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Entry version 178 (16 Oct 2019)
Sequence version 2 (19 Sep 2002)
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Protein

Muscarinic acetylcholine receptor M4

Gene

CHRM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390648 Muscarinic acetylcholine receptors
R-HSA-418594 G alpha (i) signalling events

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P08173

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHRM4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1953 CHRM4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
118495 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08173

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 31ExtracellularBy similarityAdd BLAST31
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 54Helical; Name=1By similarityAdd BLAST23
Topological domaini55 – 68CytoplasmicBy similarityAdd BLAST14
Transmembranei69 – 89Helical; Name=2By similarityAdd BLAST21
Topological domaini90 – 106ExtracellularBy similarityAdd BLAST17
Transmembranei107 – 128Helical; Name=3By similarityAdd BLAST22
Topological domaini129 – 148CytoplasmicBy similarityAdd BLAST20
Transmembranei149 – 171Helical; Name=4By similarityAdd BLAST23
Topological domaini172 – 193ExtracellularBy similarityAdd BLAST22
Transmembranei194 – 216Helical; Name=5By similarityAdd BLAST23
Topological domaini217 – 401CytoplasmicBy similarityAdd BLAST185
Transmembranei402 – 422Helical; Name=6By similarityAdd BLAST21
Topological domaini423 – 436ExtracellularBy similarityAdd BLAST14
Transmembranei437 – 456Helical; Name=7By similarityAdd BLAST20
Topological domaini457 – 479CytoplasmicBy similarityAdd BLAST23

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1132

Open Targets

More...
OpenTargetsi
ENSG00000180720

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26485

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P08173

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1821

Drug and drug target database

More...
DrugBanki
DB03128 Acetylcholine
DB08897 Aclidinium
DB05752 ALKS 27
DB00321 Amitriptyline
DB00543 Amoxapine
DB01238 Aripiprazole
DB14185 Aripiprazole lauroxil
DB00572 Atropine
DB00767 Benzquinamide
DB01019 Bethanechol
DB00835 Brompheniramine
DB00411 Carbamoylcholine
DB01239 Chlorprothixene
DB00568 Cinnarizine
DB00363 Clozapine
DB00785 Cryptenamine
DB00496 Darifenacin
DB01151 Desipramine
DB09167 Dosulepin
DB01142 Doxepin
DB09194 Etoperidone
DB06702 Fesoterodine
DB06787 Hexocyclium
DB11181 Homatropine
DB00725 Homatropine methylbromide
DB00424 Hyoscyamine
DB00458 Imipramine
DB01625 Isopropamide
DB01221 Ketamine
DB00555 Lamotrigine
DB00408 Loxapine
DB00934 Maprotiline
DB00454 Meperidine
DB01403 Methotrimeprazine
DB00340 Metixene
DB00622 Nicardipine
DB00540 Nortriptyline
DB00334 Olanzapine
DB00715 Paroxetine
DB01085 Pilocarpine
DB00387 Procyclidine
DB00420 Promazine
DB01069 Promethazine
DB00777 Propiomazine
DB12278 Propiverine
DB01224 Quetiapine
DB11855 Revefenacin
DB13581 Rociverine
DB00747 Scopolamine
DB01591 Solifenacin
DB00342 Terfenadine
DB11235 Thonzylamine
DB01409 Tiotropium
DB01036 Tolterodine
DB00376 Trihexyphenidyl
DB09089 Trimebutine
DB00726 Trimipramine
DB00809 Tropicamide
DB09076 Umeclidinium
DB00246 Ziprasidone

DrugCentral

More...
DrugCentrali
P08173

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
16

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHRM4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
23503039

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000690371 – 479Muscarinic acetylcholine receptor M4Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi105 ↔ 185PROSITE-ProRule annotation
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei459PhosphothreonineSequence analysis1
Modified residuei463PhosphothreonineSequence analysis1
Modified residuei477PhosphothreonineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P08173

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P08173

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08173

PeptideAtlas

More...
PeptideAtlasi
P08173

PRoteomics IDEntifications database

More...
PRIDEi
P08173

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
52077

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08173

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P08173

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000180720 Expressed in 55 organ(s), highest expression level in caudate nucleus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P08173 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB022444
HPA072083

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107554, 74 interactors

Database of interacting proteins

More...
DIPi
DIP-61455N

Protein interaction database and analysis system

More...
IntActi
P08173, 78 interactors

Molecular INTeraction database

More...
MINTi
P08173

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000409378

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P08173

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1479
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P08173

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4220 Eukaryota
ENOG410YCQR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160394

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231484

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08173

KEGG Orthology (KO)

More...
KOi
K04132

Identification of Orthologs from Complete Genome Data

More...
OMAi
TSTHNRY

Database of Orthologous Groups

More...
OrthoDBi
1245472at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P08173

TreeFam database of animal gene trees

More...
TreeFami
TF320495

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001432 Musac_Ach_M4_rcpt
IPR000995 Musac_Ach_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR24248:SF142 PTHR24248:SF142, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN
PR00243 MUSCARINICR
PR00541 MUSCRINICM4R

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P08173-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANFTPVNGS SGNQSVRLVT SSSHNRYETV EMVFIATVTG SLSLVTVVGN
60 70 80 90 100
ILVMLSIKVN RQLQTVNNYF LFSLACADLI IGAFSMNLYT VYIIKGYWPL
110 120 130 140 150
GAVVCDLWLA LDYVVSNASV MNLLIISFDR YFCVTKPLTY PARRTTKMAG
160 170 180 190 200
LMIAAAWVLS FVLWAPAILF WQFVVGKRTV PDNQCFIQFL SNPAVTFGTA
210 220 230 240 250
IAAFYLPVVI MTVLYIHISL ASRSRVHKHR PEGPKEKKAK TLAFLKSPLM
260 270 280 290 300
KQSVKKPPPG EAAREELRNG KLEEAPPPAL PPPPRPVADK DTSNESSSGS
310 320 330 340 350
ATQNTKERPA TELSTTEATT PAMPAPPLQP RALNPASRWS KIQIVTKQTG
360 370 380 390 400
NECVTAIEIV PATPAGMRPA ANVARKFASI ARNQVRKKRQ MAARERKVTR
410 420 430 440 450
TIFAILLAFI LTWTPYNVMV LVNTFCQSCI PDTVWSIGYW LCYVNSTINP
460 470
ACYALCNATF KKTFRHLLLC QYRNIGTAR
Length:479
Mass (Da):53,049
Last modified:September 19, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9C1B05B359A64289
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M16405 Genomic DNA Translation: AAA51571.2
X15265 Genomic DNA Translation: CAA33336.1
AF498918 mRNA Translation: AAM18941.1
CH471064 Genomic DNA Translation: EAW68004.1
BC095546 mRNA Translation: AAH95546.1
BC119775 mRNA Translation: AAI19776.1
BC119817 mRNA Translation: AAI19818.1
BC137535 mRNA Translation: AAI37536.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44581.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S10127

NCBI Reference Sequences

More...
RefSeqi
NP_000732.2, NM_000741.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000433765; ENSP00000409378; ENSG00000180720

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1132

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1132

UCSC genome browser

More...
UCSCi
uc001nct.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16405 Genomic DNA Translation: AAA51571.2
X15265 Genomic DNA Translation: CAA33336.1
AF498918 mRNA Translation: AAM18941.1
CH471064 Genomic DNA Translation: EAW68004.1
BC095546 mRNA Translation: AAH95546.1
BC119775 mRNA Translation: AAI19776.1
BC119817 mRNA Translation: AAI19818.1
BC137535 mRNA Translation: AAI37536.1
CCDSiCCDS44581.1
PIRiS10127
RefSeqiNP_000732.2, NM_000741.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DSGX-ray2.60A/B22-226[»]
A/B390-478[»]
6D9Helectron microscopy3.60R2-23[»]
SMRiP08173
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi107554, 74 interactors
DIPiDIP-61455N
IntActiP08173, 78 interactors
MINTiP08173
STRINGi9606.ENSP00000409378

Chemistry databases

BindingDBiP08173
ChEMBLiCHEMBL1821
DrugBankiDB03128 Acetylcholine
DB08897 Aclidinium
DB05752 ALKS 27
DB00321 Amitriptyline
DB00543 Amoxapine
DB01238 Aripiprazole
DB14185 Aripiprazole lauroxil
DB00572 Atropine
DB00767 Benzquinamide
DB01019 Bethanechol
DB00835 Brompheniramine
DB00411 Carbamoylcholine
DB01239 Chlorprothixene
DB00568 Cinnarizine
DB00363 Clozapine
DB00785 Cryptenamine
DB00496 Darifenacin
DB01151 Desipramine
DB09167 Dosulepin
DB01142 Doxepin
DB09194 Etoperidone
DB06702 Fesoterodine
DB06787 Hexocyclium
DB11181 Homatropine
DB00725 Homatropine methylbromide
DB00424 Hyoscyamine
DB00458 Imipramine
DB01625 Isopropamide
DB01221 Ketamine
DB00555 Lamotrigine
DB00408 Loxapine
DB00934 Maprotiline
DB00454 Meperidine
DB01403 Methotrimeprazine
DB00340 Metixene
DB00622 Nicardipine
DB00540 Nortriptyline
DB00334 Olanzapine
DB00715 Paroxetine
DB01085 Pilocarpine
DB00387 Procyclidine
DB00420 Promazine
DB01069 Promethazine
DB00777 Propiomazine
DB12278 Propiverine
DB01224 Quetiapine
DB11855 Revefenacin
DB13581 Rociverine
DB00747 Scopolamine
DB01591 Solifenacin
DB00342 Terfenadine
DB11235 Thonzylamine
DB01409 Tiotropium
DB01036 Tolterodine
DB00376 Trihexyphenidyl
DB09089 Trimebutine
DB00726 Trimipramine
DB00809 Tropicamide
DB09076 Umeclidinium
DB00246 Ziprasidone
DrugCentraliP08173
GuidetoPHARMACOLOGYi16

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP08173
PhosphoSitePlusiP08173

Polymorphism and mutation databases

BioMutaiCHRM4
DMDMi23503039

Proteomic databases

jPOSTiP08173
MassIVEiP08173
PaxDbiP08173
PeptideAtlasiP08173
PRIDEiP08173
ProteomicsDBi52077

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1132

Genome annotation databases

EnsembliENST00000433765; ENSP00000409378; ENSG00000180720
GeneIDi1132
KEGGihsa:1132
UCSCiuc001nct.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1132
DisGeNETi1132

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CHRM4
HGNCiHGNC:1953 CHRM4
HPAiCAB022444
HPA072083
MIMi118495 gene
neXtProtiNX_P08173
OpenTargetsiENSG00000180720
PharmGKBiPA26485

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4220 Eukaryota
ENOG410YCQR LUCA
GeneTreeiENSGT00940000160394
HOGENOMiHOG000231484
InParanoidiP08173
KOiK04132
OMAiTSTHNRY
OrthoDBi1245472at2759
PhylomeDBiP08173
TreeFamiTF320495

Enzyme and pathway databases

ReactomeiR-HSA-390648 Muscarinic acetylcholine receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiP08173

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Muscarinic_acetylcholine_receptor_M4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1132
PharosiP08173

Protein Ontology

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PROi
PR:P08173

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000180720 Expressed in 55 organ(s), highest expression level in caudate nucleus
GenevisibleiP08173 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001432 Musac_Ach_M4_rcpt
IPR000995 Musac_Ach_rcpt
PANTHERiPTHR24248:SF142 PTHR24248:SF142, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00243 MUSCARINICR
PR00541 MUSCRINICM4R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACM4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08173
Secondary accession number(s): B2RPP4, Q0VD60, Q4VBK7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: September 19, 2002
Last modified: October 16, 2019
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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