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Entry version 234 (29 Sep 2021)
Sequence version 3 (01 Sep 2009)
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Protein

4F2 cell-surface antigen heavy chain

Gene

SLC3A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of several heterodimeric complexes involved in amino acid transport (PubMed:11557028, PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:11311135, PubMed:30341327).

The precise substrate specificity depends on the other subunit in the heterodimer (PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:30867591, PubMed:10903140).

The complexes function as amino acid exchangers (PubMed:11557028, PubMed:10903140, PubMed:12117417, PubMed:12225859, PubMed:30867591).

The homodimer functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan (PubMed:9751058, PubMed:11557028, PubMed:11311135, PubMed:11564694, PubMed:12117417, PubMed:12225859, PubMed:25998567, PubMed:30867591).

The heterodimer formed by SLC3A2 and SLC7A6 or SLC3A2 and SLC7A7 mediates the uptake of dibasic amino acids (PubMed:9829974, PubMed:10903140).

The heterodimer with SLC7A5/LAT1 mediates the transport of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane (PubMed:11564694, PubMed:12225859).

The heterodimer with SLC7A5/LAT1 is involved in the uptake of toxic methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes (PubMed:12117417).

The heterodimer with SLC7A5/LAT1 is involved in the uptake of leucine (PubMed:25998567, PubMed:30341327).

When associated with LAPTM4B, the heterodimer with SLC7A5/LAT1 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation (PubMed:25998567).

The heterodimer with SLC7A5/LAT1 may play a role in the transport of L-DOPA across the blood-brain barrier (By similarity).

The heterodimer formed by SLC3A2 and SLC7A5/LAT1 or SLC3A2 and SLC7A8/LAT2 is involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744).

Together with ICAM1, regulates the transport activity of SLC7A8/LAT2 in polarized intestinal cells by generating and delivering intracellular signals (PubMed:12716892).

Required for targeting of SLC7A5/LAT1 and SLC7A8/LAT2 to the plasma membrane and for channel activity (PubMed:9751058, PubMed:11311135, PubMed:30867591).

Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine (PubMed:14603368).

May mediate blood-to-retina L-leucine transport across the inner blood-retinal barrier (By similarity).

By similarity20 Publications

(Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis.

1 Publication

Miscellaneous

Arginine uptake is inhibited by increasing concentrations of leucine in the presence of Na+.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=295 µM for glutamine (in the presence of NaCl)1 Publication
  2. KM=236 µM for leucine (in the presence of NaCl)1 Publication
  3. KM=120 µM for arginine (in the presence of NaCl)1 Publication
  4. KM=138 µM for arginine (in the absence of NaCl)1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:ENSG00000168003-MONOMER

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P08195

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-210991, Basigin interactions
R-HSA-352230, Amino acid transport across the plasma membrane
R-HSA-5660862, Defective SLC7A7 causes lysinuric protein intolerance (LPI)
R-HSA-71240, Tryptophan catabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P08195

Protein family/group databases

Carbohydrate-Active enZymes

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CAZyi
GH13, Glycoside Hydrolase Family 13

Transport Classification Database

More...
TCDBi
2.A.3.8.18, the amino acid-polyamine-organocation (apc) family
8.A.9.2.2, the rbat transport accessory protein (rbat) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
4F2 cell-surface antigen heavy chain1 Publication
Short name:
4F2hc1 Publication
Alternative name(s):
4F2 heavy chain antigen1 Publication
Lymphocyte activation antigen 4F2 large subunit1 Publication
Solute carrier family 3 member 21 Publication
CD_antigen: CD98
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC3A2Imported
Synonyms:MDU1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11026, SLC3A2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
158070, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08195

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000168003

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini102 – 184Cytoplasmic1 PublicationAdd BLAST83
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei185 – 205Helical; Signal-anchor for type II membrane protein1 PublicationAdd BLAST21
Topological domaini206 – 630Extracellular1 PublicationAdd BLAST425

Keywords - Cellular componenti

Cell junction, Cell membrane, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi182R → A, E, K or L: Strongly decreased transport activity. 1 Publication1
Mutagenesisi210C → S: Abolishes dimerization, leucine uptake and interaction with beta-1 integrins. 3 Publications1
Mutagenesisi234 – 630Missing : Nearly abolishes transport activity. 1 PublicationAdd BLAST397
Mutagenesisi431C → S: No effect on dimerization, leucine uptake or interaction with beta-1 integrins. 2 Publications1
Mutagenesisi532K → E: Strongly decreased transport activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6520

Open Targets

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OpenTargetsi
ENSG00000168003

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA35894

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P08195, Tbio

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
890

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC3A2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
257051063

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000643831 – 6304F2 cell-surface antigen heavy chainAdd BLAST630
Isoform 2 (identifier: P08195-2)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei103PhosphoserineCombined sources1
Modified residuei106PhosphothreonineBy similarity1
Modified residuei134PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki147Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residuei165PhosphoserineCombined sources1
Cross-linki166Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi210Interchain (with C-164 in SLC7A5)1 Publication1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi365N-linked (GlcNAc...) asparagineCombined sources4 Publications1
Glycosylationi381N-linked (GlcNAc...) asparagineCombined sources5 Publications1
Modified residuei406Phosphoserine1 Publication1
Modified residuei408Phosphoserine1 Publication1
Modified residuei410Phosphoserine1 Publication1
Glycosylationi424N-linked (GlcNAc...) (complex) asparagineCombined sources5 Publications1
Glycosylationi506N-linked (GlcNAc...) asparagineCombined sources3 Publications1
Modified residuei527Phosphoserine1 Publication1
Modified residuei531Phosphoserine1 Publication1
Isoform 2 (identifier: P08195-2)
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on Ser-406; Ser-408 or Ser-410 and on Ser-527 or Ser-531 by ecto-protein kinases favors heterotypic cell-cell interactions.1 Publication

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P08195

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P08195

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P08195

MaxQB - The MaxQuant DataBase

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MaxQBi
P08195

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08195

PeptideAtlas

More...
PeptideAtlasi
P08195

PRoteomics IDEntifications database

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PRIDEi
P08195

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
52082 [P08195-1]
52083 [P08195-2]
52084 [P08195-3]
52085 [P08195-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
984, 54 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P08195, 6 sites, 51 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P08195

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
P08195

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P08195

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P08195

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. Also expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line C2BBe1.9 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is induced in resting peripheral blood T-lymphocytes following PHA stimulation. Expression increases at the time of maximal DNA synthesis, in fibroblasts stimulated to divide. Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore. Up-regulated in response to hydrogen peroxide (PubMed:30341327).4 Publications
(Microbial infection) Up-regulated upon hepatitis C virus/HCV infection via NS3-A4 viral protein complex; the up-regulation is mediated by oxidative stress (PubMed:30341327). Up-regulation of the complex formed by SLC3A2 and SLC7A5/LAT1 upon hepatitis C virus/HCV infection (PubMed:30341327).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168003, Expressed in islet of Langerhans and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P08195, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P08195, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000168003, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Disulfide-linked heterodimer with a non-glycosylated light chain (SLC7A5/LAT1, SLC7A6, SLCA7A7, SLC7A8/LAT2, SLC7A10 or SLCA7A11) (PubMed:11557028, PubMed:9829974, PubMed:9751058, PubMed:10391915, PubMed:10574970, PubMed:10903140,PubMed:11311135, PubMed:30867591).

Interacts with TLCD3A/CT120 (PubMed:12270127).

Interacts with ICAM1 (PubMed:12716892). Constitutively and specifically associates with beta-1 integrins (alpha-2/beta-1, alpha-3/beta-1, alpha-5/beta-1 and alpha-6/beta-1), but minimally with alpha-4/beta-1 (PubMed:11696247).

Interacts with LAPTM4B; recruits SLC3A2 and SLC7A5/LAT1 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567).

18 Publications

(Microbial infection) Interacts with hepatitis C virus/HCV envelope glycoprotein E2; the interaction may facilitate viral entry into host cell.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
112411, 200 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P08195

Protein interaction database and analysis system

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IntActi
P08195, 89 interactors

Molecular INTeraction database

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MINTi
P08195

STRING: functional protein association networks

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STRINGi
9606.ENSP00000367123

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P08195, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P08195

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P08195

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni15 – 39DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC3A transporter family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0471, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000156646

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_006462_9_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P08195

Database of Orthologous Groups

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OrthoDBi
1384693at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P08195

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.1180, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006047, Glyco_hydro_13_cat_dom
IPR013780, Glyco_hydro_b
IPR017853, Glycoside_hydrolase_SF
IPR042280, SLC3A2
IPR031984, SLC3A2_N

The PANTHER Classification System

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PANTHERi
PTHR46673, PTHR46673, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00128, Alpha-amylase, 1 hit
PF16028, SLC3A2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00642, Aamy, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF51445, SSF51445, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 20 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P08195-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELQPPEASI AVVSIPRQLP GSHSEAGVQG LSAGDDSELG SHCVAQTGLE
60 70 80 90 100
LLASGDPLPS ASQNAEMIET GSDCVTQAGL QLLASSDPPA LASKNAEVTG
110 120 130 140 150
TMSQDTEVDM KEVELNELEP EKQPMNAASG AAMSLAGAEK NGLVKIKVAE
160 170 180 190 200
DEAEAAAAAK FTGLSKEELL KVAGSPGWVR TRWALLLLFW LGWLGMLAGA
210 220 230 240 250
VVIIVRAPRC RELPAQKWWH TGALYRIGDL QAFQGHGAGN LAGLKGRLDY
260 270 280 290 300
LSSLKVKGLV LGPIHKNQKD DVAQTDLLQI DPNFGSKEDF DSLLQSAKKK
310 320 330 340 350
SIRVILDLTP NYRGENSWFS TQVDTVATKV KDALEFWLQA GVDGFQVRDI
360 370 380 390 400
ENLKDASSFL AEWQNITKGF SEDRLLIAGT NSSDLQQILS LLESNKDLLL
410 420 430 440 450
TSSYLSDSGS TGEHTKSLVT QYLNATGNRW CSWSLSQARL LTSFLPAQLL
460 470 480 490 500
RLYQLMLFTL PGTPVFSYGD EIGLDAAALP GQPMEAPVML WDESSFPDIP
510 520 530 540 550
GAVSANMTVK GQSEDPGSLL SLFRRLSDQR SKERSLLHGD FHAFSAGPGL
560 570 580 590 600
FSYIRHWDQN ERFLVVLNFG DVGLSAGLQA SDLPASASLP AKADLLLSTQ
610 620 630
PGREEGSPLE LERLKLEPHE GLLLRFPYAA
Length:630
Mass (Da):67,994
Last modified:September 1, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE427F8204CC10B0
GO
Isoform 2 (identifier: P08195-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-101: Missing.

Show »
Length:529
Mass (Da):57,945
Checksum:i82F26856737E8F31
GO
Isoform 3 (identifier: P08195-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-99: Missing.

Show »
Length:568
Mass (Da):61,816
Checksum:iF2B9400F95F2E1BD
GO
Isoform 4 (identifier: P08195-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     98-98: V → VTETGFHHVSQADIEFLTSIDPTASASGSAGI

Show »
Length:661
Mass (Da):71,123
Checksum:i06C2CDFD6B1D93F5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPF3J3KPF3_HUMAN
4F2 cell-surface antigen heavy chai...
SLC3A2 hCG_2016598
631Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZS6F5GZS6_HUMAN
4F2 cell-surface antigen heavy chai...
SLC3A2
599Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0E2F5H0E2_HUMAN
4F2 cell-surface antigen heavy chai...
SLC3A2
145Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H867F5H867_HUMAN
4F2 cell-surface antigen heavy chai...
SLC3A2
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YH36H0YH36_HUMAN
4F2 cell-surface antigen heavy chai...
SLC3A2
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TBF8A0A7P0TBF8_HUMAN
4F2 cell-surface antigen heavy chai...
SLC3A2
533Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T8F1A0A7P0T8F1_HUMAN
4F2 cell-surface antigen heavy chai...
SLC3A2
398Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T8U7A0A7P0T8U7_HUMAN
4F2 cell-surface antigen heavy chai...
SLC3A2
402Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TAS6A0A7P0TAS6_HUMAN
4F2 cell-surface antigen heavy chai...
SLC3A2
415Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFS2H0YFS2_HUMAN
4F2 cell-surface antigen heavy chai...
SLC3A2
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti137G → E in AAA35536 (PubMed:3480538).Curated1
Sequence conflicti158A → P in AAA51540 (PubMed:3036867).Curated1
Sequence conflicti223A → P in AAA35536 (PubMed:3480538).Curated1
Sequence conflicti315E → D in AAA35536 (PubMed:3480538).Curated1
Sequence conflicti320S → F in AAA35489 (PubMed:3265470).Curated1
Sequence conflicti372E → G in AAA35536 (PubMed:3480538).Curated1
Sequence conflicti412 – 413GE → PQ in AAA35536 (PubMed:3480538).Curated2
Sequence conflicti465V → L in AAA35536 (PubMed:3480538).Curated1
Sequence conflicti481G → P in AAA35536 (PubMed:3480538).Curated1
Sequence conflicti549G → E in AAA35489 (PubMed:3265470).Curated1
Sequence conflicti609L → P in AAA35536 (PubMed:3480538).Curated1
Sequence conflicti612E → G in AAA35536 (PubMed:3480538).Curated1

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 57944.93 Da. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0379071 – 101Missing in isoform 2. 4 PublicationsAdd BLAST101
Alternative sequenceiVSP_03790838 – 99Missing in isoform 3. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_03790998V → VTETGFHHVSQADIEFLTSI DPTASASGSAGI in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J02939 mRNA Translation: AAA52497.1
J02769 mRNA Translation: AAA51540.1
J03569 mRNA Translation: AAA35536.1
M21904 M21903 Genomic DNA Translation: AAA35489.1
AB018010 mRNA Translation: BAA84649.1
AP001160 Genomic DNA No translation available.
BC001061 mRNA Translation: AAH01061.2
BC003000 mRNA Translation: AAH03000.2
BE794697 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31589.1 [P08195-3]
CCDS31590.1 [P08195-2]
CCDS8039.2 [P08195-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A28455, SAHU4F

NCBI Reference Sequences

More...
RefSeqi
NP_001012680.1, NM_001012662.2
NP_001012682.1, NM_001012664.2 [P08195-3]
NP_001013269.1, NM_001013251.2 [P08195-2]
NP_002385.3, NM_002394.5 [P08195-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000338663; ENSP00000340815; ENSG00000168003 [P08195-2]
ENST00000377889; ENSP00000367121; ENSG00000168003 [P08195-3]
ENST00000377890; ENSP00000367122; ENSG00000168003 [P08195-1]
ENST00000538084; ENSP00000440001; ENSG00000168003 [P08195-4]
ENST00000544377; ENSP00000442135; ENSG00000168003 [P08195-2]
ENST00000680631; ENSP00000506006; ENSG00000168003 [P08195-2]
ENST00000681657; ENSP00000505110; ENSG00000168003 [P08195-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6520

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6520

UCSC genome browser

More...
UCSCi
uc001nwd.4, human [P08195-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02939 mRNA Translation: AAA52497.1
J02769 mRNA Translation: AAA51540.1
J03569 mRNA Translation: AAA35536.1
M21904 M21903 Genomic DNA Translation: AAA35489.1
AB018010 mRNA Translation: BAA84649.1
AP001160 Genomic DNA No translation available.
BC001061 mRNA Translation: AAH01061.2
BC003000 mRNA Translation: AAH03000.2
BE794697 mRNA No translation available.
CCDSiCCDS31589.1 [P08195-3]
CCDS31590.1 [P08195-2]
CCDS8039.2 [P08195-1]
PIRiA28455, SAHU4F
RefSeqiNP_001012680.1, NM_001012662.2
NP_001012682.1, NM_001012664.2 [P08195-3]
NP_001013269.1, NM_001013251.2 [P08195-2]
NP_002385.3, NM_002394.5 [P08195-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DH2X-ray2.10A212-630[»]
2DH3X-ray2.80A/B212-630[»]
6IRSelectron microscopy3.30A1-630[»]
6IRTelectron microscopy3.50A1-630[»]
6JMQelectron microscopy3.31B2-630[»]
6JMRelectron microscopy4.10B2-630[»]
6S8VX-ray1.80B/D212-630[»]
7CCSelectron microscopy6.20A2-630[»]
SMRiP08195
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112411, 200 interactors
CORUMiP08195
IntActiP08195, 89 interactors
MINTiP08195
STRINGi9606.ENSP00000367123

Chemistry databases

GuidetoPHARMACOLOGYi890

Protein family/group databases

CAZyiGH13, Glycoside Hydrolase Family 13
TCDBi2.A.3.8.18, the amino acid-polyamine-organocation (apc) family
8.A.9.2.2, the rbat transport accessory protein (rbat) family

PTM databases

GlyConnecti984, 54 N-Linked glycans (3 sites)
GlyGeniP08195, 6 sites, 51 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
iPTMnetiP08195
MetOSiteiP08195
PhosphoSitePlusiP08195
SwissPalmiP08195

Genetic variation databases

BioMutaiSLC3A2
DMDMi257051063

Proteomic databases

EPDiP08195
jPOSTiP08195
MassIVEiP08195
MaxQBiP08195
PaxDbiP08195
PeptideAtlasiP08195
PRIDEiP08195
ProteomicsDBi52082 [P08195-1]
52083 [P08195-2]
52084 [P08195-3]
52085 [P08195-4]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P08195, 54 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
15042, 1115 antibodies

The DNASU plasmid repository

More...
DNASUi
6520

Genome annotation databases

EnsembliENST00000338663; ENSP00000340815; ENSG00000168003 [P08195-2]
ENST00000377889; ENSP00000367121; ENSG00000168003 [P08195-3]
ENST00000377890; ENSP00000367122; ENSG00000168003 [P08195-1]
ENST00000538084; ENSP00000440001; ENSG00000168003 [P08195-4]
ENST00000544377; ENSP00000442135; ENSG00000168003 [P08195-2]
ENST00000680631; ENSP00000506006; ENSG00000168003 [P08195-2]
ENST00000681657; ENSP00000505110; ENSG00000168003 [P08195-2]
GeneIDi6520
KEGGihsa:6520
UCSCiuc001nwd.4, human [P08195-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6520
DisGeNETi6520

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC3A2
HGNCiHGNC:11026, SLC3A2
HPAiENSG00000168003, Low tissue specificity
MIMi158070, gene
neXtProtiNX_P08195
OpenTargetsiENSG00000168003
PharmGKBiPA35894
VEuPathDBiHostDB:ENSG00000168003

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0471, Eukaryota
GeneTreeiENSGT00940000156646
HOGENOMiCLU_006462_9_0_1
InParanoidiP08195
OrthoDBi1384693at2759
PhylomeDBiP08195

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000168003-MONOMER
PathwayCommonsiP08195
ReactomeiR-HSA-210991, Basigin interactions
R-HSA-352230, Amino acid transport across the plasma membrane
R-HSA-5660862, Defective SLC7A7 causes lysinuric protein intolerance (LPI)
R-HSA-71240, Tryptophan catabolism
SABIO-RKiP08195

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
6520, 178 hits in 1024 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC3A2, human
EvolutionaryTraceiP08195

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC3A2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6520
PharosiP08195, Tbio

Protein Ontology

More...
PROi
PR:P08195
RNActiP08195, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168003, Expressed in islet of Langerhans and 239 other tissues
ExpressionAtlasiP08195, baseline and differential
GenevisibleiP08195, HS

Family and domain databases

Gene3Di2.60.40.1180, 1 hit
InterProiView protein in InterPro
IPR006047, Glyco_hydro_13_cat_dom
IPR013780, Glyco_hydro_b
IPR017853, Glycoside_hydrolase_SF
IPR042280, SLC3A2
IPR031984, SLC3A2_N
PANTHERiPTHR46673, PTHR46673, 1 hit
PfamiView protein in Pfam
PF00128, Alpha-amylase, 1 hit
PF16028, SLC3A2_N, 1 hit
SMARTiView protein in SMART
SM00642, Aamy, 1 hit
SUPFAMiSSF51445, SSF51445, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei4F2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08195
Secondary accession number(s): Q13543
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: September 1, 2009
Last modified: September 29, 2021
This is version 234 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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