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Protein

Chymotrypsin-like elastase family member 2B

Gene

CELA2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts upon elastin.

Catalytic activityi

Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Charge relay systemBy similarity1
Active sitei121Charge relay systemBy similarity1
Active sitei216Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.206

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like elastase family member 2B (EC:3.4.21.71)
Alternative name(s):
Elastase-2B
Gene namesi
Name:CELA2B
Synonyms:ELA2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000215704.9
HGNCiHGNC:29995 CELA2B
MIMi609444 gene
neXtProtiNX_P08218

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000215704
PharmGKBiPA165750841

Polymorphism and mutation databases

BioMutaiCELA2B
DMDMi212288098

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
PropeptideiPRO_000002769517 – 28Activation peptideAdd BLAST12
ChainiPRO_000002769629 – 269Chymotrypsin-like elastase family member 2BAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 74PROSITE-ProRule annotation
Disulfide bondi155 ↔ 222PROSITE-ProRule annotation
Disulfide bondi186 ↔ 202PROSITE-ProRule annotation
Disulfide bondi212 ↔ 243PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP08218
PeptideAtlasiP08218
PRIDEiP08218
ProteomicsDBi52087

Miscellaneous databases

PMAP-CutDBiP08218

Expressioni

Tissue specificityi

Pancreas.

Gene expression databases

BgeeiENSG00000215704 Expressed in 91 organ(s), highest expression level in duodenum
ExpressionAtlasiP08218 baseline and differential
GenevisibleiP08218 HS

Interactioni

Protein-protein interaction databases

BioGridi119238, 16 interactors
IntActiP08218, 4 interactors
MINTiP08218
STRINGi9606.ENSP00000365075

Structurei

3D structure databases

ProteinModelPortaliP08218
SMRiP08218
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 267Peptidase S1PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
InParanoidiP08218
KOiK01346
OMAiSSNTACY
OrthoDBiEOG091G0DF7
PhylomeDBiP08218
TreeFamiTF330455

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P08218-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIRTLLLSTL VAGALSCGVS TYAPDMSRML GGEEARPNSW PWQVSLQYSS
60 70 80 90 100
NGQWYHTCGG SLIANSWVLT AAHCISSSGI YRVMLGQHNL YVAESGSLAV
110 120 130 140 150
SVSKIVVHKD WNSDQVSKGN DIALLKLANP VSLTDKIQLA CLPPAGTILP
160 170 180 190 200
NNYPCYVTGW GRLQTNGALP DDLKQGQLLV VDYATCSSSG WWGSTVKTNM
210 220 230 240 250
ICAGGDGVIC TCNGDSGGPL NCQASDGRWE VHGIGSLTSV LGCNYYYKPS
260
IFTRVSNYND WINSVIANN
Length:269
Mass (Da):28,810
Last modified:July 22, 2008 - v2
Checksum:iCC81C1D18B918B5F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JRU4Q5JRU4_HUMAN
Chymotrypsin-like elastase family m...
CELA2B
125Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04453479G → R2 PublicationsCorresponds to variant dbSNP:rs3820071Ensembl.1
Natural variantiVAR_044535114D → N2 PublicationsCorresponds to variant dbSNP:rs3766160Ensembl.1
Natural variantiVAR_044536177Q → R2 PublicationsCorresponds to variant dbSNP:rs6429745Ensembl.1
Natural variantiVAR_044537235G → S. Corresponds to variant dbSNP:rs3737703Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16653 mRNA Translation: AAA52381.1
AL512883 Genomic DNA No translation available.
CH471167 Genomic DNA Translation: EAW51728.1
BC069455 mRNA Translation: AAH69455.1
BC113540 mRNA Translation: AAI13541.1
BC113542 mRNA Translation: AAI13543.1
CCDSiCCDS30605.1
PIRiC26823
RefSeqiNP_056933.2, NM_015849.2
UniGeneiHs.631871

Genome annotation databases

EnsembliENST00000375910; ENSP00000365075; ENSG00000215704
GeneIDi51032
KEGGihsa:51032
UCSCiuc001awl.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16653 mRNA Translation: AAA52381.1
AL512883 Genomic DNA No translation available.
CH471167 Genomic DNA Translation: EAW51728.1
BC069455 mRNA Translation: AAH69455.1
BC113540 mRNA Translation: AAI13541.1
BC113542 mRNA Translation: AAI13543.1
CCDSiCCDS30605.1
PIRiC26823
RefSeqiNP_056933.2, NM_015849.2
UniGeneiHs.631871

3D structure databases

ProteinModelPortaliP08218
SMRiP08218
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119238, 16 interactors
IntActiP08218, 4 interactors
MINTiP08218
STRINGi9606.ENSP00000365075

Protein family/group databases

MEROPSiS01.206

Polymorphism and mutation databases

BioMutaiCELA2B
DMDMi212288098

Proteomic databases

PaxDbiP08218
PeptideAtlasiP08218
PRIDEiP08218
ProteomicsDBi52087

Protocols and materials databases

DNASUi51032
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375910; ENSP00000365075; ENSG00000215704
GeneIDi51032
KEGGihsa:51032
UCSCiuc001awl.3 human

Organism-specific databases

CTDi51032
EuPathDBiHostDB:ENSG00000215704.9
GeneCardsiCELA2B
HGNCiHGNC:29995 CELA2B
MIMi609444 gene
neXtProtiNX_P08218
OpenTargetsiENSG00000215704
PharmGKBiPA165750841
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
InParanoidiP08218
KOiK01346
OMAiSSNTACY
OrthoDBiEOG091G0DF7
PhylomeDBiP08218
TreeFamiTF330455

Miscellaneous databases

GeneWikiiCELA2B
GenomeRNAii51032
PMAP-CutDBiP08218
PROiPR:P08218
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000215704 Expressed in 91 organ(s), highest expression level in duodenum
ExpressionAtlasiP08218 baseline and differential
GenevisibleiP08218 HS

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCEL2B_HUMAN
AccessioniPrimary (citable) accession number: P08218
Secondary accession number(s): Q14D16, Q6ISM5, Q96QV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 22, 2008
Last modified: November 7, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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