Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycerol-3-phosphate transporter

Gene

glpT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for glycerol-3-phosphate uptake.

GO - Molecular functioni

  • glycerol-3-phosphate transmembrane transporter activity Source: InterPro
  • glycerol-phosphate:inorganic phosphate antiporter activity Source: EcoCyc
  • organophosphate:inorganic phosphate antiporter activity Source: EcoCyc

GO - Biological processi

Keywordsi

Biological processGlycerol metabolism, Transport

Enzyme and pathway databases

BioCyciEcoCyc:GLPT-MONOMER
MetaCyc:GLPT-MONOMER

Protein family/group databases

TCDBi2.A.1.4.3 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate transporter
Short name:
G-3-P transporter
Alternative name(s):
G-3-P permease
Gene namesi
Name:glpT
Ordered Locus Names:b2240, JW2234
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10401 glpT

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicAdd BLAST36
Transmembranei37 – 57Helical; Name=1Add BLAST21
Topological domaini58 – 63Periplasmic6
Transmembranei64 – 84Helical; Name=2Add BLAST21
Topological domaini85 – 93Cytoplasmic9
Transmembranei94 – 112Helical; Name=3Add BLAST19
Topological domaini113 – 120Periplasmic8
Transmembranei121 – 141Helical; Name=4Add BLAST21
Topological domaini142 – 160CytoplasmicAdd BLAST19
Transmembranei161 – 180Helical; Name=5Add BLAST20
Topological domaini181 – 189Periplasmic9
Transmembranei190 – 207Helical; Name=6Add BLAST18
Topological domaini208 – 261CytoplasmicAdd BLAST54
Transmembranei262 – 282Helical; Name=7Add BLAST21
Topological domaini283 – 287Periplasmic5
Transmembranei288 – 308Helical; Name=8Add BLAST21
Topological domaini309 – 321CytoplasmicAdd BLAST13
Transmembranei322 – 341Helical; Name=9Add BLAST20
Topological domaini342 – 346Periplasmic5
Transmembranei347 – 368Helical; Name=10Add BLAST22
Topological domaini369 – 387CytoplasmicAdd BLAST19
Transmembranei388 – 409Helical; Name=11Add BLAST22
Topological domaini410 – 414Periplasmic5
Transmembranei415 – 435Helical; Name=12Add BLAST21
Topological domaini436 – 452CytoplasmicAdd BLAST17

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001998781 – 452Glycerol-3-phosphate transporterAdd BLAST452

Proteomic databases

PaxDbiP08194
PRIDEiP08194

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi4261310, 178 interactors
IntActiP08194, 1 interactor
STRINGi316385.ECDH10B_2399

Structurei

Secondary structure

1452
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08194
SMRiP08194
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08194

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CXY Bacteria
COG2271 LUCA
HOGENOMiHOG000274729
InParanoidiP08194
KOiK02445
PhylomeDBiP08194

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR005267 G3P_transporter
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR021159 Sugar-P_transporter_CS
IPR000849 Sugar_P_transporter
PANTHERiPTHR43826:SF6 PTHR43826:SF6, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PIRSFiPIRSF002808 Hexose_phosphate_transp, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00712 glpT, 1 hit
PROSITEiView protein in PROSITE
PS00942 GLPT, 1 hit
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

P08194-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSIFKPAPH KARLPAAEID PTYRRLRWQI FLGIFFGYAA YYLVRKNFAL
60 70 80 90 100
AMPYLVEQGF SRGDLGFALS GISIAYGFSK FIMGSVSDRS NPRVFLPAGL
110 120 130 140 150
ILAAAVMLFM GFVPWATSSI AVMFVLLFLC GWFQGMGWPP CGRTMVHWWS
160 170 180 190 200
QKERGGIVSV WNCAHNVGGG IPPLLFLLGM AWFNDWHAAL YMPAFCAILV
210 220 230 240 250
ALFAFAMMRD TPQSCGLPPI EEYKNDYPDD YNEKAEQELT AKQIFMQYVL
260 270 280 290 300
PNKLLWYIAI ANVFVYLLRY GILDWSPTYL KEVKHFALDK SSWAYFLYEY
310 320 330 340 350
AGIPGTLLCG WMSDKVFRGN RGATGVFFMT LVTIATIVYW MNPAGNPTVD
360 370 380 390 400
MICMIVIGFL IYGPVMLIGL HALELAPKKA AGTAAGFTGL FGYLGGSVAA
410 420 430 440 450
SAIVGYTVDF FGWDGGFMVM IGGSILAVIL LIVVMIGEKR RHEQLLQERN

GG
Length:452
Mass (Da):50,310
Last modified:August 1, 1988 - v1
Checksum:i0DE70D08D40AD445
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00536 Genomic DNA Translation: CAA68598.1
U00096 Genomic DNA Translation: AAC75300.1
AP009048 Genomic DNA Translation: BAA16059.1
PIRiS00868 JNECGT
RefSeqiNP_416743.1, NC_000913.3
WP_000948731.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75300; AAC75300; b2240
BAA16059; BAA16059; BAA16059
GeneIDi946704
KEGGiecj:JW2234
eco:b2240
PATRICifig|1411691.4.peg.4499

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00536 Genomic DNA Translation: CAA68598.1
U00096 Genomic DNA Translation: AAC75300.1
AP009048 Genomic DNA Translation: BAA16059.1
PIRiS00868 JNECGT
RefSeqiNP_416743.1, NC_000913.3
WP_000948731.1, NZ_LN832404.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PW4X-ray3.30A3-448[»]
ProteinModelPortaliP08194
SMRiP08194
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261310, 178 interactors
IntActiP08194, 1 interactor
STRINGi316385.ECDH10B_2399

Protein family/group databases

TCDBi2.A.1.4.3 the major facilitator superfamily (mfs)

Proteomic databases

PaxDbiP08194
PRIDEiP08194

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75300; AAC75300; b2240
BAA16059; BAA16059; BAA16059
GeneIDi946704
KEGGiecj:JW2234
eco:b2240
PATRICifig|1411691.4.peg.4499

Organism-specific databases

EchoBASEiEB0396
EcoGeneiEG10401 glpT

Phylogenomic databases

eggNOGiENOG4105CXY Bacteria
COG2271 LUCA
HOGENOMiHOG000274729
InParanoidiP08194
KOiK02445
PhylomeDBiP08194

Enzyme and pathway databases

BioCyciEcoCyc:GLPT-MONOMER
MetaCyc:GLPT-MONOMER

Miscellaneous databases

EvolutionaryTraceiP08194
PROiPR:P08194

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR005267 G3P_transporter
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
IPR021159 Sugar-P_transporter_CS
IPR000849 Sugar_P_transporter
PANTHERiPTHR43826:SF6 PTHR43826:SF6, 1 hit
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PIRSFiPIRSF002808 Hexose_phosphate_transp, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00712 glpT, 1 hit
PROSITEiView protein in PROSITE
PS00942 GLPT, 1 hit
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLPT_ECOLI
AccessioniPrimary (citable) accession number: P08194
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 7, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again