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Protein

Chymotrypsin-like elastase family member 2A

Gene

CELA2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts upon elastin.

Catalytic activityi

Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Charge relay systemBy similarity1
Active sitei121Charge relay systemBy similarity1
Active sitei216Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope

Protein family/group databases

MEROPSiS01.155

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like elastase family member 2A (EC:3.4.21.71)
Alternative name(s):
Elastase-2A
Gene namesi
Name:CELA2A
Synonyms:ELA2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142615.7
HGNCiHGNC:24609 CELA2A
MIMi609443 gene
neXtProtiNX_P08217

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi63036
OpenTargetsiENSG00000142615
PharmGKBiPA165750794

Chemistry databases

DrugBankiDB06901 2-(2-HYDROXY-CYCLOPENTYL)-PENT-4-ENAL

Polymorphism and mutation databases

BioMutaiCELA2A
DMDMi119255

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Add BLAST16
PropeptideiPRO_000002769317 – 28Activation peptideAdd BLAST12
ChainiPRO_000002769429 – 269Chymotrypsin-like elastase family member 2AAdd BLAST241

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 74PROSITE-ProRule annotation
Disulfide bondi155 ↔ 222PROSITE-ProRule annotation
Disulfide bondi186 ↔ 202PROSITE-ProRule annotation
Disulfide bondi212 ↔ 243PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP08217
PeptideAtlasiP08217
PRIDEiP08217
ProteomicsDBi52086

PTM databases

iPTMnetiP08217
PhosphoSitePlusiP08217

Miscellaneous databases

PMAP-CutDBiP08217

Expressioni

Tissue specificityi

Pancreas. Not detected in keratinocytes.1 Publication

Gene expression databases

BgeeiENSG00000142615 Expressed in 81 organ(s), highest expression level in body of pancreas
GenevisibleiP08217 HS

Interactioni

Subunit structurei

Interacts with CPA1.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000352639

Structurei

3D structure databases

ProteinModelPortaliP08217
SMRiP08217
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 267Peptidase S1PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000119027
HOGENOMiHOG000251820
InParanoidiP08217
KOiK01346
OMAiKIQLGCL
OrthoDBiEOG091G0DF7
PhylomeDBiP08217
TreeFamiTF330455

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08217-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIRTLLLSTL VAGALSCGDP TYPPYVTRVV GGEEARPNSW PWQVSLQYSS
60 70 80 90 100
NGKWYHTCGG SLIANSWVLT AAHCISSSRT YRVGLGRHNL YVAESGSLAV
110 120 130 140 150
SVSKIVVHKD WNSNQISKGN DIALLKLANP VSLTDKIQLA CLPPAGTILP
160 170 180 190 200
NNYPCYVTGW GRLQTNGAVP DVLQQGRLLV VDYATCSSSA WWGSSVKTSM
210 220 230 240 250
ICAGGDGVIS SCNGDSGGPL NCQASDGRWQ VHGIVSFGSR LGCNYYHKPS
260
VFTRVSNYID WINSVIANN
Length:269
Mass (Da):28,888
Last modified:August 1, 1988 - v1
Checksum:iA2E05143EFF4987C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti202C → V in BAA00165 (PubMed:2834346).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051837257N → S. Corresponds to variant dbSNP:rs2303193Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16631 mRNA Translation: AAA52374.1
M16652 mRNA Translation: AAA52380.1
D00236 mRNA Translation: BAA00165.1
AK312198 mRNA Translation: BAG35131.1
AK056678 mRNA Translation: BAG51782.1
AL512883 Genomic DNA No translation available.
CH471167 Genomic DNA Translation: EAW51727.1
BC007031 mRNA Translation: AAH07031.1
CCDSiCCDS157.1
PIRiB26823
RefSeqiNP_254275.1, NM_033440.2
UniGeneiHs.631866

Genome annotation databases

EnsembliENST00000359621; ENSP00000352639; ENSG00000142615
GeneIDi63036
KEGGihsa:63036
UCSCiuc001awk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCEL2A_HUMAN
AccessioniPrimary (citable) accession number: P08217
Secondary accession number(s): B2R5I4, Q14243
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 12, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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