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Protein

Beta-glucuronidase

Gene

GUSB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the degradation of dermatan and keratan sulfates.

Catalytic activityi

A beta-D-glucuronoside + H2O = D-glucuronate + an alcohol.

Activity regulationi

Inhibited by L-aspartic acid.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei451Proton donor1

GO - Molecular functioni

  • beta-glucuronidase activity Source: GO_Central
  • carbohydrate binding Source: GO_Central
  • protein domain specific binding Source: AgBase
  • signaling receptor binding Source: AgBase

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-HSA-2024096 HS-GAG degradation
R-HSA-2160916 Hyaluronan uptake and degradation
R-HSA-2206292 MPS VII - Sly syndrome
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

CAZyiGH2 Glycoside Hydrolase Family 2

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-glucuronidase (EC:3.2.1.31)
Alternative name(s):
Beta-G1
Gene namesi
Name:GUSB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000169919.16
HGNCiHGNC:4696 GUSB
MIMi611499 gene
neXtProtiNX_P08236

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Involvement in diseasei

Mucopolysaccharidosis 7 (MPS7)13 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive lysosomal storage disease characterized by inability to degrade glucuronic acid-containing glycosaminoglycans. The phenotype is highly variable, ranging from severe lethal hydrops fetalis to mild forms with survival into adulthood. Most patients with the intermediate phenotype show hepatomegaly, skeletal anomalies, coarse facies, and variable degrees of mental impairment.
See also OMIM:253220
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05851130P → S in MPS7. Corresponds to variant dbSNP:rs747792546Ensembl.1
Natural variantiVAR_03791438C → G in MPS7; very mild phenotype. 1 Publication1
Natural variantiVAR_03791552S → F in MPS7; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs1424546265Ensembl.1
Natural variantiVAR_037916136G → R in MPS7. 1 PublicationCorresponds to variant dbSNP:rs1417426295Ensembl.1
Natural variantiVAR_037917148P → S in MPS7. 1 PublicationCorresponds to variant dbSNP:rs121918177EnsemblClinVar.1
Natural variantiVAR_037918150E → K in MPS7. 1 Publication1
Natural variantiVAR_058512152D → G in MPS7. 1
Natural variantiVAR_037920176L → F in MPS7. 4 PublicationsCorresponds to variant dbSNP:rs121918181EnsemblClinVar.1
Natural variantiVAR_003196216R → W in MPS7. 2 PublicationsCorresponds to variant dbSNP:rs121918174EnsemblClinVar.1
Natural variantiVAR_058513243L → P in MPS7. 1
Natural variantiVAR_037921320Y → C in MPS7. 1 Publication1
Natural variantiVAR_037922320Y → S in MPS7. 1 PublicationCorresponds to variant dbSNP:rs886044680EnsemblClinVar.1
Natural variantiVAR_058514339N → S in MPS7. 1
Natural variantiVAR_037923350K → N in MPS7. 1 PublicationCorresponds to variant dbSNP:rs121918182EnsemblClinVar.1
Natural variantiVAR_037924351H → Y in MPS7. 1 PublicationCorresponds to variant dbSNP:rs191153460Ensembl.1
Natural variantiVAR_003197354A → V in MPS7. 1 PublicationCorresponds to variant dbSNP:rs121918175EnsemblClinVar.1
Natural variantiVAR_058515361 – 369Missing in MPS7. 9
Natural variantiVAR_058516362D → N in MPS7. Corresponds to variant dbSNP:rs398123234EnsemblClinVar.1
Natural variantiVAR_058517364P → L in MPS7. Corresponds to variant dbSNP:rs771629102Ensembl.1
Natural variantiVAR_037925374R → C in MPS7. 1 PublicationCorresponds to variant dbSNP:rs747572640Ensembl.1
Natural variantiVAR_003198382R → C in MPS7. 2 PublicationsCorresponds to variant dbSNP:rs121918173EnsemblClinVar.1
Natural variantiVAR_037926382R → H in MPS7. 1 Publication1
Natural variantiVAR_037927408P → S in MPS7. 1 PublicationCorresponds to variant dbSNP:rs779091113Ensembl.1
Natural variantiVAR_037928415P → L in MPS7. 1 PublicationCorresponds to variant dbSNP:rs751025746Ensembl.1
Natural variantiVAR_037929435R → P in MPS7. 1 Publication1
Natural variantiVAR_037930477R → W in MPS7. 1 PublicationCorresponds to variant dbSNP:rs774393243Ensembl.1
Natural variantiVAR_037931495Y → C in MPS7. 1 PublicationCorresponds to variant dbSNP:rs121918178EnsemblClinVar.1
Natural variantiVAR_037932508Y → C in MPS7. 1 Publication1
Natural variantiVAR_058518540E → K in MPS7. 1
Natural variantiVAR_037933572G → D in MPS7. 1 Publication1
Natural variantiVAR_037934577R → L in MPS7; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121918183EnsemblClinVar.1
Natural variantiVAR_037935606K → N in MPS7. 1 Publication1
Natural variantiVAR_058519607G → A in MPS7. Corresponds to variant dbSNP:rs1250112198Ensembl.1
Natural variantiVAR_003199611R → W in MPS7. 1 PublicationCorresponds to variant dbSNP:rs121918176EnsemblClinVar.1
Natural variantiVAR_003200619A → V in MPS7. 1 PublicationCorresponds to variant dbSNP:rs121918172EnsemblClinVar.1
Natural variantiVAR_037936626Y → H in MPS7; very mild phenotype. 1 PublicationCorresponds to variant dbSNP:rs777613366Ensembl.1
Natural variantiVAR_003201627W → C in MPS7. 2 PublicationsCorresponds to variant dbSNP:rs121918184EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mucopolysaccharidosis

Organism-specific databases

DisGeNETi2990
MalaCardsiGUSB
MIMi253220 phenotype
OpenTargetsiENSG00000169919
Orphaneti584 Mucopolysaccharidosis type 7
PharmGKBiPA29075

Chemistry databases

ChEMBLiCHEMBL2728

Polymorphism and mutation databases

BioMutaiGUSB
DMDMi146345377

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000001216123 – 651Beta-glucuronidaseAdd BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi173N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi272N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi420N-linked (GlcNAc...) asparagine1
Glycosylationi631N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

N-linked glycosylated with 3 to 4 oligosaccharide chains.3 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP08236
MaxQBiP08236
PaxDbiP08236
PeptideAtlasiP08236
PRIDEiP08236
ProteomicsDBi52092
52093 [P08236-2]

PTM databases

GlyConnecti1037
iPTMnetiP08236
PhosphoSitePlusiP08236

Expressioni

Gene expression databases

BgeeiENSG00000169919 Expressed in 234 organ(s), highest expression level in endometrium epithelium
CleanExiHS_GUSB
ExpressionAtlasiP08236 baseline and differential
GenevisibleiP08236 HS

Organism-specific databases

HPAiHPA036322
HPA036323

Interactioni

Subunit structurei

Homotetramer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109245, 12 interactors
DIPiDIP-29724N
IntActiP08236, 5 interactors
MINTiP08236
STRINGi9606.ENSP00000302728

Chemistry databases

BindingDBiP08236

Structurei

Secondary structure

1651
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08236
SMRiP08236
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08236

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2024 Eukaryota
COG3250 LUCA
GeneTreeiENSGT00390000001752
HOGENOMiHOG000120896
HOVERGENiHBG004843
InParanoidiP08236
KOiK01195
OMAiQRWTQDL
OrthoDBiEOG091G02MO
PhylomeDBiP08236
TreeFamiTF300685

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036156 Beta-gal/glucu_dom_sf
IPR008979 Galactose-bd-like_sf
IPR006101 Glyco_hydro_2
IPR023232 Glyco_hydro_2_AS
IPR006103 Glyco_hydro_2_cat
IPR023230 Glyco_hydro_2_CS
IPR006102 Glyco_hydro_2_Ig-like
IPR006104 Glyco_hydro_2_N
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00703 Glyco_hydro_2, 1 hit
PF02836 Glyco_hydro_2_C, 1 hit
PF02837 Glyco_hydro_2_N, 1 hit
PRINTSiPR00132 GLHYDRLASE2
SUPFAMiSSF49303 SSF49303, 1 hit
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00719 GLYCOSYL_HYDROL_F2_1, 1 hit
PS00608 GLYCOSYL_HYDROL_F2_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P08236-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARGSAVAWA ALGPLLWGCA LGLQGGMLYP QESPSRECKE LDGLWSFRAD
60 70 80 90 100
FSDNRRRGFE EQWYRRPLWE SGPTVDMPVP SSFNDISQDW RLRHFVGWVW
110 120 130 140 150
YEREVILPER WTQDLRTRVV LRIGSAHSYA IVWVNGVDTL EHEGGYLPFE
160 170 180 190 200
ADISNLVQVG PLPSRLRITI AINNTLTPTT LPPGTIQYLT DTSKYPKGYF
210 220 230 240 250
VQNTYFDFFN YAGLQRSVLL YTTPTTYIDD ITVTTSVEQD SGLVNYQISV
260 270 280 290 300
KGSNLFKLEV RLLDAENKVV ANGTGTQGQL KVPGVSLWWP YLMHERPAYL
310 320 330 340 350
YSLEVQLTAQ TSLGPVSDFY TLPVGIRTVA VTKSQFLING KPFYFHGVNK
360 370 380 390 400
HEDADIRGKG FDWPLLVKDF NLLRWLGANA FRTSHYPYAE EVMQMCDRYG
410 420 430 440 450
IVVIDECPGV GLALPQFFNN VSLHHHMQVM EEVVRRDKNH PAVVMWSVAN
460 470 480 490 500
EPASHLESAG YYLKMVIAHT KSLDPSRPVT FVSNSNYAAD KGAPYVDVIC
510 520 530 540 550
LNSYYSWYHD YGHLELIQLQ LATQFENWYK KYQKPIIQSE YGAETIAGFH
560 570 580 590 600
QDPPLMFTEE YQKSLLEQYH LGLDQKRRKY VVGELIWNFA DFMTEQSPTR
610 620 630 640 650
VLGNKKGIFT RQRQPKSAAF LLRERYWKIA NETRYPHSVA KSQCLENSLF

T
Length:651
Mass (Da):74,732
Last modified:May 1, 2007 - v2
Checksum:i6BA7B1D935C9ABBD
GO
Isoform 2 (identifier: P08236-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     305-355: Missing.

Show »
Length:600
Mass (Da):69,142
Checksum:i8101B66EA73520F8
GO
Isoform 3 (identifier: P08236-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-304: Missing.

Note: No experimental confirmation available.
Show »
Length:505
Mass (Da):58,345
Checksum:iDF74B0D5E57A9F70
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WBK6F8WBK6_HUMAN
Beta-glucuronidase
GUSB
134Annotation score:
F2Z3L6F2Z3L6_HUMAN
Beta-glucuronidase
GUSB
144Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05851130P → S in MPS7. Corresponds to variant dbSNP:rs747792546Ensembl.1
Natural variantiVAR_03791438C → G in MPS7; very mild phenotype. 1 Publication1
Natural variantiVAR_03791552S → F in MPS7; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs1424546265Ensembl.1
Natural variantiVAR_037916136G → R in MPS7. 1 PublicationCorresponds to variant dbSNP:rs1417426295Ensembl.1
Natural variantiVAR_037917148P → S in MPS7. 1 PublicationCorresponds to variant dbSNP:rs121918177EnsemblClinVar.1
Natural variantiVAR_037918150E → K in MPS7. 1 Publication1
Natural variantiVAR_058512152D → G in MPS7. 1
Natural variantiVAR_037919152D → N Functional polymorphism with no clinical consequences; reduced activity levels. 2 PublicationsCorresponds to variant dbSNP:rs149606212EnsemblClinVar.1
Natural variantiVAR_037920176L → F in MPS7. 4 PublicationsCorresponds to variant dbSNP:rs121918181EnsemblClinVar.1
Natural variantiVAR_003196216R → W in MPS7. 2 PublicationsCorresponds to variant dbSNP:rs121918174EnsemblClinVar.1
Natural variantiVAR_058513243L → P in MPS7. 1
Natural variantiVAR_037921320Y → C in MPS7. 1 Publication1
Natural variantiVAR_037922320Y → S in MPS7. 1 PublicationCorresponds to variant dbSNP:rs886044680EnsemblClinVar.1
Natural variantiVAR_058514339N → S in MPS7. 1
Natural variantiVAR_037923350K → N in MPS7. 1 PublicationCorresponds to variant dbSNP:rs121918182EnsemblClinVar.1
Natural variantiVAR_037924351H → Y in MPS7. 1 PublicationCorresponds to variant dbSNP:rs191153460Ensembl.1
Natural variantiVAR_003197354A → V in MPS7. 1 PublicationCorresponds to variant dbSNP:rs121918175EnsemblClinVar.1
Natural variantiVAR_058515361 – 369Missing in MPS7. 9
Natural variantiVAR_058516362D → N in MPS7. Corresponds to variant dbSNP:rs398123234EnsemblClinVar.1
Natural variantiVAR_058517364P → L in MPS7. Corresponds to variant dbSNP:rs771629102Ensembl.1
Natural variantiVAR_037925374R → C in MPS7. 1 PublicationCorresponds to variant dbSNP:rs747572640Ensembl.1
Natural variantiVAR_055884376L → F. Corresponds to variant dbSNP:rs11559283Ensembl.1
Natural variantiVAR_003198382R → C in MPS7. 2 PublicationsCorresponds to variant dbSNP:rs121918173EnsemblClinVar.1
Natural variantiVAR_037926382R → H in MPS7. 1 Publication1
Natural variantiVAR_037927408P → S in MPS7. 1 PublicationCorresponds to variant dbSNP:rs779091113Ensembl.1
Natural variantiVAR_037928415P → L in MPS7. 1 PublicationCorresponds to variant dbSNP:rs751025746Ensembl.1
Natural variantiVAR_037929435R → P in MPS7. 1 Publication1
Natural variantiVAR_037930477R → W in MPS7. 1 PublicationCorresponds to variant dbSNP:rs774393243Ensembl.1
Natural variantiVAR_037931495Y → C in MPS7. 1 PublicationCorresponds to variant dbSNP:rs121918178EnsemblClinVar.1
Natural variantiVAR_037932508Y → C in MPS7. 1 Publication1
Natural variantiVAR_058518540E → K in MPS7. 1
Natural variantiVAR_037933572G → D in MPS7. 1 Publication1
Natural variantiVAR_037934577R → L in MPS7; loss of activity. 1 PublicationCorresponds to variant dbSNP:rs121918183EnsemblClinVar.1
Natural variantiVAR_037935606K → N in MPS7. 1 Publication1
Natural variantiVAR_058519607G → A in MPS7. Corresponds to variant dbSNP:rs1250112198Ensembl.1
Natural variantiVAR_003199611R → W in MPS7. 1 PublicationCorresponds to variant dbSNP:rs121918176EnsemblClinVar.1
Natural variantiVAR_003200619A → V in MPS7. 1 PublicationCorresponds to variant dbSNP:rs121918172EnsemblClinVar.1
Natural variantiVAR_037936626Y → H in MPS7; very mild phenotype. 1 PublicationCorresponds to variant dbSNP:rs777613366Ensembl.1
Natural variantiVAR_003201627W → C in MPS7. 2 PublicationsCorresponds to variant dbSNP:rs121918184EnsemblClinVar.1
Natural variantiVAR_016179649L → P3 PublicationsCorresponds to variant dbSNP:rs9530EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054830159 – 304Missing in isoform 3. 1 PublicationAdd BLAST146
Alternative sequenceiVSP_001799305 – 355Missing in isoform 2. CuratedAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15182 mRNA Translation: AAA52561.1
AK303819 mRNA Translation: BAG64768.1
AK223406 mRNA Translation: BAD97126.1
AC073261 Genomic DNA Translation: AAQ96851.1
CH236961 Genomic DNA Translation: EAL23740.1
CH471140 Genomic DNA Translation: EAX07951.1
BC014142 mRNA Translation: AAH14142.1
M65002 Genomic DNA Translation: AAA52622.1
M10618 mRNA Translation: AAA52621.1
S72462 Genomic DNA Translation: AAD14101.1
CCDSiCCDS5530.1 [P08236-1]
CCDS64665.1 [P08236-3]
PIRiA26581
RefSeqiNP_000172.2, NM_000181.3 [P08236-1]
NP_001271219.1, NM_001284290.1 [P08236-3]
NP_001280033.1, NM_001293104.1
NP_001280034.1, NM_001293105.1
XP_005250354.1, XM_005250297.3 [P08236-2]
UniGeneiHs.255230

Genome annotation databases

EnsembliENST00000304895; ENSP00000302728; ENSG00000169919 [P08236-1]
ENST00000421103; ENSP00000391390; ENSG00000169919 [P08236-3]
GeneIDi2990
KEGGihsa:2990
UCSCiuc003tun.4 human [P08236-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15182 mRNA Translation: AAA52561.1
AK303819 mRNA Translation: BAG64768.1
AK223406 mRNA Translation: BAD97126.1
AC073261 Genomic DNA Translation: AAQ96851.1
CH236961 Genomic DNA Translation: EAL23740.1
CH471140 Genomic DNA Translation: EAX07951.1
BC014142 mRNA Translation: AAH14142.1
M65002 Genomic DNA Translation: AAA52622.1
M10618 mRNA Translation: AAA52621.1
S72462 Genomic DNA Translation: AAD14101.1
CCDSiCCDS5530.1 [P08236-1]
CCDS64665.1 [P08236-3]
PIRiA26581
RefSeqiNP_000172.2, NM_000181.3 [P08236-1]
NP_001271219.1, NM_001284290.1 [P08236-3]
NP_001280033.1, NM_001293104.1
NP_001280034.1, NM_001293105.1
XP_005250354.1, XM_005250297.3 [P08236-2]
UniGeneiHs.255230

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BHGX-ray2.53A/B21-633[»]
3HN3X-ray1.70A/B/D/E21-633[»]
ProteinModelPortaliP08236
SMRiP08236
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109245, 12 interactors
DIPiDIP-29724N
IntActiP08236, 5 interactors
MINTiP08236
STRINGi9606.ENSP00000302728

Chemistry databases

BindingDBiP08236
ChEMBLiCHEMBL2728

Protein family/group databases

CAZyiGH2 Glycoside Hydrolase Family 2

PTM databases

GlyConnecti1037
iPTMnetiP08236
PhosphoSitePlusiP08236

Polymorphism and mutation databases

BioMutaiGUSB
DMDMi146345377

Proteomic databases

EPDiP08236
MaxQBiP08236
PaxDbiP08236
PeptideAtlasiP08236
PRIDEiP08236
ProteomicsDBi52092
52093 [P08236-2]

Protocols and materials databases

DNASUi2990
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304895; ENSP00000302728; ENSG00000169919 [P08236-1]
ENST00000421103; ENSP00000391390; ENSG00000169919 [P08236-3]
GeneIDi2990
KEGGihsa:2990
UCSCiuc003tun.4 human [P08236-1]

Organism-specific databases

CTDi2990
DisGeNETi2990
EuPathDBiHostDB:ENSG00000169919.16
GeneCardsiGUSB
H-InvDBiHIX0057492
HGNCiHGNC:4696 GUSB
HPAiHPA036322
HPA036323
MalaCardsiGUSB
MIMi253220 phenotype
611499 gene
neXtProtiNX_P08236
OpenTargetsiENSG00000169919
Orphaneti584 Mucopolysaccharidosis type 7
PharmGKBiPA29075
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2024 Eukaryota
COG3250 LUCA
GeneTreeiENSGT00390000001752
HOGENOMiHOG000120896
HOVERGENiHBG004843
InParanoidiP08236
KOiK01195
OMAiQRWTQDL
OrthoDBiEOG091G02MO
PhylomeDBiP08236
TreeFamiTF300685

Enzyme and pathway databases

ReactomeiR-HSA-2024096 HS-GAG degradation
R-HSA-2160916 Hyaluronan uptake and degradation
R-HSA-2206292 MPS VII - Sly syndrome
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiGUSB human
EvolutionaryTraceiP08236
GeneWikiiGUSB
GenomeRNAii2990
PROiPR:P08236
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169919 Expressed in 234 organ(s), highest expression level in endometrium epithelium
CleanExiHS_GUSB
ExpressionAtlasiP08236 baseline and differential
GenevisibleiP08236 HS

Family and domain databases

Gene3Di2.60.120.260, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036156 Beta-gal/glucu_dom_sf
IPR008979 Galactose-bd-like_sf
IPR006101 Glyco_hydro_2
IPR023232 Glyco_hydro_2_AS
IPR006103 Glyco_hydro_2_cat
IPR023230 Glyco_hydro_2_CS
IPR006102 Glyco_hydro_2_Ig-like
IPR006104 Glyco_hydro_2_N
IPR017853 Glycoside_hydrolase_SF
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00703 Glyco_hydro_2, 1 hit
PF02836 Glyco_hydro_2_C, 1 hit
PF02837 Glyco_hydro_2_N, 1 hit
PRINTSiPR00132 GLHYDRLASE2
SUPFAMiSSF49303 SSF49303, 1 hit
SSF49785 SSF49785, 1 hit
SSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00719 GLYCOSYL_HYDROL_F2_1, 1 hit
PS00608 GLYCOSYL_HYDROL_F2_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBGLR_HUMAN
AccessioniPrimary (citable) accession number: P08236
Secondary accession number(s): B4E1F6
, E9PCV0, Q549U0, Q96CL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 201 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  7. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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