Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 158 (16 Oct 2019)
Sequence version 2 (01 Oct 1989)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Cation-independent mannose-6-phosphate receptor

Gene

IGF2R

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processTransport

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
P08169

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cation-independent mannose-6-phosphate receptor
Short name:
CI Man-6-P receptor
Short name:
CI-MPR
Short name:
M6PR
Alternative name(s):
300 kDa mannose 6-phosphate receptor
Short name:
MPR 300
Insulin-like growth factor 2 receptor
Insulin-like growth factor II receptor
Short name:
IGF-II receptor
CD_antigen: CD222
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGF2R
Synonyms:M6P
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini45 – 2313LumenalSequence analysisAdd BLAST2269
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2314 – 2336HelicalSequence analysisAdd BLAST23
Topological domaini2337 – 2499CytoplasmicSequence analysisAdd BLAST163

Keywords - Cellular componenti

Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi723Y → F: No noticeable change in Man-6-P and Man-P-GlcNAc recognition. 1 Publication1
Mutagenesisi723Y → L: Severely impairs both Man-6-P and Man-P-GlcNAc recognition. 1 Publication1
Mutagenesisi2360 – 2362YKY → AKV: Loss of interaction between HA-II adapters and these tails, but does not affect the interaction between them and HA-I. 1 Publication3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 44Sequence analysisAdd BLAST44
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001922845 – 2499Cation-independent mannose-6-phosphate receptorAdd BLAST2455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi57 ↔ 77
Disulfide bondi85 ↔ 92
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi120N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi125 ↔ 155
Disulfide bondi140 ↔ 167
Disulfide bondi180 ↔ 218
Disulfide bondi234 ↔ 241
Disulfide bondi281 ↔ 312
Disulfide bondi294 ↔ 324
Disulfide bondi334 ↔ 375
Disulfide bondi383 ↔ 391
Glycosylationi409N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi429 ↔ 463
Disulfide bondi443 ↔ 475
Glycosylationi444N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi552N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi635N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi636 ↔ 672
Disulfide bondi680 ↔ 687
Disulfide bondi739 ↔ 768
Glycosylationi755N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi879N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi959N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1030N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1321N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1525 ↔ 1562PROSITE-ProRule annotation
Disulfide bondi1568 ↔ 1575PROSITE-ProRule annotation
Disulfide bondi1607 ↔ 1643PROSITE-ProRule annotation
Disulfide bondi1623 ↔ 1655PROSITE-ProRule annotation
Disulfide bondi1661 ↔ 1704PROSITE-ProRule annotation
Glycosylationi1665N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1715 ↔ 1722PROSITE-ProRule annotation
Disulfide bondi1759 ↔ 1792PROSITE-ProRule annotation
Glycosylationi1766N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1775 ↔ 1804PROSITE-ProRule annotation
Disulfide bondi1813 ↔ 1848PROSITE-ProRule annotation
Glycosylationi1825N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1859 ↔ 1865PROSITE-ProRule annotation
Disulfide bondi1902 ↔ 1984PROSITE-ProRule annotation
Disulfide bondi1912 ↔ 1936PROSITE-ProRule annotation
Disulfide bondi1926 ↔ 1951PROSITE-ProRule annotation
Disulfide bondi1966 ↔ 1996PROSITE-ProRule annotation
Disulfide bondi2003 ↔ 2038PROSITE-ProRule annotation
Disulfide bondi2048 ↔ 2055PROSITE-ProRule annotation
Disulfide bondi2091 ↔ 2122PROSITE-ProRule annotation
Glycosylationi2094N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2105 ↔ 2134PROSITE-ProRule annotation
Glycosylationi2145N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2220N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2361N6-acetyllysineBy similarity1
Modified residuei2421PhosphoserineBy similarity1
Modified residuei2438Omega-N-methylarginineBy similarity1
Modified residuei2492PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08169

PRoteomics IDEntifications database

More...
PRIDEi
P08169

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08169

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DPP4; the interaction is direct. Binds GGA1, GGA2 and GGA3 (By similarity). Binds HA-I and HA-II plasma membrane adapters.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
159160, 5 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P08169

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000037502

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12499
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P08169

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P08169

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati45 – 1701Add BLAST126
Repeati171 – 3272Add BLAST157
Repeati328 – 4783Add BLAST151
Repeati479 – 6294Add BLAST151
Repeati630 – 7715Add BLAST142
Repeati772 – 9336Add BLAST162
Repeati934 – 10897Add BLAST156
Repeati1090 – 12298Add BLAST140
Repeati1230 – 13739Add BLAST144
Repeati1374 – 151810Add BLAST145
Repeati1519 – 165811Add BLAST140
Repeati1659 – 180712Add BLAST149
Repeati1808 – 199913Add BLAST192
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1907 – 1953Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST47
Repeati2000 – 213714Add BLAST138
Repeati2138 – 229015Add BLAST153

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MRL1/IGF2R family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4504 Eukaryota
ENOG410ZWHP LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113638

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08169

KEGG Orthology (KO)

More...
KOi
K06564

Database of Orthologous Groups

More...
OrthoDBi
290124at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00062 FN2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 1 hit
2.70.130.10, 15 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000479 CIMR_rpt
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00878 CIMR, 15 hits
PF00040 fn2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00059 FN2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57440 SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P08169-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAAAGRSSH LGPAPAGRPP RCPLLLQLQL LLLLLLLPPG WVPGAAGTQG
60 70 80 90 100
AEFPELCSYT WEAVDTKNNM LYKINICGNM GVAQCGPSSA VCMHDLKTDS
110 120 130 140 150
FHSVGDSLLK TASRSLLEFN TTVNCKQQNH KIQSSITFLC GKTLGTPEFV
160 170 180 190 200
TATDCVHYFE WRTTAACKKN IFKANKEVPC YAFDRELKKH DLNPLIKTSG
210 220 230 240 250
AYLVDDSDPD TSLFINVCRD IEVLRASSPQ VRVCPTGAAA CLVRGDRAFD
260 270 280 290 300
VGRPQEGLKL VSNDRLVLSY VKEGAGQPDF CDGHSPAVTI TFVCPSERRE
310 320 330 340 350
GTIPKLTAKS NCRFEIEWVT EYACHRDYLE SRSCSLSSAQ HDVAVDLQPL
360 370 380 390 400
SRVEASDSLF YTSEADEYTY YLSICGGSQA PICNKKDAAV CQVKKADSTQ
410 420 430 440 450
VKVAGRPQNL TLRYSDGDLT LIYFGGEECS SGFQRMSVIN FECNQTAGNN
460 470 480 490 500
GRGAPVFTGE VDCTYFFTWD TKYACVHEKE ALLCGVSDGK QRFDLSALAR
510 520 530 540 550
HSELEQNWEA VDGSQREAEK KHFFINICHR VLQTGQARGC PEDAAVCAVD
560 570 580 590 600
KNGSKNLGRF ISSPTREKGN IQLSYSDGDE CGGGQKIITN ITLMCKPGDL
610 620 630 640 650
ESAPVLTTSR ADGCFYEFEW RTAAACVLSR TEGDNCTVFD SQAGFSFDLT
660 670 680 690 700
PLTKKDAYKV ETDKYEFHIN VCGPVSVGAC PPDSGACQVS RSDRKSWNLG
710 720 730 740 750
RSNAKLSYYD GMIQLTYRDG TPYNNEKRTP RATLITFLCD RDAGVGFPEY
760 770 780 790 800
QEEDNSTYNF RWYTSYACPE EPLECIVTDP VTLDQYDLSR LAKSEGGPGG
810 820 830 840 850
NWYSLDNGGA RSTWRKYYIN VCRPLNPVPG CDRYASACQM KYQGEQGSYS
860 870 880 890 900
ETVSISNLGV AKTGPMVEDS GSLLLEYVNG SACTTSDQRR TTYTTRIHLV
910 920 930 940 950
CSTGSLYTHP IFSLNWECVV SFLWNTAAAC PIRITTDIDQ VCSIKDPNSG
960 970 980 990 1000
YVFDLNPLNN SRGYVVLGIG KTFLFNVCGD MPACGTLDGK PASGCEAEVQ
1010 1020 1030 1040 1050
MDDMKTLKPG RLVGLEKSLQ LSTEGFITLN YTGLPSHPNG RADAFIIRFV
1060 1070 1080 1090 1100
CNDDVYPGTP KFLHQDIDSS LGIRDTFFEF ETALACVPSP VDCQVTDPAG
1110 1120 1130 1140 1150
NEYDLSGLSK ARKPWTAVDT FDEGKKRTFY LSVCTPLPYI PGCHGTAVGC
1160 1170 1180 1190 1200
CLVTEDSKLN LGVVQISPQV GANGSLSLVY VNGDKCKNQR FSTRINLECA
1210 1220 1230 1240 1250
HTTGSPTFQL QNDCEYVFLW RTVEACPVVR AEGDYCEVRD PRHGNLYNLI
1260 1270 1280 1290 1300
PLGLNDTVVR AGEYTYYFRV CGELTSGVCP TSDKSKVISS CQEKRGPQGF
1310 1320 1330 1340 1350
QKVAGLFNQK LTYENGVLKM NYTGGDTCHK VYQRSTTIFF YCDRSTQAPV
1360 1370 1380 1390 1400
FLQETSDCSY LFEWRTQYAC PPYDLTECSF KNEAGETYDL SSLSRYSDNW
1410 1420 1430 1440 1450
EAVTGTGSTE HYLINVCKSL SPQAGSDPCP PEAAVCLLGG PKPVNLGRVR
1460 1470 1480 1490 1500
DSPQWSQGLT LLKYVDGDLC PDQIRKKSTT IRFTCSESHV NSRPMFISAV
1510 1520 1530 1540 1550
EDCEYTFSWP TAAACAVKSN VHDDCQVTNP ATGHLFDLSS LSGRAGFTAA
1560 1570 1580 1590 1600
YSEKGLVYLS VCGDNENCAN GVGACFGQTR ISVGKASKRL TYVDQVLQLV
1610 1620 1630 1640 1650
YEGGSPCPSK TGLSYKSVIS FVCRPEVGPT NRPMLISLDK RTCTLFFSWH
1660 1670 1680 1690 1700
TPLACEQTTE CSVRNGSSLI DLSPLIHRTG GYEAYDESED DGSDTSPDFY
1710 1720 1730 1740 1750
INICQPLNPM HGLACPAGTA VCKVPVDGPP IDIGRVAGPP ILNPIANEVY
1760 1770 1780 1790 1800
LNFESSTPCL ADRHFNYTSL ITFHCKRGVS MGTPKLLRTS VCDFVFEWET
1810 1820 1830 1840 1850
PLVCPDEVKT DGCSLTDEQL YYSFNLSSLS KSTFKVTRGP HTYSVGVCTA
1860 1870 1880 1890 1900
AAGLDEGGCK DGAVCLLSGS KGASFGRLAS MKLDYRHQDE AVILSYANGD
1910 1920 1930 1940 1950
TCPPETEDGE PCVFPFVFNG KSYEECVVES RARLWCATTA NYDRDHEWGF
1960 1970 1980 1990 2000
CKHSTSHRTS VIIFKCDEDA DVGRPQVFSE VRGCEVTFEW KTKVVCPPKK
2010 2020 2030 2040 2050
MECKFVQKHR TYDLRLLSSL TGSWSFVHNG ASYYINLCQK IYKGPQDCSE
2060 2070 2080 2090 2100
RASVCKKSTS GEVQVLGLVH TQKLDVVDDR VIVTYSKGHY CGDNKTASAV
2110 2120 2130 2140 2150
IELTCAKTVG RPSFTRFDVD SCTYHFSWDS RAACAVKPQE VQMVNGTITN
2160 2170 2180 2190 2200
PANGRSFSLG DIYFKRFSAS GDVRTNGDRY IYEIQLSSIT GSSSPACSGA
2210 2220 2230 2240 2250
SICQRKANDQ HFSRKVGTSN QTRYYVQDGD LDVVFTSSSK CGKDKTKSVS
2260 2270 2280 2290 2300
STIFFHCDPL VKDGIPEFSH ETADCQYLFS WHTSAVCPLG AGFDEEIAGD
2310 2320 2330 2340 2350
DAQEHKGLSE RSQAVGAVLS LLLVALTACL LTLLLYKKER REMVMSRLTN
2360 2370 2380 2390 2400
CCRRSANVSY KYSKVNKEEE ADENETEWLM EEIQPPAPRP GKEGQENGHV
2410 2420 2430 2440 2450
AAKSVRAADT LSALHGDEQD SEDEVLTLPE VKVRPPGRAP GAEGGPPLRP
2460 2470 2480 2490
LPRKAPPPLR ADDRVGLVRG EPARRGRPRA AATPISTFHD DSDEDLLHV
Length:2,499
Mass (Da):274,529
Last modified:October 1, 1989 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3C1C9DEF2875159D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J03527 mRNA Translation: AAA30455.1
AF342811 mRNA Translation: AAL23908.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A25908 A30788

NCBI Reference Sequences

More...
RefSeqi
NP_776777.1, NM_174352.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
281849

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:281849

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03527 mRNA Translation: AAA30455.1
AF342811 mRNA Translation: AAL23908.1
PIRiA25908 A30788
RefSeqiNP_776777.1, NM_174352.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q25X-ray1.80A45-476[»]
1SYOX-ray2.20A/B45-476[»]
1SZ0X-ray2.10A/B45-476[»]
2KVANMR-A628-769[»]
2KVBNMR-A628-769[»]
SMRiP08169
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi159160, 5 interactors
ELMiP08169
STRINGi9913.ENSBTAP00000037502

Protein family/group databases

UniLectiniP08169

PTM databases

iPTMnetiP08169

Proteomic databases

PaxDbiP08169
PRIDEiP08169

Genome annotation databases

GeneIDi281849
KEGGibta:281849

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3482

Phylogenomic databases

eggNOGiKOG4504 Eukaryota
ENOG410ZWHP LUCA
HOGENOMiHOG000113638
InParanoidiP08169
KOiK06564
OrthoDBi290124at2759

Miscellaneous databases

EvolutionaryTraceiP08169

Family and domain databases

CDDicd00062 FN2, 1 hit
Gene3Di2.10.10.10, 1 hit
2.70.130.10, 15 hits
InterProiView protein in InterPro
IPR000479 CIMR_rpt
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR009011 Man6P_isomerase_rcpt-bd_dom_sf
PfamiView protein in Pfam
PF00878 CIMR, 15 hits
PF00040 fn2, 1 hit
SMARTiView protein in SMART
SM00059 FN2, 1 hit
SUPFAMiSSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPRI_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08169
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 1, 1989
Last modified: October 16, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again