UniProtKB - P08253 (MMP2_HUMAN)
72 kDa type IV collagenase
MMP2
Functioni
Catalytic activityi
- Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.4 Publications EC:3.4.24.24
Cofactori
Protein has several cofactor binding sites:- Ca2+4 PublicationsNote: Binds 4 Ca2+ ions per subunit.3 Publications
- Zn2+4 PublicationsNote: Binds 2 Zn2+ ions per subunit.3 Publications
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 102 | Zinc 1; in inhibited formCombined sources2 Publications | 1 | |
Metal bindingi | 134 | Calcium 1Combined sources1 Publication | 1 | |
Metal bindingi | 168 | Calcium 2; via carbonyl oxygenCombined sources1 Publication | 1 | |
Metal bindingi | 178 | Zinc 2Combined sources3 Publications | 1 | |
Metal bindingi | 180 | Zinc 2Combined sources3 Publications | 1 | |
Metal bindingi | 185 | Calcium 3Combined sources1 Publication | 1 | |
Metal bindingi | 186 | Calcium 3; via carbonyl oxygenCombined sources1 Publication | 1 | |
Metal bindingi | 193 | Zinc 2Combined sources3 Publications | 1 | |
Metal bindingi | 200 | Calcium 2; via carbonyl oxygenCombined sources1 Publication | 1 | |
Metal bindingi | 202 | Calcium 2; via carbonyl oxygenCombined sources1 Publication | 1 | |
Metal bindingi | 204 | Calcium 2Combined sources1 Publication | 1 | |
Metal bindingi | 206 | Zinc 2Combined sources3 Publications | 1 | |
Metal bindingi | 208 | Calcium 3Combined sources1 Publication | 1 | |
Metal bindingi | 209 | Calcium 1Combined sources1 Publication | 1 | |
Metal bindingi | 211 | Calcium 1; via carbonyl oxygenCombined sources1 Publication | 1 | |
Metal bindingi | 211 | Calcium 3Combined sources1 Publication | 1 | |
Metal bindingi | 403 | Zinc 1; catalyticCombined sources3 Publications | 1 | |
Active sitei | 404 | PROSITE-ProRule annotation1 Publication | 1 | |
Metal bindingi | 407 | Zinc 1; catalyticCombined sources3 Publications | 1 | |
Metal bindingi | 413 | Zinc 1; catalyticCombined sources3 Publications | 1 | |
Metal bindingi | 476 | Calcium 4; via carbonyl oxygenCombined sources2 Publications | 1 | |
Metal bindingi | 521 | Calcium 4; via carbonyl oxygenCombined sources2 Publications | 1 | |
Metal bindingi | 569 | Calcium 4; via carbonyl oxygenCombined sources2 Publications | 1 | |
Metal bindingi | 618 | Calcium 4; via carbonyl oxygenCombined sources2 Publications | 1 |
GO - Molecular functioni
- endopeptidase activity Source: UniProtKB
- metalloendopeptidase activity Source: GO_Central
- metallopeptidase activity Source: UniProtKB
- serine-type endopeptidase activity Source: Reactome
- zinc ion binding Source: ProtInc
GO - Biological processi
- angiogenesis Source: UniProtKB-KW
- blood vessel maturation Source: Ensembl
- bone trabecula formation Source: Ensembl
- cellular protein metabolic process Source: Reactome
- cellular response to amino acid stimulus Source: Ensembl
- cellular response to reactive oxygen species Source: Ensembl
- cellular response to UV-A Source: UniProtKB
- collagen catabolic process Source: GO_Central
- cytokine-mediated signaling pathway Source: Reactome
- embryo implantation Source: Ensembl
- endodermal cell differentiation Source: UniProtKB
- ephrin receptor signaling pathway Source: Reactome
- extracellular matrix disassembly Source: ParkinsonsUK-UCL
- extracellular matrix organization Source: GO_Central
- face morphogenesis Source: Ensembl
- intramembranous ossification Source: Ensembl
- positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
- proteolysis Source: ParkinsonsUK-UCL
- response to amyloid-beta Source: ARUK-UCL
- response to hypoxia Source: GO_Central
- tissue remodeling Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Metalloprotease, Protease |
Biological process | Angiogenesis, Collagen degradation |
Ligand | Calcium, Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | MetaCyc:HS01565-MONOMER |
BRENDAi | 3.4.24.24, 2681 |
PathwayCommonsi | P08253 |
Reactomei | R-HSA-1442490, Collagen degradation R-HSA-1474228, Degradation of the extracellular matrix R-HSA-1592389, Activation of Matrix Metalloproteinases R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-3928665, EPH-ephrin mediated repulsion of cells R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9009391, Extra-nuclear estrogen signaling |
SIGNORi | P08253 |
Protein family/group databases
MEROPSi | M10.003 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:MMP2 Synonyms:CLG4A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000087245.12 |
HGNCi | HGNC:7166, MMP2 |
MIMi | 120360, gene |
neXtProti | NX_P08253 |
Subcellular locationi
Nucleus
Extracellular region or secreted
- extracellular matrix 1 Publication
Other locations
Note: Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.
Mitochondrion
Other locations
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- sarcomere Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Extracellular matrix, Membrane, Mitochondrion, Nucleus, SecretedPathology & Biotechi
Involvement in diseasei
Multicentric osteolysis, nodulosis, and arthropathy (MONA)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032423 | 101 | R → H in MONA. 1 PublicationCorresponds to variant dbSNP:rs121912953EnsemblClinVar. | 1 | |
Natural variantiVAR_054996 | 400 | Missing in MONA. 1 Publication | 1 | |
Natural variantiVAR_032425 | 404 | E → K in MONA. 1 PublicationCorresponds to variant dbSNP:rs121912955EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 4313 |
GeneReviewsi | MMP2 |
MalaCardsi | MMP2 |
MIMi | 259600, phenotype |
OpenTargetsi | ENSG00000087245 |
Orphaneti | 371428, Multicentric osteolysis-nodulosis-arthropathy spectrum |
PharmGKBi | PA30877 |
Miscellaneous databases
Pharosi | P08253, Tchem |
Chemistry databases
ChEMBLi | CHEMBL333 |
DrugBanki | DB05387, AE-941 DB01197, Captopril DB06423, Endostatin DB04866, Halofuginone DB00786, Marimastat DB01630, SC-74020 |
DrugCentrali | P08253 |
GuidetoPHARMACOLOGYi | 1629 |
Polymorphism and mutation databases
BioMutai | MMP2 |
DMDMi | 116856 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | 1 PublicationAdd BLAST | 29 | |
PropeptideiPRO_0000028714 | 30 – 109 | Activation peptideAdd BLAST | 80 | |
ChainiPRO_0000028715 | 110 – 660 | 72 kDa type IV collagenaseAdd BLAST | 551 | |
ChainiPRO_0000391626 | 445 – 660 | PEXAdd BLAST | 216 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 233 ↔ 259 | PROSITE-ProRule annotationCombined sources2 Publications | ||
Disulfide bondi | 247 ↔ 274 | PROSITE-ProRule annotationCombined sources2 Publications | ||
Disulfide bondi | 291 ↔ 317 | PROSITE-ProRule annotationCombined sources3 Publications | ||
Disulfide bondi | 305 ↔ 332 | PROSITE-ProRule annotationCombined sources3 Publications | ||
Disulfide bondi | 349 ↔ 375 | PROSITE-ProRule annotationCombined sources3 Publications | ||
Disulfide bondi | 363 ↔ 390 | PROSITE-ProRule annotationCombined sources3 Publications | ||
Disulfide bondi | 469 ↔ 660 | PROSITE-ProRule annotationCombined sources3 Publications | ||
Glycosylationi | 573 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 642 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Autocatalytic cleavage, Disulfide bond, Glycoprotein, Phosphoprotein, ZymogenProteomic databases
CPTACi | non-CPTAC-2615 |
EPDi | P08253 |
jPOSTi | P08253 |
MassIVEi | P08253 |
MaxQBi | P08253 |
PaxDbi | P08253 |
PeptideAtlasi | P08253 |
PRIDEi | P08253 |
ProteomicsDBi | 19808 52101 [P08253-1] 5336 |
PTM databases
CarbonylDBi | P08253 |
GlyGeni | P08253, 3 sites, 2 O-linked glycans (1 site) |
iPTMneti | P08253 |
PhosphoSitePlusi | P08253 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000087245, Expressed in stromal cell of endometrium and 221 other tissues |
ExpressionAtlasi | P08253, baseline and differential |
Genevisiblei | P08253, HS |
Organism-specific databases
HPAi | ENSG00000087245, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells.
Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity.
Interacts with GSK3B.
8 PublicationsBinary interactionsi
Hide detailsP08253
Protein-protein interaction databases
BioGRIDi | 110457, 43 interactors |
CORUMi | P08253 |
IntActi | P08253, 40 interactors |
MINTi | P08253 |
STRINGi | 9606.ENSP00000219070 |
Chemistry databases
BindingDBi | P08253 |
Miscellaneous databases
RNActi | P08253, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P08253 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08253 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 228 – 276 | Fibronectin type-II 1PROSITE-ProRule annotationAdd BLAST | 49 | |
Domaini | 286 – 334 | Fibronectin type-II 2PROSITE-ProRule annotationAdd BLAST | 49 | |
Domaini | 344 – 392 | Fibronectin type-II 3PROSITE-ProRule annotationAdd BLAST | 49 | |
Repeati | 472 – 516 | Hemopexin 1Add BLAST | 45 | |
Repeati | 517 – 563 | Hemopexin 2Add BLAST | 47 | |
Repeati | 565 – 613 | Hemopexin 3Add BLAST | 49 | |
Repeati | 614 – 660 | Hemopexin 4Add BLAST | 47 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 110 – 221 | Collagenase-like 1Add BLAST | 112 | |
Regioni | 222 – 396 | Collagen-bindingAdd BLAST | 175 | |
Regioni | 397 – 465 | Collagenase-like 2Add BLAST | 69 | |
Regioni | 414 – 660 | Required for inhibitor TIMP2 binding1 PublicationAdd BLAST | 247 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 100 – 107 | Cysteine switchBy similarity | 8 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG1565, Eukaryota |
GeneTreei | ENSGT00940000158511 |
HOGENOMi | CLU_015489_6_2_1 |
InParanoidi | P08253 |
OMAi | MWCATTK |
OrthoDBi | 965164at2759 |
PhylomeDBi | P08253 |
TreeFami | TF315428 |
Family and domain databases
CDDi | cd00062, FN2, 3 hits cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 1.10.101.10, 1 hit 2.10.10.10, 3 hits 2.110.10.10, 1 hit 3.40.390.10, 1 hit |
IDEALi | IID00296 |
InterProi | View protein in InterPro IPR028708, 72kDa_collagenase IPR000562, FN_type2_dom IPR036943, FN_type2_sf IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR013806, Kringle-like IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR021158, Pept_M10A_Zn_BS IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf IPR036366, PGBDSf |
PANTHERi | PTHR10201:SF29, PTHR10201:SF29, 1 hit |
Pfami | View protein in Pfam PF00040, fn2, 3 hits PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00059, FN2, 3 hits SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit SSF57440, SSF57440, 3 hits |
PROSITEi | View protein in PROSITE PS00546, CYSTEINE_SWITCH, 1 hit PS00023, FN2_1, 3 hits PS51092, FN2_2, 3 hits PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits PS00142, ZINC_PROTEASE, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEALMARGAL TGPLRALCLL GCLLSHAAAA PSPIIKFPGD VAPKTDKELA
60 70 80 90 100
VQYLNTFYGC PKESCNLFVL KDTLKKMQKF FGLPQTGDLD QNTIETMRKP
110 120 130 140 150
RCGNPDVANY NFFPRKPKWD KNQITYRIIG YTPDLDPETV DDAFARAFQV
160 170 180 190 200
WSDVTPLRFS RIHDGEADIM INFGRWEHGD GYPFDGKDGL LAHAFAPGTG
210 220 230 240 250
VGGDSHFDDD ELWTLGEGQV VRVKYGNADG EYCKFPFLFN GKEYNSCTDT
260 270 280 290 300
GRSDGFLWCS TTYNFEKDGK YGFCPHEALF TMGGNAEGQP CKFPFRFQGT
310 320 330 340 350
SYDSCTTEGR TDGYRWCGTT EDYDRDKKYG FCPETAMSTV GGNSEGAPCV
360 370 380 390 400
FPFTFLGNKY ESCTSAGRSD GKMWCATTAN YDDDRKWGFC PDQGYSLFLV
410 420 430 440 450
AAHEFGHAMG LEHSQDPGAL MAPIYTYTKN FRLSQDDIKG IQELYGASPD
460 470 480 490 500
IDLGTGPTPT LGPVTPEICK QDIVFDGIAQ IRGEIFFFKD RFIWRTVTPR
510 520 530 540 550
DKPMGPLLVA TFWPELPEKI DAVYEAPQEE KAVFFAGNEY WIYSASTLER
560 570 580 590 600
GYPKPLTSLG LPPDVQRVDA AFNWSKNKKT YIFAGDKFWR YNEVKKKMDP
610 620 630 640 650
GFPKLIADAW NAIPDNLDAV VDLQGGGHSY FFKGAYYLKL ENQSLKSVKF
660
GSIKSDWLGC
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BR66 | H3BR66_HUMAN | PEX | MMP2 | 201 | Annotation score: | ||
H3BS34 | H3BS34_HUMAN | 72 kDa type IV collagenase | MMP2 | 251 | Annotation score: | ||
H3BV48 | H3BV48_HUMAN | 72 kDa type IV collagenase | MMP2 | 118 | Annotation score: | ||
J3KRB7 | J3KRB7_HUMAN | 72 kDa type IV collagenase | MMP2 | 22 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 235 | F → S in AK310314 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 546 | S → G in BAG35588 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 618 | D → G in BAG35588 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032423 | 101 | R → H in MONA. 1 PublicationCorresponds to variant dbSNP:rs121912953EnsemblClinVar. | 1 | |
Natural variantiVAR_032424 | 210 | D → Y1 Publication | 1 | |
Natural variantiVAR_036136 | 228 | A → T in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs759302357Ensembl. | 1 | |
Natural variantiVAR_054996 | 400 | Missing in MONA. 1 Publication | 1 | |
Natural variantiVAR_032425 | 404 | E → K in MONA. 1 PublicationCorresponds to variant dbSNP:rs121912955EnsemblClinVar. | 1 | |
Natural variantiVAR_020616 | 447 | A → V1 PublicationCorresponds to variant dbSNP:rs17859943EnsemblClinVar. | 1 | |
Natural variantiVAR_036137 | 498 | T → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs764961297Ensembl. | 1 | |
Natural variantiVAR_020617 | 621 | V → L1 PublicationCorresponds to variant dbSNP:rs16955280EnsemblClinVar. | 1 | |
Natural variantiVAR_036138 | 644 | S → I in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044631 | 1 – 76 | Missing in isoform 2. 1 PublicationAdd BLAST | 76 | |
Alternative sequenceiVSP_045704 | 1 – 51 | MEALM…KELAV → M in isoform 3. 1 PublicationAdd BLAST | 51 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M55593 , M58552, M55582, M55583, M55584, M55585, M55586, M55587, M55588, M55589, M55590, M55591, M55592 Genomic DNA Translation: AAA52028.1 AK301536 mRNA Translation: BAG63035.1 AK310314 mRNA No translation available. AK312711 mRNA Translation: BAG35588.1 AY738117 Genomic DNA Translation: AAU10089.1 AC007336 Genomic DNA No translation available. AC092722 Genomic DNA No translation available. BC002576 mRNA Translation: AAH02576.1 M33789 Genomic DNA Translation: AAA52027.1 J03210 mRNA Translation: AAA35701.1 |
CCDSi | CCDS10752.1 [P08253-1] CCDS45487.1 [P08253-3] CCDS76869.1 [P08253-2] |
PIRi | A28153 |
RefSeqi | NP_001121363.1, NM_001127891.2 [P08253-3] NP_001289437.1, NM_001302508.1 [P08253-2] NP_001289438.1, NM_001302509.1 [P08253-2] NP_001289439.1, NM_001302510.1 [P08253-2] NP_004521.1, NM_004530.5 [P08253-1] |
Genome annotation databases
Ensembli | ENST00000219070; ENSP00000219070; ENSG00000087245 [P08253-1] ENST00000437642; ENSP00000394237; ENSG00000087245 [P08253-3] ENST00000543485; ENSP00000444143; ENSG00000087245 [P08253-2] ENST00000570308; ENSP00000461421; ENSG00000087245 [P08253-2] |
GeneIDi | 4313 |
KEGGi | hsa:4313 |
UCSCi | uc002ehz.5, human [P08253-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M55593 , M58552, M55582, M55583, M55584, M55585, M55586, M55587, M55588, M55589, M55590, M55591, M55592 Genomic DNA Translation: AAA52028.1 AK301536 mRNA Translation: BAG63035.1 AK310314 mRNA No translation available. AK312711 mRNA Translation: BAG35588.1 AY738117 Genomic DNA Translation: AAU10089.1 AC007336 Genomic DNA No translation available. AC092722 Genomic DNA No translation available. BC002576 mRNA Translation: AAH02576.1 M33789 Genomic DNA Translation: AAA52027.1 J03210 mRNA Translation: AAA35701.1 |
CCDSi | CCDS10752.1 [P08253-1] CCDS45487.1 [P08253-3] CCDS76869.1 [P08253-2] |
PIRi | A28153 |
RefSeqi | NP_001121363.1, NM_001127891.2 [P08253-3] NP_001289437.1, NM_001302508.1 [P08253-2] NP_001289438.1, NM_001302509.1 [P08253-2] NP_001289439.1, NM_001302510.1 [P08253-2] NP_004521.1, NM_004530.5 [P08253-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CK7 | X-ray | 2.80 | A | 30-660 | [»] | |
1CXW | NMR | - | A | 278-336 | [»] | |
1EAK | X-ray | 2.66 | A/B/C/D | 32-452 | [»] | |
1GEN | X-ray | 2.15 | A | 443-660 | [»] | |
1GXD | X-ray | 3.10 | A/B | 30-660 | [»] | |
1HOV | NMR | - | A | 110-214 | [»] | |
A | 395-446 | [»] | ||||
1J7M | NMR | - | A | 337-394 | [»] | |
1KS0 | NMR | - | A | 223-282 | [»] | |
1QIB | X-ray | 2.80 | A | 115-213 | [»] | |
A | 394-449 | [»] | ||||
1RTG | X-ray | 2.60 | A | 451-660 | [»] | |
3AYU | X-ray | 2.00 | A | 110-450 | [»] | |
SMRi | P08253 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110457, 43 interactors |
CORUMi | P08253 |
IntActi | P08253, 40 interactors |
MINTi | P08253 |
STRINGi | 9606.ENSP00000219070 |
Chemistry databases
BindingDBi | P08253 |
ChEMBLi | CHEMBL333 |
DrugBanki | DB05387, AE-941 DB01197, Captopril DB06423, Endostatin DB04866, Halofuginone DB00786, Marimastat DB01630, SC-74020 |
DrugCentrali | P08253 |
GuidetoPHARMACOLOGYi | 1629 |
Protein family/group databases
MEROPSi | M10.003 |
PTM databases
CarbonylDBi | P08253 |
GlyGeni | P08253, 3 sites, 2 O-linked glycans (1 site) |
iPTMneti | P08253 |
PhosphoSitePlusi | P08253 |
Polymorphism and mutation databases
BioMutai | MMP2 |
DMDMi | 116856 |
Proteomic databases
CPTACi | non-CPTAC-2615 |
EPDi | P08253 |
jPOSTi | P08253 |
MassIVEi | P08253 |
MaxQBi | P08253 |
PaxDbi | P08253 |
PeptideAtlasi | P08253 |
PRIDEi | P08253 |
ProteomicsDBi | 19808 52101 [P08253-1] 5336 |
Protocols and materials databases
ABCDi | P08253, 1 sequenced antibody |
Antibodypediai | 773, 1592 antibodies |
DNASUi | 4313 |
Genome annotation databases
Ensembli | ENST00000219070; ENSP00000219070; ENSG00000087245 [P08253-1] ENST00000437642; ENSP00000394237; ENSG00000087245 [P08253-3] ENST00000543485; ENSP00000444143; ENSG00000087245 [P08253-2] ENST00000570308; ENSP00000461421; ENSG00000087245 [P08253-2] |
GeneIDi | 4313 |
KEGGi | hsa:4313 |
UCSCi | uc002ehz.5, human [P08253-1] |
Organism-specific databases
CTDi | 4313 |
DisGeNETi | 4313 |
EuPathDBi | HostDB:ENSG00000087245.12 |
GeneCardsi | MMP2 |
GeneReviewsi | MMP2 |
HGNCi | HGNC:7166, MMP2 |
HPAi | ENSG00000087245, Low tissue specificity |
MalaCardsi | MMP2 |
MIMi | 120360, gene 259600, phenotype |
neXtProti | NX_P08253 |
OpenTargetsi | ENSG00000087245 |
Orphaneti | 371428, Multicentric osteolysis-nodulosis-arthropathy spectrum |
PharmGKBi | PA30877 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1565, Eukaryota |
GeneTreei | ENSGT00940000158511 |
HOGENOMi | CLU_015489_6_2_1 |
InParanoidi | P08253 |
OMAi | MWCATTK |
OrthoDBi | 965164at2759 |
PhylomeDBi | P08253 |
TreeFami | TF315428 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS01565-MONOMER |
BRENDAi | 3.4.24.24, 2681 |
PathwayCommonsi | P08253 |
Reactomei | R-HSA-1442490, Collagen degradation R-HSA-1474228, Degradation of the extracellular matrix R-HSA-1592389, Activation of Matrix Metalloproteinases R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-3928665, EPH-ephrin mediated repulsion of cells R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9009391, Extra-nuclear estrogen signaling |
SIGNORi | P08253 |
Miscellaneous databases
BioGRID-ORCSi | 4313, 4 hits in 848 CRISPR screens |
ChiTaRSi | MMP2, human |
EvolutionaryTracei | P08253 |
GeneWikii | MMP2 |
GenomeRNAii | 4313 |
Pharosi | P08253, Tchem |
PROi | PR:P08253 |
RNActi | P08253, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000087245, Expressed in stromal cell of endometrium and 221 other tissues |
ExpressionAtlasi | P08253, baseline and differential |
Genevisiblei | P08253, HS |
Family and domain databases
CDDi | cd00062, FN2, 3 hits cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 1.10.101.10, 1 hit 2.10.10.10, 3 hits 2.110.10.10, 1 hit 3.40.390.10, 1 hit |
IDEALi | IID00296 |
InterProi | View protein in InterPro IPR028708, 72kDa_collagenase IPR000562, FN_type2_dom IPR036943, FN_type2_sf IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR013806, Kringle-like IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR021158, Pept_M10A_Zn_BS IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf IPR036366, PGBDSf |
PANTHERi | PTHR10201:SF29, PTHR10201:SF29, 1 hit |
Pfami | View protein in Pfam PF00040, fn2, 3 hits PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00059, FN2, 3 hits SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit SSF57440, SSF57440, 3 hits |
PROSITEi | View protein in PROSITE PS00546, CYSTEINE_SWITCH, 1 hit PS00023, FN2_1, 3 hits PS51092, FN2_2, 3 hits PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits PS00142, ZINC_PROTEASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MMP2_HUMAN | |
Accessioni | P08253Primary (citable) accession number: P08253 Secondary accession number(s): B2R6U1 Q9UCJ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | February 1, 1991 | |
Last modified: | December 2, 2020 | |
This is version 242 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries