UniProtKB - P08174 (DAF_HUMAN)
Complement decay-accelerating factor
CD55
Functioni
GO - Molecular functioni
- lipid binding Source: UniProtKB
- virus receptor activity Source: UniProtKB
GO - Biological processi
- complement activation, classical pathway Source: UniProtKB-KW
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
- innate immune response Source: UniProtKB-KW
- negative regulation of complement activation Source: UniProtKB
- neutrophil degranulation Source: Reactome
- positive regulation of CD4-positive, alpha-beta T cell activation Source: UniProtKB
- positive regulation of CD4-positive, alpha-beta T cell proliferation Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB
- positive regulation of T cell cytokine production Source: UniProtKB
- regulation of complement activation Source: MGI
- regulation of complement-dependent cytotoxicity Source: MGI
- regulation of lipopolysaccharide-mediated signaling pathway Source: UniProtKB
- respiratory burst Source: UniProtKB
Keywordsi
Molecular function | Blood group antigen, Host cell receptor for virus entry, Receptor |
Biological process | Complement pathway, Host-virus interaction, Immunity, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | P08174 |
Reactomei | R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-6798695, Neutrophil degranulation R-HSA-6807878, COPI-mediated anterograde transport R-HSA-977606, Regulation of Complement cascade |
SIGNORi | P08174 |
Names & Taxonomyi
Protein namesi | Recommended name: Complement decay-accelerating factorAlternative name(s): CD_antigen: CD55 |
Gene namesi | Name:CD55 Synonyms:CR, DAF |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2665, CD55 |
MIMi | 125240, gene |
neXtProti | NX_P08174 |
VEuPathDBi | HostDB:ENSG00000196352.14 |
Subcellular locationi
Plasma membrane
Plasma membrane
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- Secreted 1 Publication
Plasma membrane
- Cell membrane 1 Publication; GPI-anchor 1 Publication
Plasma membrane
- Cell membrane 1 Publication; GPI-anchor 1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Golgi apparatus
- Golgi membrane Source: Reactome
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- anchored component of membrane Source: UniProtKB-KW
- cell surface Source: UniProtKB
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: Reactome
- ficolin-1-rich granule membrane Source: Reactome
- membrane raft Source: UniProtKB
- secretory granule membrane Source: Reactome
- transport vesicle Source: Reactome
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079373 | 267 | C → S in CHAPLE; increased complement activation. 1 PublicationCorresponds to variant dbSNP:rs1135402917EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 1604 |
MalaCardsi | CD55 |
MIMi | 226300, phenotype 613793, phenotype |
NIAGADSi | ENSG00000196352 |
OpenTargetsi | ENSG00000196352 |
PharmGKBi | PA27137 |
Miscellaneous databases
Pharosi | P08174, Tbio |
Chemistry databases
DrugBanki | DB00446, Chloramphenicol |
Genetic variation databases
BioMutai | CD55 |
DMDMi | 60416353 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | 2 PublicationsAdd BLAST | 34 | |
ChainiPRO_0000006000 | 35 – 353 | Complement decay-accelerating factorAdd BLAST | 319 | |
PropeptideiPRO_0000006001 | 354 – 381 | Removed in mature formAdd BLAST | 28 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 36 ↔ 81 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 65 ↔ 94 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 95 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 98 ↔ 145 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 129 ↔ 158 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 163 ↔ 204 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 190 ↔ 220 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 225 ↔ 267 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 253 ↔ 283 | PROSITE-ProRule annotation1 Publication | ||
Lipidationi | 353 | GPI-anchor amidated serine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
jPOSTi | P08174 |
MassIVEi | P08174 |
MaxQBi | P08174 |
PaxDbi | P08174 |
PeptideAtlasi | P08174 |
PRIDEi | P08174 |
ProteomicsDBi | 52078 [P08174-1] 52079 [P08174-2] 60351 60352 60353 |
PTM databases
GlyConnecti | 1151, 6 N-Linked glycans (1 site) |
GlyGeni | P08174, 1 site |
iPTMneti | P08174 |
PhosphoSitePlusi | P08174 |
SwissPalmi | P08174 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000196352, Expressed in nasal cavity epithelium and 238 other tissues |
ExpressionAtlasi | P08174, baseline and differential |
Genevisiblei | P08174, HS |
Organism-specific databases
HPAi | ENSG00000196352, Low tissue specificity |
Interactioni
Subunit structurei
Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form).
Interacts with ADGRE5 (PubMed:11297558).
1 Publication2 Publications(Microbial infection) Interacts with coxsackievirus A21, coxsackieviruses B1, B3 and B5 capsid proteins.
1 Publication(Microbial infection) Interacts with human enterovirus 70 and D68 capsid proteins (Probable).
1 Publication(Microbial infection) Interacts with human echoviruses 6, 7, 11, 12, 20 and 21 capsid proteins.
1 PublicationProtein-protein interaction databases
BioGRIDi | 107974, 41 interactors |
IntActi | P08174, 11 interactors |
STRINGi | 9606.ENSP00000356030 |
Miscellaneous databases
RNActi | P08174, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P08174 |
SMRi | P08174 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08174 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 96 | Sushi 1PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 96 – 160 | Sushi 2PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 161 – 222 | Sushi 3PROSITE-ProRule annotationAdd BLAST | 62 | |
Domaini | 223 – 285 | Sushi 4PROSITE-ProRule annotationAdd BLAST | 63 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 287 – 356 | Ser/Thr-richAdd BLAST | 70 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, SushiPhylogenomic databases
eggNOGi | ENOG502SKPE, Eukaryota |
GeneTreei | ENSGT00940000162307 |
InParanoidi | P08174 |
PhylomeDBi | P08174 |
TreeFami | TF334137 |
Family and domain databases
CDDi | cd00033, CCP, 4 hits |
InterProi | View protein in InterPro IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00084, Sushi, 4 hits |
SMARTi | View protein in SMART SM00032, CCP, 4 hits |
SUPFAMi | SSF57535, SSF57535, 4 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 4 hits |
s (7+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTVARPSVPA ALPLLGELPR LLLLVLLCLP AVWGDCGLPP DVPNAQPALE
60 70 80 90 100
GRTSFPEDTV ITYKCEESFV KIPGEKDSVI CLKGSQWSDI EEFCNRSCEV
110 120 130 140 150
PTRLNSASLK QPYITQNYFP VGTVVEYECR PGYRREPSLS PKLTCLQNLK
160 170 180 190 200
WSTAVEFCKK KSCPNPGEIR NGQIDVPGGI LFGATISFSC NTGYKLFGST
210 220 230 240 250
SSFCLISGSS VQWSDPLPEC REIYCPAPPQ IDNGIIQGER DHYGYRQSVT
260 270 280 290 300
YACNKGFTMI GEHSIYCTVN NDEGEWSGPP PECRGKSLTS KVPPTVQKPT
310 320 330 340 350
TVNVPTTEVS PTSQKTTTKT TTPNAQATRS TPVSRTTKHF HETTPNKGSG
360 370 380
TTSGTTRLLS GHTCFTLTGL LGTLVTMGLL T
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1AP13 | B1AP13_HUMAN | Complement decay-accelerating facto... | CD55 | 444 | Annotation score: | ||
H3BLV0 | H3BLV0_HUMAN | Complement decay-accelerating facto... | CD55 | 326 | Annotation score: | ||
B1AP15 | B1AP15_HUMAN | CD55 antigen, decay accelerating fa... | CD55 hCG_22206 | 317 | Annotation score: | ||
H7BY55 | H7BY55_HUMAN | Complement decay-accelerating facto... | CD55 | 550 | Annotation score: | ||
A0A2R8YEC5 | A0A2R8YEC5_HUMAN | Complement decay-accelerating facto... | CD55 | 268 | Annotation score: | ||
A0A2R8YDY3 | A0A2R8YDY3_HUMAN | Complement decay-accelerating facto... | CD55 | 194 | Annotation score: | ||
A0A2R8Y4B4 | A0A2R8Y4B4_HUMAN | Complement decay-accelerating facto... | CD55 | 61 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 80 | I → T in AAA52170 (PubMed:1711208).Curated | 1 | |
Sequence conflicti | 80 | I → T in AAA52167 (PubMed:2436222).Curated | 1 | |
Sequence conflicti | 85 | S → M in AAA52167 (PubMed:2436222).Curated | 1 | |
Sequence conflicti | 187 | S → T in AAB48622 (Ref. 10) Curated | 1 | |
Sequence conflicti | 297 | Q → H in AAB48622 (Ref. 10) Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_001997 | 52 | R → L in Tc(b) antigen. 1 PublicationCorresponds to variant dbSNP:rs28371588EnsemblClinVar. | 1 | |
Natural variantiVAR_001998 | 52 | R → P in Tc(c) antigen. Corresponds to variant dbSNP:rs28371588EnsemblClinVar. | 1 | |
Natural variantiVAR_001999 | 82 | L → R in WES(a) antigen. Corresponds to variant dbSNP:rs147474393Ensembl. | 1 | |
Natural variantiVAR_002000 | 199 | S → L in Dr(a-) antigen. 1 PublicationCorresponds to variant dbSNP:rs1135402914EnsemblClinVar. | 1 | |
Natural variantiVAR_002001 | 227 | A → P in Cr(a-) antigen. Corresponds to variant dbSNP:rs60822373Ensembl. | 1 | |
Natural variantiVAR_015884 | 240 | R → H in GUTI(-) antigen. 1 PublicationCorresponds to variant dbSNP:rs199705465Ensembl. | 1 | |
Natural variantiVAR_079373 | 267 | C → S in CHAPLE; increased complement activation. 1 PublicationCorresponds to variant dbSNP:rs1135402917EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047634 | 326 | Q → QGTETPSVLQKHTTENVSAT RTPPTPQKPTTVNVPATIVT PTPQKPTTINVPATGVSSTP QRHTIVNVSATGTLPTLQKP TRANDSATKSPAAAQTSFIS KTLSTKTPSAAQNPMMTNAS ATQATLTAQKFTTAKVAFTQ SPSAARKSTNVHSPVTNGLK STQRFPSAHIT in isoform 7. 1 Publication | 1 | |
Alternative sequenceiVSP_047635 | 327 | A → GTETPSVLQKHTTENVSATR TPPTPQKPTTVNVPATIVTP TPQKPTTINVPATGVSSTPQ RHTIVNVSATGTLPTLQKPT RANDSATKSPAAAQTSFISK TLSTKTPSAAQNPMMTNASA TQATLTAQKFTTAKVAFTQS PSAAP in isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_047636 | 361 – 381 | GHTCF…MGLLT → ALQVRPFEVSGSSHISSKKM MCIL in isoform 3. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_047637 | 361 – 381 | GHTCF…MGLLT → VLFM in isoform 4. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_047638 | 361 – 381 | GHTCF…MGLLT → ETVFHRVIQDGLDLLASRSA CLGLPKCWDYRREPPHLARA HVFHVDRFAWDASNHGLADL AKEELRRKYTQVYRLFLVS in isoform 5. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_001200 | 362 – 381 | HTCFT…MGLLT → SRPVTQAGMRWCDRSSLQSR TPGFKRSFHFSLPSSWYYRA HVFHVDRFAWDASNHGLADL AKEELRRKYTQVYRLFLVS in isoform 1. 2 PublicationsAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31516 mRNA Translation: AAA52169.1 M30142 mRNA Translation: AAA52168.1 AB240566 mRNA Translation: BAE97422.1 AB240567 mRNA Translation: BAE97423.1 AB240568 mRNA Translation: BAE97424.1 AB240569 mRNA Translation: BAE97425.1 AB240570 mRNA Translation: BAE97426.1 BT007159 mRNA Translation: AAP35823.1 AY851161 Genomic DNA Translation: AAW29942.1 AL391597 Genomic DNA No translation available. AL596218 Genomic DNA No translation available. CH471100 Genomic DNA Translation: EAW93485.1 CH471100 Genomic DNA Translation: EAW93487.1 CH471100 Genomic DNA Translation: EAW93488.1 CH471100 Genomic DNA Translation: EAW93491.1 BC001288 mRNA Translation: AAH01288.1 M64653, M64356 Genomic DNA Translation: AAA52170.1 M15799 mRNA Translation: AAA52167.1 U88576 mRNA Translation: AAB48622.1 S72858 Genomic DNA Translation: AAC60633.1 |
CCDSi | CCDS31006.1 [P08174-1] CCDS44307.1 [P08174-2] CCDS86046.1 [P08174-5] CCDS86047.1 [P08174-3] |
PIRi | A26359 B26359 |
RefSeqi | NP_000565.1, NM_000574.4 [P08174-1] NP_001108224.1, NM_001114752.2 [P08174-2] NP_001287832.1, NM_001300903.1 [P08174-5] NP_001287833.1, NM_001300904.1 [P08174-3] |
Genome annotation databases
Ensembli | ENST00000314754; ENSP00000316333; ENSG00000196352 [P08174-2] ENST00000367064; ENSP00000356031; ENSG00000196352 [P08174-1] ENST00000644836; ENSP00000495518; ENSG00000196352 [P08174-3] ENST00000645323; ENSP00000496251; ENSG00000196352 [P08174-5] |
GeneIDi | 1604 |
KEGGi | hsa:1604 |
UCSCi | uc001hfq.5, human [P08174-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
dbRBC/BGMUT Blood group antigen gene mutation database |
CD55base CD55 mutation db |
Wikipedia Decay-accelerating factor entry |
SeattleSNPs |
Virus Particle ExploreR db Icosahedral capsid structure |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M31516 mRNA Translation: AAA52169.1 M30142 mRNA Translation: AAA52168.1 AB240566 mRNA Translation: BAE97422.1 AB240567 mRNA Translation: BAE97423.1 AB240568 mRNA Translation: BAE97424.1 AB240569 mRNA Translation: BAE97425.1 AB240570 mRNA Translation: BAE97426.1 BT007159 mRNA Translation: AAP35823.1 AY851161 Genomic DNA Translation: AAW29942.1 AL391597 Genomic DNA No translation available. AL596218 Genomic DNA No translation available. CH471100 Genomic DNA Translation: EAW93485.1 CH471100 Genomic DNA Translation: EAW93487.1 CH471100 Genomic DNA Translation: EAW93488.1 CH471100 Genomic DNA Translation: EAW93491.1 BC001288 mRNA Translation: AAH01288.1 M64653, M64356 Genomic DNA Translation: AAA52170.1 M15799 mRNA Translation: AAA52167.1 U88576 mRNA Translation: AAB48622.1 S72858 Genomic DNA Translation: AAC60633.1 |
CCDSi | CCDS31006.1 [P08174-1] CCDS44307.1 [P08174-2] CCDS86046.1 [P08174-5] CCDS86047.1 [P08174-3] |
PIRi | A26359 B26359 |
RefSeqi | NP_000565.1, NM_000574.4 [P08174-1] NP_001108224.1, NM_001114752.2 [P08174-2] NP_001287832.1, NM_001300903.1 [P08174-5] NP_001287833.1, NM_001300904.1 [P08174-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1H03 | X-ray | 1.70 | P/Q | 161-285 | [»] | |
1H04 | X-ray | 2.00 | P | 161-285 | [»] | |
1H2P | X-ray | 2.80 | P | 161-285 | [»] | |
1H2Q | X-ray | 3.00 | P | 161-285 | [»] | |
1M11 | electron microscopy | 16.00 | R | 35-277 | [»] | |
1NWV | NMR | - | A | 96-222 | [»] | |
1OJV | X-ray | 2.30 | A/B | 35-285 | [»] | |
1OJW | X-ray | 2.30 | A/B | 35-285 | [»] | |
1OJY | X-ray | 2.60 | A/B/C/D | 35-285 | [»] | |
1OK1 | X-ray | 2.60 | A/B | 35-285 | [»] | |
1OK2 | X-ray | 2.50 | A/B | 35-285 | [»] | |
1OK3 | X-ray | 2.20 | A/B | 35-285 | [»] | |
1OK9 | X-ray | 3.00 | A/B | 35-285 | [»] | |
1UOT | X-ray | 3.00 | P | 161-285 | [»] | |
1UPN | electron microscopy | 16.00 | E | 157-285 | [»] | |
2C8I | electron microscopy | 14.00 | E | 35-285 | [»] | |
2QZD | electron microscopy | - | A | 222-285 | [»] | |
2QZF | electron microscopy | - | A | 35-94 | [»] | |
2QZH | electron microscopy | 14.00 | A | 96-222 | [»] | |
3IYP | electron microscopy | - | F | 1-381 | [»] | |
3J24 | electron microscopy | 9.00 | B | 35-285 | [»] | |
5FOA | X-ray | 4.19 | E/F | 97-285 | [»] | |
6ILJ | electron microscopy | 3.60 | E | 94-285 | [»] | |
6ILK | electron microscopy | 3.00 | E | 94-285 | [»] | |
6LA5 | electron microscopy | 2.86 | E | 161-285 | [»] | |
7C9W | electron microscopy | 3.60 | E | 94-285 | [»] | |
BMRBi | P08174 | |||||
SMRi | P08174 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107974, 41 interactors |
IntActi | P08174, 11 interactors |
STRINGi | 9606.ENSP00000356030 |
Chemistry databases
DrugBanki | DB00446, Chloramphenicol |
PTM databases
GlyConnecti | 1151, 6 N-Linked glycans (1 site) |
GlyGeni | P08174, 1 site |
iPTMneti | P08174 |
PhosphoSitePlusi | P08174 |
SwissPalmi | P08174 |
Genetic variation databases
BioMutai | CD55 |
DMDMi | 60416353 |
Proteomic databases
jPOSTi | P08174 |
MassIVEi | P08174 |
MaxQBi | P08174 |
PaxDbi | P08174 |
PeptideAtlasi | P08174 |
PRIDEi | P08174 |
ProteomicsDBi | 52078 [P08174-1] 52079 [P08174-2] 60351 60352 60353 |
Protocols and materials databases
ABCDi | P08174, 5 sequenced antibodies |
Antibodypediai | 710, 1580 antibodies |
DNASUi | 1604 |
Genome annotation databases
Ensembli | ENST00000314754; ENSP00000316333; ENSG00000196352 [P08174-2] ENST00000367064; ENSP00000356031; ENSG00000196352 [P08174-1] ENST00000644836; ENSP00000495518; ENSG00000196352 [P08174-3] ENST00000645323; ENSP00000496251; ENSG00000196352 [P08174-5] |
GeneIDi | 1604 |
KEGGi | hsa:1604 |
UCSCi | uc001hfq.5, human [P08174-1] |
Organism-specific databases
CTDi | 1604 |
DisGeNETi | 1604 |
GeneCardsi | CD55 |
HGNCi | HGNC:2665, CD55 |
HPAi | ENSG00000196352, Low tissue specificity |
MalaCardsi | CD55 |
MIMi | 125240, gene 226300, phenotype 613793, phenotype |
neXtProti | NX_P08174 |
NIAGADSi | ENSG00000196352 |
OpenTargetsi | ENSG00000196352 |
PharmGKBi | PA27137 |
VEuPathDBi | HostDB:ENSG00000196352.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SKPE, Eukaryota |
GeneTreei | ENSGT00940000162307 |
InParanoidi | P08174 |
PhylomeDBi | P08174 |
TreeFami | TF334137 |
Enzyme and pathway databases
PathwayCommonsi | P08174 |
Reactomei | R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-6798695, Neutrophil degranulation R-HSA-6807878, COPI-mediated anterograde transport R-HSA-977606, Regulation of Complement cascade |
SIGNORi | P08174 |
Miscellaneous databases
BioGRID-ORCSi | 1604, 3 hits in 999 CRISPR screens |
ChiTaRSi | CD55, human |
EvolutionaryTracei | P08174 |
GeneWikii | Decay-accelerating_factor |
GenomeRNAii | 1604 |
Pharosi | P08174, Tbio |
PROi | PR:P08174 |
RNActi | P08174, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196352, Expressed in nasal cavity epithelium and 238 other tissues |
ExpressionAtlasi | P08174, baseline and differential |
Genevisiblei | P08174, HS |
Family and domain databases
CDDi | cd00033, CCP, 4 hits |
InterProi | View protein in InterPro IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00084, Sushi, 4 hits |
SMARTi | View protein in SMART SM00032, CCP, 4 hits |
SUPFAMi | SSF57535, SSF57535, 4 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DAF_HUMAN | |
Accessioni | P08174Primary (citable) accession number: P08174 Secondary accession number(s): B1AP14 Q14UF6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | March 1, 2005 | |
Last modified: | April 7, 2021 | |
This is version 230 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Blood group antigen proteins
Nomenclature of blood group antigens and list of entries - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families