E3 SUMO-protein ligase EGR2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.14

    "An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer."
    Dillon R.L., Brown S.T., Ling C., Shioda T., Muller W.J.
    Mol. Cell. Biol. 27:8648-8657(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH CITED1 AND SFN, MUTAGENESIS OF SER-377, DNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
• DNA binding Source: MGIInferred from direct assayⁱ
  • Ref.8

    "The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation."
    Sham M.H., Vesque C., Nonchev S., Marshall H., Frain M., Gupta R.D., Whiting J., Wilkinson D., Charnay P., Krumlauf R.
    Cell 72:183-196(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
• DNA-binding transcription factor activity Source: UniProtKBInferred from direct assayⁱ
  • Ref.10

    "Krox-20 controls SCIP expression, cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells."
    Zorick T.S., Syroid D.E., Brown A., Gridley T., Lemke G.
    Development 126:1397-1406(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • Ref.14

    "An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer."
    Dillon R.L., Brown S.T., Ling C., Shioda T., Muller W.J.
    Mol. Cell. Biol. 27:8648-8657(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH CITED1 AND SFN, MUTAGENESIS OF SER-377, DNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: UniProtKBInferred from direct assayⁱ
  • Ref.17

    "A de novo EGR2 variant, c.1232A > G p.Asp411Gly, causes severe early-onset Charcot-Marie-Tooth Neuropathy Type 3 (Dejerine-Sottas Neuropathy)."
    Grosz B.R., Golovchenko N.B., Ellis M., Kumar K., Nicholson G.A., Antonellis A., Kennerson M.L.
    Sci. Rep. 9:19336-19336(2019) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, MUTAGENESIS OF ASP-408.
• HMG box domain binding Source: MGI
• metal ion binding Source: UniProtKB-KW
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site."
    Vesque C., Maconochie M., Nonchev S., Ariza-McNaughton L., Kuroiwa A., Charnay P., Krumlauf R.
    EMBO J 15:5383-5396(1996) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Transcriptional regulation of adipogenesis by KLF4."
    Birsoy K., Chen Z., Friedman J.
    Cell Metab 7:339-347(2008) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.12

    "Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain."
    Manzanares M., Nardelli J., Gilardi-Hebenstreit P., Marshall H., Giudicelli F., Martinez-Pastor M.T., Krumlauf R., Charnay P.
    EMBO J. 21:365-376(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • Ref.8

    "The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation."
    Sham M.H., Vesque C., Nonchev S., Marshall H., Frain M., Gupta R.D., Whiting J., Wilkinson D., Charnay P., Krumlauf R.
    Cell 72:183-196(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• sequence-specific double-stranded DNA binding Source: MGI
• SUMO ligase activity Source: ARUK-UCLInferred from direct assayⁱ
  • "The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators."
    Garcia-Gutierrez P., Juarez-Vicente F., Gallardo-Chamizo F., Charnay P., Garcia-Dominguez M.
    EMBO Rep. 12:1018-1023(2011) [PubMed] [Europe PMC] [Abstract]
• transcription cis-regulatory region binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.14

    "An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer."
    Dillon R.L., Brown S.T., Ling C., Shioda T., Muller W.J.
    Mol. Cell. Biol. 27:8648-8657(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH CITED1 AND SFN, MUTAGENESIS OF SER-377, DNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
• ubiquitin protein ligase binding Source: MGI

GO - Biological processⁱ

• aorta development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes."
    Odelin G., Faure E., Kober F., Maurel-Zaffran C., Theron A., Coulpier F., Guillet B., Bernard M., Avierinos J.F., Charnay P., Topilko P., Zaffran S.
    Cardiovasc Res 104:443-455(2014) [PubMed] [Europe PMC] [Abstract]
• brain segmentation Source: MGIInferred from mutant phenotypeⁱ
  • "Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain."
    Schneider-Maunoury S., Topilko P., Seitandou T., Levi G., Cohen-Tannoudji M., Pournin S., Babinet C., Charnay P.
    Cell 75:1199-1214(1993) [PubMed] [Europe PMC] [Abstract]
• cellular response to organic substance Source: MGIInferred from direct assayⁱ
  • "Regulation of GATA-3 expression during CD4 lineage differentiation."
    Gimferrer I., Hu T., Simmons A., Wang C., Souabni A., Busslinger M., Bender T.P., Hernandez-Hoyos G., Alberola-Ila J.
    J Immunol 186:3892-3898(2011) [PubMed] [Europe PMC] [Abstract]
• facial nerve structural organization Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.10

    "Krox-20 controls SCIP expression, cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells."
    Zorick T.S., Syroid D.E., Brown A., Gridley T., Lemke G.
    Development 126:1397-1406(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • Ref.9

    "Krox-20 controls myelination in the peripheral nervous system."
    Topilko P., Schneider-Maunoury S., Levi G., Baron-Van Evercooren A., Chennoufi A.B., Seitanidou T., Babinet C., Charnay P.
    Nature 371:796-799(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
• fat cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.13

    "Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms."
    Chen Z., Torrens J.I., Anand A., Spiegelman B.M., Friedman J.M.
    Cell Metab. 1:93-106(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes."
    Odelin G., Faure E., Kober F., Maurel-Zaffran C., Theron A., Coulpier F., Guillet B., Bernard M., Avierinos J.F., Charnay P., Topilko P., Zaffran S.
    Cardiovasc Res 104:443-455(2014) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504."
    Reddy M.A., Das S., Zhuo C., Jin W., Wang M., Lanting L., Natarajan R.
    Arterioscler Thromb Vasc Biol 36:864-873(2016) [PubMed] [Europe PMC] [Abstract]
• learning or memory Source: Ensembl
• motor neuron axon guidance Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Hoxa1 and Krox-20 synergize to control the development of rhombomere 3."
    Helmbacher F., Pujades C., Desmarquet C., Frain M., Rijli F.M., Chambon P., Charnay P.
    Development 125:4739-4748(1998) [PubMed] [Europe PMC] [Abstract]
• myelination Source: MGIInferred from mutant phenotypeⁱ
  • "A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool."
    Garratt A.N., Voiculescu O., Topilko P., Charnay P., Birchmeier C.
    J Cell Biol 148:1035-1046(2000) [PubMed] [Europe PMC] [Abstract]
  • "Nab proteins are essential for peripheral nervous system myelination."
    Le N., Nagarajan R., Wang J.Y., Svaren J., LaPash C., Araki T., Schmidt R.E., Milbrandt J.
    Nat Neurosci 8:932-940(2005) [PubMed] [Europe PMC] [Abstract]
  • "CNS/PNS boundary transgression by central glia in the absence of Schwann cells or Krox20/Egr2 function."
    Coulpier F., Decker L., Funalot B., Vallat J.M., Garcia-Bragado F., Charnay P., Topilko P.
    J Neurosci 30:5958-5967(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of myelination Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.9

    "Krox-20 controls myelination in the peripheral nervous system."
    Topilko P., Schneider-Maunoury S., Levi G., Baron-Van Evercooren A., Chennoufi A.B., Seitanidou T., Babinet C., Charnay P.
    Nature 371:796-799(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
• positive regulation of Schwann cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.10

    "Krox-20 controls SCIP expression, cell cycle exit and susceptibility to apoptosis in developing myelinating Schwann cells."
    Zorick T.S., Syroid D.E., Brown A., Gridley T., Lemke G.
    Development 126:1397-1406(1999) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.12

    "Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain."
    Manzanares M., Nardelli J., Gilardi-Hebenstreit P., Marshall H., Giudicelli F., Martinez-Pastor M.T., Krumlauf R., Charnay P.
    EMBO J. 21:365-376(2002) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  • Ref.14

    "An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer."
    Dillon R.L., Brown S.T., Ling C., Shioda T., Muller W.J.
    Mol. Cell. Biol. 27:8648-8657(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH CITED1 AND SFN, MUTAGENESIS OF SER-377, DNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
• positive regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • Ref.8

    "The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation."
    Sham M.H., Vesque C., Nonchev S., Marshall H., Frain M., Gupta R.D., Whiting J., Wilkinson D., Charnay P., Krumlauf R.
    Cell 72:183-196(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• protein export from nucleus Source: UniProtKBInferred from direct assayⁱ
  • Ref.14

    "An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer."
    Dillon R.L., Brown S.T., Ling C., Shioda T., Muller W.J.
    Mol. Cell. Biol. 27:8648-8657(2007) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH CITED1 AND SFN, MUTAGENESIS OF SER-377, DNA-BINDING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
• protein sumoylation Source: ARUK-UCLInferred from direct assayⁱ
  • "The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators."
    Garcia-Gutierrez P., Juarez-Vicente F., Gallardo-Chamizo F., Charnay P., Garcia-Dominguez M.
    EMBO Rep. 12:1018-1023(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of neuronal synaptic plasticity Source: Ensembl
• regulation of ossification Source: MGIInferred from mutant phenotypeⁱ
  • "Defective bone formation in Krox-20 mutant mice."
    Levi G., Topilko P., Schneider-Maunoury S., Lasagna M., Mantero S., Cancedda R., Charnay P.
    Development 122:113-120(1996) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: MGIInferred from mutant phenotypeⁱ
  • "A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool."
    Garratt A.N., Voiculescu O., Topilko P., Charnay P., Birchmeier C.
    J Cell Biol 148:1035-1046(2000) [PubMed] [Europe PMC] [Abstract]
  • "Nab proteins are essential for peripheral nervous system myelination."
    Le N., Nagarajan R., Wang J.Y., Svaren J., LaPash C., Araki T., Schmidt R.E., Milbrandt J.
    Nat Neurosci 8:932-940(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to insulin Source: MGI
• rhombomere 3 development Source: MGIInferred from genetic interactionⁱ
  • "Hoxa1 and Krox-20 synergize to control the development of rhombomere 3."
    Helmbacher F., Pujades C., Desmarquet C., Frain M., Rijli F.M., Chambon P., Charnay P.
    Development 125:4739-4748(1998) [PubMed] [Europe PMC] [Abstract]
• rhombomere 3 formation Source: MGIInferred from mutant phenotypeⁱ
  • "Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain."
    Schneider-Maunoury S., Topilko P., Seitandou T., Levi G., Cohen-Tannoudji M., Pournin S., Babinet C., Charnay P.
    Cell 75:1199-1214(1993) [PubMed] [Europe PMC] [Abstract]
• rhombomere 3 structural organization Source: UniProtKBInferred from direct assayⁱ
  • Ref.8

    "The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation."
    Sham M.H., Vesque C., Nonchev S., Marshall H., Frain M., Gupta R.D., Whiting J., Wilkinson D., Charnay P., Krumlauf R.
    Cell 72:183-196(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• rhombomere 5 formation Source: MGIInferred from mutant phenotypeⁱ
  • "Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain."
    Schneider-Maunoury S., Topilko P., Seitandou T., Levi G., Cohen-Tannoudji M., Pournin S., Babinet C., Charnay P.
    Cell 75:1199-1214(1993) [PubMed] [Europe PMC] [Abstract]
• rhombomere 5 structural organization Source: UniProtKBInferred from direct assayⁱ
  • Ref.8

    "The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation."
    Sham M.H., Vesque C., Nonchev S., Marshall H., Frain M., Gupta R.D., Whiting J., Wilkinson D., Charnay P., Krumlauf R.
    Cell 72:183-196(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
• rhythmic behavior Source: MGIInferred from direct assayⁱ
  • "Reorganization of pontine rhythmogenic neuronal networks in Krox-20 knockout mice."
    Jacquin T.D., Borday V., Schneider-Maunoury S., Topilko P., Ghilini G., Kato F., Charnay P., Champagnat J.
    Neuron 17:747-758(1996) [PubMed] [Europe PMC] [Abstract]
• Schwann cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.9

    "Krox-20 controls myelination in the peripheral nervous system."
    Topilko P., Schneider-Maunoury S., Levi G., Baron-Van Evercooren A., Chennoufi A.B., Seitanidou T., Babinet C., Charnay P.
    Nature 371:796-799(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
• skeletal muscle cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.11

    "The Krox-20 null mutation differentially affects the development of masticatory muscles."
    Turman J.E. Jr., Chopiuk N.B., Shuler C.F.
    Dev. Neurosci. 23:113-121(2001) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• HMG box domain binding Source: MGI
• RNA polymerase II-specific DNA-binding transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Transcriptional regulation of adipogenesis by KLF4."
    Birsoy K., Chen Z., Friedman J.
    Cell Metab 7:339-347(2008) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MMTAKAVDKI PVTLSGFMHQ LPDSLYPVED LAASSVTIFP NGELGGPFDQ 
        60         70         80         90        100
MNGVAGDGMI NIDMTGEKRP LDLPYPSSFA PISAPRNQTF TYMGKFSIDP 
       110        120        130        140        150
QYPGASCYPE GIINIVSAGI LQGVTPPAST TASSSVTSAS PNPLATGPLG 
       160        170        180        190        200
VCTMSQTQPE LDHLYSPPPP PPPYSGCTGD LYQDPSAFLS PPSTTSTSSL 
       210        220        230        240        250
AYQPPPSYPS PKPAMDPGLI PMIPDYPGFF PSPCQRDPHG AAGPDRKPFP 
       260        270        280        290        300
CPLDSLRVPP PLTPLSTIRN FTLGGPGAGV TGPGASGGGE GPRLPGSGSA 
       310        320        330        340        350
AVTATPYNPH HLPLRPILRP RKYPNRPSKT PVHERPYPCP AEGCDRRFSR 
       360        370        380        390        400
SDELTRHIRI HTGHKPFQCR ICMRNFSRSD HLTTHIRTHT GEKPFACDYC 
       410        420        430        440        450
GRKFARSDER KRHTKIHLRQ KERKSSAPSA PPSAQSSASG PGGSQAGGSL 
       460        470
CGNSAIGGPL ASCTSRTRTP                                  

        10         20         30         40         50
MNGVAGDGMI NIDMTGEKRP LDLPYPSSFA PISAPRNQTF TYMGKFSIDP 
        60         70         80         90        100
QYPGASCYPE GIINIVSAGI LQGVTPPAST TASSSVTSAS PNPLATGPLG 
       110        120        130        140        150
VCTMSQTQPE LDHLYSPPPP PPPYSGCTGD LYQDPSAFLS PPSTTSTSSL 
       160        170        180        190        200
AYQPPPSYPS PKPAMDPGLI PMIPDYPGFF PSPCQRDPHG AAGPDRKPFP 
       210        220        230        240        250
CPLDSLRVPP PLTPLSTIRN FTLGGPGAGV TGPGASGGGE GPRLPGSGSA 
       260        270        280        290        300
AVTATPYNPH HLPLRPILRP RKYPNRPSKT PVHERPYPCP AEGCDRRFSR 
       310        320        330        340        350
SDELTRHIRI HTGHKPFQCR ICMRNFSRSD HLTTHIRTHT GEKPFACDYC 
       360        370        380        390        400
GRKFARSDER KRHTKIHLRQ KERKSSAPSA PPSAQSSASG PGGSQAGGSL 
       410        420
CGNSAIGGPL ASCTSRTRTP                                  

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. PATHWAY comments
   Index of metabolic and biosynthesis pathways
3. SIMILARITY comments
   Index of protein domains and families