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Protein

E3 SUMO-protein ligase EGR2

Gene

Egr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2. May play a role in the regulation of hindbrain segmentation, might act in combination with the Hox network to specify odd and even rhombomeres, and might participate in the control of the expression of some of the homeobox containing genes.3 Publications
E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.By similarity

Pathwayi: protein sumoylation

This protein is involved in the pathway protein sumoylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein sumoylation and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri337 – 361C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri367 – 389C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Transferase
Biological processTranscription, Transcription regulation, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayi
UPA00886

Names & Taxonomyi

Protein namesi
Recommended name:
E3 SUMO-protein ligase EGR2 (EC:2.3.2.-)
Alternative name(s):
E3 SUMO-protein transferase ERG2Curated
Early growth response protein 2
Short name:
EGR-2
Zinc finger protein Krox-20
Gene namesi
Name:Egr2
Synonyms:Egr-2, Krox-20, Zfp-25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:95296 Egr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi174Y → F: Abolishes interaction with WWP2; if associated with F-208. 1 Publication1
Mutagenesisi208Y → F: Abolishes interaction with WWP2; if associated with F-174. 1 Publication1
Mutagenesisi377S → A: Inhibits interaction with SFN. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471201 – 470E3 SUMO-protein ligase EGR2Add BLAST470

Post-translational modificationi

Ubiquitinated by WWP2 leading to proteasomal degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP08152
PRIDEiP08152

PTM databases

iPTMnetiP08152
PhosphoSitePlusiP08152

Expressioni

Tissue specificityi

Expressed in mammary tumors (at protein level). Expressed mainly in adult thymus and embryonic nervous system.1 Publication

Inductioni

Activated during G0/G1 transition in cultured cells.

Gene expression databases

BgeeiENSMUSG00000037868 Expressed in 203 organ(s), highest expression level in sciatic nerve
CleanExiMM_EGR2
ExpressionAtlasiP08152 baseline and differential
GenevisibleiP08152 MM

Interactioni

Subunit structurei

Interacts with HCFC1. Interacts with UBC9 (By similarity). Interacts with WWP2. Interacts with CITED1. Interacts (via phosphorylated form) with SFN.By similarity2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199405, 5 interactors
ELMiP08152
IntActiP08152, 5 interactors
MINTiP08152
STRINGi10090.ENSMUSP00000041053

Structurei

3D structure databases

ProteinModelPortaliP08152
SMRiP08152
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi167 – 173Poly-Pro7

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri337 – 361C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri367 – 389C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri395 – 417C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000036856
HOVERGENiHBG003909
InParanoidiP08152
KOiK12496
OrthoDBiEOG091G06VX
PhylomeDBiP08152
TreeFamiTF318980

Family and domain databases

InterProiView protein in InterPro
IPR021849 EGR
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF11928 DUF3446, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform Long (identifier: P08152-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMTAKAVDKI PVTLSGFMHQ LPDSLYPVED LAASSVTIFP NGELGGPFDQ
60 70 80 90 100
MNGVAGDGMI NIDMTGEKRP LDLPYPSSFA PISAPRNQTF TYMGKFSIDP
110 120 130 140 150
QYPGASCYPE GIINIVSAGI LQGVTPPAST TASSSVTSAS PNPLATGPLG
160 170 180 190 200
VCTMSQTQPE LDHLYSPPPP PPPYSGCTGD LYQDPSAFLS PPSTTSTSSL
210 220 230 240 250
AYQPPPSYPS PKPAMDPGLI PMIPDYPGFF PSPCQRDPHG AAGPDRKPFP
260 270 280 290 300
CPLDSLRVPP PLTPLSTIRN FTLGGPGAGV TGPGASGGGE GPRLPGSGSA
310 320 330 340 350
AVTATPYNPH HLPLRPILRP RKYPNRPSKT PVHERPYPCP AEGCDRRFSR
360 370 380 390 400
SDELTRHIRI HTGHKPFQCR ICMRNFSRSD HLTTHIRTHT GEKPFACDYC
410 420 430 440 450
GRKFARSDER KRHTKIHLRQ KERKSSAPSA PPSAQSSASG PGGSQAGGSL
460 470
CGNSAIGGPL ASCTSRTRTP
Length:470
Mass (Da):49,819
Last modified:November 1, 1997 - v3
Checksum:i67712733C77960F0
GO
Isoform Short (identifier: P08152-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.

Show »
Length:420
Mass (Da):44,500
Checksum:i945C01B7DF6F20E3
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z3K7D3Z3K7_MOUSE
E3 SUMO-protein ligase EGR2
Egr2
412Annotation score:
D3YYY2D3YYY2_MOUSE
E3 SUMO-protein ligase EGR2
Egr2
281Annotation score:
D3Z4G7D3Z4G7_MOUSE
E3 SUMO-protein ligase EGR2
Egr2
236Annotation score:
D3YXS2D3YXS2_MOUSE
E3 SUMO-protein ligase EGR2
Egr2
72Annotation score:
D3Z4X9D3Z4X9_MOUSE
E3 SUMO-protein ligase EGR2
Egr2
36Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0068641 – 50Missing in isoform Short. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24377, M24376 Genomic DNA Translation: AAA39379.1
M24377, M24376 Genomic DNA Translation: AAA39380.1
X06746 mRNA Translation: CAA29921.1
BC009093 mRNA Translation: AAH09093.1
M20759 Genomic DNA Translation: AAA39381.1
CCDSiCCDS35927.2 [P08152-1]
CCDS83706.1 [P08152-2]
PIRiA30136
S00256
RefSeqiNP_001334387.1, NM_001347458.1 [P08152-2]
NP_034248.2, NM_010118.3 [P08152-1]
XP_006513272.1, XM_006513209.2 [P08152-2]
XP_006513273.1, XM_006513210.2 [P08152-2]
XP_006513274.1, XM_006513211.2 [P08152-2]
XP_006513276.1, XM_006513213.3 [P08152-2]
XP_011241670.1, XM_011243368.2 [P08152-2]
UniGeneiMm.290421

Genome annotation databases

EnsembliENSMUST00000048289; ENSMUSP00000041053; ENSMUSG00000037868 [P08152-1]
ENSMUST00000105438; ENSMUSP00000101078; ENSMUSG00000037868 [P08152-2]
ENSMUST00000229738; ENSMUSP00000155634; ENSMUSG00000116458 [P08152-1]
ENSMUST00000231046; ENSMUSP00000155032; ENSMUSG00000116458 [P08152-2]
GeneIDi13654
KEGGimmu:13654
UCSCiuc007flx.1 mouse [P08152-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24377, M24376 Genomic DNA Translation: AAA39379.1
M24377, M24376 Genomic DNA Translation: AAA39380.1
X06746 mRNA Translation: CAA29921.1
BC009093 mRNA Translation: AAH09093.1
M20759 Genomic DNA Translation: AAA39381.1
CCDSiCCDS35927.2 [P08152-1]
CCDS83706.1 [P08152-2]
PIRiA30136
S00256
RefSeqiNP_001334387.1, NM_001347458.1 [P08152-2]
NP_034248.2, NM_010118.3 [P08152-1]
XP_006513272.1, XM_006513209.2 [P08152-2]
XP_006513273.1, XM_006513210.2 [P08152-2]
XP_006513274.1, XM_006513211.2 [P08152-2]
XP_006513276.1, XM_006513213.3 [P08152-2]
XP_011241670.1, XM_011243368.2 [P08152-2]
UniGeneiMm.290421

3D structure databases

ProteinModelPortaliP08152
SMRiP08152
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199405, 5 interactors
ELMiP08152
IntActiP08152, 5 interactors
MINTiP08152
STRINGi10090.ENSMUSP00000041053

PTM databases

iPTMnetiP08152
PhosphoSitePlusiP08152

Proteomic databases

PaxDbiP08152
PRIDEiP08152

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048289; ENSMUSP00000041053; ENSMUSG00000037868 [P08152-1]
ENSMUST00000105438; ENSMUSP00000101078; ENSMUSG00000037868 [P08152-2]
ENSMUST00000229738; ENSMUSP00000155634; ENSMUSG00000116458 [P08152-1]
ENSMUST00000231046; ENSMUSP00000155032; ENSMUSG00000116458 [P08152-2]
GeneIDi13654
KEGGimmu:13654
UCSCiuc007flx.1 mouse [P08152-1]

Organism-specific databases

CTDi1959
MGIiMGI:95296 Egr2

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000036856
HOVERGENiHBG003909
InParanoidiP08152
KOiK12496
OrthoDBiEOG091G06VX
PhylomeDBiP08152
TreeFamiTF318980

Enzyme and pathway databases

UniPathwayi
UPA00886

Miscellaneous databases

PROiPR:P08152
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037868 Expressed in 203 organ(s), highest expression level in sciatic nerve
CleanExiMM_EGR2
ExpressionAtlasiP08152 baseline and differential
GenevisibleiP08152 MM

Family and domain databases

InterProiView protein in InterPro
IPR021849 EGR
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF11928 DUF3446, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEGR2_MOUSE
AccessioniPrimary (citable) accession number: P08152
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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