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Protein

Signal recognition particle receptor subunit alpha

Gene

SRPRA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi425 – 432GTPBy similarity8
Nucleotide bindingi520 – 524GTPBy similarity5
Nucleotide bindingi588 – 591GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • signal recognition particle binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor subunit alpha
Short name:
SR-alpha
Alternative name(s):
Docking protein alpha
Short name:
DP-alpha
Gene namesi
Name:SRPRAImported
Synonyms:SRPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000182934.11
HGNCiHGNC:11307 SRPRA
MIMi182180 gene
neXtProtiNX_P08240

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6734
OpenTargetsiENSG00000182934
PharmGKBiPA36131

Polymorphism and mutation databases

BioMutaiSRPR
DMDMi20455516

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012131 – 638Signal recognition particle receptor subunit alphaAdd BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177PhosphoserineCombined sources1
Modified residuei284PhosphothreonineCombined sources1
Modified residuei296PhosphoserineCombined sources1
Modified residuei297PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei578PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP08240
MaxQBiP08240
PaxDbiP08240
PeptideAtlasiP08240
PRIDEiP08240
ProteomicsDBi52097

PTM databases

iPTMnetiP08240
PhosphoSitePlusiP08240
SwissPalmiP08240

Expressioni

Gene expression databases

BgeeiENSG00000182934 Expressed in 230 organ(s), highest expression level in parotid gland
CleanExiHS_SRPR
GenevisibleiP08240 HS

Interactioni

Subunit structurei

Heterodimer with SRPRB.1 Publication

Protein-protein interaction databases

BioGridi112612, 47 interactors
IntActiP08240, 51 interactors
MINTiP08240
STRINGi9606.ENSP00000328023

Structurei

Secondary structure

1638
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00893
ProteinModelPortaliP08240
SMRiP08240
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08240

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP-binding SRP family.Curated

Phylogenomic databases

eggNOGiKOG0781 Eukaryota
COG0552 LUCA
GeneTreeiENSGT00550000074936
HOGENOMiHOG000201671
HOVERGENiHBG047566
InParanoidiP08240
KOiK13431
OMAiVSMVHAT
OrthoDBiEOG091G05TG
PhylomeDBiP08240
TreeFamiTF106189

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011012 Longin-like_dom_sf
IPR027417 P-loop_NTPase
IPR007222 Sig_recog_particle_rcpt_asu_N
IPR013822 Signal_recog_particl_SRP54_hlx
IPR036225 SRP/SRP_N
IPR000897 SRP54_GTPase_dom
PfamiView protein in Pfam
PF04086 SRP-alpha_N, 1 hit
PF00448 SRP54, 1 hit
PF02881 SRP54_N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00962 SRP54, 1 hit
SM00963 SRP54_N, 1 hit
SUPFAMiSSF47364 SSF47364, 1 hit
SSF52540 SSF52540, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00300 SRP54, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P08240-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLDFFTIFSK GGLVLWCFQG VSDSCTGPVN ALIRSVLLQE RGGNNSFTHE
60 70 80 90 100
ALTLKYKLDN QFELVFVVGF QKILTLTYVD KLIDDVHRLF RDKYRTEIQQ
110 120 130 140 150
QSALSLLNGT FDFQNDFLRL LREAEESSKI RAPTTMKKFE DSEKAKKPVR
160 170 180 190 200
SMIETRGEKP KEKAKNSKKK GAKKEGSDGP LATSKPVPAE KSGLPVGPEN
210 220 230 240 250
GVELSKEELI RRKREEFIQK HGRGMEKSNK STKSDAPKEK GKKAPRVWEL
260 270 280 290 300
GGCANKEVLD YSTPTTNGTP EAALSEDINL IRGTGSGGQL QDLDCSSSDD
310 320 330 340 350
EGAAQNSTKP SATKGTLGGM FGMLKGLVGS KSLSREDMES VLDKMRDHLI
360 370 380 390 400
AKNVAADIAV QLCESVANKL EGKVMGTFST VTSTVKQALQ ESLVQILQPQ
410 420 430 440 450
RRVDMLRDIM DAQRRQRPYV VTFCGVNGVG KSTNLAKISF WLLENGFSVL
460 470 480 490 500
IAACDTFRAG AVEQLRTHTR RLSALHPPEK HGGRTMVQLF EKGYGKDAAG
510 520 530 540 550
IAMEAIAFAR NQGFDVVLVD TAGRMQDNAP LMTALAKLIT VNTPDLVLFV
560 570 580 590 600
GEALVGNEAV DQLVKFNRAL ADHSMAQTPR LIDGIVLTKF DTIDDKVGAA
610 620 630
ISMTYITSKP IVFVGTGQTY CDLRSLNAKA VVAALMKA
Length:638
Mass (Da):69,811
Last modified:May 2, 2002 - v2
Checksum:i967F943CEE3FA79E
GO
Isoform 2 (identifier: P08240-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-67: Missing.

Note: No experimental confirmation available.
Show »
Length:610
Mass (Da):66,559
Checksum:i7A561BCA1C06A29E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81K → R in CAA29608 (PubMed:3340536).Curated1
Sequence conflicti201G → E in CAA29608 (PubMed:3340536).Curated1
Sequence conflicti306 – 307NS → TL in CAA29608 (PubMed:3340536).Curated2
Sequence conflicti632V → L in BAG64435 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04605540 – 67Missing in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06272 mRNA Translation: CAA29608.1
AK303379 mRNA Translation: BAG64435.1
AK312377 mRNA Translation: BAG35295.1
AP001318 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67686.1
BC001162 mRNA Translation: AAH01162.1
BC009110 mRNA Translation: AAH09110.1
BC013583 mRNA Translation: AAH13583.1
CCDSiCCDS31717.1 [P08240-1]
CCDS53722.1 [P08240-2]
PIRiA29440
RefSeqiNP_001171313.1, NM_001177842.1 [P08240-2]
NP_003130.2, NM_003139.3 [P08240-1]
UniGeneiHs.368376

Genome annotation databases

EnsembliENST00000332118; ENSP00000328023; ENSG00000182934 [P08240-1]
ENST00000532259; ENSP00000435508; ENSG00000182934 [P08240-2]
GeneIDi6734
KEGGihsa:6734
UCSCiuc001qdh.4 human [P08240-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06272 mRNA Translation: CAA29608.1
AK303379 mRNA Translation: BAG64435.1
AK312377 mRNA Translation: BAG35295.1
AP001318 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67686.1
BC001162 mRNA Translation: AAH01162.1
BC009110 mRNA Translation: AAH09110.1
BC013583 mRNA Translation: AAH13583.1
CCDSiCCDS31717.1 [P08240-1]
CCDS53722.1 [P08240-2]
PIRiA29440
RefSeqiNP_001171313.1, NM_001177842.1 [P08240-2]
NP_003130.2, NM_003139.3 [P08240-1]
UniGeneiHs.368376

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FH5X-ray2.45A3-176[»]
2GO5electron microscopy7.4013-176[»]
5L3QX-ray3.20B/D1-638[»]
DisProtiDP00893
ProteinModelPortaliP08240
SMRiP08240
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112612, 47 interactors
IntActiP08240, 51 interactors
MINTiP08240
STRINGi9606.ENSP00000328023

PTM databases

iPTMnetiP08240
PhosphoSitePlusiP08240
SwissPalmiP08240

Polymorphism and mutation databases

BioMutaiSRPR
DMDMi20455516

Proteomic databases

EPDiP08240
MaxQBiP08240
PaxDbiP08240
PeptideAtlasiP08240
PRIDEiP08240
ProteomicsDBi52097

Protocols and materials databases

DNASUi6734
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332118; ENSP00000328023; ENSG00000182934 [P08240-1]
ENST00000532259; ENSP00000435508; ENSG00000182934 [P08240-2]
GeneIDi6734
KEGGihsa:6734
UCSCiuc001qdh.4 human [P08240-1]

Organism-specific databases

CTDi6734
DisGeNETi6734
EuPathDBiHostDB:ENSG00000182934.11
GeneCardsiSRPRA
HGNCiHGNC:11307 SRPRA
MIMi182180 gene
neXtProtiNX_P08240
OpenTargetsiENSG00000182934
PharmGKBiPA36131
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0781 Eukaryota
COG0552 LUCA
GeneTreeiENSGT00550000074936
HOGENOMiHOG000201671
HOVERGENiHBG047566
InParanoidiP08240
KOiK13431
OMAiVSMVHAT
OrthoDBiEOG091G05TG
PhylomeDBiP08240
TreeFamiTF106189

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-381038 XBP1(S) activates chaperone genes

Miscellaneous databases

ChiTaRSiSRPRA human
EvolutionaryTraceiP08240
GenomeRNAii6734
PROiPR:P08240
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182934 Expressed in 230 organ(s), highest expression level in parotid gland
CleanExiHS_SRPR
GenevisibleiP08240 HS

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011012 Longin-like_dom_sf
IPR027417 P-loop_NTPase
IPR007222 Sig_recog_particle_rcpt_asu_N
IPR013822 Signal_recog_particl_SRP54_hlx
IPR036225 SRP/SRP_N
IPR000897 SRP54_GTPase_dom
PfamiView protein in Pfam
PF04086 SRP-alpha_N, 1 hit
PF00448 SRP54, 1 hit
PF02881 SRP54_N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00962 SRP54, 1 hit
SM00963 SRP54_N, 1 hit
SUPFAMiSSF47364 SSF47364, 1 hit
SSF52540 SSF52540, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00300 SRP54, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRPRA_HUMAN
AccessioniPrimary (citable) accession number: P08240
Secondary accession number(s): A6NIB3
, B2R5Z8, B4E0H3, E9PJS4, Q9BVJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 2, 2002
Last modified: November 7, 2018
This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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