ABCB1

Functionⁱ

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Catalytic activityⁱ

ATP + H₂O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	427 – 434	ATP 1PROSITE-ProRule annotation		8
Nucleotide bindingⁱ	1070 – 1077	ATP 2PROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATPase activity, coupled to transmembrane movement of substances
Source: ProtInc
Traceable author statementⁱ
- 3022150
ATP binding
Source: ProtInc
Traceable author statementⁱ
- 3768958
ceramide-translocating ATPase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8898203
phosphatidylcholine-translocating ATPase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8898203
phosphatidylethanolamine-translocating ATPase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8898203
transporter activity
Source: ProtInc
Traceable author statementⁱ
- 3022150
xenobiotic transmembrane transporting ATPase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ceramide translocation
Source: BHF-UCL
Inferred from direct assayⁱ
- 8898203
G2/M transition of mitotic cell cycle
Source: DFLAT
Inferred from direct assayⁱ
- 19384922
phospholipid translocation
Source: BHF-UCL
Inferred from direct assayⁱ
- 8898203
positive regulation of anion channel activity
Source: CAFA
Inferred from mutant phenotypeⁱ
- 7828597
regulation of chloride transport
Source: CAFA
Inferred from mutant phenotypeⁱ
- 7828597
regulation of response to osmotic stress
Source: CAFA
Inferred from mutant phenotypeⁱ
- 7828597
response to drug
Source: ProtInc
Traceable author statementⁱ
- 3022150
stem cell proliferation
Source: DFLAT
Inferred from mutant phenotypeⁱ
- 19384922
transmembrane transport Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Translocase
Biological process	Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	3.6.3.44 2681
Reactomeⁱ	R-HSA-2161517 Abacavir transmembrane transport R-HSA-382556 ABC-family proteins mediated transport
SIGNORⁱ	P08183

Protein family/group databases

MoonDBⁱ	P08183 Curated
MoonProtⁱ	P08183
TCDBⁱ	3.A.1.201.1 the atp-binding cassette (abc) superfamily

Chemistry databases

SwissLipidsⁱ	SLP:000000385

SwissLipidsⁱ

SLP:000000385

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Multidrug resistance protein 1 (EC:7.6.2.2) Alternative name(s): ATP-binding cassette sub-family B member 1 P-glycoprotein 1 CD_antigen: CD243
Gene namesⁱ	Name:ABCB1 Synonyms:MDR1, PGY1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000085563.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:40 ABCB1
MIMⁱ	171050 gene
neXtProtⁱ	NX_P08183

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 44	CytoplasmicBy similarityAdd BLAST	44
Transmembraneⁱ	45 – 67	HelicalPROSITE-ProRule annotationAdd BLAST	23
Topological domainⁱ	68 – 116	ExtracellularBy similarityAdd BLAST	49
Transmembraneⁱ	117 – 137	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	138 – 186	CytoplasmicBy similarityAdd BLAST	49
Transmembraneⁱ	187 – 208	HelicalPROSITE-ProRule annotationAdd BLAST	22
Topological domainⁱ	209 – 215	ExtracellularBy similarity	7
Transmembraneⁱ	216 – 236	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	237 – 292	CytoplasmicBy similarityAdd BLAST	56
Transmembraneⁱ	293 – 316	HelicalPROSITE-ProRule annotationAdd BLAST	24
Topological domainⁱ	317 – 330	ExtracellularBy similarityAdd BLAST	14
Transmembraneⁱ	331 – 352	HelicalPROSITE-ProRule annotationAdd BLAST	22
Topological domainⁱ	353 – 711	CytoplasmicBy similarityAdd BLAST	359
Transmembraneⁱ	712 – 732	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	733 – 756	ExtracellularBy similarityAdd BLAST	24
Transmembraneⁱ	757 – 777	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	778 – 832	CytoplasmicBy similarityAdd BLAST	55
Transmembraneⁱ	833 – 853	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	854	ExtracellularBy similarity	1
Transmembraneⁱ	855 – 874	HelicalPROSITE-ProRule annotationAdd BLAST	20
Topological domainⁱ	875 – 934	CytoplasmicBy similarityAdd BLAST	60
Transmembraneⁱ	935 – 957	HelicalPROSITE-ProRule annotationAdd BLAST	23
Topological domainⁱ	958 – 973	ExtracellularBy similarityAdd BLAST	16
Transmembraneⁱ	974 – 995	HelicalPROSITE-ProRule annotationAdd BLAST	22
Topological domainⁱ	996 – 1280	CytoplasmicBy similarityAdd BLAST	285

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Inflammatory bowel disease 13 (IBD13)

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5243
MalaCards human disease database More...MalaCardsⁱ	ABCB1
MIMⁱ	612244 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000085563
Orphanetⁱ	771 NON RARE IN EUROPE: Ulcerative colitis
PharmGKBⁱ	PA267

Chemistry databases

ChEMBLⁱ	CHEMBL4302
Drug and drug target database More...DrugBankⁱ	DB01193 Acebutolol DB00316 Acetaminophen DB00945 Acetylsalicylic acid DB00171 Adenosine triphosphate DB08916 Afatinib DB00518 Albendazole DB04630 Aldosterone DB11363 Alectinib DB00802 Alfentanil DB00523 Alitretinoin DB00915 Amantadine DB06403 Ambrisentan DB00345 Aminohippuric acid DB01118 Amiodarone DB00321 Amitriptyline DB00381 Amlodipine DB00701 Amprenavir DB00276 Amsacrine DB06605 Apixaban DB01169 Arsenic trioxide DB00637 Astemizole DB01072 Atazanavir DB00335 Atenolol DB01076 Atorvastatin DB06626 Axitinib DB00972 Azelastine DB00207 Azithromycin DB01086 Benzocaine DB01244 Bepridil DB00443 Betamethasone DB00810 Biperiden DB08873 Boceprevir DB06616 Bosutinib DB08870 Brentuximab vedotin DB01200 Bromocriptine DB00921 Buprenorphine DB00490 Buspirone DB06772 Cabazitaxel DB00201 Caffeine DB04690 Camptothecin DB08907 Canagliflozin DB00796 Candesartan DB01197 Captopril DB00564 Carbamazepine DB08889 Carfilzomib DB01136 Carvedilol DB00520 Caspofungin DB09063 Ceritinib DB00439 Cerivastatin DB00608 Chloroquine DB00477 Chlorpromazine DB00672 Chlorpropamide DB01239 Chlorprothixene DB04540 Cholesterol DB02659 Cholic Acid DB01340 Cilazapril DB00501 Cimetidine DB00537 Ciprofloxacin DB00515 Cisplatin DB00215 Citalopram DB01211 Clarithromycin DB00349 Clobazam DB00845 Clofazimine DB00882 Clomifene DB01242 Clomipramine DB00575 Clonidine DB00758 Clopidogrel DB00257 Clotrimazole DB00363 Clozapine DB09065 Cobicistat DB05239 Cobimetinib DB01394 Colchicine DB02587 Colforsin DB00286 Conjugated Equine Estrogens DB08865 Crizotinib DB00531 Cyclophosphamide DB00091 Cyclosporine DB06695 Dabigatran etexilate DB08912 Dabrafenib DB09102 Daclatasvir DB00970 Dactinomycin DB06292 Dapagliflozin DB01254 Dasatinib DB00694 Daunorubicin DB04840 Debrisoquin DB01151 Desipramine DB00967 Desloratadine DB01234 Dexamethasone DB00514 Dextromethorphan DB00829 Diazepam DB00586 Diclofenac DB00255 Diethylstilbestrol DB01396 Digitoxin DB00390 Digoxin DB00320 Dihydroergotamine DB02901 Dihydrotestosterone DB00343 Diltiazem DB00975 Dipyridamole DB01248 Docetaxel DB01184 Domperidone DB00590 Doxazosin DB01142 Doxepin DB00997 Doxorubicin DB00470 Dronabinol DB04855 Dronedarone DB09075 Edoxaban DB04881 Elacridar DB11574 Elbasvir DB00216 Eletriptan DB00584 Enalapril DB08899 Enzalutamide DB00751 Epinastine DB01253 Ergonovine DB00696 Ergotamine DB00530 Erlotinib DB00199 Erythromycin DB00783 Estradiol DB01196 Estramustine DB04573 Estriol DB00655 Estrone DB00977 Ethinyl Estradiol DB00773 Etoposide DB06414 Etravirine DB00973 Ezetimibe DB01023 Felodipine DB00813 Fentanyl DB06702 Fesoterodine DB00950 Fexofenadine DB08874 Fidaxomicin DB00196 Fluconazole DB00472 Fluoxetine DB00875 Flupentixol DB00623 Fluphenazine DB00690 Flurazepam DB08906 Fluticasone furoate DB00176 Fluvoxamine DB05449 FM-VP4 DB00317 Gefitinib DB00441 Gemcitabine DB01645 Genistein DB01016 Glyburide DB09462 Glycerin DB04077 Glycerol DB00027 Gramicidin D DB11575 Grazoprevir DB00365 Grepafloxacin DB00502 Haloperidol DB00741 Hydrocortisone DB01050 Ibuprofen DB09054 Idelalisib DB00619 Imatinib DB00458 Imipramine DB05039 Indacaterol DB00224 Indinavir DB00328 Indomethacin DB00762 Irinotecan DB06636 Isavuconazonium DB01167 Itraconazole DB08820 Ivacaftor DB00602 Ivermectin DB01221 Ketamine DB01587 Ketazolam DB01026 Ketoconazole DB00709 Lamivudine DB00555 Lamotrigine DB00448 Lansoprazole DB01259 Lapatinib DB00480 Lenalidomide DB09078 Lenvatinib DB01202 Levetiracetam DB01137 Levofloxacin DB08918 Levomilnacipran DB00451 Levothyroxine DB00281 Lidocaine DB08882 Linagliptin DB00279 Liothyronine DB01583 Liotrix DB00722 Lisinopril DB08827 Lomitapide DB00836 Loperamide DB01601 Lopinavir DB00455 Loratadine DB00678 Losartan DB00227 Lovastatin DB00742 Mannitol DB00934 Maprotiline DB00643 Mebendazole DB00358 Mefloquine DB00351 Megestrol acetate DB00371 Meprobamate DB00333 Methadone DB00563 Methotrexate DB00959 Methylprednisolone DB00264 Metoprolol DB01388 Mibefradil DB01110 Miconazole DB00683 Midazolam DB00834 Mifepristone DB08893 Mirabegron DB00305 Mitomycin DB01204 Mitoxantrone DB00295 Morphine DB00688 Mycophenolate mofetil DB01203 Nadolol DB01183 Naloxone DB00704 Naltrexone DB03467 Naringenin DB01149 Nefazodone DB00220 Nelfinavir DB01400 Neostigmine DB00622 Nicardipine DB01115 Nifedipine DB04868 Nilotinib DB09079 Nintedanib DB00401 Nisoldipine DB01595 Nitrazepam DB01054 Nitrendipine DB00585 Nizatidine DB00717 Norethisterone DB00334 Olanzapine DB09296 Ombitasvir DB00338 Omeprazole DB09330 Osimertinib DB04417 P-Nitrophenol DB01229 Paclitaxel DB03796 Palmitic Acid DB06603 Panobinostat DB00213 Pantoprazole DB00715 Paroxetine DB06589 Pazopanib DB00790 Perindopril DB01174 Phenobarbital DB00252 Phenytoin DB01100 Pimozide DB08860 Pitavastatin DB02261 Platelet Activating Factor DB08910 Pomalidomide DB08901 Ponatinib DB01263 Posaconazole DB00175 Pravastatin DB00457 Prazosin DB00860 Prednisolone DB00635 Prednisone DB01032 Probenecid DB00396 Progesterone DB01069 Promethazine DB01182 Propafenone DB00571 Propranolol DB00344 Protriptyline DB04216 Quercetin DB01224 Quetiapine DB01103 Quinacrine DB00908 Quinidine DB00468 Quinine DB00863 Ranitidine DB00234 Reboxetine DB08896 Regorafenib DB00206 Reserpine DB01045 Rifampicin DB08864 Rilpivirine DB00734 Risperidone DB00503 Ritonavir DB06228 Rivaroxaban DB09291 Rolapitant DB06176 Romidepsin DB00778 Roxithromycin DB00936 Salicylic acid DB01232 Saquinavir DB00747 Scopolamine DB01037 Selegiline DB11362 Selexipag DB01104 Sertraline DB06207 Silodosin DB06290 Simeprevir DB00641 Simvastatin DB00877 Sirolimus DB01261 Sitagliptin DB08934 Sofosbuvir DB00398 Sorafenib DB01208 Sparfloxacin DB03203 Sphingosine DB00421 Spironolactone DB01323 St. John's Wort DB02010 Staurosporine DB00428 Streptozocin DB01138 Sulfinpyrazone DB00669 Sumatriptan DB01268 Sunitinib DB00382 Tacrine DB00864 Tacrolimus DB00675 Tamoxifen DB04348 Taurocholic Acid DB09161 Technetium Tc-99m sestamibi DB05521 Telaprevir DB00966 Telmisartan DB06287 Temsirolimus DB01162 Terazosin DB00342 Terfenadine DB04905 Tesmilifene DB00624 Testosterone DB08816 Ticagrelor DB00373 Timolol DB06212 Tolvaptan DB01030 Topotecan DB00539 Toremifene DB05773 Trastuzumab emtansine DB00656 Trazodone DB00831 Trifluoperazine DB00508 Triflupromazine DB00440 Trimethoprim DB00726 Trimipramine DB01361 Troleandomycin DB08867 Ulipristal DB09076 Umeclidinium DB01339 Vecuronium DB11581 Venetoclax DB00285 Venlafaxine DB00661 Verapamil DB00570 Vinblastine DB00541 Vincristine DB00361 Vinorelbine DB08828 Vismodegib DB04877 Voacamine DB00495 Zidovudine DB04832 Zimelidine

ChEMBLⁱ

CHEMBL4302

DrugBankⁱ

DB01193 Acebutolol
DB00316 Acetaminophen
DB00945 Acetylsalicylic acid
DB00171 Adenosine triphosphate
DB08916 Afatinib
DB00518 Albendazole
DB04630 Aldosterone
DB11363 Alectinib
DB00802 Alfentanil
DB00523 Alitretinoin
DB00915 Amantadine
DB06403 Ambrisentan
DB00345 Aminohippuric acid
DB01118 Amiodarone
DB00321 Amitriptyline
DB00381 Amlodipine
DB00701 Amprenavir
DB00276 Amsacrine
DB06605 Apixaban
DB01169 Arsenic trioxide
DB00637 Astemizole
DB01072 Atazanavir
DB00335 Atenolol
DB01076 Atorvastatin
DB06626 Axitinib
DB00972 Azelastine
DB00207 Azithromycin
DB01086 Benzocaine
DB01244 Bepridil
DB00443 Betamethasone
DB00810 Biperiden
DB08873 Boceprevir
DB06616 Bosutinib
DB08870 Brentuximab vedotin
DB01200 Bromocriptine
DB00921 Buprenorphine
DB00490 Buspirone
DB06772 Cabazitaxel
DB00201 Caffeine
DB04690 Camptothecin
DB08907 Canagliflozin
DB00796 Candesartan
DB01197 Captopril
DB00564 Carbamazepine
DB08889 Carfilzomib
DB01136 Carvedilol
DB00520 Caspofungin
DB09063 Ceritinib
DB00439 Cerivastatin
DB00608 Chloroquine
DB00477 Chlorpromazine
DB00672 Chlorpropamide
DB01239 Chlorprothixene
DB04540 Cholesterol
DB02659 Cholic Acid
DB01340 Cilazapril
DB00501 Cimetidine
DB00537 Ciprofloxacin
DB00515 Cisplatin
DB00215 Citalopram
DB01211 Clarithromycin
DB00349 Clobazam
DB00845 Clofazimine
DB00882 Clomifene
DB01242 Clomipramine
DB00575 Clonidine
DB00758 Clopidogrel
DB00257 Clotrimazole
DB00363 Clozapine
DB09065 Cobicistat
DB05239 Cobimetinib
DB01394 Colchicine
DB02587 Colforsin
DB00286 Conjugated Equine Estrogens
DB08865 Crizotinib
DB00531 Cyclophosphamide
DB00091 Cyclosporine
DB06695 Dabigatran etexilate
DB08912 Dabrafenib
DB09102 Daclatasvir
DB00970 Dactinomycin
DB06292 Dapagliflozin
DB01254 Dasatinib
DB00694 Daunorubicin
DB04840 Debrisoquin
DB01151 Desipramine
DB00967 Desloratadine
DB01234 Dexamethasone
DB00514 Dextromethorphan
DB00829 Diazepam
DB00586 Diclofenac
DB00255 Diethylstilbestrol
DB01396 Digitoxin
DB00390 Digoxin
DB00320 Dihydroergotamine
DB02901 Dihydrotestosterone
DB00343 Diltiazem
DB00975 Dipyridamole
DB01248 Docetaxel
DB01184 Domperidone
DB00590 Doxazosin
DB01142 Doxepin
DB00997 Doxorubicin
DB00470 Dronabinol
DB04855 Dronedarone
DB09075 Edoxaban
DB04881 Elacridar
DB11574 Elbasvir
DB00216 Eletriptan
DB00584 Enalapril
DB08899 Enzalutamide
DB00751 Epinastine
DB01253 Ergonovine
DB00696 Ergotamine
DB00530 Erlotinib
DB00199 Erythromycin
DB00783 Estradiol
DB01196 Estramustine
DB04573 Estriol
DB00655 Estrone
DB00977 Ethinyl Estradiol
DB00773 Etoposide
DB06414 Etravirine
DB00973 Ezetimibe
DB01023 Felodipine
DB00813 Fentanyl
DB06702 Fesoterodine
DB00950 Fexofenadine
DB08874 Fidaxomicin
DB00196 Fluconazole
DB00472 Fluoxetine
DB00875 Flupentixol
DB00623 Fluphenazine
DB00690 Flurazepam
DB08906 Fluticasone furoate
DB00176 Fluvoxamine
DB05449 FM-VP4
DB00317 Gefitinib
DB00441 Gemcitabine
DB01645 Genistein
DB01016 Glyburide
DB09462 Glycerin
DB04077 Glycerol
DB00027 Gramicidin D
DB11575 Grazoprevir
DB00365 Grepafloxacin
DB00502 Haloperidol
DB00741 Hydrocortisone
DB01050 Ibuprofen
DB09054 Idelalisib
DB00619 Imatinib
DB00458 Imipramine
DB05039 Indacaterol
DB00224 Indinavir
DB00328 Indomethacin
DB00762 Irinotecan
DB06636 Isavuconazonium
DB01167 Itraconazole
DB08820 Ivacaftor
DB00602 Ivermectin
DB01221 Ketamine
DB01587 Ketazolam
DB01026 Ketoconazole
DB00709 Lamivudine
DB00555 Lamotrigine
DB00448 Lansoprazole
DB01259 Lapatinib
DB00480 Lenalidomide
DB09078 Lenvatinib
DB01202 Levetiracetam
DB01137 Levofloxacin
DB08918 Levomilnacipran
DB00451 Levothyroxine
DB00281 Lidocaine
DB08882 Linagliptin
DB00279 Liothyronine
DB01583 Liotrix
DB00722 Lisinopril
DB08827 Lomitapide
DB00836 Loperamide
DB01601 Lopinavir
DB00455 Loratadine
DB00678 Losartan
DB00227 Lovastatin
DB00742 Mannitol
DB00934 Maprotiline
DB00643 Mebendazole
DB00358 Mefloquine
DB00351 Megestrol acetate
DB00371 Meprobamate
DB00333 Methadone
DB00563 Methotrexate
DB00959 Methylprednisolone
DB00264 Metoprolol
DB01388 Mibefradil
DB01110 Miconazole
DB00683 Midazolam
DB00834 Mifepristone
DB08893 Mirabegron
DB00305 Mitomycin
DB01204 Mitoxantrone
DB00295 Morphine
DB00688 Mycophenolate mofetil
DB01203 Nadolol
DB01183 Naloxone
DB00704 Naltrexone
DB03467 Naringenin
DB01149 Nefazodone
DB00220 Nelfinavir
DB01400 Neostigmine
DB00622 Nicardipine
DB01115 Nifedipine
DB04868 Nilotinib
DB09079 Nintedanib
DB00401 Nisoldipine
DB01595 Nitrazepam
DB01054 Nitrendipine
DB00585 Nizatidine
DB00717 Norethisterone
DB00334 Olanzapine
DB09296 Ombitasvir
DB00338 Omeprazole
DB09330 Osimertinib
DB04417 P-Nitrophenol
DB01229 Paclitaxel
DB03796 Palmitic Acid
DB06603 Panobinostat
DB00213 Pantoprazole
DB00715 Paroxetine
DB06589 Pazopanib
DB00790 Perindopril
DB01174 Phenobarbital
DB00252 Phenytoin
DB01100 Pimozide
DB08860 Pitavastatin
DB02261 Platelet Activating Factor
DB08910 Pomalidomide
DB08901 Ponatinib
DB01263 Posaconazole
DB00175 Pravastatin
DB00457 Prazosin
DB00860 Prednisolone
DB00635 Prednisone
DB01032 Probenecid
DB00396 Progesterone
DB01069 Promethazine
DB01182 Propafenone
DB00571 Propranolol
DB00344 Protriptyline
DB04216 Quercetin
DB01224 Quetiapine
DB01103 Quinacrine
DB00908 Quinidine
DB00468 Quinine
DB00863 Ranitidine
DB00234 Reboxetine
DB08896 Regorafenib
DB00206 Reserpine
DB01045 Rifampicin
DB08864 Rilpivirine
DB00734 Risperidone
DB00503 Ritonavir
DB06228 Rivaroxaban
DB09291 Rolapitant
DB06176 Romidepsin
DB00778 Roxithromycin
DB00936 Salicylic acid
DB01232 Saquinavir
DB00747 Scopolamine
DB01037 Selegiline
DB11362 Selexipag
DB01104 Sertraline
DB06207 Silodosin
DB06290 Simeprevir
DB00641 Simvastatin
DB00877 Sirolimus
DB01261 Sitagliptin
DB08934 Sofosbuvir
DB00398 Sorafenib
DB01208 Sparfloxacin
DB03203 Sphingosine
DB00421 Spironolactone
DB01323 St. John's Wort
DB02010 Staurosporine
DB00428 Streptozocin
DB01138 Sulfinpyrazone
DB00669 Sumatriptan
DB01268 Sunitinib
DB00382 Tacrine
DB00864 Tacrolimus
DB00675 Tamoxifen
DB04348 Taurocholic Acid
DB09161 Technetium Tc-99m sestamibi
DB05521 Telaprevir
DB00966 Telmisartan
DB06287 Temsirolimus
DB01162 Terazosin
DB00342 Terfenadine
DB04905 Tesmilifene
DB00624 Testosterone
DB08816 Ticagrelor
DB00373 Timolol
DB06212 Tolvaptan
DB01030 Topotecan
DB00539 Toremifene
DB05773 Trastuzumab emtansine
DB00656 Trazodone
DB00831 Trifluoperazine
DB00508 Triflupromazine
DB00440 Trimethoprim
DB00726 Trimipramine
DB01361 Troleandomycin
DB08867 Ulipristal
DB09076 Umeclidinium
DB01339 Vecuronium
DB11581 Venetoclax
DB00285 Venlafaxine
DB00661 Verapamil
DB00570 Vinblastine
DB00541 Vincristine
DB00361 Vinorelbine
DB08828 Vismodegib
DB04877 Voacamine
DB00495 Zidovudine
DB04832 Zimelidine

Polymorphism and mutation databases

BioMutaⁱ	ABCB1
DMDMⁱ	238054374

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000093332	1 – 1280	Multidrug resistance protein 1Add BLAST		1280

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	91	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	94	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	99	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	660	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P08183
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P08183
PaxDbⁱ	P08183
PeptideAtlas More...PeptideAtlasⁱ	P08183
PRIDEⁱ	P08183
ProteomicsDBⁱ	52080

PTM databases

iPTMnetⁱ	P08183
PhosphoSitePlusⁱ	P08183

Expressionⁱ

Tissue specificityⁱ

Expressed in liver, kidney, small intestine and brain.

Gene expression databases

Bgeeⁱ	ENSG00000085563 Expressed in 186 organ(s), highest expression level in right adrenal gland
CleanExⁱ	HS_ABCB1
ExpressionAtlasⁱ	P08183 baseline and differential
Genevisibleⁱ	P08183 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB001716 HPA002199

HPAⁱ

CAB001716
HPA002199

Interactionⁱ

Subunit structureⁱ

Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LAPTM4B	Q86VI4	2	EBI-1057359,EBI-3267258
RNF2	Q99496	2	EBI-1057359,EBI-722416

Protein-protein interaction databases

BioGridⁱ	111262, 17 interactors
IntActⁱ	P08183, 6 interactors
Molecular INTeraction database More...MINTⁱ	P08183
STRINGⁱ	9606.ENSP00000265724

Chemistry databases

BindingDBⁱ

P08183

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	45 – 67	Combined sources	23
Helixⁱ	70 – 78	Combined sources	9
Helixⁱ	106 – 156	Combined sources	51
Helixⁱ	160 – 165	Combined sources	6
Helixⁱ	168 – 170	Combined sources	3
Helixⁱ	171 – 185	Combined sources	15
Helixⁱ	188 – 210	Combined sources	23
Helixⁱ	214 – 219	Combined sources	6
Helixⁱ	222 – 259	Combined sources	38
Helixⁱ	261 – 267	Combined sources	7
Helixⁱ	270 – 318	Combined sources	49
Helixⁱ	320 – 323	Combined sources	4
Helixⁱ	328 – 361	Combined sources	34
Helixⁱ	363 – 370	Combined sources	8
Beta strandⁱ	391 – 396	Combined sources	6
Beta strandⁱ	410 – 412	Combined sources	3
Beta strandⁱ	414 – 420	Combined sources	7
Beta strandⁱ	422 – 426	Combined sources	5
Helixⁱ	433 – 440	Combined sources	8
Beta strandⁱ	447 – 449	Combined sources	3
Turnⁱ	458 – 460	Combined sources	3
Helixⁱ	463 – 467	Combined sources	5
Beta strandⁱ	470 – 473	Combined sources	4
Beta strandⁱ	481 – 483	Combined sources	3
Helixⁱ	484 – 489	Combined sources	6
Helixⁱ	497 – 507	Combined sources	11
Helixⁱ	511 – 515	Combined sources	5
Beta strandⁱ	516 – 518	Combined sources	3
Helixⁱ	533 – 547	Combined sources	15
Beta strandⁱ	550 – 556	Combined sources	7
Beta strandⁱ	559 – 561	Combined sources	3
Helixⁱ	563 – 575	Combined sources	13
Beta strandⁱ	580 – 585	Combined sources	6
Helixⁱ	590 – 593	Combined sources	4
Beta strandⁱ	596 – 602	Combined sources	7
Beta strandⁱ	605 – 610	Combined sources	6
Helixⁱ	612 – 617	Combined sources	6
Helixⁱ	621 – 629	Combined sources	9
Helixⁱ	697 – 703	Combined sources	7
Helixⁱ	708 – 722	Combined sources	15
Helixⁱ	724 – 739	Combined sources	16
Beta strandⁱ	741 – 743	Combined sources	3
Helixⁱ	748 – 796	Combined sources	49
Helixⁱ	801 – 804	Combined sources	4
Beta strandⁱ	806 – 808	Combined sources	3
Helixⁱ	811 – 829	Combined sources	19
Helixⁱ	831 – 852	Combined sources	22
Helixⁱ	858 – 862	Combined sources	5
Helixⁱ	865 – 902	Combined sources	38
Helixⁱ	904 – 910	Combined sources	7
Helixⁱ	914 – 923	Combined sources	10
Helixⁱ	925 – 965	Combined sources	41
Helixⁱ	971 – 981	Combined sources	11
Helixⁱ	984 – 992	Combined sources	9
Helixⁱ	995 – 1013	Combined sources	19
Beta strandⁱ	1035 – 1042	Combined sources	8
Beta strandⁱ	1045 – 1047	Combined sources	3
Beta strandⁱ	1052 – 1060	Combined sources	9
Beta strandⁱ	1065 – 1069	Combined sources	5
Beta strandⁱ	1074 – 1076	Combined sources	3
Helixⁱ	1077 – 1083	Combined sources	7
Beta strandⁱ	1090 – 1100	Combined sources	11
Turnⁱ	1101 – 1103	Combined sources	3
Helixⁱ	1106 – 1112	Combined sources	7
Beta strandⁱ	1114 – 1116	Combined sources	3
Beta strandⁱ	1124 – 1126	Combined sources	3
Helixⁱ	1127 – 1132	Combined sources	6
Helixⁱ	1142 – 1152	Combined sources	11
Helixⁱ	1155 – 1160	Combined sources	6
Helixⁱ	1164 – 1166	Combined sources	3
Helixⁱ	1178 – 1190	Combined sources	13
Beta strandⁱ	1195 – 1201	Combined sources	7
Helixⁱ	1208 – 1220	Combined sources	13
Beta strandⁱ	1225 – 1230	Combined sources	6
Helixⁱ	1234 – 1239	Combined sources	6
Beta strandⁱ	1240 – 1247	Combined sources	8
Beta strandⁱ	1250 – 1255	Combined sources	6
Helixⁱ	1257 – 1262	Combined sources	6
Helixⁱ	1266 – 1272	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P08183
SMRⁱ	P08183
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	51 – 357	ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST	307
Domainⁱ	392 – 628	ABC transporter 1PROSITE-ProRule annotationAdd BLAST	237
Domainⁱ	711 – 1000	ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST	290
Domainⁱ	1035 – 1273	ABC transporter 2PROSITE-ProRule annotationAdd BLAST	239

Sequence similaritiesⁱ

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0055 Eukaryota COG1132 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062896
HOVERGENⁱ	HBG080809
InParanoidⁱ	P08183
KEGG Orthology (KO) More...KOⁱ	K05658
OMAⁱ	THRMANA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HVA
PhylomeDBⁱ	P08183
TreeFamⁱ	TF105193

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 2 hits
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR030258 MDR1 IPR027417 P-loop_NTPase IPR039421 Type_I_exporter
PANTHERⁱ	PTHR24221 PTHR24221, 1 hit PTHR24221:SF251 PTHR24221:SF251, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 2 hits PF00005 ABC_tran, 2 hits
SMARTⁱ	View protein in SMART SM00382 AAA, 2 hits
SUPFAMⁱ	SSF52540 SSF52540, 2 hits SSF90123 SSF90123, 2 hits
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 2 hits PS00211 ABC_TRANSPORTER_1, 2 hits PS50893 ABC_TRANSPORTER_2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P08183-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY 
        60         70         80         90        100
MVVGTLAAII HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND 
       110        120        130        140        150
TGFFMNLEED MTRYAYYYSG IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ 
       160        170        180        190        200
FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS KINEGIGDKI GMFFQSMATF 
       210        220        230        240        250
FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT DKELLAYAKA 
       260        270        280        290        300
GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG 
       310        320        330        340        350
AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFFSVLI GAFSVGQASP 
       360        370        380        390        400
SIEAFANARG AAYEIFKIID NKPSIDSYSK SGHKPDNIKG NLEFRNVHFS 
       410        420        430        440        450
YPSRKEVKIL KGLNLKVQSG QTVALVGNSG CGKSTTVQLM QRLYDPTEGM 
       460        470        480        490        500
VSVDGQDIRT INVRFLREII GVVSQEPVLF ATTIAENIRY GRENVTMDEI 
       510        520        530        540        550
EKAVKEANAY DFIMKLPHKF DTLVGERGAQ LSGGQKQRIA IARALVRNPK 
       560        570        580        590        600
ILLLDEATSA LDTESEAVVQ VALDKARKGR TTIVIAHRLS TVRNADVIAG 
       610        620        630        640        650
FDDGVIVEKG NHDELMKEKG IYFKLVTMQT AGNEVELENA ADESKSEIDA 
       660        670        680        690        700
LEMSSNDSRS SLIRKRSTRR SVRGSQAQDR KLSTKEALDE SIPPVSFWRI 
       710        720        730        740        750
MKLNLTEWPY FVVGVFCAII NGGLQPAFAI IFSKIIGVFT RIDDPETKRQ 
       760        770        780        790        800
NSNLFSLLFL ALGIISFITF FLQGFTFGKA GEILTKRLRY MVFRSMLRQD 
       810        820        830        840        850
VSWFDDPKNT TGALTTRLAN DAAQVKGAIG SRLAVITQNI ANLGTGIIIS 
       860        870        880        890        900
FIYGWQLTLL LLAIVPIIAI AGVVEMKMLS GQALKDKKEL EGSGKIATEA 
       910        920        930        940        950
IENFRTVVSL TQEQKFEHMY AQSLQVPYRN SLRKAHIFGI TFSFTQAMMY 
       960        970        980        990       1000
FSYAGCFRFG AYLVAHKLMS FEDVLLVFSA VVFGAMAVGQ VSSFAPDYAK 
      1010       1020       1030       1040       1050
AKISAAHIIM IIEKTPLIDS YSTEGLMPNT LEGNVTFGEV VFNYPTRPDI 
      1060       1070       1080       1090       1100
PVLQGLSLEV KKGQTLALVG SSGCGKSTVV QLLERFYDPL AGKVLLDGKE 
      1110       1120       1130       1140       1150
IKRLNVQWLR AHLGIVSQEP ILFDCSIAEN IAYGDNSRVV SQEEIVRAAK 
      1160       1170       1180       1190       1200
EANIHAFIES LPNKYSTKVG DKGTQLSGGQ KQRIAIARAL VRQPHILLLD 
      1210       1220       1230       1240       1250
EATSALDTES EKVVQEALDK AREGRTCIVI AHRLSTIQNA DLIVVFQNGR 
      1260       1270       1280
VKEHGTHQQL LAQKGIYFSM VSVQAGTKRQ

Length:1,280

Mass (Da):141,479

Last modified:May 26, 2009 - v3

Checksum:ⁱF0230744AB288C73

GO

Isoform 2 (identifier: P08183-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
113-177: RYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTD → S

« Hide

        10         20         30         40         50
MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY 
        60         70         80         90        100
MVVGTLAAII HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND 
       110        120        130        140        150
TGFFMNLEED MTSDVSKINE GIGDKIGMFF QSMATFFTGF IVGFTRGWKL 
       160        170        180        190        200
TLVILAISPV LGLSAAVWAK ILSSFTDKEL LAYAKAGAVA EEVLAAIRTV 
       210        220        230        240        250
IAFGGQKKEL ERYNKNLEEA KRIGIKKAIT ANISIGAAFL LIYASYALAF 
       260        270        280        290        300
WYGTTLVLSG EYSIGQVLTV FFSVLIGAFS VGQASPSIEA FANARGAAYE 
       310        320        330        340        350
IFKIIDNKPS IDSYSKSGHK PDNIKGNLEF RNVHFSYPSR KEVKILKGLN 
       360        370        380        390        400
LKVQSGQTVA LVGNSGCGKS TTVQLMQRLY DPTEGMVSVD GQDIRTINVR 
       410        420        430        440        450
FLREIIGVVS QEPVLFATTI AENIRYGREN VTMDEIEKAV KEANAYDFIM 
       460        470        480        490        500
KLPHKFDTLV GERGAQLSGG QKQRIAIARA LVRNPKILLL DEATSALDTE 
       510        520        530        540        550
SEAVVQVALD KARKGRTTIV IAHRLSTVRN ADVIAGFDDG VIVEKGNHDE 
       560        570        580        590        600
LMKEKGIYFK LVTMQTAGNE VELENAADES KSEIDALEMS SNDSRSSLIR 
       610        620        630        640        650
KRSTRRSVRG SQAQDRKLST KEALDESIPP VSFWRIMKLN LTEWPYFVVG 
       660        670        680        690        700
VFCAIINGGL QPAFAIIFSK IIGVFTRIDD PETKRQNSNL FSLLFLALGI 
       710        720        730        740        750
ISFITFFLQG FTFGKAGEIL TKRLRYMVFR SMLRQDVSWF DDPKNTTGAL 
       760        770        780        790        800
TTRLANDAAQ VKGAIGSRLA VITQNIANLG TGIIISFIYG WQLTLLLLAI 
       810        820        830        840        850
VPIIAIAGVV EMKMLSGQAL KDKKELEGSG KIATEAIENF RTVVSLTQEQ 
       860        870        880        890        900
KFEHMYAQSL QVPYRNSLRK AHIFGITFSF TQAMMYFSYA GCFRFGAYLV 
       910        920        930        940        950
AHKLMSFEDV LLVFSAVVFG AMAVGQVSSF APDYAKAKIS AAHIIMIIEK 
       960        970        980        990       1000
TPLIDSYSTE GLMPNTLEGN VTFGEVVFNY PTRPDIPVLQ GLSLEVKKGQ 
      1010       1020       1030       1040       1050
TLALVGSSGC GKSTVVQLLE RFYDPLAGKV LLDGKEIKRL NVQWLRAHLG 
      1060       1070       1080       1090       1100
IVSQEPILFD CSIAENIAYG DNSRVVSQEE IVRAAKEANI HAFIESLPNK 
      1110       1120       1130       1140       1150
YSTKVGDKGT QLSGGQKQRI AIARALVRQP HILLLDEATS ALDTESEKVV 
      1160       1170       1180       1190       1200
QEALDKAREG RTCIVIAHRL STIQNADLIV VFQNGRVKEH GTHQQLLAQK 
      1210 
GIYFSMVSVQ AGTKRQ

Show »

Length:1,216

Mass (Da):134,032

Checksum:ⁱ227233F5F2259A8C

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E7EWT8	E7EWT8_HUMAN		Multidrug resistance protein 1 Multidrug resistance protein 1	ABCB1	48	Annotation score:

Sequence cautionⁱ

The sequence AAM49149 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	23	S → R in CAA41558 (PubMed:2568832).Curated		1
Sequence conflictⁱ	336	Missing in AAB69423 (PubMed:9038218).Curated		1

Polymorphismⁱ

Genetic variation in ABCB1 may play a role in patients who do not respond to drug treatment.3 Publications

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_022276	17	F → L1 PublicationCorresponds to variant dbSNP:rs28381804Ensembl.	1
Natural variantⁱVAR_014704	21	N → D5 PublicationsCorresponds to variant dbSNP:rs9282564Ensembl.	1
Natural variantⁱVAR_055423	44	N → S. Corresponds to variant dbSNP:rs1202183Ensembl.	1
Natural variantⁱVAR_055424	80	A → E. Corresponds to variant dbSNP:rs9282565Ensembl.	1
Natural variantⁱVAR_015001	103	F → L Rare polymorphism. 1 Publication	1
Natural variantⁱVAR_018351	108	E → K1 Publication	1
Natural variantⁱVAR_015002	185	G → V in a colchicine-selected multidrug-resistant cell line; confers increased resistance to colchicine. 3 PublicationsCorresponds to variant dbSNP:rs1128501EnsemblClinVar.	1
Natural variantⁱVAR_055425	261	I → V. Corresponds to variant dbSNP:rs36008564Ensembl.	1
Natural variantⁱVAR_015003	400	S → N3 PublicationsCorresponds to variant dbSNP:rs2229109EnsemblClinVar.	1
Natural variantⁱVAR_022277	566	E → K1 PublicationCorresponds to variant dbSNP:rs28381902Ensembl.	1
Natural variantⁱVAR_022278	593	R → C1 PublicationCorresponds to variant dbSNP:rs28381914Ensembl.	1
Natural variantⁱVAR_055426	599	A → T. Corresponds to variant dbSNP:rs2235036Ensembl.	1
Natural variantⁱVAR_055427	669	R → C. Corresponds to variant dbSNP:rs35023033Ensembl.	1
Natural variantⁱVAR_055428	801	V → M. Corresponds to variant dbSNP:rs2235039Ensembl.	1
Natural variantⁱVAR_055429	829	I → V. Corresponds to variant dbSNP:rs2032581Ensembl.	1
Natural variantⁱVAR_022279	836	I → V1 PublicationCorresponds to variant dbSNP:rs28381967Ensembl.	1
Natural variantⁱVAR_035737	887	K → N in a colorectal cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_013361	893	S → A Common allele; associated with susceptibility to IBD13; has decreased enzyme activity. 8 PublicationsCorresponds to variant dbSNP:rs2032582EnsemblClinVar.	1
Natural variantⁱVAR_013362	893	S → T Rare allele. 3 PublicationsCorresponds to variant dbSNP:rs2032582EnsemblClinVar.	1
Natural variantⁱVAR_018352	986	M → V. Corresponds to variant dbSNP:rs926081975Ensembl.	1
Natural variantⁱVAR_015004	999	A → T1 PublicationCorresponds to variant dbSNP:rs72552784Ensembl.	1
Natural variantⁱVAR_022280	1051	P → A1 PublicationCorresponds to variant dbSNP:rs28401798Ensembl.	1
Natural variantⁱVAR_015005	1107	Q → P1 PublicationCorresponds to variant dbSNP:rs55852620Ensembl.	1
Natural variantⁱVAR_022281	1141	S → T1 PublicationCorresponds to variant dbSNP:rs2229107Ensembl.	1
Natural variantⁱVAR_018353	1251	V → I2 PublicationsCorresponds to variant dbSNP:rs28364274Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055769	113 – 177	RYAYY…TRLTD → S in isoform 2. 1 PublicationAdd BLAST		65

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14758 mRNA Translation: AAA59575.1 M29447 M29446 Genomic DNA Translation: AAA59576.1 AF016535 mRNA Translation: AAB69423.1 EU854148 mRNA Translation: ACF94688.1 AY910577 Genomic DNA Translation: AAW82430.1 AK290159 mRNA Translation: BAF82848.1 AC002457 Genomic DNA Translation: AAM49149.1 Sequence problems. AC005068 Genomic DNA No translation available. M37724 Genomic DNA Translation: AAA88047.1 M37725 Genomic DNA Translation: AAA88048.1 X58723 Genomic DNA Translation: CAA41558.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5608.1 [P08183-1]
PIRⁱ	A34914 DVHU1
NCBI Reference Sequences More...RefSeqⁱ	NP_000918.2, NM_000927.4 [P08183-1]
UniGeneⁱ	Hs.489033 Hs.689936 Hs.737655

Genome annotation databases

Ensemblⁱ	ENST00000265724; ENSP00000265724; ENSG00000085563 [P08183-1] ENST00000543898; ENSP00000444095; ENSG00000085563 [P08183-2] ENST00000622132; ENSP00000478255; ENSG00000085563 [P08183-1]
GeneIDⁱ	5243
KEGGⁱ	hsa:5243
UCSC genome browser More...UCSCⁱ	uc003uiz.3 human [P08183-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08183	ATP-binding cassette, sub-family B (MDR/TAP), member 1, isoform CRA_c		HUMAN		1280	UniRef100_P08183
UPI0009890710		HUMAN		1350

Protein	Similar proteins		Species	Score	Length	Source
P08183	ATP-binding cassette, sub-family B (MDR/TAP), member 1, isoform CRA_c		HUMAN		1280	UniRef90_P08183
Multidrug resistance p-glycoprotein		MACFA		1283
Multidrug resistance protein		MACMU		1283
Uncharacterized protein		FELCA		1282
Multidrug resistance protein 1		FELSI		1262
+129

Protein	Similar proteins		Species	Score	Length	Source
P08183	Phosphatidylcholine translocator ABCB4		HUMAN		1286	UniRef50_P21439
Phosphatidylcholine translocator ABCB4		CRIGR		1281
Phosphatidylcholine translocator ABCB4		RAT		1278
Phosphatidylcholine translocator ABCB4		MOUSE		1276
ATP binding cassette subfamily B member 4		SAIBB		1324
+649

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NIEHS-SNPs

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

P-glycoprotein entry

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14758 mRNA Translation: AAA59575.1 M29447 M29446 Genomic DNA Translation: AAA59576.1 AF016535 mRNA Translation: AAB69423.1 EU854148 mRNA Translation: ACF94688.1 AY910577 Genomic DNA Translation: AAW82430.1 AK290159 mRNA Translation: BAF82848.1 AC002457 Genomic DNA Translation: AAM49149.1 Sequence problems. AC005068 Genomic DNA No translation available. M37724 Genomic DNA Translation: AAA88047.1 M37725 Genomic DNA Translation: AAA88048.1 X58723 Genomic DNA Translation: CAA41558.1
CCDSⁱ	CCDS5608.1 [P08183-1]
PIRⁱ	A34914 DVHU1
RefSeqⁱ	NP_000918.2, NM_000927.4 [P08183-1]
UniGeneⁱ	Hs.489033 Hs.689936 Hs.737655

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6C0V	electron microscopy	3.40	A	1-1280	[»]
	6FN1	electron microscopy	3.58	A	32-1279	[»]
	6FN4	electron microscopy	4.14	A	1-1279	[»]
ProteinModelPortalⁱ	P08183
SMRⁱ	P08183
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111262, 17 interactors
IntActⁱ	P08183, 6 interactors
MINTⁱ	P08183
STRINGⁱ	9606.ENSP00000265724

Chemistry databases

BindingDBⁱ	P08183
ChEMBLⁱ	CHEMBL4302
DrugBankⁱ	DB01193 Acebutolol DB00316 Acetaminophen DB00945 Acetylsalicylic acid DB00171 Adenosine triphosphate DB08916 Afatinib DB00518 Albendazole DB04630 Aldosterone DB11363 Alectinib DB00802 Alfentanil DB00523 Alitretinoin DB00915 Amantadine DB06403 Ambrisentan DB00345 Aminohippuric acid DB01118 Amiodarone DB00321 Amitriptyline DB00381 Amlodipine DB00701 Amprenavir DB00276 Amsacrine DB06605 Apixaban DB01169 Arsenic trioxide DB00637 Astemizole DB01072 Atazanavir DB00335 Atenolol DB01076 Atorvastatin DB06626 Axitinib DB00972 Azelastine DB00207 Azithromycin DB01086 Benzocaine DB01244 Bepridil DB00443 Betamethasone DB00810 Biperiden DB08873 Boceprevir DB06616 Bosutinib DB08870 Brentuximab vedotin DB01200 Bromocriptine DB00921 Buprenorphine DB00490 Buspirone DB06772 Cabazitaxel DB00201 Caffeine DB04690 Camptothecin DB08907 Canagliflozin DB00796 Candesartan DB01197 Captopril DB00564 Carbamazepine DB08889 Carfilzomib DB01136 Carvedilol DB00520 Caspofungin DB09063 Ceritinib DB00439 Cerivastatin DB00608 Chloroquine DB00477 Chlorpromazine DB00672 Chlorpropamide DB01239 Chlorprothixene DB04540 Cholesterol DB02659 Cholic Acid DB01340 Cilazapril DB00501 Cimetidine DB00537 Ciprofloxacin DB00515 Cisplatin DB00215 Citalopram DB01211 Clarithromycin DB00349 Clobazam DB00845 Clofazimine DB00882 Clomifene DB01242 Clomipramine DB00575 Clonidine DB00758 Clopidogrel DB00257 Clotrimazole DB00363 Clozapine DB09065 Cobicistat DB05239 Cobimetinib DB01394 Colchicine DB02587 Colforsin DB00286 Conjugated Equine Estrogens DB08865 Crizotinib DB00531 Cyclophosphamide DB00091 Cyclosporine DB06695 Dabigatran etexilate DB08912 Dabrafenib DB09102 Daclatasvir DB00970 Dactinomycin DB06292 Dapagliflozin DB01254 Dasatinib DB00694 Daunorubicin DB04840 Debrisoquin DB01151 Desipramine DB00967 Desloratadine DB01234 Dexamethasone DB00514 Dextromethorphan DB00829 Diazepam DB00586 Diclofenac DB00255 Diethylstilbestrol DB01396 Digitoxin DB00390 Digoxin DB00320 Dihydroergotamine DB02901 Dihydrotestosterone DB00343 Diltiazem DB00975 Dipyridamole DB01248 Docetaxel DB01184 Domperidone DB00590 Doxazosin DB01142 Doxepin DB00997 Doxorubicin DB00470 Dronabinol DB04855 Dronedarone DB09075 Edoxaban DB04881 Elacridar DB11574 Elbasvir DB00216 Eletriptan DB00584 Enalapril DB08899 Enzalutamide DB00751 Epinastine DB01253 Ergonovine DB00696 Ergotamine DB00530 Erlotinib DB00199 Erythromycin DB00783 Estradiol DB01196 Estramustine DB04573 Estriol DB00655 Estrone DB00977 Ethinyl Estradiol DB00773 Etoposide DB06414 Etravirine DB00973 Ezetimibe DB01023 Felodipine DB00813 Fentanyl DB06702 Fesoterodine DB00950 Fexofenadine DB08874 Fidaxomicin DB00196 Fluconazole DB00472 Fluoxetine DB00875 Flupentixol DB00623 Fluphenazine DB00690 Flurazepam DB08906 Fluticasone furoate DB00176 Fluvoxamine DB05449 FM-VP4 DB00317 Gefitinib DB00441 Gemcitabine DB01645 Genistein DB01016 Glyburide DB09462 Glycerin DB04077 Glycerol DB00027 Gramicidin D DB11575 Grazoprevir DB00365 Grepafloxacin DB00502 Haloperidol DB00741 Hydrocortisone DB01050 Ibuprofen DB09054 Idelalisib DB00619 Imatinib DB00458 Imipramine DB05039 Indacaterol DB00224 Indinavir DB00328 Indomethacin DB00762 Irinotecan DB06636 Isavuconazonium DB01167 Itraconazole DB08820 Ivacaftor DB00602 Ivermectin DB01221 Ketamine DB01587 Ketazolam DB01026 Ketoconazole DB00709 Lamivudine DB00555 Lamotrigine DB00448 Lansoprazole DB01259 Lapatinib DB00480 Lenalidomide DB09078 Lenvatinib DB01202 Levetiracetam DB01137 Levofloxacin DB08918 Levomilnacipran DB00451 Levothyroxine DB00281 Lidocaine DB08882 Linagliptin DB00279 Liothyronine DB01583 Liotrix DB00722 Lisinopril DB08827 Lomitapide DB00836 Loperamide DB01601 Lopinavir DB00455 Loratadine DB00678 Losartan DB00227 Lovastatin DB00742 Mannitol DB00934 Maprotiline DB00643 Mebendazole DB00358 Mefloquine DB00351 Megestrol acetate DB00371 Meprobamate DB00333 Methadone DB00563 Methotrexate DB00959 Methylprednisolone DB00264 Metoprolol DB01388 Mibefradil DB01110 Miconazole DB00683 Midazolam DB00834 Mifepristone DB08893 Mirabegron DB00305 Mitomycin DB01204 Mitoxantrone DB00295 Morphine DB00688 Mycophenolate mofetil DB01203 Nadolol DB01183 Naloxone DB00704 Naltrexone DB03467 Naringenin DB01149 Nefazodone DB00220 Nelfinavir DB01400 Neostigmine DB00622 Nicardipine DB01115 Nifedipine DB04868 Nilotinib DB09079 Nintedanib DB00401 Nisoldipine DB01595 Nitrazepam DB01054 Nitrendipine DB00585 Nizatidine DB00717 Norethisterone DB00334 Olanzapine DB09296 Ombitasvir DB00338 Omeprazole DB09330 Osimertinib DB04417 P-Nitrophenol DB01229 Paclitaxel DB03796 Palmitic Acid DB06603 Panobinostat DB00213 Pantoprazole DB00715 Paroxetine DB06589 Pazopanib DB00790 Perindopril DB01174 Phenobarbital DB00252 Phenytoin DB01100 Pimozide DB08860 Pitavastatin DB02261 Platelet Activating Factor DB08910 Pomalidomide DB08901 Ponatinib DB01263 Posaconazole DB00175 Pravastatin DB00457 Prazosin DB00860 Prednisolone DB00635 Prednisone DB01032 Probenecid DB00396 Progesterone DB01069 Promethazine DB01182 Propafenone DB00571 Propranolol DB00344 Protriptyline DB04216 Quercetin DB01224 Quetiapine DB01103 Quinacrine DB00908 Quinidine DB00468 Quinine DB00863 Ranitidine DB00234 Reboxetine DB08896 Regorafenib DB00206 Reserpine DB01045 Rifampicin DB08864 Rilpivirine DB00734 Risperidone DB00503 Ritonavir DB06228 Rivaroxaban DB09291 Rolapitant DB06176 Romidepsin DB00778 Roxithromycin DB00936 Salicylic acid DB01232 Saquinavir DB00747 Scopolamine DB01037 Selegiline DB11362 Selexipag DB01104 Sertraline DB06207 Silodosin DB06290 Simeprevir DB00641 Simvastatin DB00877 Sirolimus DB01261 Sitagliptin DB08934 Sofosbuvir DB00398 Sorafenib DB01208 Sparfloxacin DB03203 Sphingosine DB00421 Spironolactone DB01323 St. John's Wort DB02010 Staurosporine DB00428 Streptozocin DB01138 Sulfinpyrazone DB00669 Sumatriptan DB01268 Sunitinib DB00382 Tacrine DB00864 Tacrolimus DB00675 Tamoxifen DB04348 Taurocholic Acid DB09161 Technetium Tc-99m sestamibi DB05521 Telaprevir DB00966 Telmisartan DB06287 Temsirolimus DB01162 Terazosin DB00342 Terfenadine DB04905 Tesmilifene DB00624 Testosterone DB08816 Ticagrelor DB00373 Timolol DB06212 Tolvaptan DB01030 Topotecan DB00539 Toremifene DB05773 Trastuzumab emtansine DB00656 Trazodone DB00831 Trifluoperazine DB00508 Triflupromazine DB00440 Trimethoprim DB00726 Trimipramine DB01361 Troleandomycin DB08867 Ulipristal DB09076 Umeclidinium DB01339 Vecuronium DB11581 Venetoclax DB00285 Venlafaxine DB00661 Verapamil DB00570 Vinblastine DB00541 Vincristine DB00361 Vinorelbine DB08828 Vismodegib DB04877 Voacamine DB00495 Zidovudine DB04832 Zimelidine
SwissLipidsⁱ	SLP:000000385

Protein family/group databases

MoonDBⁱ	P08183 Curated
MoonProtⁱ	P08183
TCDBⁱ	3.A.1.201.1 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetⁱ	P08183
PhosphoSitePlusⁱ	P08183

Polymorphism and mutation databases

BioMutaⁱ	ABCB1
DMDMⁱ	238054374

Proteomic databases

EPDⁱ	P08183
MaxQBⁱ	P08183
PaxDbⁱ	P08183
PeptideAtlasⁱ	P08183
PRIDEⁱ	P08183
ProteomicsDBⁱ	52080

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5243
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000265724; ENSP00000265724; ENSG00000085563 [P08183-1] ENST00000543898; ENSP00000444095; ENSG00000085563 [P08183-2] ENST00000622132; ENSP00000478255; ENSG00000085563 [P08183-1]
GeneIDⁱ	5243
KEGGⁱ	hsa:5243
UCSCⁱ	uc003uiz.3 human [P08183-1]

Organism-specific databases

CTDⁱ	5243
DisGeNETⁱ	5243
EuPathDBⁱ	HostDB:ENSG00000085563.14
GeneCardsⁱ	ABCB1
H-InvDBⁱ	HIX0033521
HGNCⁱ	HGNC:40 ABCB1
HPAⁱ	CAB001716 HPA002199
MalaCardsⁱ	ABCB1
MIMⁱ	171050 gene 612244 phenotype
neXtProtⁱ	NX_P08183
OpenTargetsⁱ	ENSG00000085563
Orphanetⁱ	771 NON RARE IN EUROPE: Ulcerative colitis
PharmGKBⁱ	PA267
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0055 Eukaryota COG1132 LUCA
GeneTreeⁱ	ENSGT00530000062896
HOVERGENⁱ	HBG080809
InParanoidⁱ	P08183
KOⁱ	K05658
OMAⁱ	THRMANA
OrthoDBⁱ	EOG091G0HVA
PhylomeDBⁱ	P08183
TreeFamⁱ	TF105193

Enzyme and pathway databases

BRENDAⁱ	3.6.3.44 2681
Reactomeⁱ	R-HSA-2161517 Abacavir transmembrane transport R-HSA-382556 ABC-family proteins mediated transport
SIGNORⁱ	P08183

Miscellaneous databases

ChiTaRSⁱ	ABCB1 human
GeneWikiⁱ	P-glycoprotein
GenomeRNAiⁱ	5243
Protein Ontology More...PROⁱ	PR:P08183
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000085563 Expressed in 186 organ(s), highest expression level in right adrenal gland
CleanExⁱ	HS_ABCB1
ExpressionAtlasⁱ	P08183 baseline and differential
Genevisibleⁱ	P08183 HS

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 2 hits
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR030258 MDR1 IPR027417 P-loop_NTPase IPR039421 Type_I_exporter
PANTHERⁱ	PTHR24221 PTHR24221, 1 hit PTHR24221:SF251 PTHR24221:SF251, 1 hit
Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 2 hits PF00005 ABC_tran, 2 hits
SMARTⁱ	View protein in SMART SM00382 AAA, 2 hits
SUPFAMⁱ	SSF52540 SSF52540, 2 hits SSF90123 SSF90123, 2 hits
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 2 hits PS00211 ABC_TRANSPORTER_1, 2 hits PS50893 ABC_TRANSPORTER_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MDR1_HUMAN
Accessionⁱ	P08183Primary (citable) accession number: P08183 Secondary accession number(s): A8K294 , B5AK60, Q12755, Q14812
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	May 26, 2009
	Last modified:	November 7, 2018
	This is version 216 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - P08183 (MDR1_HUMAN)

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Multidrug resistance protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Plasma Membrane

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Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Inflammatory bowel disease 13 (IBD13)

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ