Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein S100-A10

Gene

S100a10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

Miscellaneous

Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-75205 Dissolution of Fibrin Clot

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A10
Alternative name(s):
Calpactin I light chain
Calpactin-1 light chain
Cellular ligand of annexin II
S100 calcium-binding protein A10
p10 protein
p11
Gene namesi
Name:S100a10
Synonyms:Cal1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1339468 S100a10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440041 – 97Protein S100-A10Add BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineCombined sources1
Modified residuei28N6-acetyllysineBy similarity1
Modified residuei54N6-acetyllysineBy similarity1
Modified residuei57N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP08207
PaxDbiP08207
PeptideAtlasiP08207
PRIDEiP08207

PTM databases

iPTMnetiP08207
PhosphoSitePlusiP08207

Expressioni

Gene expression databases

BgeeiENSMUSG00000041959 Expressed in 338 organ(s), highest expression level in cornea
CleanExiMM_S100A10
ExpressionAtlasiP08207 baseline and differential
GenevisibleiP08207 MM

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Anxa2P073562EBI-643986,EBI-738510

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203049, 5 interactors
ComplexPortaliCPX-898 Annexin A2 - S100-A10 complex
CPX-899 SMARCA3 - Annexin A2 - S100-A10 complex
CPX-905 AHNAK - Annexin A2 - S100-A10 complex
CORUMiP08207
IntActiP08207, 8 interactors
MINTiP08207
STRINGi10090.ENSMUSP00000036949

Structurei

3D structure databases

ProteinModelPortaliP08207
SMRiP08207
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 71Ancestral calcium siteAdd BLAST12

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXW9 Eukaryota
ENOG410YSSI LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP08207
KOiK17274
OMAiAMETLMF
OrthoDBiEOG091G10QT
PhylomeDBiP08207
TreeFamiTF332727

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR028476 S100-A10
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF74 PTHR11639:SF74, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

P08207-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSQMEHAME TMMLTFHRFA GDKDHLTKED LRVLMEREFP GFLENQKDPL
60 70 80 90
AVDKIMKDLD QCRDGKVGFQ SFLSLVAGLT IACNDYFVVN MKQKGKK
Length:97
Mass (Da):11,186
Last modified:January 23, 2007 - v2
Checksum:iE7F092D4DAF6B43E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16465 mRNA Translation: AAA37363.1
BC025044 mRNA Translation: AAH25044.1
CCDSiCCDS38526.1
PIRiA28489
RefSeqiNP_033138.1, NM_009112.2
UniGeneiMm.1

Genome annotation databases

EnsembliENSMUST00000045756; ENSMUSP00000036949; ENSMUSG00000041959
ENSMUST00000170612; ENSMUSP00000130712; ENSMUSG00000041959
GeneIDi20194
KEGGimmu:20194
UCSCiuc008qfk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16465 mRNA Translation: AAA37363.1
BC025044 mRNA Translation: AAH25044.1
CCDSiCCDS38526.1
PIRiA28489
RefSeqiNP_033138.1, NM_009112.2
UniGeneiMm.1

3D structure databases

ProteinModelPortaliP08207
SMRiP08207
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203049, 5 interactors
ComplexPortaliCPX-898 Annexin A2 - S100-A10 complex
CPX-899 SMARCA3 - Annexin A2 - S100-A10 complex
CPX-905 AHNAK - Annexin A2 - S100-A10 complex
CORUMiP08207
IntActiP08207, 8 interactors
MINTiP08207
STRINGi10090.ENSMUSP00000036949

PTM databases

iPTMnetiP08207
PhosphoSitePlusiP08207

Proteomic databases

EPDiP08207
PaxDbiP08207
PeptideAtlasiP08207
PRIDEiP08207

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045756; ENSMUSP00000036949; ENSMUSG00000041959
ENSMUST00000170612; ENSMUSP00000130712; ENSMUSG00000041959
GeneIDi20194
KEGGimmu:20194
UCSCiuc008qfk.1 mouse

Organism-specific databases

CTDi6281
MGIiMGI:1339468 S100a10

Phylogenomic databases

eggNOGiENOG410IXW9 Eukaryota
ENOG410YSSI LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP08207
KOiK17274
OMAiAMETLMF
OrthoDBiEOG091G10QT
PhylomeDBiP08207
TreeFamiTF332727

Enzyme and pathway databases

ReactomeiR-MMU-75205 Dissolution of Fibrin Clot

Miscellaneous databases

PROiPR:P08207
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041959 Expressed in 338 organ(s), highest expression level in cornea
CleanExiMM_S100A10
ExpressionAtlasiP08207 baseline and differential
GenevisibleiP08207 MM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR028476 S100-A10
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PANTHERiPTHR11639:SF74 PTHR11639:SF74, 1 hit
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS10AA_MOUSE
AccessioniPrimary (citable) accession number: P08207
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again