UniProtKB - P08235 (MCR_HUMAN)
Mineralocorticoid receptor
NR3C2
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 770 | Steroid | 1 | |
Binding sitei | 776 | Steroid | 1 | |
Binding sitei | 817 | Steroid | 1 | |
Binding sitei | 945 | Steroid | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 603 – 668 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 66 | |
Zinc fingeri | 603 – 623 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 639 – 663 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- nuclear receptor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- steroid binding Source: UniProtKB-KW
- steroid hormone receptor activity Source: ProtInc
- zinc ion binding Source: InterPro
GO - Biological processi
- intracellular steroid hormone receptor signaling pathway Source: GO_Central
- positive regulation of NIK/NF-kappaB signaling Source: ARUK-UCL
- regulation of transcription by RNA polymerase II Source: GO_Central
- signal transduction Source: ProtInc
- transcription initiation from RNA polymerase II promoter Source: Reactome
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Lipid-binding, Metal-binding, Steroid-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P08235 |
Reactomei | R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-4090294, SUMOylation of intracellular receptors |
SignaLinki | P08235 |
SIGNORi | P08235 |
Names & Taxonomyi
Protein namesi | Recommended name: Mineralocorticoid receptorShort name: MR Alternative name(s): Nuclear receptor subfamily 3 group C member 2 |
Gene namesi | Name:NR3C2 Synonyms:MCR, MLR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000151623.14 |
HGNCi | HGNC:7979, NR3C2 |
MIMi | 600983, gene |
neXtProti | NX_P08235 |
Subcellular locationi
Endoplasmic reticulum
Nucleus
Other locations
Note: Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleoplasm Source: HPA
Other locations
- receptor complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, Endoplasmic reticulum, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Pseudohypoaldosteronism 1, autosomal dominant (PHA1A)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031268 | 633 | G → R in PHA1A; reduces transcription transactivation upon aldosterone binding. 1 PublicationCorresponds to variant dbSNP:rs121912566EnsemblClinVar. | 1 | |
Natural variantiVAR_031269 | 645 | C → S in PHA1A. 1 Publication | 1 | |
Natural variantiVAR_031270 | 659 | R → S in PHA1A. 1 Publication | 1 | |
Natural variantiVAR_031271 | 759 | P → S in PHA1A. 1 Publication | 1 | |
Natural variantiVAR_031272 | 769 | L → P in PHA1A. 1 Publication | 1 | |
Natural variantiVAR_031273 | 770 | N → K in PHA1A. 1 Publication | 1 | |
Natural variantiVAR_031274 | 776 | Q → R in PHA1A; reduces aldosterone binding. 1 PublicationCorresponds to variant dbSNP:rs121912565EnsemblClinVar. | 1 | |
Natural variantiVAR_031275 | 805 | S → P in PHA1A. 1 Publication | 1 | |
Natural variantiVAR_031276 | 815 | S → R in PHA1A. 1 Publication | 1 | |
Natural variantiVAR_031277 | 818 | S → L in PHA1A; abolishes translocation to the nucleus and transcription transactivation upon aldosterone binding. 1 PublicationCorresponds to variant dbSNP:rs121912573EnsemblClinVar. | 1 | |
Natural variantiVAR_015627 | 924 | L → P in PHA1A; abolishes transcription transactivation upon aldosterone binding. 2 PublicationsCorresponds to variant dbSNP:rs121912563EnsemblClinVar. | 1 | |
Natural variantiVAR_031278 | 972 | E → G in PHA1A; reduces affinity for aldosterone and transcription transactivation. 1 PublicationCorresponds to variant dbSNP:rs121912574EnsemblClinVar. | 1 | |
Natural variantiVAR_031279 | 979 | L → P in PHA1A; loss of aldosterone binding and transcription transactivation. 1 PublicationCorresponds to variant dbSNP:rs121912567EnsemblClinVar. | 1 |
Early-onset hypertension with severe exacerbation in pregnancy (EOHSEP)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_015626 | 810 | S → L in EOHSEP; alters receptor specificity and leads to constitutive activation. 3 PublicationsCorresponds to variant dbSNP:rs41511344EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 767 | S → N: Loss of transcription transactivation. 1 Publication | 1 | |
Mutagenesisi | 767 | S → Q: Strong decrease of transcription transactivation. 1 Publication | 1 | |
Mutagenesisi | 770 | N → A, D, H, Q, S or T: Abolishes aldosterone binding and transcription transactivation. 2 Publications | 1 | |
Mutagenesisi | 776 | Q → A: Reduces aldosterone binding and transcription transactivation. 2 Publications | 1 | |
Mutagenesisi | 782 | K → E: Decreased coactivator binding. 1 Publication | 1 | |
Mutagenesisi | 785 | K → E: Loss of coactivator binding. 1 Publication | 1 | |
Mutagenesisi | 796 | E → R: Decreased coactivator binding. 1 Publication | 1 | |
Mutagenesisi | 808 | C → S: Increases aldosterone-binding. 1 Publication | 1 | |
Mutagenesisi | 810 | S → M: Alters receptor specificity. 1 Publication | 1 | |
Mutagenesisi | 817 | R → A: Reduces aldosterone binding and transcription transactivation. 2 Publications | 1 | |
Mutagenesisi | 849 | C → S: Strongly decreases affinity for aldosterone and transcription transactivation. 1 Publication | 1 | |
Mutagenesisi | 942 | C → S: Abolishes steroid binding and transcription transactivation. 1 Publication | 1 | |
Mutagenesisi | 945 | T → A: Decreases aldosterone-binding and cortisol-binding. 2 Publications | 1 | |
Mutagenesisi | 952 | L → A: Reduces transcription transactivation. 1 Publication | 1 | |
Mutagenesisi | 953 | K → A: Slightly reduces aldosterone binding and abolishes transcription transactivation. 1 Publication | 1 | |
Mutagenesisi | 954 | V → A: Reduces aldosterone binding and abolishes transcription transactivation. 1 Publication | 1 | |
Mutagenesisi | 956 | F → A: Abolishes aldosterone binding and transcription transactivation. 1 Publication | 1 | |
Mutagenesisi | 957 | P → A: Slightly reduces aldosterone binding and transcription transactivation. 1 Publication | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 4306 |
MalaCardsi | NR3C2 |
MIMi | 177735, phenotype 605115, phenotype |
OpenTargetsi | ENSG00000151623 |
Orphaneti | 171871, Renal pseudohypoaldosteronism type 1 |
PharmGKBi | PA242 |
Miscellaneous databases
Pharosi | P08235, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1994 |
DrugBanki | DB04630, Aldosterone DB01013, Clobetasol propionate DB04652, Corticosterone DB06780, Desoxycorticosterone acetate DB01134, Desoxycorticosterone pivalate DB01395, Drospirenone DB00700, Eplerenone DB01023, Felodipine DB00687, Fludrocortisone DB13867, Fluticasone DB08906, Fluticasone furoate DB00588, Fluticasone propionate DB02998, Metribolone DB00393, Nimodipine DB00396, Progesterone DB00421, Spironolactone DB02901, Stanolone DB13951, Stanolone acetate DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate |
DrugCentrali | P08235 |
GuidetoPHARMACOLOGYi | 626 |
Polymorphism and mutation databases
BioMutai | NR3C2 |
DMDMi | 126885 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053682 | 1 – 984 | Mineralocorticoid receptorAdd BLAST | 984 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 250 | PhosphoserineBy similarity | 1 | |
Modified residuei | 259 | PhosphoserineBy similarity | 1 | |
Modified residuei | 283 | PhosphoserineBy similarity | 1 | |
Modified residuei | 287 | PhosphoserineBy similarity | 1 | |
Modified residuei | 299 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P08235 |
MassIVEi | P08235 |
MaxQBi | P08235 |
PaxDbi | P08235 |
PeptideAtlasi | P08235 |
PRIDEi | P08235 |
ProteomicsDBi | 2889 2891 52088 [P08235-1] 52089 [P08235-2] 52090 [P08235-3] 52091 [P08235-4] |
PTM databases
iPTMneti | P08235 |
PhosphoSitePlusi | P08235 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000151623, Expressed in colonic mucosa and 230 other tissues |
ExpressionAtlasi | P08235, baseline and differential |
Organism-specific databases
HPAi | ENSG00000151623, Low tissue specificity |
Interactioni
Subunit structurei
Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4, in the absence of ligand. After ligand binding, it translocates to the nucleus and binds to DNA as a homodimer and as a heterodimer with NR3C1. May interact with HSD11B2 in the absence of ligand. Binds the coactivators NCOA1, NCOA2, TIF1 and NRIP1.
4 PublicationsProtein-protein interaction databases
BioGRIDi | 110451, 32 interactors |
CORUMi | P08235 |
IntActi | P08235, 7 interactors |
STRINGi | 9606.ENSP00000350815 |
Chemistry databases
BindingDBi | P08235 |
Miscellaneous databases
RNActi | P08235, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P08235 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08235 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 726 – 964 | NR LBDPROSITE-ProRule annotationAdd BLAST | 239 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 602 | ModulatingAdd BLAST | 602 | |
Regioni | 669 – 725 | HingeAdd BLAST | 57 | |
Regioni | 782 – 785 | Important for coactivator binding | 4 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 603 – 623 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 639 – 663 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000159333 |
InParanoidi | P08235 |
OMAi | SFDGNCE |
OrthoDBi | 146963at2759 |
PhylomeDBi | P08235 |
Family and domain databases
DisProti | DP01561 |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
METKGYHSLP EGLDMERRWG QVSQAVERSS LGPTERTDEN NYMEIVNVSC
60 70 80 90 100
VSGAIPNNST QGSSKEKQEL LPCLQQDNNR PGILTSDIKT ELESKELSAT
110 120 130 140 150
VAESMGLYMD SVRDADYSYE QQNQQGSMSP AKIYQNVEQL VKFYKGNGHR
160 170 180 190 200
PSTLSCVNTP LRSFMSDSGS SVNGGVMRAV VKSPIMCHEK SPSVCSPLNM
210 220 230 240 250
TSSVCSPAGI NSVSSTTASF GSFPVHSPIT QGTPLTCSPN VENRGSRSHS
260 270 280 290 300
PAHASNVGSP LSSPLSSMKS SISSPPSHCS VKSPVSSPNN VTLRSSVSSP
310 320 330 340 350
ANINNSRCSV SSPSNTNNRS TLSSPAASTV GSICSPVNNA FSYTASGTSA
360 370 380 390 400
GSSTLRDVVP SPDTQEKGAQ EVPFPKTEEV ESAISNGVTG QLNIVQYIKP
410 420 430 440 450
EPDGAFSSSC LGGNSKINSD SSFSVPIKQE STKHSCSGTS FKGNPTVNPF
460 470 480 490 500
PFMDGSYFSF MDDKDYYSLS GILGPPVPGF DGNCEGSGFP VGIKQEPDDG
510 520 530 540 550
SYYPEASIPS SAIVGVNSGG QSFHYRIGAQ GTISLSRSAR DQSFQHLSSF
560 570 580 590 600
PPVNTLVESW KSHGDLSSRR SDGYPVLEYI PENVSSSTLR SVSTGSSRPS
610 620 630 640 650
KICLVCGDEA SGCHYGVVTC GSCKVFFKRA VEGQHNYLCA GRNDCIIDKI
660 670 680 690 700
RRKNCPACRL QKCLQAGMNL GARKSKKLGK LKGIHEEQPQ QQQPPPPPPP
710 720 730 740 750
PQSPEEGTTY IAPAKEPSVN TALVPQLSTI SRALTPSPVM VLENIEPEIV
760 770 780 790 800
YAGYDSSKPD TAENLLSTLN RLAGKQMIQV VKWAKVLPGF KNLPLEDQIT
810 820 830 840 850
LIQYSWMCLS SFALSWRSYK HTNSQFLYFA PDLVFNEEKM HQSAMYELCQ
860 870 880 890 900
GMHQISLQFV RLQLTFEEYT IMKVLLLLST IPKDGLKSQA AFEEMRTNYI
910 920 930 940 950
KELRKMVTKC PNNSGQSWQR FYQLTKLLDS MHDLVSDLLE FCFYTFRESH
960 970 980
ALKVEFPAML VEIISDQLPK VESGNAKPLY FHRK
The sequence of this isoform differs from the canonical sequence as follows:
672-706: ARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEE → ERRCISLPCMNYARGCTKSAFSSFDCSSPLKNTPS
707-984: Missing.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 946 | F → I in AAI11759 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036063 | 7 | H → Q in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_014623 | 180 | V → I Common polymorphism; decreased mineralocorticoid receptor activity. 3 PublicationsCorresponds to variant dbSNP:rs5522EnsemblClinVar. | 1 | |
Natural variantiVAR_015625 | 241 | V → A Polymorphism; changed mineralocorticoid receptor activity; changed response curve to aldosterone stimulation. 2 Publications | 1 | |
Natural variantiVAR_014624 | 444 | N → T1 PublicationCorresponds to variant dbSNP:rs5523EnsemblClinVar. | 1 | |
Natural variantiVAR_014625 | 537 | R → Q1 PublicationCorresponds to variant dbSNP:rs5526Ensembl. | 1 | |
Natural variantiVAR_014626 | 554 | N → S1 PublicationCorresponds to variant dbSNP:rs5527EnsemblClinVar. | 1 | |
Natural variantiVAR_031268 | 633 | G → R in PHA1A; reduces transcription transactivation upon aldosterone binding. 1 PublicationCorresponds to variant dbSNP:rs121912566EnsemblClinVar. | 1 | |
Natural variantiVAR_031269 | 645 | C → S in PHA1A. 1 Publication | 1 | |
Natural variantiVAR_031270 | 659 | R → S in PHA1A. 1 Publication | 1 | |
Natural variantiVAR_031271 | 759 | P → S in PHA1A. 1 Publication | 1 | |
Natural variantiVAR_031272 | 769 | L → P in PHA1A. 1 Publication | 1 | |
Natural variantiVAR_031273 | 770 | N → K in PHA1A. 1 Publication | 1 | |
Natural variantiVAR_031274 | 776 | Q → R in PHA1A; reduces aldosterone binding. 1 PublicationCorresponds to variant dbSNP:rs121912565EnsemblClinVar. | 1 | |
Natural variantiVAR_031275 | 805 | S → P in PHA1A. 1 Publication | 1 | |
Natural variantiVAR_015626 | 810 | S → L in EOHSEP; alters receptor specificity and leads to constitutive activation. 3 PublicationsCorresponds to variant dbSNP:rs41511344EnsemblClinVar. | 1 | |
Natural variantiVAR_031276 | 815 | S → R in PHA1A. 1 Publication | 1 | |
Natural variantiVAR_031277 | 818 | S → L in PHA1A; abolishes translocation to the nucleus and transcription transactivation upon aldosterone binding. 1 PublicationCorresponds to variant dbSNP:rs121912573EnsemblClinVar. | 1 | |
Natural variantiVAR_029311 | 826 | F → Y. Corresponds to variant dbSNP:rs13306592Ensembl. | 1 | |
Natural variantiVAR_015627 | 924 | L → P in PHA1A; abolishes transcription transactivation upon aldosterone binding. 2 PublicationsCorresponds to variant dbSNP:rs121912563EnsemblClinVar. | 1 | |
Natural variantiVAR_031278 | 972 | E → G in PHA1A; reduces affinity for aldosterone and transcription transactivation. 1 PublicationCorresponds to variant dbSNP:rs121912574EnsemblClinVar. | 1 | |
Natural variantiVAR_031279 | 979 | L → P in PHA1A; loss of aldosterone binding and transcription transactivation. 1 PublicationCorresponds to variant dbSNP:rs121912567EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007357 | 633 | G → GKCSW in isoform 3. Curated | 1 | |
Alternative sequenceiVSP_007360 | 672 – 788 | Missing in isoform 4. 2 PublicationsAdd BLAST | 117 | |
Alternative sequenceiVSP_007358 | 672 – 706 | ARKSK…QSPEE → ERRCISLPCMNYARGCTKSA FSSFDCSSPLKNTPS in isoform 2. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_007359 | 707 – 984 | Missing in isoform 2. 1 PublicationAdd BLAST | 278 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16801 mRNA Translation: AAA59571.1 AJ315514 mRNA Translation: CAC67405.1 AJ315515 mRNA Translation: CAC67406.1 EU326312 Genomic DNA Translation: ACA05924.1 EU326312 Genomic DNA Translation: ACA05925.1 FJ515829 Genomic DNA Translation: ACS13716.1 FJ515829 Genomic DNA Translation: ACS13717.1 AC069272 Genomic DNA No translation available. AC093678 Genomic DNA No translation available. AC093881 Genomic DNA No translation available. AC104691 Genomic DNA No translation available. AC106899 Genomic DNA No translation available. BC111758 mRNA Translation: AAI11759.1 AH006913 Genomic DNA Translation: AAC63513.1 |
CCDSi | CCDS3772.1 [P08235-1] CCDS54811.1 [P08235-4] |
PIRi | A29513 |
RefSeqi | NP_000892.2, NM_000901.4 [P08235-1] NP_001159576.1, NM_001166104.1 [P08235-4] XP_011530277.1, XM_011531975.1 [P08235-3] XP_011530278.1, XM_011531976.2 XP_011530279.1, XM_011531977.2 XP_016863706.1, XM_017008217.1 |
Genome annotation databases
Ensembli | ENST00000342437; ENSP00000343907; ENSG00000151623 [P08235-2] ENST00000344721; ENSP00000341390; ENSG00000151623 [P08235-1] ENST00000358102; ENSP00000350815; ENSG00000151623 [P08235-1] ENST00000511528; ENSP00000421481; ENSG00000151623 [P08235-3] ENST00000512865; ENSP00000423510; ENSG00000151623 [P08235-4] ENST00000625323; ENSP00000486719; ENSG00000151623 [P08235-3] |
GeneIDi | 4306 |
KEGGi | hsa:4306 |
UCSCi | uc003ilk.5, human [P08235-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Wikipedia Mineralocorticoid receptor entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16801 mRNA Translation: AAA59571.1 AJ315514 mRNA Translation: CAC67405.1 AJ315515 mRNA Translation: CAC67406.1 EU326312 Genomic DNA Translation: ACA05924.1 EU326312 Genomic DNA Translation: ACA05925.1 FJ515829 Genomic DNA Translation: ACS13716.1 FJ515829 Genomic DNA Translation: ACS13717.1 AC069272 Genomic DNA No translation available. AC093678 Genomic DNA No translation available. AC093881 Genomic DNA No translation available. AC104691 Genomic DNA No translation available. AC106899 Genomic DNA No translation available. BC111758 mRNA Translation: AAI11759.1 AH006913 Genomic DNA Translation: AAC63513.1 |
CCDSi | CCDS3772.1 [P08235-1] CCDS54811.1 [P08235-4] |
PIRi | A29513 |
RefSeqi | NP_000892.2, NM_000901.4 [P08235-1] NP_001159576.1, NM_001166104.1 [P08235-4] XP_011530277.1, XM_011531975.1 [P08235-3] XP_011530278.1, XM_011531976.2 XP_011530279.1, XM_011531977.2 XP_016863706.1, XM_017008217.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Y9R | X-ray | 1.96 | A/B | 731-984 | [»] | |
1YA3 | X-ray | 2.34 | A/B/C | 731-984 | [»] | |
2A3I | X-ray | 1.95 | A | 732-984 | [»] | |
2AA2 | X-ray | 1.95 | A | 712-984 | [»] | |
2AA5 | X-ray | 2.20 | A/B | 712-984 | [»] | |
2AA6 | X-ray | 1.95 | A/B | 712-984 | [»] | |
2AA7 | X-ray | 2.20 | A | 712-984 | [»] | |
2AAX | X-ray | 1.75 | A/B | 712-984 | [»] | |
2AB2 | X-ray | 1.85 | A/B | 712-984 | [»] | |
2ABI | X-ray | 2.33 | A/B/C | 731-984 | [»] | |
2OAX | X-ray | 2.29 | A/B/C/D/E/F | 731-984 | [»] | |
3VHU | X-ray | 2.11 | A | 712-984 | [»] | |
3VHV | X-ray | 1.35 | A | 727-984 | [»] | |
3WFF | X-ray | 2.05 | A | 712-984 | [»] | |
3WFG | X-ray | 1.40 | A | 712-984 | [»] | |
4PF3 | X-ray | 1.10 | A | 712-984 | [»] | |
4TNT | X-ray | 2.39 | A/B | 593-671 | [»] | |
4UDA | X-ray | 2.03 | A | 735-984 | [»] | |
4UDB | X-ray | 2.36 | A | 735-984 | [»] | |
5HCV | X-ray | 2.50 | A/B/C | 732-984 | [»] | |
5L7E | X-ray | 1.86 | A | 735-984 | [»] | |
5L7G | X-ray | 2.01 | A | 735-984 | [»] | |
5L7H | X-ray | 1.84 | A | 735-984 | [»] | |
5MWP | X-ray | 1.82 | A | 735-984 | [»] | |
5MWY | X-ray | 1.75 | A | 735-984 | [»] | |
6GEV | X-ray | 1.54 | A | 735-984 | [»] | |
6GG8 | X-ray | 1.80 | A | 735-984 | [»] | |
6GGG | X-ray | 1.71 | A | 735-984 | [»] | |
6L88 | X-ray | 3.00 | A/B/C/D | 735-984 | [»] | |
SMRi | P08235 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110451, 32 interactors |
CORUMi | P08235 |
IntActi | P08235, 7 interactors |
STRINGi | 9606.ENSP00000350815 |
Chemistry databases
BindingDBi | P08235 |
ChEMBLi | CHEMBL1994 |
DrugBanki | DB04630, Aldosterone DB01013, Clobetasol propionate DB04652, Corticosterone DB06780, Desoxycorticosterone acetate DB01134, Desoxycorticosterone pivalate DB01395, Drospirenone DB00700, Eplerenone DB01023, Felodipine DB00687, Fludrocortisone DB13867, Fluticasone DB08906, Fluticasone furoate DB00588, Fluticasone propionate DB02998, Metribolone DB00393, Nimodipine DB00396, Progesterone DB00421, Spironolactone DB02901, Stanolone DB13951, Stanolone acetate DB00624, Testosterone DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB13946, Testosterone undecanoate |
DrugCentrali | P08235 |
GuidetoPHARMACOLOGYi | 626 |
PTM databases
iPTMneti | P08235 |
PhosphoSitePlusi | P08235 |
Polymorphism and mutation databases
BioMutai | NR3C2 |
DMDMi | 126885 |
Proteomic databases
jPOSTi | P08235 |
MassIVEi | P08235 |
MaxQBi | P08235 |
PaxDbi | P08235 |
PeptideAtlasi | P08235 |
PRIDEi | P08235 |
ProteomicsDBi | 2889 2891 52088 [P08235-1] 52089 [P08235-2] 52090 [P08235-3] 52091 [P08235-4] |
Protocols and materials databases
Antibodypediai | 3971, 291 antibodies |
Genome annotation databases
Ensembli | ENST00000342437; ENSP00000343907; ENSG00000151623 [P08235-2] ENST00000344721; ENSP00000341390; ENSG00000151623 [P08235-1] ENST00000358102; ENSP00000350815; ENSG00000151623 [P08235-1] ENST00000511528; ENSP00000421481; ENSG00000151623 [P08235-3] ENST00000512865; ENSP00000423510; ENSG00000151623 [P08235-4] ENST00000625323; ENSP00000486719; ENSG00000151623 [P08235-3] |
GeneIDi | 4306 |
KEGGi | hsa:4306 |
UCSCi | uc003ilk.5, human [P08235-1] |
Organism-specific databases
CTDi | 4306 |
DisGeNETi | 4306 |
EuPathDBi | HostDB:ENSG00000151623.14 |
GeneCardsi | NR3C2 |
HGNCi | HGNC:7979, NR3C2 |
HPAi | ENSG00000151623, Low tissue specificity |
MalaCardsi | NR3C2 |
MIMi | 177735, phenotype 600983, gene 605115, phenotype |
neXtProti | NX_P08235 |
OpenTargetsi | ENSG00000151623 |
Orphaneti | 171871, Renal pseudohypoaldosteronism type 1 |
PharmGKBi | PA242 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000159333 |
InParanoidi | P08235 |
OMAi | SFDGNCE |
OrthoDBi | 146963at2759 |
PhylomeDBi | P08235 |
Enzyme and pathway databases
PathwayCommonsi | P08235 |
Reactomei | R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-4090294, SUMOylation of intracellular receptors |
SignaLinki | P08235 |
SIGNORi | P08235 |
Miscellaneous databases
BioGRID-ORCSi | 4306, 5 hits in 871 CRISPR screens |
ChiTaRSi | NR3C2, human |
EvolutionaryTracei | P08235 |
GeneWikii | Mineralocorticoid_receptor |
GenomeRNAii | 4306 |
Pharosi | P08235, Tclin |
PROi | PR:P08235 |
RNActi | P08235, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151623, Expressed in colonic mucosa and 230 other tissues |
ExpressionAtlasi | P08235, baseline and differential |
Family and domain databases
DisProti | DP01561 |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MCR_HUMAN | |
Accessioni | P08235Primary (citable) accession number: P08235 Secondary accession number(s): B0ZBF5 Q96KQ9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | September 12, 2018 | |
Last modified: | December 2, 2020 | |
This is version 227 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations