UniProtKB - P08183 (MDR1_HUMAN)
Protein
ATP-dependent translocase ABCB1
Gene
ABCB1
Organism
Homo sapiens (Human)
Status
Functioni
Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218).3 Publications
Catalytic activityi
- a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H+ + phosphate1 Publication
- a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + H+ + phosphate1 Publication
- a β-D-glucosyl-(1↔1ʼ)-N-acylsphing-4-enine(in) + ATP + H2O = a β-D-glucosyl-(1↔1ʼ)-N-acylsphing-4-enine(out) + ADP + H+ + phosphate1 Publication
- ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).1 Publication EC:7.6.2.2
- ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).1 Publication EC:7.6.2.1
Activity regulationi
Translocase activity is inhibited by verapamil and is sensitive to energy depletion.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 427 – 434 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1070 – 1077 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: ARUK-UCL
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATPase-coupled xenobiotic transmembrane transporter activity Source: UniProtKB-EC
- ATP binding Source: ARUK-UCL
- ceramide floppase activity Source: BHF-UCL
- efflux transmembrane transporter activity Source: ARUK-UCL
- floppase activity Source: UniProtKB
- phosphatidylcholine floppase activity Source: BHF-UCL
- phosphatidylethanolamine flippase activity Source: BHF-UCL
- transporter activity Source: ProtInc
- ubiquitin protein ligase binding Source: ARUK-UCL
- xenobiotic transmembrane transporter activity Source: ARUK-UCL
GO - Biological processi
- ceramide translocation Source: BHF-UCL
- export across plasma membrane Source: ARUK-UCL
- G2/M transition of mitotic cell cycle Source: DFLAT
- phospholipid translocation Source: BHF-UCL
- positive regulation of anion channel activity Source: CAFA
- regulation of chloride transport Source: CAFA
- regulation of response to osmotic stress Source: CAFA
- response to drug Source: ProtInc
- stem cell proliferation Source: DFLAT
- transepithelial transport Source: ARUK-UCL
- transmembrane transport Source: Reactome
- transport across blood-brain barrier Source: ARUK-UCL
- xenobiotic transport across blood-brain barrier Source: ARUK-UCL
Keywordsi
Molecular function | Translocase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 3.6.3.44, 2681 |
PathwayCommonsi | P08183 |
Reactomei | R-HSA-2161517, Abacavir transmembrane transport R-HSA-382556, ABC-family proteins mediated transport |
SIGNORi | P08183 |
Protein family/group databases
MoonDBi | P08183, Curated |
MoonProti | P08183 |
TCDBi | 3.A.1.201.1, the atp-binding cassette (abc) superfamily |
Chemistry databases
SwissLipidsi | SLP:000000385 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000085563.14 |
HGNCi | HGNC:40, ABCB1 |
MIMi | 171050, gene |
neXtProti | NX_P08183 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation
- Apical cell membrane 1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: ARUK-UCL
- external side of apical plasma membrane Source: ARUK-UCL
- plasma membrane Source: ARUK-UCL
Other locations
- cell surface Source: DFLAT
- integral component of membrane Source: ProtInc
- membrane Source: ARUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 44 | CytoplasmicBy similarityAdd BLAST | 44 | |
Transmembranei | 45 – 67 | HelicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Topological domaini | 68 – 116 | ExtracellularBy similarityAdd BLAST | 49 | |
Transmembranei | 117 – 137 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 138 – 186 | CytoplasmicBy similarityAdd BLAST | 49 | |
Transmembranei | 187 – 208 | HelicalPROSITE-ProRule annotationAdd BLAST | 22 | |
Topological domaini | 209 – 215 | ExtracellularBy similarity | 7 | |
Transmembranei | 216 – 236 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 237 – 292 | CytoplasmicBy similarityAdd BLAST | 56 | |
Transmembranei | 293 – 316 | HelicalPROSITE-ProRule annotationAdd BLAST | 24 | |
Topological domaini | 317 – 330 | ExtracellularBy similarityAdd BLAST | 14 | |
Transmembranei | 331 – 352 | HelicalPROSITE-ProRule annotationAdd BLAST | 22 | |
Topological domaini | 353 – 711 | CytoplasmicBy similarityAdd BLAST | 359 | |
Transmembranei | 712 – 732 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 733 – 756 | ExtracellularBy similarityAdd BLAST | 24 | |
Transmembranei | 757 – 777 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 778 – 832 | CytoplasmicBy similarityAdd BLAST | 55 | |
Transmembranei | 833 – 853 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 854 | ExtracellularBy similarity | 1 | |
Transmembranei | 855 – 874 | HelicalPROSITE-ProRule annotationAdd BLAST | 20 | |
Topological domaini | 875 – 934 | CytoplasmicBy similarityAdd BLAST | 60 | |
Transmembranei | 935 – 957 | HelicalPROSITE-ProRule annotationAdd BLAST | 23 | |
Topological domaini | 958 – 973 | ExtracellularBy similarityAdd BLAST | 16 | |
Transmembranei | 974 – 995 | HelicalPROSITE-ProRule annotationAdd BLAST | 22 | |
Topological domaini | 996 – 1280 | CytoplasmicBy similarityAdd BLAST | 285 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Inflammatory bowel disease 13 (IBD13)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Related information in OMIMOrganism-specific databases
DisGeNETi | 5243 |
MalaCardsi | ABCB1 |
MIMi | 612244, phenotype |
OpenTargetsi | ENSG00000085563 |
Orphaneti | 413667, Antidepressant or antipsychotic toxicity or dose selection 574637, Ivermectin toxicity 771, NON RARE IN EUROPE: Ulcerative colitis 529825, Resistance to colchicine |
PharmGKBi | PA267 |
Miscellaneous databases
Pharosi | P08183, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4302 |
DrugBanki | DB12001, Abemaciclib DB01193, Acebutolol DB01418, Acenocoumarol DB00316, Acetaminophen DB00945, Acetylsalicylic acid DB08916, Afatinib DB00518, Albendazole DB04630, Aldosterone DB11363, Alectinib DB00802, Alfentanil DB09026, Aliskiren DB00523, Alitretinoin DB12015, Alpelisib DB14003, alpha-Tocopherol acetate DB06403, Ambrisentan DB01118, Amiodarone DB00321, Amitriptyline DB00381, Amlodipine DB00613, Amodiaquine DB00701, Amprenavir DB00276, Amsacrine DB01217, Anastrozole DB06420, Annamycin DB11901, Apalutamide DB06605, Apixaban DB05676, Apremilast DB01169, Arsenic trioxide DB09274, Artesunate DB00637, Astemizole DB11586, Asunaprevir DB01072, Atazanavir DB01076, Atorvastatin DB01117, Atovaquone DB00171, ATP DB15233, Avapritinib DB11995, Avatrombopag DB06626, Axitinib DB00993, Azathioprine DB00972, Azelastine DB00207, Azithromycin DB11817, Baricitinib DB00394, Beclomethasone dipropionate DB05015, Belinostat DB01086, Benzocaine DB01244, Bepridil DB00443, Betamethasone DB14669, Betamethasone phosphate DB12364, Betrixaban DB01128, Bicalutamide DB04851, Biricodar DB00612, Bisoprolol DB08873, Boceprevir DB00188, Bortezomib DB06616, Bosutinib DB01200, Bromocriptine DB01222, Budesonide DB00921, Buprenorphine DB00490, Buspirone DB06772, Cabazitaxel DB00248, Cabergoline DB04690, Camptothecin DB08907, Canagliflozin DB13919, Candesartan DB00796, Candesartan cilexetil DB11791, Capmatinib DB01197, Captopril DB00564, Carbamazepine DB08889, Carfilzomib DB01136, Carvedilol DB00520, Caspofungin DB01212, Ceftriaxone DB00482, Celecoxib DB09063, Ceritinib DB00439, Cerivastatin DB06419, Cethromycin DB00341, Cetirizine DB07565, Chloramphenicol succinate DB00608, Chloroquine DB00477, Chlorpromazine DB01239, Chlorprothixene DB04540, Cholesterol DB02659, Cholic Acid DB01340, Cilazapril DB00501, Cimetidine DB00537, Ciprofloxacin DB00515, Cisplatin DB00215, Citalopram DB01211, Clarithromycin DB01190, Clindamycin DB00349, Clobazam DB00845, Clofazimine DB00882, Clomifene DB01242, Clomipramine DB00575, Clonidine DB00758, Clopidogrel DB00257, Clotrimazole DB00363, Clozapine DB09065, Cobicistat DB05239, Cobimetinib DB01394, Colchicine DB02587, Colforsin DB14062, Concanamycin A DB00872, Conivaptan DB00286, Conjugated estrogens DB12483, Copanlisib DB08865, Crizotinib DB11672, Curcumin DB14635, Curcumin sulfate DB00091, Cyclosporine DB06695, Dabigatran etexilate DB08912, Dabrafenib DB09102, Daclatasvir DB11963, Dacomitinib DB00970, Dactinomycin DB06292, Dapagliflozin DB12941, Darolutamide DB01264, Darunavir DB09183, Dasabuvir DB01254, Dasatinib DB00694, Daunorubicin DB04840, Debrisoquine DB01151, Desipramine DB00967, Desloratadine DB14071, Desmethylsertraline DB01234, Dexamethasone DB14649, Dexamethasone acetate DB09213, Dexibuprofen DB14068, Dexniguldipine DB14063, Dexverapamil DB00829, Diazepam DB00586, Diclofenac DB00255, Diethylstilbestrol DB01396, Digitoxin DB00390, Digoxin DB00320, Dihydroergotamine DB00343, Diltiazem DB00975, Dipyridamole DB01248, Docetaxel DB14067, Dofequidar DB08930, Dolutegravir DB01184, Domperidone DB05928, Dovitinib DB00590, Doxazosin DB01142, Doxepin DB00997, Doxorubicin DB00470, Dronabinol DB04855, Dronedarone DB00476, Duloxetine DB11952, Duvelisib DB09075, Edoxaban DB04881, Elacridar DB11979, Elagolix DB11574, Elbasvir DB00216, Eletriptan DB15444, Elexacaftor DB09039, Eliglustat DB14064, Emopamil DB09038, Empagliflozin DB00584, Enalapril DB13874, Enasidenib DB13007, Enfortumab vedotin DB11986, Entrectinib DB08899, Enzalutamide DB00751, Epinastine DB12147, Erdafitinib DB01253, Ergometrine DB00696, Ergotamine DB00530, Erlotinib DB11827, Ertugliflozin DB00199, Erythromycin DB01175, Escitalopram DB00736, Esomeprazole DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB01196, Estramustine DB04573, Estriol DB14641, Estriol tripropionate DB00655, Estrone DB00977, Ethinylestradiol DB00773, Etoposide DB06414, Etravirine DB01590, Everolimus DB00973, Ezetimibe DB12466, Favipiravir DB12500, Fedratinib DB01023, Felodipine DB00813, Fentanyl DB06702, Fesoterodine DB00950, Fexofenadine DB08874, Fidaxomicin DB08868, Fingolimod DB01195, Flecainide DB04908, Flibanserin DB00196, Fluconazole DB00472, Fluoxetine DB00875, Flupentixol DB00623, Fluphenazine DB00690, Flurazepam DB13867, Fluticasone DB08906, Fluticasone furoate DB00588, Fluticasone propionate DB00176, Fluvoxamine DB05449, FM-VP4 DB00674, Galantamine DB12923, Gallopamil DB00317, Gefitinib DB00441, Gemcitabine DB01645, Genistein DB12141, Gilteritinib DB11978, Glasdegib DB13879, Glecaprevir DB01016, Glyburide DB00027, Gramicidin D DB12836, Grapiprant DB11575, Grazoprevir DB00365, Grepafloxacin DB00502, Haloperidol DB14070, HM-30181 DB14061, Hycanthone DB00741, Hydrocortisone DB14538, Hydrocortisone aceponate DB14539, Hydrocortisone acetate DB14540, Hydrocortisone butyrate DB14541, Hydrocortisone cypionate DB14542, Hydrocortisone phosphate DB14543, Hydrocortisone probutate DB14544, Hydrocortisone valerate DB01611, Hydroxychloroquine DB00557, Hydroxyzine DB01050, Ibuprofen DB09054, Idelalisib DB00619, Imatinib DB00458, Imipramine DB05039, Indacaterol DB00224, Indinavir DB00328, Indomethacin DB05889, Inotuzumab ozogamicin DB00762, Irinotecan DB11633, Isavuconazole DB06636, Isavuconazonium DB11757, Istradefylline DB01167, Itraconazole DB08820, Ivacaftor DB00602, Ivermectin DB14568, Ivosidenib DB04845, Ixabepilone DB01587, Ketazolam DB01026, Ketoconazole DB00709, Lamivudine DB00555, Lamotrigine DB12799, Laniquidar DB00448, Lansoprazole DB01259, Lapatinib DB14723, Larotrectinib DB11732, Lasmiditan DB09027, Ledipasvir DB12825, Lefamulin DB11951, Lemborexant DB00480, Lenalidomide DB09078, Lenvatinib DB12070, Letermovir DB01006, Letrozole DB09237, Levamlodipine DB01202, Levetiracetam DB01137, Levofloxacin DB08918, Levomilnacipran DB00451, Levothyroxine DB00281, Lidocaine DB08882, Linagliptin DB00279, Liothyronine DB01583, Liotrix DB09198, Lobeglitazone DB14065, Lomerizine DB08827, Lomitapide DB06448, Lonafarnib DB00836, Loperamide DB01601, Lopinavir DB00455, Loratadine DB00678, Losartan DB00227, Lovastatin DB14146, Loxicodegol DB09280, Lumacaftor DB12674, Lurbinectedin DB13125, Lusutrombopag DB00603, Medroxyprogesterone acetate DB00253, Medrysone DB00358, Mefloquine DB00351, Megestrol acetate DB00454, Meperidine DB00333, Methadone DB00563, Methotrexate DB09241, Methylene blue DB00959, Methylprednisolone DB01233, Metoclopramide DB00916, Metronidazole DB01388, Mibefradil DB01110, Miconazole DB00834, Mifepristone DB09031, Miltefosine DB08893, Mirabegron DB00648, Mitotane DB01204, Mitoxantrone DB11430, Monensin DB00295, Morphine DB00688, Mycophenolate mofetil DB01203, Nadolol DB01183, Naloxone DB00788, Naproxen DB03467, Naringenin DB01149, Nefazodone DB00220, Nelfinavir DB11828, Neratinib DB09048, Netupitant DB00622, Nicardipine DB01115, Nifedipine DB09239, Niguldipine DB04868, Nilotinib DB09079, Nintedanib DB00401, Nisoldipine DB01054, Nitrendipine DB00698, Nitrofurantoin DB00585, Nizatidine DB00717, Norethisterone DB00957, Norgestimate DB00540, Nortriptyline DB06670, Odanacatib DB00334, Olanzapine DB09074, Olaparib DB00768, Olopatadine DB12455, Omadacycline DB09296, Ombitasvir DB00338, Omeprazole DB14069, ONT-093 DB09330, Osimertinib DB00776, Oxcarbazepine DB12612, Ozanimod DB01229, Paclitaxel DB09073, Palbociclib DB01267, Paliperidone DB06603, Panobinostat DB00213, Pantoprazole DB09297, Paritaprevir DB00715, Paroxetine DB06589, Pazopanib DB15102, Pemigatinib DB00652, Pentazocine DB01174, Phenobarbital DB00252, Phenytoin DB13878, Pibrentasvir DB01100, Pimozide DB12582, Piperine DB08860, Pitavastatin DB02261, Platelet Activating Factor DB09287, Polyethylene glycol DB11077, Polyethylene glycol 400 DB08910, Pomalidomide DB08901, Ponatinib DB01263, Posaconazole DB00175, Pravastatin DB00457, Prazosin DB00860, Prednisolone DB15566, Prednisolone acetate DB14631, Prednisolone phosphate DB00635, Prednisone DB01087, Primaquine DB00396, Progesterone DB01069, Promethazine DB01182, Propafenone DB00818, Propofol DB00571, Propranolol DB00344, Protriptyline DB06480, Prucalopride DB04216, Quercetin DB01224, Quetiapine DB01103, Quinacrine DB00908, Quinidine DB00468, Quinine DB00481, Raloxifene DB00863, Ranitidine DB00243, Ranolazine DB00234, Reboxetine DB08896, Regorafenib DB14761, Remdesivir DB00206, Reserpine DB11855, Revefenacin DB14072, Reversin 121 DB03825, Rhodamine 6G DB00615, Rifabutin DB01045, Rifampicin DB11753, Rifamycin DB08864, Rilpivirine DB12457, Rimegepant DB14840, Ripretinib DB00734, Risperidone DB00503, Ritonavir DB06228, Rivaroxaban DB09291, Rolapitant DB06176, Romidepsin DB00778, Roxithromycin DB12332, Rucaparib DB11544, Salinomycin DB01232, Saquinavir DB12035, Sarecycline DB00747, Scopolamine DB01037, Selegiline DB11362, Selexipag DB15685, Selpercatinib DB11689, Selumetinib DB01104, Sertraline DB00203, Sildenafil DB06207, Silodosin DB06290, Simeprevir DB00641, Simvastatin DB00877, Sirolimus DB01261, Sitagliptin DB08934, Sofosbuvir DB09099, Somatostatin DB00398, Sorafenib DB01208, Sparfloxacin DB03203, Sphingosine DB00421, Spironolactone DB01323, St. John's Wort DB02901, Stanolone DB13951, Stanolone acetate DB02010, Staurosporine DB00428, Streptozocin DB00669, Sumatriptan DB01268, Sunitinib DB09034, Suvorexant DB00382, Tacrine DB00864, Tacrolimus DB11760, Talazoparib DB11770, Talinolol DB00675, Tamoxifen DB06240, Tariquidar DB04348, Taurocholic acid DB12887, Tazemetostat DB09161, Technetium Tc-99m sestamibi DB09160, Technetium Tc-99m tetrofosmin DB01079, Tegaserod DB05521, Telaprevir DB00966, Telmisartan DB06287, Temsirolimus DB14126, Tenofovir DB09299, Tenofovir alafenamide DB00300, Tenofovir disoproxil DB01162, Terazosin DB00342, Terfenadine DB04905, Tesmilifene DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB01420, Testosterone propionate DB13946, Testosterone undecanoate DB14066, Tetrandrine DB11712, Tezacaftor DB08816, Ticagrelor DB00373, Timolol DB04960, Tipifarnib DB00932, Tipranavir DB11635, Tocofersolan DB11251, Tocopherol DB06212, Tolvaptan DB00273, Topiramate DB01030, Topotecan DB00539, Toremifene DB14962, Trastuzumab deruxtecan DB05773, Trastuzumab emtansine DB00656, Trazodone DB00831, Trifluoperazine DB00508, Triflupromazine DB00440, Trimethoprim DB00726, Trimipramine DB13179, Troleandomycin DB11652, Tucatinib DB09270, Ubidecarenone DB15328, Ubrogepant DB09076, Umeclidinium DB15091, Upadacitinib DB14057, Valinomycin DB11869, Valspodar DB05294, Vandetanib DB00862, Vardenafil DB01339, Vecuronium DB11613, Velpatasvir DB08881, Vemurafenib DB11581, Venetoclax DB00285, Venlafaxine DB00661, Verapamil DB00570, Vinblastine DB00541, Vincristine DB11641, Vinflunine DB08828, Vismodegib DB04877, Voacamine DB09030, Vorapaxar DB12026, Voxilaprevir DB15035, Zanubrutinib DB00495, Zidovudine DB04832, Zimelidine DB00246, Ziprasidone DB00315, Zolmitriptan DB00909, Zonisamide DB06191, Zosuquidar |
DrugCentrali | P08183 |
GuidetoPHARMACOLOGYi | 768 |
Polymorphism and mutation databases
BioMutai | ABCB1 |
DMDMi | 238054374 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093332 | 1 – 1280 | ATP-dependent translocase ABCB1Add BLAST | 1280 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 91 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 94 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 99 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 660 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | P08183 |
jPOSTi | P08183 |
MassIVEi | P08183 |
MaxQBi | P08183 |
PaxDbi | P08183 |
PeptideAtlasi | P08183 |
PRIDEi | P08183 |
ProteomicsDBi | 52080 [P08183-1] 5934 |
PTM databases
GlyGeni | P08183, 3 sites |
iPTMneti | P08183 |
PhosphoSitePlusi | P08183 |
Expressioni
Tissue specificityi
Expressed in liver, kidney, small intestine and brain.
Gene expression databases
Bgeei | ENSG00000085563, Expressed in right adrenal gland and 196 other tissues |
ExpressionAtlasi | P08183, baseline and differential |
Genevisiblei | P08183, HS |
Organism-specific databases
HPAi | ENSG00000085563, Tissue enhanced (adrenal gland, intestine) |
Interactioni
Subunit structurei
Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.
2 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- ubiquitin protein ligase binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 111262, 18 interactors |
CORUMi | P08183 |
IntActi | P08183, 10 interactors |
MINTi | P08183 |
STRINGi | 9606.ENSP00000478255 |
Chemistry databases
BindingDBi | P08183 |
Miscellaneous databases
RNActi | P08183, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P08183 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 51 – 357 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 307 | |
Domaini | 392 – 628 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 237 | |
Domaini | 711 – 1000 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 290 | |
Domaini | 1035 – 1273 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 239 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0055, Eukaryota |
GeneTreei | ENSGT00940000155287 |
HOGENOMi | CLU_000604_17_2_1 |
InParanoidi | P08183 |
OMAi | IGHKGTR |
OrthoDBi | 186078at2759 |
PhylomeDBi | P08183 |
TreeFami | TF105193 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR030258, MDR1 IPR027417, P-loop_NTPase IPR039421, Type_I_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit PTHR24221:SF251, PTHR24221:SF251, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P08183-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY
60 70 80 90 100
MVVGTLAAII HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND
110 120 130 140 150
TGFFMNLEED MTRYAYYYSG IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ
160 170 180 190 200
FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS KINEGIGDKI GMFFQSMATF
210 220 230 240 250
FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT DKELLAYAKA
260 270 280 290 300
GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG
310 320 330 340 350
AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFFSVLI GAFSVGQASP
360 370 380 390 400
SIEAFANARG AAYEIFKIID NKPSIDSYSK SGHKPDNIKG NLEFRNVHFS
410 420 430 440 450
YPSRKEVKIL KGLNLKVQSG QTVALVGNSG CGKSTTVQLM QRLYDPTEGM
460 470 480 490 500
VSVDGQDIRT INVRFLREII GVVSQEPVLF ATTIAENIRY GRENVTMDEI
510 520 530 540 550
EKAVKEANAY DFIMKLPHKF DTLVGERGAQ LSGGQKQRIA IARALVRNPK
560 570 580 590 600
ILLLDEATSA LDTESEAVVQ VALDKARKGR TTIVIAHRLS TVRNADVIAG
610 620 630 640 650
FDDGVIVEKG NHDELMKEKG IYFKLVTMQT AGNEVELENA ADESKSEIDA
660 670 680 690 700
LEMSSNDSRS SLIRKRSTRR SVRGSQAQDR KLSTKEALDE SIPPVSFWRI
710 720 730 740 750
MKLNLTEWPY FVVGVFCAII NGGLQPAFAI IFSKIIGVFT RIDDPETKRQ
760 770 780 790 800
NSNLFSLLFL ALGIISFITF FLQGFTFGKA GEILTKRLRY MVFRSMLRQD
810 820 830 840 850
VSWFDDPKNT TGALTTRLAN DAAQVKGAIG SRLAVITQNI ANLGTGIIIS
860 870 880 890 900
FIYGWQLTLL LLAIVPIIAI AGVVEMKMLS GQALKDKKEL EGSGKIATEA
910 920 930 940 950
IENFRTVVSL TQEQKFEHMY AQSLQVPYRN SLRKAHIFGI TFSFTQAMMY
960 970 980 990 1000
FSYAGCFRFG AYLVAHKLMS FEDVLLVFSA VVFGAMAVGQ VSSFAPDYAK
1010 1020 1030 1040 1050
AKISAAHIIM IIEKTPLIDS YSTEGLMPNT LEGNVTFGEV VFNYPTRPDI
1060 1070 1080 1090 1100
PVLQGLSLEV KKGQTLALVG SSGCGKSTVV QLLERFYDPL AGKVLLDGKE
1110 1120 1130 1140 1150
IKRLNVQWLR AHLGIVSQEP ILFDCSIAEN IAYGDNSRVV SQEEIVRAAK
1160 1170 1180 1190 1200
EANIHAFIES LPNKYSTKVG DKGTQLSGGQ KQRIAIARAL VRQPHILLLD
1210 1220 1230 1240 1250
EATSALDTES EKVVQEALDK AREGRTCIVI AHRLSTIQNA DLIVVFQNGR
1260 1270 1280
VKEHGTHQQL LAQKGIYFSM VSVQAGTKRQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE7EWT8 | E7EWT8_HUMAN | ATP-dependent translocase ABCB1 | ABCB1 | 48 | Annotation score: |
Sequence cautioni
The sequence AAM49149 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | S → R in CAA41558 (PubMed:2568832).Curated | 1 | |
Sequence conflicti | 336 | Missing in AAB69423 (PubMed:9038218).Curated | 1 |
Polymorphismi
Genetic variation in ABCB1 may play a role in patients who do not respond to drug treatment.3 Publications
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_022276 | 17 | F → L1 PublicationCorresponds to variant dbSNP:rs28381804Ensembl. | 1 | |
Natural variantiVAR_014704 | 21 | N → D5 PublicationsCorresponds to variant dbSNP:rs9282564EnsemblClinVar. | 1 | |
Natural variantiVAR_055423 | 44 | N → S. Corresponds to variant dbSNP:rs1202183Ensembl. | 1 | |
Natural variantiVAR_055424 | 80 | A → E. Corresponds to variant dbSNP:rs9282565Ensembl. | 1 | |
Natural variantiVAR_015001 | 103 | F → L Rare polymorphism. 1 Publication | 1 | |
Natural variantiVAR_018351 | 108 | E → K1 Publication | 1 | |
Natural variantiVAR_015002 | 185 | G → V in a colchicine-selected multidrug-resistant cell line; confers increased resistance to colchicine. 3 PublicationsCorresponds to variant dbSNP:rs1128501EnsemblClinVar. | 1 | |
Natural variantiVAR_055425 | 261 | I → V. Corresponds to variant dbSNP:rs36008564EnsemblClinVar. | 1 | |
Natural variantiVAR_015003 | 400 | S → N3 PublicationsCorresponds to variant dbSNP:rs2229109EnsemblClinVar. | 1 | |
Natural variantiVAR_022277 | 566 | E → K1 PublicationCorresponds to variant dbSNP:rs28381902Ensembl. | 1 | |
Natural variantiVAR_022278 | 593 | R → C1 PublicationCorresponds to variant dbSNP:rs28381914Ensembl. | 1 | |
Natural variantiVAR_055426 | 599 | A → T. Corresponds to variant dbSNP:rs2235036Ensembl. | 1 | |
Natural variantiVAR_055427 | 669 | R → C. Corresponds to variant dbSNP:rs35023033Ensembl. | 1 | |
Natural variantiVAR_055428 | 801 | V → M. Corresponds to variant dbSNP:rs2235039Ensembl. | 1 | |
Natural variantiVAR_055429 | 829 | I → V. Corresponds to variant dbSNP:rs2032581Ensembl. | 1 | |
Natural variantiVAR_022279 | 836 | I → V1 PublicationCorresponds to variant dbSNP:rs28381967Ensembl. | 1 | |
Natural variantiVAR_035737 | 887 | K → N in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_013361 | 893 | S → A Common allele; associated with susceptibility to IBD13; has decreased enzyme activity. 8 PublicationsCorresponds to variant dbSNP:rs2032582EnsemblClinVar. | 1 | |
Natural variantiVAR_013362 | 893 | S → T Rare allele. 3 PublicationsCorresponds to variant dbSNP:rs2032582EnsemblClinVar. | 1 | |
Natural variantiVAR_018352 | 986 | M → V. Corresponds to variant dbSNP:rs926081975Ensembl. | 1 | |
Natural variantiVAR_015004 | 999 | A → T1 PublicationCorresponds to variant dbSNP:rs72552784Ensembl. | 1 | |
Natural variantiVAR_022280 | 1051 | P → A1 PublicationCorresponds to variant dbSNP:rs28401798Ensembl. | 1 | |
Natural variantiVAR_015005 | 1107 | Q → P1 PublicationCorresponds to variant dbSNP:rs55852620EnsemblClinVar. | 1 | |
Natural variantiVAR_022281 | 1141 | S → T1 PublicationCorresponds to variant dbSNP:rs2229107Ensembl. | 1 | |
Natural variantiVAR_018353 | 1251 | V → I2 PublicationsCorresponds to variant dbSNP:rs28364274EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055769 | 113 – 177 | RYAYY…TRLTD → S in isoform 2. 1 PublicationAdd BLAST | 65 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14758 mRNA Translation: AAA59575.1 M29447 , M29424, M29425, M29426, M29427, M29428, M29429, M29430, M29431, M29432, M29433, M29434, M29435, M29436, M29437, M29438, M29439, M29440, M29441, M29442, M29443, M29444, M29445, M29446 Genomic DNA Translation: AAA59576.1 AF016535 mRNA Translation: AAB69423.1 EU854148 mRNA Translation: ACF94688.1 AY910577 Genomic DNA Translation: AAW82430.1 AK290159 mRNA Translation: BAF82848.1 AC002457 Genomic DNA Translation: AAM49149.1 Sequence problems. AC005068 Genomic DNA No translation available. M37724 Genomic DNA Translation: AAA88047.1 M37725 Genomic DNA Translation: AAA88048.1 X58723 Genomic DNA Translation: CAA41558.1 |
CCDSi | CCDS5608.1 [P08183-1] |
PIRi | A34914, DVHU1 |
RefSeqi | NP_000918.2, NM_000927.4 [P08183-1] |
Genome annotation databases
Ensembli | ENST00000265724; ENSP00000265724; ENSG00000085563 [P08183-1] ENST00000543898; ENSP00000444095; ENSG00000085563 [P08183-2] ENST00000622132; ENSP00000478255; ENSG00000085563 [P08183-1] |
GeneIDi | 5243 |
KEGGi | hsa:5243 |
UCSCi | uc003uiz.3, human [P08183-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
SHMPD The Singapore human mutation and polymorphism database |
Wikipedia P-glycoprotein entry |
ABCMdb Database for mutations in ABC proteins |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14758 mRNA Translation: AAA59575.1 M29447 , M29424, M29425, M29426, M29427, M29428, M29429, M29430, M29431, M29432, M29433, M29434, M29435, M29436, M29437, M29438, M29439, M29440, M29441, M29442, M29443, M29444, M29445, M29446 Genomic DNA Translation: AAA59576.1 AF016535 mRNA Translation: AAB69423.1 EU854148 mRNA Translation: ACF94688.1 AY910577 Genomic DNA Translation: AAW82430.1 AK290159 mRNA Translation: BAF82848.1 AC002457 Genomic DNA Translation: AAM49149.1 Sequence problems. AC005068 Genomic DNA No translation available. M37724 Genomic DNA Translation: AAA88047.1 M37725 Genomic DNA Translation: AAA88048.1 X58723 Genomic DNA Translation: CAA41558.1 |
CCDSi | CCDS5608.1 [P08183-1] |
PIRi | A34914, DVHU1 |
RefSeqi | NP_000918.2, NM_000927.4 [P08183-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6C0V | electron microscopy | 3.40 | A | 1-1280 | [»] | |
6FN1 | electron microscopy | 3.58 | A | 32-1279 | [»] | |
6FN4 | electron microscopy | 4.14 | A | 1-1279 | [»] | |
6QEX | electron microscopy | 3.60 | A | 1-1280 | [»] | |
SMRi | P08183 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111262, 18 interactors |
CORUMi | P08183 |
IntActi | P08183, 10 interactors |
MINTi | P08183 |
STRINGi | 9606.ENSP00000478255 |
Chemistry databases
BindingDBi | P08183 |
ChEMBLi | CHEMBL4302 |
DrugBanki | DB12001, Abemaciclib DB01193, Acebutolol DB01418, Acenocoumarol DB00316, Acetaminophen DB00945, Acetylsalicylic acid DB08916, Afatinib DB00518, Albendazole DB04630, Aldosterone DB11363, Alectinib DB00802, Alfentanil DB09026, Aliskiren DB00523, Alitretinoin DB12015, Alpelisib DB14003, alpha-Tocopherol acetate DB06403, Ambrisentan DB01118, Amiodarone DB00321, Amitriptyline DB00381, Amlodipine DB00613, Amodiaquine DB00701, Amprenavir DB00276, Amsacrine DB01217, Anastrozole DB06420, Annamycin DB11901, Apalutamide DB06605, Apixaban DB05676, Apremilast DB01169, Arsenic trioxide DB09274, Artesunate DB00637, Astemizole DB11586, Asunaprevir DB01072, Atazanavir DB01076, Atorvastatin DB01117, Atovaquone DB00171, ATP DB15233, Avapritinib DB11995, Avatrombopag DB06626, Axitinib DB00993, Azathioprine DB00972, Azelastine DB00207, Azithromycin DB11817, Baricitinib DB00394, Beclomethasone dipropionate DB05015, Belinostat DB01086, Benzocaine DB01244, Bepridil DB00443, Betamethasone DB14669, Betamethasone phosphate DB12364, Betrixaban DB01128, Bicalutamide DB04851, Biricodar DB00612, Bisoprolol DB08873, Boceprevir DB00188, Bortezomib DB06616, Bosutinib DB01200, Bromocriptine DB01222, Budesonide DB00921, Buprenorphine DB00490, Buspirone DB06772, Cabazitaxel DB00248, Cabergoline DB04690, Camptothecin DB08907, Canagliflozin DB13919, Candesartan DB00796, Candesartan cilexetil DB11791, Capmatinib DB01197, Captopril DB00564, Carbamazepine DB08889, Carfilzomib DB01136, Carvedilol DB00520, Caspofungin DB01212, Ceftriaxone DB00482, Celecoxib DB09063, Ceritinib DB00439, Cerivastatin DB06419, Cethromycin DB00341, Cetirizine DB07565, Chloramphenicol succinate DB00608, Chloroquine DB00477, Chlorpromazine DB01239, Chlorprothixene DB04540, Cholesterol DB02659, Cholic Acid DB01340, Cilazapril DB00501, Cimetidine DB00537, Ciprofloxacin DB00515, Cisplatin DB00215, Citalopram DB01211, Clarithromycin DB01190, Clindamycin DB00349, Clobazam DB00845, Clofazimine DB00882, Clomifene DB01242, Clomipramine DB00575, Clonidine DB00758, Clopidogrel DB00257, Clotrimazole DB00363, Clozapine DB09065, Cobicistat DB05239, Cobimetinib DB01394, Colchicine DB02587, Colforsin DB14062, Concanamycin A DB00872, Conivaptan DB00286, Conjugated estrogens DB12483, Copanlisib DB08865, Crizotinib DB11672, Curcumin DB14635, Curcumin sulfate DB00091, Cyclosporine DB06695, Dabigatran etexilate DB08912, Dabrafenib DB09102, Daclatasvir DB11963, Dacomitinib DB00970, Dactinomycin DB06292, Dapagliflozin DB12941, Darolutamide DB01264, Darunavir DB09183, Dasabuvir DB01254, Dasatinib DB00694, Daunorubicin DB04840, Debrisoquine DB01151, Desipramine DB00967, Desloratadine DB14071, Desmethylsertraline DB01234, Dexamethasone DB14649, Dexamethasone acetate DB09213, Dexibuprofen DB14068, Dexniguldipine DB14063, Dexverapamil DB00829, Diazepam DB00586, Diclofenac DB00255, Diethylstilbestrol DB01396, Digitoxin DB00390, Digoxin DB00320, Dihydroergotamine DB00343, Diltiazem DB00975, Dipyridamole DB01248, Docetaxel DB14067, Dofequidar DB08930, Dolutegravir DB01184, Domperidone DB05928, Dovitinib DB00590, Doxazosin DB01142, Doxepin DB00997, Doxorubicin DB00470, Dronabinol DB04855, Dronedarone DB00476, Duloxetine DB11952, Duvelisib DB09075, Edoxaban DB04881, Elacridar DB11979, Elagolix DB11574, Elbasvir DB00216, Eletriptan DB15444, Elexacaftor DB09039, Eliglustat DB14064, Emopamil DB09038, Empagliflozin DB00584, Enalapril DB13874, Enasidenib DB13007, Enfortumab vedotin DB11986, Entrectinib DB08899, Enzalutamide DB00751, Epinastine DB12147, Erdafitinib DB01253, Ergometrine DB00696, Ergotamine DB00530, Erlotinib DB11827, Ertugliflozin DB00199, Erythromycin DB01175, Escitalopram DB00736, Esomeprazole DB00783, Estradiol DB13952, Estradiol acetate DB13953, Estradiol benzoate DB13954, Estradiol cypionate DB13955, Estradiol dienanthate DB13956, Estradiol valerate DB01196, Estramustine DB04573, Estriol DB14641, Estriol tripropionate DB00655, Estrone DB00977, Ethinylestradiol DB00773, Etoposide DB06414, Etravirine DB01590, Everolimus DB00973, Ezetimibe DB12466, Favipiravir DB12500, Fedratinib DB01023, Felodipine DB00813, Fentanyl DB06702, Fesoterodine DB00950, Fexofenadine DB08874, Fidaxomicin DB08868, Fingolimod DB01195, Flecainide DB04908, Flibanserin DB00196, Fluconazole DB00472, Fluoxetine DB00875, Flupentixol DB00623, Fluphenazine DB00690, Flurazepam DB13867, Fluticasone DB08906, Fluticasone furoate DB00588, Fluticasone propionate DB00176, Fluvoxamine DB05449, FM-VP4 DB00674, Galantamine DB12923, Gallopamil DB00317, Gefitinib DB00441, Gemcitabine DB01645, Genistein DB12141, Gilteritinib DB11978, Glasdegib DB13879, Glecaprevir DB01016, Glyburide DB00027, Gramicidin D DB12836, Grapiprant DB11575, Grazoprevir DB00365, Grepafloxacin DB00502, Haloperidol DB14070, HM-30181 DB14061, Hycanthone DB00741, Hydrocortisone DB14538, Hydrocortisone aceponate DB14539, Hydrocortisone acetate DB14540, Hydrocortisone butyrate DB14541, Hydrocortisone cypionate DB14542, Hydrocortisone phosphate DB14543, Hydrocortisone probutate DB14544, Hydrocortisone valerate DB01611, Hydroxychloroquine DB00557, Hydroxyzine DB01050, Ibuprofen DB09054, Idelalisib DB00619, Imatinib DB00458, Imipramine DB05039, Indacaterol DB00224, Indinavir DB00328, Indomethacin DB05889, Inotuzumab ozogamicin DB00762, Irinotecan DB11633, Isavuconazole DB06636, Isavuconazonium DB11757, Istradefylline DB01167, Itraconazole DB08820, Ivacaftor DB00602, Ivermectin DB14568, Ivosidenib DB04845, Ixabepilone DB01587, Ketazolam DB01026, Ketoconazole DB00709, Lamivudine DB00555, Lamotrigine DB12799, Laniquidar DB00448, Lansoprazole DB01259, Lapatinib DB14723, Larotrectinib DB11732, Lasmiditan DB09027, Ledipasvir DB12825, Lefamulin DB11951, Lemborexant DB00480, Lenalidomide DB09078, Lenvatinib DB12070, Letermovir DB01006, Letrozole DB09237, Levamlodipine DB01202, Levetiracetam DB01137, Levofloxacin DB08918, Levomilnacipran DB00451, Levothyroxine DB00281, Lidocaine DB08882, Linagliptin DB00279, Liothyronine DB01583, Liotrix DB09198, Lobeglitazone DB14065, Lomerizine DB08827, Lomitapide DB06448, Lonafarnib DB00836, Loperamide DB01601, Lopinavir DB00455, Loratadine DB00678, Losartan DB00227, Lovastatin DB14146, Loxicodegol DB09280, Lumacaftor DB12674, Lurbinectedin DB13125, Lusutrombopag DB00603, Medroxyprogesterone acetate DB00253, Medrysone DB00358, Mefloquine DB00351, Megestrol acetate DB00454, Meperidine DB00333, Methadone DB00563, Methotrexate DB09241, Methylene blue DB00959, Methylprednisolone DB01233, Metoclopramide DB00916, Metronidazole DB01388, Mibefradil DB01110, Miconazole DB00834, Mifepristone DB09031, Miltefosine DB08893, Mirabegron DB00648, Mitotane DB01204, Mitoxantrone DB11430, Monensin DB00295, Morphine DB00688, Mycophenolate mofetil DB01203, Nadolol DB01183, Naloxone DB00788, Naproxen DB03467, Naringenin DB01149, Nefazodone DB00220, Nelfinavir DB11828, Neratinib DB09048, Netupitant DB00622, Nicardipine DB01115, Nifedipine DB09239, Niguldipine DB04868, Nilotinib DB09079, Nintedanib DB00401, Nisoldipine DB01054, Nitrendipine DB00698, Nitrofurantoin DB00585, Nizatidine DB00717, Norethisterone DB00957, Norgestimate DB00540, Nortriptyline DB06670, Odanacatib DB00334, Olanzapine DB09074, Olaparib DB00768, Olopatadine DB12455, Omadacycline DB09296, Ombitasvir DB00338, Omeprazole DB14069, ONT-093 DB09330, Osimertinib DB00776, Oxcarbazepine DB12612, Ozanimod DB01229, Paclitaxel DB09073, Palbociclib DB01267, Paliperidone DB06603, Panobinostat DB00213, Pantoprazole DB09297, Paritaprevir DB00715, Paroxetine DB06589, Pazopanib DB15102, Pemigatinib DB00652, Pentazocine DB01174, Phenobarbital DB00252, Phenytoin DB13878, Pibrentasvir DB01100, Pimozide DB12582, Piperine DB08860, Pitavastatin DB02261, Platelet Activating Factor DB09287, Polyethylene glycol DB11077, Polyethylene glycol 400 DB08910, Pomalidomide DB08901, Ponatinib DB01263, Posaconazole DB00175, Pravastatin DB00457, Prazosin DB00860, Prednisolone DB15566, Prednisolone acetate DB14631, Prednisolone phosphate DB00635, Prednisone DB01087, Primaquine DB00396, Progesterone DB01069, Promethazine DB01182, Propafenone DB00818, Propofol DB00571, Propranolol DB00344, Protriptyline DB06480, Prucalopride DB04216, Quercetin DB01224, Quetiapine DB01103, Quinacrine DB00908, Quinidine DB00468, Quinine DB00481, Raloxifene DB00863, Ranitidine DB00243, Ranolazine DB00234, Reboxetine DB08896, Regorafenib DB14761, Remdesivir DB00206, Reserpine DB11855, Revefenacin DB14072, Reversin 121 DB03825, Rhodamine 6G DB00615, Rifabutin DB01045, Rifampicin DB11753, Rifamycin DB08864, Rilpivirine DB12457, Rimegepant DB14840, Ripretinib DB00734, Risperidone DB00503, Ritonavir DB06228, Rivaroxaban DB09291, Rolapitant DB06176, Romidepsin DB00778, Roxithromycin DB12332, Rucaparib DB11544, Salinomycin DB01232, Saquinavir DB12035, Sarecycline DB00747, Scopolamine DB01037, Selegiline DB11362, Selexipag DB15685, Selpercatinib DB11689, Selumetinib DB01104, Sertraline DB00203, Sildenafil DB06207, Silodosin DB06290, Simeprevir DB00641, Simvastatin DB00877, Sirolimus DB01261, Sitagliptin DB08934, Sofosbuvir DB09099, Somatostatin DB00398, Sorafenib DB01208, Sparfloxacin DB03203, Sphingosine DB00421, Spironolactone DB01323, St. John's Wort DB02901, Stanolone DB13951, Stanolone acetate DB02010, Staurosporine DB00428, Streptozocin DB00669, Sumatriptan DB01268, Sunitinib DB09034, Suvorexant DB00382, Tacrine DB00864, Tacrolimus DB11760, Talazoparib DB11770, Talinolol DB00675, Tamoxifen DB06240, Tariquidar DB04348, Taurocholic acid DB12887, Tazemetostat DB09161, Technetium Tc-99m sestamibi DB09160, Technetium Tc-99m tetrofosmin DB01079, Tegaserod DB05521, Telaprevir DB00966, Telmisartan DB06287, Temsirolimus DB14126, Tenofovir DB09299, Tenofovir alafenamide DB00300, Tenofovir disoproxil DB01162, Terazosin DB00342, Terfenadine DB04905, Tesmilifene DB13943, Testosterone cypionate DB13944, Testosterone enanthate DB01420, Testosterone propionate DB13946, Testosterone undecanoate DB14066, Tetrandrine DB11712, Tezacaftor DB08816, Ticagrelor DB00373, Timolol DB04960, Tipifarnib DB00932, Tipranavir DB11635, Tocofersolan DB11251, Tocopherol DB06212, Tolvaptan DB00273, Topiramate DB01030, Topotecan DB00539, Toremifene DB14962, Trastuzumab deruxtecan DB05773, Trastuzumab emtansine DB00656, Trazodone DB00831, Trifluoperazine DB00508, Triflupromazine DB00440, Trimethoprim DB00726, Trimipramine DB13179, Troleandomycin DB11652, Tucatinib DB09270, Ubidecarenone DB15328, Ubrogepant DB09076, Umeclidinium DB15091, Upadacitinib DB14057, Valinomycin DB11869, Valspodar DB05294, Vandetanib DB00862, Vardenafil DB01339, Vecuronium DB11613, Velpatasvir DB08881, Vemurafenib DB11581, Venetoclax DB00285, Venlafaxine DB00661, Verapamil DB00570, Vinblastine DB00541, Vincristine DB11641, Vinflunine DB08828, Vismodegib DB04877, Voacamine DB09030, Vorapaxar DB12026, Voxilaprevir DB15035, Zanubrutinib DB00495, Zidovudine DB04832, Zimelidine DB00246, Ziprasidone DB00315, Zolmitriptan DB00909, Zonisamide DB06191, Zosuquidar |
DrugCentrali | P08183 |
GuidetoPHARMACOLOGYi | 768 |
SwissLipidsi | SLP:000000385 |
Protein family/group databases
MoonDBi | P08183, Curated |
MoonProti | P08183 |
TCDBi | 3.A.1.201.1, the atp-binding cassette (abc) superfamily |
PTM databases
GlyGeni | P08183, 3 sites |
iPTMneti | P08183 |
PhosphoSitePlusi | P08183 |
Polymorphism and mutation databases
BioMutai | ABCB1 |
DMDMi | 238054374 |
Proteomic databases
EPDi | P08183 |
jPOSTi | P08183 |
MassIVEi | P08183 |
MaxQBi | P08183 |
PaxDbi | P08183 |
PeptideAtlasi | P08183 |
PRIDEi | P08183 |
ProteomicsDBi | 52080 [P08183-1] 5934 |
Protocols and materials databases
ABCDi | P08183, 2 sequenced antibodies |
Antibodypediai | 3443, 1351 antibodies |
CPTCi | P08183, 6 antibodies |
DNASUi | 5243 |
Genome annotation databases
Ensembli | ENST00000265724; ENSP00000265724; ENSG00000085563 [P08183-1] ENST00000543898; ENSP00000444095; ENSG00000085563 [P08183-2] ENST00000622132; ENSP00000478255; ENSG00000085563 [P08183-1] |
GeneIDi | 5243 |
KEGGi | hsa:5243 |
UCSCi | uc003uiz.3, human [P08183-1] |
Organism-specific databases
CTDi | 5243 |
DisGeNETi | 5243 |
EuPathDBi | HostDB:ENSG00000085563.14 |
GeneCardsi | ABCB1 |
HGNCi | HGNC:40, ABCB1 |
HPAi | ENSG00000085563, Tissue enhanced (adrenal gland, intestine) |
MalaCardsi | ABCB1 |
MIMi | 171050, gene 612244, phenotype |
neXtProti | NX_P08183 |
OpenTargetsi | ENSG00000085563 |
Orphaneti | 413667, Antidepressant or antipsychotic toxicity or dose selection 574637, Ivermectin toxicity 771, NON RARE IN EUROPE: Ulcerative colitis 529825, Resistance to colchicine |
PharmGKBi | PA267 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0055, Eukaryota |
GeneTreei | ENSGT00940000155287 |
HOGENOMi | CLU_000604_17_2_1 |
InParanoidi | P08183 |
OMAi | IGHKGTR |
OrthoDBi | 186078at2759 |
PhylomeDBi | P08183 |
TreeFami | TF105193 |
Enzyme and pathway databases
BRENDAi | 3.6.3.44, 2681 |
PathwayCommonsi | P08183 |
Reactomei | R-HSA-2161517, Abacavir transmembrane transport R-HSA-382556, ABC-family proteins mediated transport |
SIGNORi | P08183 |
Miscellaneous databases
BioGRID-ORCSi | 5243, 11 hits in 844 CRISPR screens |
ChiTaRSi | ABCB1, human |
GeneWikii | P-glycoprotein |
GenomeRNAii | 5243 |
Pharosi | P08183, Tchem |
PROi | PR:P08183 |
RNActi | P08183, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000085563, Expressed in right adrenal gland and 196 other tissues |
ExpressionAtlasi | P08183, baseline and differential |
Genevisiblei | P08183, HS |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR030258, MDR1 IPR027417, P-loop_NTPase IPR039421, Type_I_exporter |
PANTHERi | PTHR24221, PTHR24221, 1 hit PTHR24221:SF251, PTHR24221:SF251, 1 hit |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MDR1_HUMAN | |
Accessioni | P08183Primary (citable) accession number: P08183 Secondary accession number(s): A8K294 Q14812 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | May 26, 2009 | |
Last modified: | December 2, 2020 | |
This is version 232 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries