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UniProtKB - P08204 (ARAB_ECOLI)
Protein
Ribulokinase
Gene
araB
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalytic activityi
: L-arabinose degradation via L-ribulose Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes D-xylulose 5-phosphate from L-arabinose (bacterial route). This subpathway is part of the pathway L-arabinose degradation via L-ribulose, which is itself part of Carbohydrate degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-xylulose 5-phosphate from L-arabinose (bacterial route), the pathway L-arabinose degradation via L-ribulose and in Carbohydrate degradation.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- D-ribulokinase activity Source: RHEA
- phosphotransferase activity, alcohol group as acceptor Source: EcoliWiki
- ribulokinase activity Source: EcoCyc
GO - Biological processi
- arabinose catabolic process Source: EcoliWiki
- carbohydrate catabolic process Source: EcoliWiki
- L-arabinose catabolic process Source: EcoliWiki
- L-arabinose catabolic process to xylulose 5-phosphate Source: EcoCyc
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Arabinose catabolism, Carbohydrate metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:RIBULOKIN-MONOMER |
UniPathwayi | UPA00145;UER00566 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:araB Ordered Locus Names:b0063, JW0062 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000198358 | 2 – 566 | RibulokinaseAdd BLAST | 565 |
Proteomic databases
PaxDbi | P08204 |
PRIDEi | P08204 |
Expressioni
Inductioni
Induced by arabinose. Transcription is dependent on the transcription factor AraC, the cAMP receptor protein (CRP) and cAMP.2 Publications
Family & Domainsi
Sequence similaritiesi
Belongs to the ribulokinase family.Curated
Phylogenomic databases
eggNOGi | COG1069, Bacteria |
HOGENOMi | CLU_009281_9_1_6 |
InParanoidi | P08204 |
PhylomeDBi | P08204 |
Family and domain databases
CDDi | cd07781, FGGY_RBK, 1 hit |
HAMAPi | MF_00520, Ribulokinase, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018485, Carb_kinase_FGGY_C IPR005929, Ribulokinase |
Pfami | View protein in Pfam PF02782, FGGY_C, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
TIGRFAMsi | TIGR01234, L-ribulokinase, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P08204-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAIAIGLDFG SDSVRALAVD CATGEEIATS VEWYPRWQKG QFCDAPNNQF
60 70 80 90 100
RHHPRDYIES MEAALKTVLA ELSVEQRAAV VGIGVDSTGS TPAPIDADGN
110 120 130 140 150
VLALRPEFAE NPNAMFVLWK DHTAVEEAEE ITRLCHAPGN VDYSRYIGGI
160 170 180 190 200
YSSEWFWAKI LHVTRQDSAV AQSAASWIEL CDWVPALLSG TTRPQDIRRG
210 220 230 240 250
RCSAGHKSLW HESWGGLPPA SFFDELDPIL NRHLPSPLFT DTWTADIPVG
260 270 280 290 300
TLCPEWAQRL GLPESVVISG GAFDCHMGAV GAGAQPNALV KVIGTSTCDI
310 320 330 340 350
LIADKQSVGE RAVKGICGQV DGSVVPGFIG LEAGQSAFGD IYAWFGRVLG
360 370 380 390 400
WPLEQLAAQH PELKTQINAS QKQLLPALTE AWAKNPSLDH LPVVLDWFNG
410 420 430 440 450
RRTPNANQRL KGVITDLNLA TDAPLLFGGL IAATAFGARA IMECFTDQGI
460 470 480 490 500
AVNNVMALGG IARKNQVIMQ ACCDVLNRPL QIVASDQCCA LGAAIFAAVA
510 520 530 540 550
AKVHADIPSA QQKMASAVEK TLQPCSEQAQ RFEQLYRRYQ QWAMSAEQHY
560
LPTSAPAQAA QAVATL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | T → S in AAA23462 (PubMed:3549454).Curated | 1 | |
Sequence conflicti | 127 – 128 | EA → RS in AAA23462 (PubMed:3549454).Curated | 2 | |
Sequence conflicti | 350 | G → S in AAA23462 (PubMed:3549454).Curated | 1 | |
Sequence conflicti | 365 | T → A in AAA23462 (PubMed:3549454).Curated | 1 | |
Sequence conflicti | 403 | T → S in AAA23462 (PubMed:3549454).Curated | 1 | |
Sequence conflicti | 525 | C → R in AAA23462 (PubMed:3549454).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15263 Genomic DNA Translation: AAA23462.1 J01641 Genomic DNA Translation: AAA23467.1 U00096 Genomic DNA Translation: AAC73174.1 AP009048 Genomic DNA Translation: BAB96632.2 K01304 mRNA Translation: AAA23465.1 |
PIRi | G64727, KIECRU |
RefSeqi | NP_414605.1, NC_000913.3 WP_000951856.1, NZ_STEB01000010.1 |
Genome annotation databases
EnsemblBacteriai | AAC73174; AAC73174; b0063 BAB96632; BAB96632; BAB96632 |
GeneIDi | 946017 |
KEGGi | ecj:JW0062 eco:b0063 |
PATRICi | fig|1411691.4.peg.2220 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15263 Genomic DNA Translation: AAA23462.1 J01641 Genomic DNA Translation: AAA23467.1 U00096 Genomic DNA Translation: AAC73174.1 AP009048 Genomic DNA Translation: BAB96632.2 K01304 mRNA Translation: AAA23465.1 |
PIRi | G64727, KIECRU |
RefSeqi | NP_414605.1, NC_000913.3 WP_000951856.1, NZ_STEB01000010.1 |
3D structure databases
SMRi | P08204 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P08204, 1 interactor |
STRINGi | 511145.b0063 |
Proteomic databases
PaxDbi | P08204 |
PRIDEi | P08204 |
Protocols and materials databases
DNASUi | 946017 |
Genome annotation databases
EnsemblBacteriai | AAC73174; AAC73174; b0063 BAB96632; BAB96632; BAB96632 |
GeneIDi | 946017 |
KEGGi | ecj:JW0062 eco:b0063 |
PATRICi | fig|1411691.4.peg.2220 |
Organism-specific databases
EchoBASEi | EB0051 |
Phylogenomic databases
eggNOGi | COG1069, Bacteria |
HOGENOMi | CLU_009281_9_1_6 |
InParanoidi | P08204 |
PhylomeDBi | P08204 |
Enzyme and pathway databases
UniPathwayi | UPA00145;UER00566 |
BioCyci | EcoCyc:RIBULOKIN-MONOMER |
Miscellaneous databases
PROi | PR:P08204 |
Family and domain databases
CDDi | cd07781, FGGY_RBK, 1 hit |
HAMAPi | MF_00520, Ribulokinase, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR018485, Carb_kinase_FGGY_C IPR005929, Ribulokinase |
Pfami | View protein in Pfam PF02782, FGGY_C, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
TIGRFAMsi | TIGR01234, L-ribulokinase, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARAB_ECOLI | |
Accessioni | P08204Primary (citable) accession number: P08204 Secondary accession number(s): P78041 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 161 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families