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Entry version 192 (10 Apr 2019)
Sequence version 1 (01 Aug 1988)
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Protein

Muscarinic acetylcholine receptor M2

Gene

CHRM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390648 Muscarinic acetylcholine receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P08172

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P08172

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Muscarinic acetylcholine receptor M2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHRM2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000181072.11

Human Gene Nomenclature Database

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HGNCi
HGNC:1951 CHRM2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
118493 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08172

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 22ExtracellularAdd BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei23 – 45Helical; Name=1Add BLAST23
Topological domaini46 – 59CytoplasmicAdd BLAST14
Transmembranei60 – 80Helical; Name=2Add BLAST21
Topological domaini81 – 97ExtracellularAdd BLAST17
Transmembranei98 – 119Helical; Name=3Add BLAST22
Topological domaini120 – 139CytoplasmicAdd BLAST20
Transmembranei140 – 162Helical; Name=4Add BLAST23
Topological domaini163 – 184ExtracellularAdd BLAST22
Transmembranei185 – 209Helical; Name=5Add BLAST25
Topological domaini210 – 387CytoplasmicAdd BLAST178
Transmembranei388 – 410Helical; Name=6Add BLAST23
Topological domaini411 – 418Extracellular8
Transmembranei419 – 442Helical; Name=7Add BLAST24
Topological domaini443 – 466CytoplasmicAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Major depressive disorder (MDD)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.
See also OMIM:608516

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58N → A: Nearly abolishes signaling via downstream effectors. 1 Publication1
Mutagenesisi103D → E: Reduced affinity for acetylcholine. Abolishes signaling via downstream effectors. 1 Publication1
Mutagenesisi206Y → F: Abolishes signaling via downstream effectors. 1 Publication1
Mutagenesisi404N → Q: Reduced affinity for acetylcholine. Reduces signaling via downstream effectors. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1129
MIMi103780 phenotype
608516 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000181072

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA111

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL211

Drug and drug target database

More...
DrugBanki
DB08897 Aclidinium
DB05752 ALKS 27
DB00321 Amitriptyline
DB00543 Amoxapine
DB00517 Anisotropine Methylbromide
DB01238 Aripiprazole
DB00572 Atropine
DB00767 Benzquinamide
DB01019 Bethanechol
DB00835 Brompheniramine
DB00411 Carbachol
DB01239 Chlorprothixene
DB00568 Cinnarizine
DB00363 Clozapine
DB00907 Cocaine
DB00785 Cryptenamine
DB00434 Cyproheptadine
DB00496 Darifenacin
DB01151 Desipramine
DB00804 Dicyclomine
DB08801 Dimetindene
DB01075 Diphenhydramine
DB01231 Diphenidol
DB00280 Disopyramide
DB01135 Doxacurium chloride
DB01142 Doxepin
DB00392 Ethopropazine
DB06702 Fesoterodine
DB01148 Flavoxate
DB00483 Gallamine Triethiodide
DB00986 Glycopyrronium
DB00725 Homatropine Methylbromide
DB00424 Hyoscyamine
DB00458 Imipramine
DB00332 Ipratropium bromide
DB01221 Ketamine
DB00408 Loxapine
DB00934 Maprotiline
DB01403 Methotrimeprazine
DB00462 Methylscopolamine bromide
DB00340 Metixene
DB01336 Metocurine
DB01226 Mivacurium
DB00622 Nicardipine
DB00540 Nortriptyline
DB00334 Olanzapine
DB01062 Oxybutynin
DB00383 Oxyphencyclimine
DB01337 Pancuronium
DB00715 Paroxetine
DB00454 Pethidine
DB01085 Pilocarpine
DB01338 Pipecuronium
DB00387 Procyclidine
DB00420 Promazine
DB01069 Promethazine
DB00777 Propiomazine
DB01224 Quetiapine
DB00728 Rocuronium
DB00747 Scopolamine
DB01591 Solifenacin
DB00202 Succinylcholine
DB00342 Terfenadine
DB01409 Tiotropium
DB01036 Tolterodine
DB00505 Tridihexethyl
DB00508 Triflupromazine
DB00376 Trihexyphenidyl
DB00726 Trimipramine
DB00809 Tropicamide
DB09076 Umeclidinium
DB00246 Ziprasidone

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
14

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHRM2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
113122

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000690211 – 466Muscarinic acetylcholine receptor M2Add BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi96 ↔ 176
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei232PhosphoserineBy similarity1
Disulfide bondi413 ↔ 416
Modified residuei446PhosphothreonineSequence analysis1
Modified residuei450PhosphothreonineSequence analysis1
Modified residuei465PhosphothreonineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in response to agonist treatment.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P08172

PeptideAtlas

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PeptideAtlasi
P08172

PRoteomics IDEntifications database

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PRIDEi
P08172

ProteomicsDB human proteome resource

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ProteomicsDBi
52076

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08172

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P08172

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P08172

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in response to enterovirus 71 (EV71) infection.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000181072 Expressed in 60 organ(s), highest expression level in heart

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P08172 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB022338
HPA029795

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARRB1 and ARRB2. Interacts with RACK1; the interaction regulates CHRM2 internalization.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107551, 4 interactors

Database of interacting proteins

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DIPi
DIP-56282N

Protein interaction database and analysis system

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IntActi
P08172, 23 interactors

Molecular INTeraction database

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MINTi
P08172

STRING: functional protein association networks

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STRINGi
9606.ENSP00000399745

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P08172

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1466
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LUBmodel-A1-50[»]
3UONX-ray3.00A1-217[»]
A377-466[»]
4MQSX-ray3.50A1-466[»]
4MQTX-ray3.70A1-466[»]
5YC8X-ray2.50A10-466[»]
5ZK3X-ray2.60A10-466[»]
5ZK8X-ray3.00A10-466[»]
5ZKBX-ray2.95A10-466[»]
5ZKCX-ray2.30A10-466[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P08172

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P08172

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni103 – 107Agonist bindingCurated5
Regioni403 – 404Agonist bindingCurated2
Regioni426 – 430Agonist bindingCurated5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi120 – 122Important for signaling3
Motifi436 – 440Important for signaling5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4220 Eukaryota
ENOG410YCQR LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158940

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231484

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG105720

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P08172

KEGG Orthology (KO)

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KOi
K04130

Identification of Orthologs from Complete Genome Data

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OMAi
CIKIVTK

Database of Orthologous Groups

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OrthoDBi
1025450at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P08172

TreeFam database of animal gene trees

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TreeFami
TF320495

Family and domain databases

Conserved Domains Database

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CDDi
cd15297 7tmA_mAChR_M2, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001065 Musac_Ach_M2_rcpt
IPR000995 Musac_Ach_rcpt

Pfam protein domain database

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Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00237 GPCRRHODOPSN
PR00243 MUSCARINICR
PR00539 MUSCRINICM2R

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P08172-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNSTNSSNN SLALTSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV
60 70 80 90 100
NRHLQTVNNY FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL
110 120 130 140 150
ALDYVVSNAS VMNLLIISFD RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL
160 170 180 190 200
SFILWAPAIL FWQFIVGVRT VEDGECYIQF FSNAAVTFGT AIAAFYLPVI
210 220 230 240 250
IMTVLYWHIS RASKSRIKKD KKEPVANQDP VSPSLVQGRI VKPNNNNMPS
260 270 280 290 300
SDDGLEHNKI QNGKAPRDPV TENCVQGEEK ESSNDSTSVS AVASNMRDDE
310 320 330 340 350
ITQDENTVST SLGHSKDENS KQTCIRIGTK TPKSDSCTPT NTTVEVVGSS
360 370 380 390 400
GQNGDEKQNI VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW
410 420 430 440 450
APYNVMVLIN TFCAPCIPNT VWTIGYWLCY INSTINPACY ALCNATFKKT
460
FKHLLMCHYK NIGATR
Length:466
Mass (Da):51,715
Last modified:August 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FC2FD7748C22BEC
GO

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in CHRM2 can influence susceptibility to alcoholism [MIMi:103780].1 Publication

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M16404 Genomic DNA Translation: AAA51570.1
X15264 Genomic DNA Translation: CAA33335.1
AF498916 mRNA Translation: AAM18939.1
BC095547 mRNA Translation: AAH95547.1
BC106741 mRNA Translation: AAI06742.1
BC106742 mRNA Translation: AAI06743.1
AB041391 Genomic DNA Translation: BAA94476.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5843.1

Protein sequence database of the Protein Information Resource

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PIRi
S10126

NCBI Reference Sequences

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RefSeqi
NP_000730.1, NM_000739.2
NP_001006627.1, NM_001006626.1
NP_001006628.1, NM_001006627.1
NP_001006629.1, NM_001006628.1
NP_001006630.1, NM_001006629.1
NP_001006631.1, NM_001006630.1
NP_001006632.1, NM_001006631.1
NP_001006633.1, NM_001006632.1
XP_011514071.1, XM_011515769.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.535891

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000320658; ENSP00000319984; ENSG00000181072
ENST00000401861; ENSP00000384401; ENSG00000181072
ENST00000445907; ENSP00000399745; ENSG00000181072
ENST00000453373; ENSP00000415386; ENSG00000181072

Database of genes from NCBI RefSeq genomes

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GeneIDi
1129

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1129

UCSC genome browser

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UCSCi
uc003vtg.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16404 Genomic DNA Translation: AAA51570.1
X15264 Genomic DNA Translation: CAA33335.1
AF498916 mRNA Translation: AAM18939.1
BC095547 mRNA Translation: AAH95547.1
BC106741 mRNA Translation: AAI06742.1
BC106742 mRNA Translation: AAI06743.1
AB041391 Genomic DNA Translation: BAA94476.1
CCDSiCCDS5843.1
PIRiS10126
RefSeqiNP_000730.1, NM_000739.2
NP_001006627.1, NM_001006626.1
NP_001006628.1, NM_001006627.1
NP_001006629.1, NM_001006628.1
NP_001006630.1, NM_001006629.1
NP_001006631.1, NM_001006630.1
NP_001006632.1, NM_001006631.1
NP_001006633.1, NM_001006632.1
XP_011514071.1, XM_011515769.2
UniGeneiHs.535891

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LUBmodel-A1-50[»]
3UONX-ray3.00A1-217[»]
A377-466[»]
4MQSX-ray3.50A1-466[»]
4MQTX-ray3.70A1-466[»]
5YC8X-ray2.50A10-466[»]
5ZK3X-ray2.60A10-466[»]
5ZK8X-ray3.00A10-466[»]
5ZKBX-ray2.95A10-466[»]
5ZKCX-ray2.30A10-466[»]
ProteinModelPortaliP08172
SMRiP08172
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107551, 4 interactors
DIPiDIP-56282N
IntActiP08172, 23 interactors
MINTiP08172
STRINGi9606.ENSP00000399745

Chemistry databases

BindingDBiP08172
ChEMBLiCHEMBL211
DrugBankiDB08897 Aclidinium
DB05752 ALKS 27
DB00321 Amitriptyline
DB00543 Amoxapine
DB00517 Anisotropine Methylbromide
DB01238 Aripiprazole
DB00572 Atropine
DB00767 Benzquinamide
DB01019 Bethanechol
DB00835 Brompheniramine
DB00411 Carbachol
DB01239 Chlorprothixene
DB00568 Cinnarizine
DB00363 Clozapine
DB00907 Cocaine
DB00785 Cryptenamine
DB00434 Cyproheptadine
DB00496 Darifenacin
DB01151 Desipramine
DB00804 Dicyclomine
DB08801 Dimetindene
DB01075 Diphenhydramine
DB01231 Diphenidol
DB00280 Disopyramide
DB01135 Doxacurium chloride
DB01142 Doxepin
DB00392 Ethopropazine
DB06702 Fesoterodine
DB01148 Flavoxate
DB00483 Gallamine Triethiodide
DB00986 Glycopyrronium
DB00725 Homatropine Methylbromide
DB00424 Hyoscyamine
DB00458 Imipramine
DB00332 Ipratropium bromide
DB01221 Ketamine
DB00408 Loxapine
DB00934 Maprotiline
DB01403 Methotrimeprazine
DB00462 Methylscopolamine bromide
DB00340 Metixene
DB01336 Metocurine
DB01226 Mivacurium
DB00622 Nicardipine
DB00540 Nortriptyline
DB00334 Olanzapine
DB01062 Oxybutynin
DB00383 Oxyphencyclimine
DB01337 Pancuronium
DB00715 Paroxetine
DB00454 Pethidine
DB01085 Pilocarpine
DB01338 Pipecuronium
DB00387 Procyclidine
DB00420 Promazine
DB01069 Promethazine
DB00777 Propiomazine
DB01224 Quetiapine
DB00728 Rocuronium
DB00747 Scopolamine
DB01591 Solifenacin
DB00202 Succinylcholine
DB00342 Terfenadine
DB01409 Tiotropium
DB01036 Tolterodine
DB00505 Tridihexethyl
DB00508 Triflupromazine
DB00376 Trihexyphenidyl
DB00726 Trimipramine
DB00809 Tropicamide
DB09076 Umeclidinium
DB00246 Ziprasidone
GuidetoPHARMACOLOGYi14

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiP08172
PhosphoSitePlusiP08172
SwissPalmiP08172

Polymorphism and mutation databases

BioMutaiCHRM2
DMDMi113122

Proteomic databases

PaxDbiP08172
PeptideAtlasiP08172
PRIDEiP08172
ProteomicsDBi52076

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1129
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320658; ENSP00000319984; ENSG00000181072
ENST00000401861; ENSP00000384401; ENSG00000181072
ENST00000445907; ENSP00000399745; ENSG00000181072
ENST00000453373; ENSP00000415386; ENSG00000181072
GeneIDi1129
KEGGihsa:1129
UCSCiuc003vtg.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1129
DisGeNETi1129
EuPathDBiHostDB:ENSG00000181072.11

GeneCards: human genes, protein and diseases

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GeneCardsi
CHRM2
HGNCiHGNC:1951 CHRM2
HPAiCAB022338
HPA029795
MIMi103780 phenotype
118493 gene
608516 phenotype
neXtProtiNX_P08172
OpenTargetsiENSG00000181072
PharmGKBiPA111

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4220 Eukaryota
ENOG410YCQR LUCA
GeneTreeiENSGT00940000158940
HOGENOMiHOG000231484
HOVERGENiHBG105720
InParanoidiP08172
KOiK04130
OMAiCIKIVTK
OrthoDBi1025450at2759
PhylomeDBiP08172
TreeFamiTF320495

Enzyme and pathway databases

ReactomeiR-HSA-390648 Muscarinic acetylcholine receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
SignaLinkiP08172
SIGNORiP08172

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CHRM2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Muscarinic_acetylcholine_receptor_M2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1129

Protein Ontology

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PROi
PR:P08172

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000181072 Expressed in 60 organ(s), highest expression level in heart
GenevisibleiP08172 HS

Family and domain databases

CDDicd15297 7tmA_mAChR_M2, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001065 Musac_Ach_M2_rcpt
IPR000995 Musac_Ach_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00243 MUSCARINICR
PR00539 MUSCRINICM2R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACM2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08172
Secondary accession number(s): Q4VBK6, Q9P1X9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 10, 2019
This is version 192 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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