UniProtKB - P08151 (GLI1_HUMAN)

BLAST

>sp|P08151|GLI1_HUMAN Zinc finger protein GLI1 OS=Homo sapiens OX=9606 GN=GLI1 PE=1 SV=1
MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETN
SCTEGPLFSSPRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGS
YGHLSIGTMSPSLGFPAQMNHQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLK
SELDMLVGKCREEPLEGDMSSPNSTGIQDPLLGMLDGREDLEREEKREPESVYETDCRWD
GCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKP
HKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAKHQNRTHSNEK
PYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREG
GPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSS
LDEGPCIAGTGLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLE
RRSSSSSSISSAYTVSRRSSLASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGG
TSPTAASSLDRIGGLPMPPWRSRAEYPGYNPNAGVTRRASDPAQAADRPAPARVQRFKSL
GCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDARGLQEEPEVGTSMVGSGLNP
YMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQASYPDPTQETW
GEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEG
PPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCN
YVQSQQELLWEGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHK
SGSYPTPSPCHENFVVGANRASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLG
GGPALYPPPEGQVCNPLDSLDLDNTQLDFVAILDEPQGLSPPPSHDQRGSSGHTPPPSGP
PNMAVGNMSVLLRSLPGETEFLNSSA

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Format
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History
Entry version 208 (10 Oct 2018)
Sequence version 1 (01 Aug 1988)
Previous versions | rss
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Protein

Zinc finger protein GLI1

Gene

GLI1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable).Curated8 Publications

Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	235 – 260	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	268 – 295	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	28
Zinc fingerⁱ	301 – 325	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	331 – 356	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	362 – 387	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	26

GO - Molecular functionⁱ

chromatin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19706761
DNA binding
Source: MGI
Inferred from direct assayⁱ
- 9118802
metal ion binding Source: UniProtKB-KW
microtubule binding Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 18298960
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19706761
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl
transcription regulatory region DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17035233

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

canonical Wnt signaling pathway Source: Ensembl
cerebellar cortex morphogenesis Source: Ensembl
digestive tract morphogenesis
Source: BHF-UCL
Traceable author statementⁱ
- 11001584
dorsal/ventral pattern formation Source: Ensembl
epidermal cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 12165851
liver regeneration Source: Ensembl
lung development Source: Ensembl
negative regulation of canonical Wnt signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17035233
notochord regression Source: Ensembl
osteoblast differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 12165851
pituitary gland development Source: Ensembl
positive regulation of cardiac muscle cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 28583401
positive regulation of cell cycle G1/S phase transition
Source: BHF-UCL
Inferred from direct assayⁱ
- 28583401
positive regulation of cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 19706761
positive regulation of cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12165851
positive regulation of DNA replication
Source: UniProtKB
Inferred from direct assayⁱ
- 12165851
positive regulation of smoothened signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 17035233
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 12165851
prostate gland development Source: Ensembl
proximal/distal pattern formation Source: Ensembl
regulation of hepatocyte proliferation Source: Ensembl
regulation of osteoblast differentiation Source: Ensembl
regulation of smoothened signaling pathway
Source: UniProtKB
Traceable author statementⁱ
- 11238441
response to wounding Source: Ensembl
smoothened signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 19878745
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: Ensembl
spermatogenesis Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW
ventral midline development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Differentiation, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5610780 Degradation of GLI1 by the proteasome R-HSA-5610787 Hedgehog 'off' state R-HSA-5632684 Hedgehog 'on' state R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription
SignaLinkⁱ	P08151
SIGNORⁱ	P08151

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein GLI1 Alternative name(s): Glioma-associated oncogene Oncogene GLI
Gene namesⁱ	Name:GLI1 Synonyms:GLI
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111087.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4317 GLI1
MIMⁱ	165220 gene
neXtProtⁱ	NX_P08151

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2735
MalaCards human disease database More...MalaCardsⁱ	GLI1
Open Targets More...OpenTargetsⁱ	ENSG00000111087
PharmGKBⁱ	PA28720

Chemistry databases

ChEMBLⁱ	CHEMBL5461

ChEMBLⁱ

CHEMBL5461

Polymorphism and mutation databases

BioMutaⁱ	GLI1
DMDMⁱ	121323

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047197	1 – 1106	Zinc finger protein GLI1Add BLAST		1106

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	518	N6-acetyllysine1 Publication		1
Cross-linkⁱ	1003	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationⁱ

Phosphorylated in vitro by ULK3.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P08151
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P08151
PaxDbⁱ	P08151
PeptideAtlas More...PeptideAtlasⁱ	P08151
PRIDEⁱ	P08151
ProteomicsDBⁱ	52074 52075 [P08151-2]

PTM databases

iPTMnetⁱ	P08151
PhosphoSitePlusⁱ	P08151

Expressionⁱ

Tissue specificityⁱ

Detected in testis (at protein level) (PubMed:2105456). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745). Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761).3 Publications

Inductionⁱ

Isoform 1 and isoform 2 are amplified in glioblastoma cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000111087 Expressed in 139 organ(s), highest expression level in tibial nerve
CleanExⁱ	HS_GLI1
ExpressionAtlasⁱ	P08151 baseline and differential
Genevisibleⁱ	P08151 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB009460 HPA065172 HPA068903

HPAⁱ

CAB009460
HPA065172
HPA068903

Interactionⁱ

Subunit structureⁱ

Interacts with KIF7 (By similarity). Interacts with STK36 (PubMed:10806483). Interacts with ZIC1; the interaction enhances transcription activation (PubMed:11238441). Interacts with SUFU; this inhibits transcriptional activation by GLI1 (PubMed:10806483, PubMed:24311597, PubMed:24217340, PubMed:28965847).By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CRYBA4	P53673	3	EBI-308084,EBI-7519711
GCC1	Q96CN9	3	EBI-308084,EBI-746252
ITCH	Q96J02	4	EBI-308084,EBI-1564678
Numb	Q9QZS3-2	4	EBI-308084,EBI-3896014	From a different organism.
PRKAA2	P54646	3	EBI-308084,EBI-1383852
PRKCI	P41743	3	EBI-16038799,EBI-286199
RPS6KB1	P23443	4	EBI-308084,EBI-1775921
RPS6KB1	P23443-2	2	EBI-308084,EBI-6093204
STK36	Q9NRP7	2	EBI-308084,EBI-863797
SUFU	Q9UMX1	25	EBI-308084,EBI-740595
SUFU	Q9UMX1-1	2	EBI-308084,EBI-740615
SUFU	Q9UMX1-2	4	EBI-308084,EBI-740621
TRIM42	Q8IWZ5	3	EBI-308084,EBI-5235829
VHL	P40337-1	2	EBI-308084,EBI-3504450
VHL	P40337-3	2	EBI-308084,EBI-301270
Zic1	P46684	2	EBI-308084,EBI-308006	From Mus musculus.

GO - Molecular functionⁱ

microtubule binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108997, 69 interactors
ComplexPortalⁱ	CPX-56 GLI1-SUFU complex
Database of interacting proteins More...DIPⁱ	DIP-32536N
ELMⁱ	P08151
IntActⁱ	P08151, 41 interactors
Molecular INTeraction database More...MINTⁱ	P08151
STRINGⁱ	9606.ENSP00000228682

Chemistry databases

BindingDBⁱ

P08151

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	120 – 123	Combined sources	4
Helixⁱ	249 – 259	Combined sources	11
Beta strandⁱ	261 – 263	Combined sources	3
Turnⁱ	276 – 279	Combined sources	4
Helixⁱ	285 – 291	Combined sources	7
Helixⁱ	293 – 296	Combined sources	4
Helixⁱ	315 – 324	Combined sources	10
Beta strandⁱ	341 – 346	Combined sources	6
Helixⁱ	349 – 354	Combined sources	6
Turnⁱ	367 – 369	Combined sources	3
Beta strandⁱ	372 – 375	Combined sources	4
Helixⁱ	376 – 381	Combined sources	6
Turnⁱ	382 – 384	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P08151
SMRⁱ	P08151
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P08151

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 20	SNAG domainBy similarityAdd BLAST	20
Regionⁱ	120 – 124	Interaction with SUFU2 Publications	5
Regionⁱ	283 – 291	Interaction with DNA1 Publication	9
Regionⁱ	345 – 350	Interaction with DNA1 Publication	6
Regionⁱ	375 – 381	Interaction with DNA1 Publication	7

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	1038 – 1055	Asp/Glu-rich (acidic)Add BLAST		18

Sequence similaritiesⁱ

Belongs to the GLI C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	235 – 260	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	268 – 295	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	28
Zinc fingerⁱ	301 – 325	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	331 – 356	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	26
Zinc fingerⁱ	362 – 387	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	26

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140802
HOGENOMⁱ	HOG000290688
HOVERGENⁱ	HBG080668
InParanoidⁱ	P08151
KEGG Orthology (KO) More...KOⁱ	K16797
OMAⁱ	VTKRHRG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01XS
PhylomeDBⁱ	P08151
TreeFamⁱ	TF350216

Family and domain databases

InterProⁱ	View protein in InterPro IPR032850 GLI1 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR19818:SF2 PTHR19818:SF2, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P08151-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MFNSMTPPPI SSYGEPCCLR PLPSQGAPSV GTEGLSGPPF CHQANLMSGP 
        60         70         80         90        100
HSYGPARETN SCTEGPLFSS PRSAVKLTKK RALSISPLSD ASLDLQTVIR 
       110        120        130        140        150
TSPSSLVAFI NSRCTSPGGS YGHLSIGTMS PSLGFPAQMN HQKGPSPSFG 
       160        170        180        190        200
VQPCGPHDSA RGGMIPHPQS RGPFPTCQLK SELDMLVGKC REEPLEGDMS 
       210        220        230        240        250
SPNSTGIQDP LLGMLDGRED LEREEKREPE SVYETDCRWD GCSQEFDSQE 
       260        270        280        290        300
QLVHHINSEH IHGERKEFVC HWGGCSRELR PFKAQYMLVV HMRRHTGEKP 
       310        320        330        340        350
HKCTFEGCRK SYSRLENLKT HLRSHTGEKP YMCEHEGCSK AFSNASDRAK 
       360        370        380        390        400
HQNRTHSNEK PYVCKLPGCT KRYTDPSSLR KHVKTVHGPD AHVTKRHRGD 
       410        420        430        440        450
GPLPRAPSIS TVEPKREREG GPIREESRLT VPEGAMKPQP SPGAQSSCSS 
       460        470        480        490        500
DHSPAGSAAN TDSGVEMTGN AGGSTEDLSS LDEGPCIAGT GLSTLRRLEN 
       510        520        530        540        550
LRLDQLHQLR PIGTRGLKLP SLSHTGTTVS RRVGPPVSLE RRSSSSSSIS 
       560        570        580        590        600
SAYTVSRRSS LASPFPPGSP PENGASSLPG LMPAQHYLLR ARYASARGGG 
       610        620        630        640        650
TSPTAASSLD RIGGLPMPPW RSRAEYPGYN PNAGVTRRAS DPAQAADRPA 
       660        670        680        690        700
PARVQRFKSL GCVHTPPTVA GGGQNFDPYL PTSVYSPQPP SITENAAMDA 
       710        720        730        740        750
RGLQEEPEVG TSMVGSGLNP YMDFPPTDTL GYGGPEGAAA EPYGARGPGS 
       760        770        780        790        800
LPLGPGPPTN YGPNPCPQQA SYPDPTQETW GEFPSHSGLY PGPKALGGTY 
       810        820        830        840        850
SQCPRLEHYG QVQVKPEQGC PVGSDSTGLA PCLNAHPSEG PPHPQPLFSH 
       860        870        880        890        900
YPQPSPPQYL QSGPYTQPPP DYLPSEPRPC LDFDSPTHST GQLKAQLVCN 
       910        920        930        940        950
YVQSQQELLW EGGGREDAPA QEPSYQSPKF LGGSQVSPSR AKAPVNTYGP 
       960        970        980        990       1000
GFGPNLPNHK SGSYPTPSPC HENFVVGANR ASHRAAAPPR LLPPLPTCYG 
      1010       1020       1030       1040       1050
PLKVGGTNPS CGHPEVGRLG GGPALYPPPE GQVCNPLDSL DLDNTQLDFV 
      1060       1070       1080       1090       1100
AILDEPQGLS PPPSHDQRGS SGHTPPPSGP PNMAVGNMSV LLRSLPGETE 

FLNSSA

Length:1,106

Mass (Da):117,904

Last modified:August 1, 1988 - v1

Checksum:ⁱE29B11D1A6CD3D91

Isoform 2 (identifier: P08151-2) [UniParc]FASTA Add to basket

Also known as: tGLI1

The sequence of this isoform differs from the canonical sequence as follows:
34-74: Missing.

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        10         20         30         40         50
MFNSMTPPPI SSYGEPCCLR PLPSQGAPSV GTEVKLTKKR ALSISPLSDA 
        60         70         80         90        100
SLDLQTVIRT SPSSLVAFIN SRCTSPGGSY GHLSIGTMSP SLGFPAQMNH 
       110        120        130        140        150
QKGPSPSFGV QPCGPHDSAR GGMIPHPQSR GPFPTCQLKS ELDMLVGKCR 
       160        170        180        190        200
EEPLEGDMSS PNSTGIQDPL LGMLDGREDL EREEKREPES VYETDCRWDG 
       210        220        230        240        250
CSQEFDSQEQ LVHHINSEHI HGERKEFVCH WGGCSRELRP FKAQYMLVVH 
       260        270        280        290        300
MRRHTGEKPH KCTFEGCRKS YSRLENLKTH LRSHTGEKPY MCEHEGCSKA 
       310        320        330        340        350
FSNASDRAKH QNRTHSNEKP YVCKLPGCTK RYTDPSSLRK HVKTVHGPDA 
       360        370        380        390        400
HVTKRHRGDG PLPRAPSIST VEPKREREGG PIREESRLTV PEGAMKPQPS 
       410        420        430        440        450
PGAQSSCSSD HSPAGSAANT DSGVEMTGNA GGSTEDLSSL DEGPCIAGTG 
       460        470        480        490        500
LSTLRRLENL RLDQLHQLRP IGTRGLKLPS LSHTGTTVSR RVGPPVSLER 
       510        520        530        540        550
RSSSSSSISS AYTVSRRSSL ASPFPPGSPP ENGASSLPGL MPAQHYLLRA 
       560        570        580        590        600
RYASARGGGT SPTAASSLDR IGGLPMPPWR SRAEYPGYNP NAGVTRRASD 
       610        620        630        640        650
PAQAADRPAP ARVQRFKSLG CVHTPPTVAG GGQNFDPYLP TSVYSPQPPS 
       660        670        680        690        700
ITENAAMDAR GLQEEPEVGT SMVGSGLNPY MDFPPTDTLG YGGPEGAAAE 
       710        720        730        740        750
PYGARGPGSL PLGPGPPTNY GPNPCPQQAS YPDPTQETWG EFPSHSGLYP 
       760        770        780        790        800
GPKALGGTYS QCPRLEHYGQ VQVKPEQGCP VGSDSTGLAP CLNAHPSEGP 
       810        820        830        840        850
PHPQPLFSHY PQPSPPQYLQ SGPYTQPPPD YLPSEPRPCL DFDSPTHSTG 
       860        870        880        890        900
QLKAQLVCNY VQSQQELLWE GGGREDAPAQ EPSYQSPKFL GGSQVSPSRA 
       910        920        930        940        950
KAPVNTYGPG FGPNLPNHKS GSYPTPSPCH ENFVVGANRA SHRAAAPPRL 
       960        970        980        990       1000
LPPLPTCYGP LKVGGTNPSC GHPEVGRLGG GPALYPPPEG QVCNPLDSLD 
      1010       1020       1030       1040       1050
LDNTQLDFVA ILDEPQGLSP PPSHDQRGSS GHTPPPSGPP NMAVGNMSVL 
      1060 
LRSLPGETEF LNSSA

Note: Undetectable in normal cells but highly expressed in cancer cells.

Show »

Length:1,065

Mass (Da):113,676

Checksum:ⁱBEDBBC5D160A6A1C

Isoform 3 (identifier: P08151-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-128: Missing.

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        10         20         30         40         50
MSPSLGFPAQ MNHQKGPSPS FGVQPCGPHD SARGGMIPHP QSRGPFPTCQ 
        60         70         80         90        100
LKSELDMLVG KCREEPLEGD MSSPNSTGIQ DPLLGMLDGR EDLEREEKRE 
       110        120        130        140        150
PESVYETDCR WDGCSQEFDS QEQLVHHINS EHIHGERKEF VCHWGGCSRE 
       160        170        180        190        200
LRPFKAQYML VVHMRRHTGE KPHKCTFEGC RKSYSRLENL KTHLRSHTGE 
       210        220        230        240        250
KPYMCEHEGC SKAFSNASDR AKHQNRTHSN EKPYVCKLPG CTKRYTDPSS 
       260        270        280        290        300
LRKHVKTVHG PDAHVTKRHR GDGPLPRAPS ISTVEPKRER EGGPIREESR 
       310        320        330        340        350
LTVPEGAMKP QPSPGAQSSC SSDHSPAGSA ANTDSGVEMT GNAGGSTEDL 
       360        370        380        390        400
SSLDEGPCIA GTGLSTLRRL ENLRLDQLHQ LRPIGTRGLK LPSLSHTGTT 
       410        420        430        440        450
VSRRVGPPVS LERRSSSSSS ISSAYTVSRR SSLASPFPPG SPPENGASSL 
       460        470        480        490        500
PGLMPAQHYL LRARYASARG GGTSPTAASS LDRIGGLPMP PWRSRAEYPG 
       510        520        530        540        550
YNPNAGVTRR ASDPAQAADR PAPARVQRFK SLGCVHTPPT VAGGGQNFDP 
       560        570        580        590        600
YLPTSVYSPQ PPSITENAAM DARGLQEEPE VGTSMVGSGL NPYMDFPPTD 
       610        620        630        640        650
TLGYGGPEGA AAEPYGARGP GSLPLGPGPP TNYGPNPCPQ QASYPDPTQE 
       660        670        680        690        700
TWGEFPSHSG LYPGPKALGG TYSQCPRLEH YGQVQVKPEQ GCPVGSDSTG 
       710        720        730        740        750
LAPCLNAHPS EGPPHPQPLF SHYPQPSPPQ YLQSGPYTQP PPDYLPSEPR 
       760        770        780        790        800
PCLDFDSPTH STGQLKAQLV CNYVQSQQEL LWEGGGREDA PAQEPSYQSP 
       810        820        830        840        850
KFLGGSQVSP SRAKAPVNTY GPGFGPNLPN HKSGSYPTPS PCHENFVVGA 
       860        870        880        890        900
NRASHRAAAP PRLLPPLPTC YGPLKVGGTN PSCGHPEVGR LGGGPALYPP 
       910        920        930        940        950
PEGQVCNPLD SLDLDNTQLD FVAILDEPQG LSPPPSHDQR GSSGHTPPPS 
       960        970 
GPPNMAVGNM SVLLRSLPGE TEFLNSSA

Note: No experimental confirmation available. Gene prediction based on partial mRNA and EST data.

Show »

Length:978

Mass (Da):104,627

Checksum:ⁱ947FFF4234D96403

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PIB9	E9PIB9_HUMAN	Zinc finger protein GLI1 Zinc finger protein GLI1	GLI1	175	Annotation score:
E9PQQ1	E9PQQ1_HUMAN	Zinc finger protein GLI1 Zinc finger protein GLI1	GLI1	129	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	1106	A → AS in ACX35434 (PubMed:19706761).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_035557	210	P → A in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_035558	514	T → I in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_035559	817	E → Q in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_015114	884	D → A1 Publication	1
Natural variantⁱVAR_015115	933	G → D2 PublicationsCorresponds to variant dbSNP:rs2228224Ensembl.	1
Natural variantⁱVAR_052723	1012	G → V. Corresponds to variant dbSNP:rs2229300Ensembl.	1
Natural variantⁱVAR_015116	1100	E → Q2 PublicationsCorresponds to variant dbSNP:rs2228226Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_054829	1 – 128	Missing in isoform 3. CuratedAdd BLAST		128
Alternative sequenceⁱVSP_042215	34 – 74	Missing in isoform 2. 1 PublicationAdd BLAST		41

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X07384 mRNA Translation: CAA30297.1 AF316573 Genomic DNA Translation: AAM13391.1 GQ890670 mRNA Translation: ACX35434.1 AC022506 Genomic DNA No translation available. BC013000 mRNA Translation: AAH13000.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS53806.1 [P08151-2] CCDS53807.1 [P08151-3] CCDS8940.1 [P08151-1]
PIRⁱ	S00672 TVHUGL
NCBI Reference Sequences More...RefSeqⁱ	NP_001153517.1, NM_001160045.1 [P08151-3] NP_001161081.1, NM_001167609.1 [P08151-2] NP_005260.1, NM_005269.2 [P08151-1] XP_011536491.1, XM_011538189.2 [P08151-1]
UniGeneⁱ	Hs.632702

Genome annotation databases

Ensemblⁱ	ENST00000228682; ENSP00000228682; ENSG00000111087 [P08151-1] ENST00000528467; ENSP00000434408; ENSG00000111087 [P08151-2] ENST00000543426; ENSP00000437607; ENSG00000111087 [P08151-3] ENST00000546141; ENSP00000441006; ENSG00000111087 [P08151-2]
GeneIDⁱ	2735
KEGGⁱ	hsa:2735
UCSC genome browser More...UCSCⁱ	uc001snx.4 human [P08151-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08151	Isoform 3 of Zinc finger protein GLI1		HUMAN		978	UniRef100_P08151
GLI1 isoform 5 (Fragment)		PANTR		175
Glioma-associated oncogene 1 (Fragment)		HUMAN		44
Zinc finger protein GLI1 (Fragment)		HUMAN		175
Zinc finger protein GLI1 (Fragment)		HUMAN		129
+1

Protein	Similar proteins		Species	Score	Length	Source
P08151	Isoform 3 of Zinc finger protein GLI1		HUMAN		978	UniRef90_P08151
GLI1 isoform 5 (Fragment)		PANTR		175
Uncharacterized protein		OTOGA		1108
GLI family zinc finger 1		SHEEP		1107
Zinc finger protein GLI1 isoform 1		MACMU		1106
+146
P08151-2	GLI family zinc finger 1		PANTR		1065	UniRef90_P08151-2
GLI family zinc finger 1		SAIBB		1065
Uncharacterized protein		PROCO		1065
Uncharacterized protein		MACMU		1065
Uncharacterized protein		CALJA		1065
+17

Protein	Similar proteins		Species	Score	Length	Source
P08151	Zinc finger protein GLI1		MOUSE		1111	UniRef50_P08151
Isoform 3 of Zinc finger protein GLI1		HUMAN		978
GLI1 isoform 5 (Fragment)		PANTR		175
Uncharacterized protein		OTOGA		1108
GLI family zinc finger 1		SHEEP		1107
+265

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X07384 mRNA Translation: CAA30297.1 AF316573 Genomic DNA Translation: AAM13391.1 GQ890670 mRNA Translation: ACX35434.1 AC022506 Genomic DNA No translation available. BC013000 mRNA Translation: AAH13000.1
CCDSⁱ	CCDS53806.1 [P08151-2] CCDS53807.1 [P08151-3] CCDS8940.1 [P08151-1]
PIRⁱ	S00672 TVHUGL
RefSeqⁱ	NP_001153517.1, NM_001160045.1 [P08151-3] NP_001161081.1, NM_001167609.1 [P08151-2] NP_005260.1, NM_005269.2 [P08151-1] XP_011536491.1, XM_011538189.2 [P08151-1]
UniGeneⁱ	Hs.632702

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2GLI	X-ray	2.60	A	234-388	[»]
	4BLB	X-ray	2.80	E/F/G/H	115-131	[»]
	4KMD	X-ray	1.70	B	112-128	[»]
	5OM0	X-ray	3.20	A/B	637-645	[»]
ProteinModelPortalⁱ	P08151
SMRⁱ	P08151
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108997, 69 interactors
ComplexPortalⁱ	CPX-56 GLI1-SUFU complex
DIPⁱ	DIP-32536N
ELMⁱ	P08151
IntActⁱ	P08151, 41 interactors
MINTⁱ	P08151
STRINGⁱ	9606.ENSP00000228682

Chemistry databases

BindingDBⁱ	P08151
ChEMBLⁱ	CHEMBL5461

PTM databases

iPTMnetⁱ	P08151
PhosphoSitePlusⁱ	P08151

Polymorphism and mutation databases

BioMutaⁱ	GLI1
DMDMⁱ	121323

Proteomic databases

EPDⁱ	P08151
MaxQBⁱ	P08151
PaxDbⁱ	P08151
PeptideAtlasⁱ	P08151
PRIDEⁱ	P08151
ProteomicsDBⁱ	52074 52075 [P08151-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000228682; ENSP00000228682; ENSG00000111087 [P08151-1] ENST00000528467; ENSP00000434408; ENSG00000111087 [P08151-2] ENST00000543426; ENSP00000437607; ENSG00000111087 [P08151-3] ENST00000546141; ENSP00000441006; ENSG00000111087 [P08151-2]
GeneIDⁱ	2735
KEGGⁱ	hsa:2735
UCSCⁱ	uc001snx.4 human [P08151-1]

Organism-specific databases

CTDⁱ	2735
DisGeNETⁱ	2735
EuPathDBⁱ	HostDB:ENSG00000111087.9
GeneCardsⁱ	GLI1
H-InvDBⁱ	HIX0010767
HGNCⁱ	HGNC:4317 GLI1
HPAⁱ	CAB009460 HPA065172 HPA068903
MalaCardsⁱ	GLI1
MIMⁱ	165220 gene
neXtProtⁱ	NX_P08151
OpenTargetsⁱ	ENSG00000111087
PharmGKBⁱ	PA28720
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00900000140802
HOGENOMⁱ	HOG000290688
HOVERGENⁱ	HBG080668
InParanoidⁱ	P08151
KOⁱ	K16797
OMAⁱ	VTKRHRG
OrthoDBⁱ	EOG091G01XS
PhylomeDBⁱ	P08151
TreeFamⁱ	TF350216

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5610780 Degradation of GLI1 by the proteasome R-HSA-5610787 Hedgehog 'off' state R-HSA-5632684 Hedgehog 'on' state R-HSA-5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription
SignaLinkⁱ	P08151
SIGNORⁱ	P08151

Miscellaneous databases

EvolutionaryTraceⁱ	P08151
GeneWikiⁱ	GLI1
GenomeRNAiⁱ	2735
Protein Ontology More...PROⁱ	PR:P08151
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000111087 Expressed in 139 organ(s), highest expression level in tibial nerve
CleanExⁱ	HS_GLI1
ExpressionAtlasⁱ	P08151 baseline and differential
Genevisibleⁱ	P08151 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR032850 GLI1 IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
PANTHERⁱ	PTHR19818:SF2 PTHR19818:SF2, 1 hit
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 5 hits
SUPFAMⁱ	SSF57667 SSF57667, 3 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 4 hits PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GLI1_HUMAN
Accessionⁱ	P08151Primary (citable) accession number: P08151 Secondary accession number(s): D0EUY3 , E9PQQ9, F5H6H8, Q8TDN9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	August 1, 1988
	Last modified:	October 10, 2018
	This is version 208 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P08151 (GLI1_HUMAN)

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Zinc finger protein GLI1

GLI1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Nucleus

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Cytoskeleton

Cytosol

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Enzyme and pathway databases

Miscellaneous databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ