UniProtKB - P08194 (GLPT_ECOLI)
Protein
Glycerol-3-phosphate transporter
Gene
glpT
Organism
Escherichia coli (strain K12)
Status
Functioni
Responsible for glycerol-3-phosphate uptake.
GO - Molecular functioni
- glycerol-3-phosphate transmembrane transporter activity Source: InterPro
- glycerol-phosphate:inorganic phosphate antiporter activity Source: EcoCyc
- organophosphate:inorganic phosphate antiporter activity Source: EcoCyc
GO - Biological processi
- glycerol-3-phosphate transmembrane transport Source: EcoCyc
- glycerol metabolic process Source: UniProtKB-KW
- glycerol transport Source: EcoCyc
Keywordsi
Biological process | Glycerol metabolism, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:GLPT-MONOMER MetaCyc:GLPT-MONOMER |
Protein family/group databases
TCDBi | 2.A.1.4.3, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Glycerol-3-phosphate transporterShort name: G-3-P transporter Alternative name(s): G-3-P permease |
Gene namesi | Name:glpT Ordered Locus Names:b2240, JW2234 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: EcoCyc
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 36 | CytoplasmicAdd BLAST | 36 | |
Transmembranei | 37 – 57 | Helical; Name=1Add BLAST | 21 | |
Topological domaini | 58 – 63 | Periplasmic | 6 | |
Transmembranei | 64 – 84 | Helical; Name=2Add BLAST | 21 | |
Topological domaini | 85 – 93 | Cytoplasmic | 9 | |
Transmembranei | 94 – 112 | Helical; Name=3Add BLAST | 19 | |
Topological domaini | 113 – 120 | Periplasmic | 8 | |
Transmembranei | 121 – 141 | Helical; Name=4Add BLAST | 21 | |
Topological domaini | 142 – 160 | CytoplasmicAdd BLAST | 19 | |
Transmembranei | 161 – 180 | Helical; Name=5Add BLAST | 20 | |
Topological domaini | 181 – 189 | Periplasmic | 9 | |
Transmembranei | 190 – 207 | Helical; Name=6Add BLAST | 18 | |
Topological domaini | 208 – 261 | CytoplasmicAdd BLAST | 54 | |
Transmembranei | 262 – 282 | Helical; Name=7Add BLAST | 21 | |
Topological domaini | 283 – 287 | Periplasmic | 5 | |
Transmembranei | 288 – 308 | Helical; Name=8Add BLAST | 21 | |
Topological domaini | 309 – 321 | CytoplasmicAdd BLAST | 13 | |
Transmembranei | 322 – 341 | Helical; Name=9Add BLAST | 20 | |
Topological domaini | 342 – 346 | Periplasmic | 5 | |
Transmembranei | 347 – 368 | Helical; Name=10Add BLAST | 22 | |
Topological domaini | 369 – 387 | CytoplasmicAdd BLAST | 19 | |
Transmembranei | 388 – 409 | Helical; Name=11Add BLAST | 22 | |
Topological domaini | 410 – 414 | Periplasmic | 5 | |
Transmembranei | 415 – 435 | Helical; Name=12Add BLAST | 21 | |
Topological domaini | 436 – 452 | CytoplasmicAdd BLAST | 17 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000199878 | 1 – 452 | Glycerol-3-phosphate transporterAdd BLAST | 452 |
Proteomic databases
jPOSTi | P08194 |
PaxDbi | P08194 |
PRIDEi | P08194 |
Interactioni
Subunit structurei
Monomer.
Protein-protein interaction databases
BioGRIDi | 4261310, 178 interactors |
IntActi | P08194, 1 interactor |
STRINGi | 511145.b2240 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P08194 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08194 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG2271, Bacteria |
HOGENOMi | CLU_001265_31_0_6 |
InParanoidi | P08194 |
PhylomeDBi | P08194 |
Family and domain databases
InterProi | View protein in InterPro IPR005267, G3P_transporter IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR021159, Sugar-P_transporter_CS IPR000849, Sugar_P_transporter |
PANTHERi | PTHR43826:SF6, PTHR43826:SF6, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PIRSFi | PIRSF002808, Hexose_phosphate_transp, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00712, glpT, 1 hit |
PROSITEi | View protein in PROSITE PS00942, GLPT, 1 hit PS50850, MFS, 1 hit |
i Sequence
Sequence statusi: Complete.
P08194-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLSIFKPAPH KARLPAAEID PTYRRLRWQI FLGIFFGYAA YYLVRKNFAL
60 70 80 90 100
AMPYLVEQGF SRGDLGFALS GISIAYGFSK FIMGSVSDRS NPRVFLPAGL
110 120 130 140 150
ILAAAVMLFM GFVPWATSSI AVMFVLLFLC GWFQGMGWPP CGRTMVHWWS
160 170 180 190 200
QKERGGIVSV WNCAHNVGGG IPPLLFLLGM AWFNDWHAAL YMPAFCAILV
210 220 230 240 250
ALFAFAMMRD TPQSCGLPPI EEYKNDYPDD YNEKAEQELT AKQIFMQYVL
260 270 280 290 300
PNKLLWYIAI ANVFVYLLRY GILDWSPTYL KEVKHFALDK SSWAYFLYEY
310 320 330 340 350
AGIPGTLLCG WMSDKVFRGN RGATGVFFMT LVTIATIVYW MNPAGNPTVD
360 370 380 390 400
MICMIVIGFL IYGPVMLIGL HALELAPKKA AGTAAGFTGL FGYLGGSVAA
410 420 430 440 450
SAIVGYTVDF FGWDGGFMVM IGGSILAVIL LIVVMIGEKR RHEQLLQERN
GG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00536 Genomic DNA Translation: CAA68598.1 U00096 Genomic DNA Translation: AAC75300.1 AP009048 Genomic DNA Translation: BAA16059.1 |
PIRi | S00868, JNECGT |
RefSeqi | NP_416743.1, NC_000913.3 WP_000948731.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC75300; AAC75300; b2240 BAA16059; BAA16059; BAA16059 |
GeneIDi | 57727978 946704 |
KEGGi | ecj:JW2234 eco:b2240 |
PATRICi | fig|1411691.4.peg.4499 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00536 Genomic DNA Translation: CAA68598.1 U00096 Genomic DNA Translation: AAC75300.1 AP009048 Genomic DNA Translation: BAA16059.1 |
PIRi | S00868, JNECGT |
RefSeqi | NP_416743.1, NC_000913.3 WP_000948731.1, NZ_LN832404.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1PW4 | X-ray | 3.30 | A | 3-448 | [»] | |
SMRi | P08194 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4261310, 178 interactors |
IntActi | P08194, 1 interactor |
STRINGi | 511145.b2240 |
Protein family/group databases
TCDBi | 2.A.1.4.3, the major facilitator superfamily (mfs) |
Proteomic databases
jPOSTi | P08194 |
PaxDbi | P08194 |
PRIDEi | P08194 |
Genome annotation databases
EnsemblBacteriai | AAC75300; AAC75300; b2240 BAA16059; BAA16059; BAA16059 |
GeneIDi | 57727978 946704 |
KEGGi | ecj:JW2234 eco:b2240 |
PATRICi | fig|1411691.4.peg.4499 |
Organism-specific databases
EchoBASEi | EB0396 |
Phylogenomic databases
eggNOGi | COG2271, Bacteria |
HOGENOMi | CLU_001265_31_0_6 |
InParanoidi | P08194 |
PhylomeDBi | P08194 |
Enzyme and pathway databases
BioCyci | EcoCyc:GLPT-MONOMER MetaCyc:GLPT-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P08194 |
PROi | PR:P08194 |
Family and domain databases
InterProi | View protein in InterPro IPR005267, G3P_transporter IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf IPR021159, Sugar-P_transporter_CS IPR000849, Sugar_P_transporter |
PANTHERi | PTHR43826:SF6, PTHR43826:SF6, 1 hit |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
PIRSFi | PIRSF002808, Hexose_phosphate_transp, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00712, glpT, 1 hit |
PROSITEi | View protein in PROSITE PS00942, GLPT, 1 hit PS50850, MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLPT_ECOLI | |
Accessioni | P08194Primary (citable) accession number: P08194 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | August 1, 1988 | |
Last modified: | April 7, 2021 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families