UniProtKB - P08218 (CEL2B_HUMAN)
Protein
Chymotrypsin-like elastase family member 2B
Gene
CELA2B
Organism
Homo sapiens (Human)
Status
Functioni
Acts upon elastin.
Catalytic activityi
- Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin. EC:3.4.21.71
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 73 | Charge relay systemBy similarity | 1 | |
Active sitei | 121 | Charge relay systemBy similarity | 1 | |
Active sitei | 216 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- serine-type endopeptidase activity Source: GO_Central
GO - Biological processi
- proteolysis Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Enzyme and pathway databases
PathwayCommonsi | P08218 |
Protein family/group databases
MEROPSi | S01.206 |
Names & Taxonomyi
Protein namesi | Recommended name: Chymotrypsin-like elastase family member 2B (EC:3.4.21.71)Alternative name(s): Elastase-2B |
Gene namesi | Name:CELA2B Synonyms:ELA2B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29995, CELA2B |
MIMi | 609444, gene |
neXtProti | NX_P08218 |
VEuPathDBi | HostDB:ENSG00000215704.9 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: ProtInc
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 51032 |
OpenTargetsi | ENSG00000215704 |
PharmGKBi | PA165750841 |
Miscellaneous databases
Pharosi | P08218, Tdark |
Genetic variation databases
BioMutai | CELA2B |
DMDMi | 212288098 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Add BLAST | 16 | |
PropeptideiPRO_0000027695 | 17 – 28 | Activation peptideAdd BLAST | 12 | |
ChainiPRO_0000027696 | 29 – 269 | Chymotrypsin-like elastase family member 2BAdd BLAST | 241 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 58 ↔ 74 | PROSITE-ProRule annotation | ||
Disulfide bondi | 155 ↔ 222 | PROSITE-ProRule annotation | ||
Disulfide bondi | 186 ↔ 202 | PROSITE-ProRule annotation | ||
Disulfide bondi | 212 ↔ 243 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, ZymogenProteomic databases
MassIVEi | P08218 |
PaxDbi | P08218 |
PeptideAtlasi | P08218 |
PRIDEi | P08218 |
ProteomicsDBi | 52087 |
Expressioni
Tissue specificityi
Pancreas.
Gene expression databases
Bgeei | ENSG00000215704, Expressed in pancreas and 111 other tissues |
ExpressionAtlasi | P08218, baseline and differential |
Genevisiblei | P08218, HS |
Organism-specific databases
HPAi | ENSG00000215704, Tissue enriched (pancreas) |
Interactioni
Binary interactionsi
Hide detailsP08218
With | #Exp. | IntAct |
---|---|---|
CALCOCO2 [Q13137] | 3 | EBI-11478642,EBI-739580 |
KRTAP3-1 [Q9BYR8] | 3 | EBI-11478642,EBI-9996449 |
ZDHHC15 [Q96MV8] | 3 | EBI-11478642,EBI-12837904 |
Protein-protein interaction databases
BioGRIDi | 119238, 19 interactors |
IntActi | P08218, 15 interactors |
MINTi | P08218 |
STRINGi | 9606.ENSP00000365075 |
Miscellaneous databases
RNActi | P08218, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 267 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 239 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT01010000222358 |
HOGENOMi | CLU_006842_0_4_1 |
InParanoidi | P08218 |
OMAi | AHCIGSY |
OrthoDBi | 1314811at2759 |
PhylomeDBi | P08218 |
TreeFami | TF330455 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P08218-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIRTLLLSTL VAGALSCGVS TYAPDMSRML GGEEARPNSW PWQVSLQYSS
60 70 80 90 100
NGQWYHTCGG SLIANSWVLT AAHCISSSGI YRVMLGQHNL YVAESGSLAV
110 120 130 140 150
SVSKIVVHKD WNSDQVSKGN DIALLKLANP VSLTDKIQLA CLPPAGTILP
160 170 180 190 200
NNYPCYVTGW GRLQTNGALP DDLKQGQLLV VDYATCSSSG WWGSTVKTNM
210 220 230 240 250
ICAGGDGVIC TCNGDSGGPL NCQASDGRWE VHGIGSLTSV LGCNYYYKPS
260
IFTRVSNYND WINSVIANN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5JRU4 | Q5JRU4_HUMAN | Chymotrypsin-like elastase family m... | CELA2B | 125 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_044534 | 79 | G → R2 PublicationsCorresponds to variant dbSNP:rs3820071Ensembl. | 1 | |
Natural variantiVAR_044535 | 114 | D → N2 PublicationsCorresponds to variant dbSNP:rs3766160Ensembl. | 1 | |
Natural variantiVAR_044536 | 177 | Q → R2 PublicationsCorresponds to variant dbSNP:rs6429745Ensembl. | 1 | |
Natural variantiVAR_044537 | 235 | G → S. Corresponds to variant dbSNP:rs3737703Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16653 mRNA Translation: AAA52381.1 AL512883 Genomic DNA No translation available. CH471167 Genomic DNA Translation: EAW51728.1 BC069455 mRNA Translation: AAH69455.1 BC113540 mRNA Translation: AAI13541.1 BC113542 mRNA Translation: AAI13543.1 |
CCDSi | CCDS30605.1 |
PIRi | C26823 |
RefSeqi | NP_056933.2, NM_015849.2 |
Genome annotation databases
Ensembli | ENST00000375910; ENSP00000365075; ENSG00000215704 |
GeneIDi | 51032 |
KEGGi | hsa:51032 |
UCSCi | uc001awl.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M16653 mRNA Translation: AAA52381.1 AL512883 Genomic DNA No translation available. CH471167 Genomic DNA Translation: EAW51728.1 BC069455 mRNA Translation: AAH69455.1 BC113540 mRNA Translation: AAI13541.1 BC113542 mRNA Translation: AAI13543.1 |
CCDSi | CCDS30605.1 |
PIRi | C26823 |
RefSeqi | NP_056933.2, NM_015849.2 |
3D structure databases
SMRi | P08218 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119238, 19 interactors |
IntActi | P08218, 15 interactors |
MINTi | P08218 |
STRINGi | 9606.ENSP00000365075 |
Protein family/group databases
MEROPSi | S01.206 |
Genetic variation databases
BioMutai | CELA2B |
DMDMi | 212288098 |
Proteomic databases
MassIVEi | P08218 |
PaxDbi | P08218 |
PeptideAtlasi | P08218 |
PRIDEi | P08218 |
ProteomicsDBi | 52087 |
Protocols and materials databases
Antibodypediai | 53459, 8 antibodies |
DNASUi | 51032 |
Genome annotation databases
Ensembli | ENST00000375910; ENSP00000365075; ENSG00000215704 |
GeneIDi | 51032 |
KEGGi | hsa:51032 |
UCSCi | uc001awl.3, human |
Organism-specific databases
CTDi | 51032 |
DisGeNETi | 51032 |
GeneCardsi | CELA2B |
HGNCi | HGNC:29995, CELA2B |
HPAi | ENSG00000215704, Tissue enriched (pancreas) |
MIMi | 609444, gene |
neXtProti | NX_P08218 |
OpenTargetsi | ENSG00000215704 |
PharmGKBi | PA165750841 |
VEuPathDBi | HostDB:ENSG00000215704.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT01010000222358 |
HOGENOMi | CLU_006842_0_4_1 |
InParanoidi | P08218 |
OMAi | AHCIGSY |
OrthoDBi | 1314811at2759 |
PhylomeDBi | P08218 |
TreeFami | TF330455 |
Enzyme and pathway databases
PathwayCommonsi | P08218 |
Miscellaneous databases
BioGRID-ORCSi | 51032, 5 hits in 983 CRISPR screens |
GeneWikii | CELA2B |
GenomeRNAii | 51032 |
Pharosi | P08218, Tdark |
PROi | PR:P08218 |
RNActi | P08218, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000215704, Expressed in pancreas and 111 other tissues |
ExpressionAtlasi | P08218, baseline and differential |
Genevisiblei | P08218, HS |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CEL2B_HUMAN | |
Accessioni | P08218Primary (citable) accession number: P08218 Secondary accession number(s): Q14D16, Q6ISM5, Q96QV5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | July 22, 2008 | |
Last modified: | April 7, 2021 | |
This is version 177 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families