotation score:
H3BS34H3BS34_HUMAN
72 kDa type IV collagenase
MMP2
251Annotation score:
J3KRB7J3KRB7_HUMAN
72 kDa type IV collagenase
MMP2
22Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235F → S in AK310314 (PubMed:14702039).Curated1
Sequence conflicti546S → G in BAG35588 (PubMed:14702039).Curated1
Sequence conflicti618D → G in BAG35588 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032423101R → H in MONA. 1 PublicationCorresponds to variant dbSNP:rs121912953EnsemblClinVar.1
Natural variantiVAR_032424210D → Y1 Publication1
Natural variantiVAR_036136228A → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs759302357Ensembl.1
Natural variantiVAR_054996400Missing in MONA. 1 Publication1
Natural variantiVAR_032425404E → K in MONA. 1 PublicationCorresponds to variant dbSNP:rs121912955EnsemblClinVar.1
Natural variantiVAR_020616447A → V1 PublicationCorresponds to variant dbSNP:rs17859943EnsemblClinVar.1
Natural variantiVAR_036137498T → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs764961297Ensembl.1
Natural variantiVAR_020617621V → L1 PublicationCorresponds to variant dbSNP:rs16955280Ensembl.1
Natural variantiVAR_036138644S → I in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0446311 – 76Missing in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_0457041 – 51MEALM…KELAV → M in isoform 3. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55593
, M58552, M55582, M55583, M55584, M55585, M55586, M55587, M55588, M55589, M55590, M55591, M55592 Genomic DNA Translation: AAA52028.1
AK301536 mRNA Translation: BAG63035.1
AK310314 mRNA No translation available.
AK312711 mRNA Translation: BAG35588.1
AY738117 Genomic DNA Translation: AAU10089.1
AC007336 Genomic DNA No translation available.
AC092722 Genomic DNA No translation available.
BC002576 mRNA Translation: AAH02576.1
M33789 Genomic DNA Translation: AAA52027.1
J03210 mRNA Translation: AAA35701.1
CCDSiCCDS10752.1 [P08253-1]
CCDS45487.1 [P08253-3]
CCDS76869.1 [P08253-2]
PIRiA28153
RefSeqiNP_001121363.1, NM_001127891.2 [P08253-3]
NP_001289437.1, NM_001302508.1 [P08253-2]
NP_001289438.1, NM_001302509.1 [P08253-2]
NP_001289439.1, NM_001302510.1 [P08253-2]
NP_004521.1, NM_004530.5 [P08253-1]
UniGeneiHs.513617

Genome annotation databases

EnsembliENST00000219070; ENSP00000219070; ENSG00000087245 [P08253-1]
ENST00000437642; ENSP00000394237; ENSG00000087245 [P08253-3]
ENST00000543485; ENSP00000444143; ENSG00000087245 [P08253-2]
ENST00000570308; ENSP00000461421; ENSG00000087245 [P08253-2]
GeneIDi4313
KEGGihsa:4313
UCSCiuc002ehz.5 human [P08253-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55593
, M58552, M55582, M55583, M55584, M55585, M55586, M55587, M55588, M55589, M55590, M55591, M55592 Genomic DNA Translation: AAA52028.1
AK301536 mRNA Translation: BAG63035.1
AK310314 mRNA No translation available.
AK312711 mRNA Translation: BAG35588.1
AY738117 Genomic DNA Translation: AAU10089.1
AC007336 Genomic DNA No translation available.
AC092722 Genomic DNA No translation available.
BC002576 mRNA Translation: AAH02576.1
M33789 Genomic DNA Translation: AAA52027.1
J03210 mRNA Translation: AAA35701.1
CCDSiCCDS10752.1 [P08253-1]
CCDS45487.1 [P08253-3]
CCDS76869.1 [P08253-2]
PIRiA28153
RefSeqiNP_001121363.1, NM_001127891.2 [P08253-3]
NP_001289437.1, NM_001302508.1 [P08253-2]
NP_001289438.1, NM_001302509.1 [P08253-2]
NP_001289439.1, NM_001302510.1 [P08253-2]
NP_004521.1, NM_004530.5 [P08253-1]
UniGeneiHs.513617

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CK7X-ray2.80A30-660[»]
1CXWNMR-A278-336[»]
1EAKX-ray2.66A/B/C/D32-452[»]
1GENX-ray2.15A443-660[»]
1GXDX-ray3.10A/B30-660[»]
1HOVNMR-A110-214[»]
1J7MNMR-A337-394[»]
1KS0NMR-A223-282[»]
1QIBX-ray2.80A115-213[»]
A394-449[»]
1RTGX-ray2.60A451-660[»]
3AYUX-ray2.00A110-450[»]
ProteinModelPortaliP08253
SMRiP08253
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110457, 38 interactors
CORUMiP08253
IntActiP08253, 21 interactors
MINTiP08253
STRINGi9606.ENSP00000219070

Chemistry databases

BindingDBiP08253
ChEMBLiCHEMBL333
DrugBankiDB05387 AE-941
DB01197 Captopril
DB04866 Halofuginone
DB00786 Marimastat
DB01630 SC-74020
GuidetoPHARMACOLOGYi1629

Protein family/group databases

MEROPSiM10.003

PTM databases

CarbonylDBiP08253
iPTMnetiP08253
PhosphoSitePlusiP08253

Polymorphism and mutation databases

BioMutaiMMP2
DMDMi116856

Proteomic databases

EPDiP08253
MaxQBiP08253
PaxDbiP08253
PeptideAtlasiP08253
PRIDEiP08253
ProteomicsDBi52101

Protocols and materials databases

DNASUi4313
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219070; ENSP00000219070; ENSG00000087245 [P08253-1]
ENST00000437642; ENSP00000394237; ENSG00000087245 [P08253-3]
ENST00000543485; ENSP00000444143; ENSG00000087245 [P08253-2]
ENST00000570308; ENSP00000461421; ENSG00000087245 [P08253-2]
GeneIDi4313
KEGGihsa:4313
UCSCiuc002ehz.5 human [P08253-1]

Organism-specific databases

CTDi4313
DisGeNETi4313
EuPathDBiHostDB:ENSG00000087245.12
GeneCardsiMMP2
HGNCiHGNC:7166 MMP2
HPAiCAB002788
HPA001939
MalaCardsiMMP2
MIMi120360 gene
259600 phenotype
neXtProtiNX_P08253
OpenTargetsiENSG00000087245
Orphaneti85196 Nodulosis-arthropathy-osteolysis syndrome
3460 Torg-Winchester syndrome
PharmGKBiPA30877
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1565 Eukaryota
ENOG410XQ5D LUCA
GeneTreeiENSGT00910000144034
HOGENOMiHOG000217926
HOVERGENiHBG052484
InParanoidiP08253
KOiK01398
OMAiHESCTSA
OrthoDBiEOG091G03DP
PhylomeDBiP08253
TreeFamiTF315428

Enzyme and pathway databases

BioCyciMetaCyc:HS01565-MONOMER
BRENDAi3.4.24.24 2681
ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SIGNORiP08253

Miscellaneous databases

ChiTaRSiMMP2 human
EvolutionaryTraceiP08253
GeneWikiiMMP2
GenomeRNAii4313
PMAP-CutDBiP08253
PROiPR:P08253
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000087245 Expressed in 208 organ(s), highest expression level in mucosa of stomach
CleanExiHS_MMP2
ExpressionAtlasiP08253 baseline and differential
GenevisibleiP08253 HS

Family and domain databases

CDDicd00062 FN2, 3 hits
cd00094 HX, 1 hit
cd04278 ZnMc_MMP, 1 hit
Gene3Di1.10.101.10, 1 hit
2.10.10.10, 3 hits
2.110.10.10, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR028708 72kDa_collagenase
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR000585 Hemopexin-like_dom
IPR036375 Hemopexin-like_dom_sf
IPR018487 Hemopexin-like_repeat
IPR018486 Hemopexin_CS
IPR013806 Kringle-like
IPR033739 M10A_MMP
IPR024079 MetalloPept_cat_dom_sf
IPR001818 Pept_M10_metallopeptidase
IPR021190 Pept_M10A
IPR021158 Pept_M10A_Zn_BS
IPR006026 Peptidase_Metallo
IPR002477 Peptidoglycan-bd-like
IPR036365 PGBD-like_sf
IPR036366 PGBDSf
PANTHERiPTHR10201:SF29 PTHR10201:SF29, 4 hits
PfamiView protein in Pfam
PF00040 fn2, 3 hits
PF00045 Hemopexin, 4 hits
PF00413 Peptidase_M10, 1 hit
PF01471 PG_binding_1, 1 hit
PIRSFiPIRSF001191 Peptidase_M10A_matrix, 1 hit
PRINTSiPR00138 MATRIXIN
SMARTiView protein in SMART
SM00059 FN2, 3 hits
SM00120 HX, 4 hits
SM00235 ZnMc, 1 hit
SUPFAMiSSF47090 SSF47090, 1 hit
SSF50923 SSF50923, 1 hit
SSF57440 SSF57440, 3 hits
PROSITEiView protein in PROSITE
PS00546 CYSTEINE_SWITCH, 1 hit
PS00023 FN2_1, 3 hits
PS51092 FN2_2, 3 hits
PS00024 HEMOPEXIN, 1 hit
PS51642 HEMOPEXIN_2, 4 hits
PS00142 ZINC_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMMP2_HUMAN
AccessioniPrimary (citable) accession number: P08253
Secondary accession number(s): B2R6U1
, B4DWH3, E9PE45, Q9UCJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 1, 1991
Last modified: November 7, 2018
This is version 226 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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