UniProtKB - P08151 (GLI1_HUMAN)
Zinc finger protein GLI1
GLI1
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 235 – 260 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 268 – 295 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 301 – 325 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 331 – 356 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 362 – 387 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- chromatin binding Source: UniProtKB
- DNA binding Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- microtubule binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: UniProtKB
- transcription regulatory region sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- canonical Wnt signaling pathway Source: Ensembl
- cerebellar cortex morphogenesis Source: Ensembl
- digestive tract morphogenesis Source: BHF-UCL
- dorsal/ventral pattern formation Source: Ensembl
- epidermal cell differentiation Source: UniProtKB
- liver regeneration Source: Ensembl
- lung development Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: UniProtKB
- notochord regression Source: Ensembl
- osteoblast differentiation Source: UniProtKB
- pituitary gland development Source: Ensembl
- positive regulation of cardiac muscle cell proliferation Source: BHF-UCL
- positive regulation of cell cycle G1/S phase transition Source: BHF-UCL
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of DNA replication Source: UniProtKB
- positive regulation of smoothened signaling pathway Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- prostate gland development Source: Ensembl
- proximal/distal pattern formation Source: Ensembl
- regulation of hepatocyte proliferation Source: Ensembl
- regulation of osteoblast differentiation Source: Ensembl
- regulation of smoothened signaling pathway Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to wounding Source: Ensembl
- smoothened signaling pathway Source: UniProtKB
- smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: Ensembl
- spermatogenesis Source: Ensembl
- ventral midline development Source: Ensembl
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Differentiation, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P08151 |
Reactomei | R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610787, Hedgehog 'off' state R-HSA-5632684, Hedgehog 'on' state R-HSA-5635851, GLI proteins bind promoters of Hh responsive genes to promote transcription |
SignaLinki | P08151 |
SIGNORi | P08151 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein GLI1Alternative name(s): Glioma-associated oncogene Oncogene GLI |
Gene namesi | Name:GLI1 Synonyms:GLI |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4317, GLI1 |
MIMi | 165220, gene |
neXtProti | NX_P08151 |
VEuPathDBi | HostDB:ENSG00000111087.9 |
Subcellular locationi
Nucleus
- Nucleus 5 Publications
Cytoplasm and Cytosol
- Cytoplasm 3 Publications
Note: Tethered in the cytoplasm by binding to SUFU (PubMed:10806483). Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483). Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745). Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441).3 Publications
Cytoskeleton
- axoneme Source: Ensembl
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- ciliary base Source: Reactome
- ciliary tip Source: Reactome
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Polydactyly, postaxial, A8 (PAPA8)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081480 | 113 – 1106 | Missing in PAPA8. 1 PublicationAdd BLAST | 994 | |
Natural variantiVAR_081481 | 644 – 1106 | Missing in PAPA8. 1 PublicationAdd BLAST | 463 | |
Natural variantiVAR_081482 | 780 – 1106 | Missing in PAPA8; decreased transcriptional activity; reduced expression of the GLI1 target PTCH1 observed in patient fibroblasts after chemical induction of the hedgehog pathway. 1 PublicationAdd BLAST | 327 |
Polydactyly, preaxial 1 (PPD1)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_082590 | 506 | L → Q in PPD1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs753690500EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Proto-oncogeneOrganism-specific databases
DisGeNETi | 2735 |
MalaCardsi | GLI1 |
MIMi | 174400, phenotype 618123, phenotype |
OpenTargetsi | ENSG00000111087 |
Orphaneti | 289, Ellis Van Creveld syndrome 93339, Polydactyly of a biphalangeal thumb 93334, Postaxial polydactyly type A 93335, Postaxial polydactyly type B |
PharmGKBi | PA28720 |
Miscellaneous databases
Pharosi | P08151, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5461 |
Genetic variation databases
BioMutai | GLI1 |
DMDMi | 121323 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047197 | 1 – 1106 | Zinc finger protein GLI1Add BLAST | 1106 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 518 | N6-acetyllysine1 Publication | 1 | |
Cross-linki | 1003 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P08151 |
jPOSTi | P08151 |
MassIVEi | P08151 |
MaxQBi | P08151 |
PaxDbi | P08151 |
PeptideAtlasi | P08151 |
PRIDEi | P08151 |
ProteomicsDBi | 27194 52074 [P08151-1] 52075 [P08151-2] |
PTM databases
iPTMneti | P08151 |
PhosphoSitePlusi | P08151 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000111087, Expressed in tibial nerve and 163 other tissues |
ExpressionAtlasi | P08151, baseline and differential |
Genevisiblei | P08151, HS |
Organism-specific databases
HPAi | ENSG00000111087, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with KIF7 (By similarity).
Interacts with STK36 (PubMed:10806483).
Interacts with ZIC1; the interaction enhances transcription activation (PubMed:11238441).
Interacts with SUFU; this inhibits transcriptional activation by GLI1 (PubMed:10806483, PubMed:24311597, PubMed:24217340, PubMed:28965847).
By similarity5 PublicationsBinary interactionsi
Hide detailsP08151
Isoform 1 [P08151-1]
With | #Exp. | IntAct |
---|---|---|
PRKCI [P41743] | 3 | EBI-16038799,EBI-286199 |
GO - Molecular functioni
- microtubule binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 108997, 88 interactors |
ComplexPortali | CPX-56, GLI1-SUFU complex |
DIPi | DIP-32536N |
ELMi | P08151 |
IntActi | P08151, 41 interactors |
MINTi | P08151 |
STRINGi | 9606.ENSP00000228682 |
Chemistry databases
BindingDBi | P08151 |
Miscellaneous databases
RNActi | P08151, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P08151 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08151 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | SNAG domainBy similarityAdd BLAST | 20 | |
Regioni | 120 – 124 | Interaction with SUFU2 Publications | 5 | |
Regioni | 283 – 291 | Interaction with DNA1 Publication | 9 | |
Regioni | 345 – 350 | Interaction with DNA1 Publication | 6 | |
Regioni | 375 – 381 | Interaction with DNA1 Publication | 7 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1038 – 1055 | Asp/Glu-rich (acidic)Add BLAST | 18 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 235 – 260 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 268 – 295 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 301 – 325 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 331 – 356 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 362 – 387 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160235 |
HOGENOMi | CLU_003666_0_0_1 |
InParanoidi | P08151 |
OMAi | CPQQVSY |
OrthoDBi | 135929at2759 |
PhylomeDBi | P08151 |
TreeFami | TF350216 |
Family and domain databases
InterProi | View protein in InterPro IPR043359, GLI-like IPR032850, GLI1 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45718, PTHR45718, 2 hits PTHR45718:SF2, PTHR45718:SF2, 2 hits |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MFNSMTPPPI SSYGEPCCLR PLPSQGAPSV GTEGLSGPPF CHQANLMSGP
60 70 80 90 100
HSYGPARETN SCTEGPLFSS PRSAVKLTKK RALSISPLSD ASLDLQTVIR
110 120 130 140 150
TSPSSLVAFI NSRCTSPGGS YGHLSIGTMS PSLGFPAQMN HQKGPSPSFG
160 170 180 190 200
VQPCGPHDSA RGGMIPHPQS RGPFPTCQLK SELDMLVGKC REEPLEGDMS
210 220 230 240 250
SPNSTGIQDP LLGMLDGRED LEREEKREPE SVYETDCRWD GCSQEFDSQE
260 270 280 290 300
QLVHHINSEH IHGERKEFVC HWGGCSRELR PFKAQYMLVV HMRRHTGEKP
310 320 330 340 350
HKCTFEGCRK SYSRLENLKT HLRSHTGEKP YMCEHEGCSK AFSNASDRAK
360 370 380 390 400
HQNRTHSNEK PYVCKLPGCT KRYTDPSSLR KHVKTVHGPD AHVTKRHRGD
410 420 430 440 450
GPLPRAPSIS TVEPKREREG GPIREESRLT VPEGAMKPQP SPGAQSSCSS
460 470 480 490 500
DHSPAGSAAN TDSGVEMTGN AGGSTEDLSS LDEGPCIAGT GLSTLRRLEN
510 520 530 540 550
LRLDQLHQLR PIGTRGLKLP SLSHTGTTVS RRVGPPVSLE RRSSSSSSIS
560 570 580 590 600
SAYTVSRRSS LASPFPPGSP PENGASSLPG LMPAQHYLLR ARYASARGGG
610 620 630 640 650
TSPTAASSLD RIGGLPMPPW RSRAEYPGYN PNAGVTRRAS DPAQAADRPA
660 670 680 690 700
PARVQRFKSL GCVHTPPTVA GGGQNFDPYL PTSVYSPQPP SITENAAMDA
710 720 730 740 750
RGLQEEPEVG TSMVGSGLNP YMDFPPTDTL GYGGPEGAAA EPYGARGPGS
760 770 780 790 800
LPLGPGPPTN YGPNPCPQQA SYPDPTQETW GEFPSHSGLY PGPKALGGTY
810 820 830 840 850
SQCPRLEHYG QVQVKPEQGC PVGSDSTGLA PCLNAHPSEG PPHPQPLFSH
860 870 880 890 900
YPQPSPPQYL QSGPYTQPPP DYLPSEPRPC LDFDSPTHST GQLKAQLVCN
910 920 930 940 950
YVQSQQELLW EGGGREDAPA QEPSYQSPKF LGGSQVSPSR AKAPVNTYGP
960 970 980 990 1000
GFGPNLPNHK SGSYPTPSPC HENFVVGANR ASHRAAAPPR LLPPLPTCYG
1010 1020 1030 1040 1050
PLKVGGTNPS CGHPEVGRLG GGPALYPPPE GQVCNPLDSL DLDNTQLDFV
1060 1070 1080 1090 1100
AILDEPQGLS PPPSHDQRGS SGHTPPPSGP PNMAVGNMSV LLRSLPGETE
FLNSSA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PIB9 | E9PIB9_HUMAN | Zinc finger protein GLI1 | GLI1 | 175 | Annotation score: | ||
E9PQQ1 | E9PQQ1_HUMAN | Zinc finger protein GLI1 | GLI1 | 129 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1106 | A → AS in ACX35434 (PubMed:19706761).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081480 | 113 – 1106 | Missing in PAPA8. 1 PublicationAdd BLAST | 994 | |
Natural variantiVAR_035557 | 210 | P → A in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_082590 | 506 | L → Q in PPD1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs753690500EnsemblClinVar. | 1 | |
Natural variantiVAR_035558 | 514 | T → I in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_081481 | 644 – 1106 | Missing in PAPA8. 1 PublicationAdd BLAST | 463 | |
Natural variantiVAR_081482 | 780 – 1106 | Missing in PAPA8; decreased transcriptional activity; reduced expression of the GLI1 target PTCH1 observed in patient fibroblasts after chemical induction of the hedgehog pathway. 1 PublicationAdd BLAST | 327 | |
Natural variantiVAR_035559 | 817 | E → Q in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_015114 | 884 | D → A1 Publication | 1 | |
Natural variantiVAR_015115 | 933 | G → D2 PublicationsCorresponds to variant dbSNP:rs2228224Ensembl. | 1 | |
Natural variantiVAR_052723 | 1012 | G → V. Corresponds to variant dbSNP:rs2229300EnsemblClinVar. | 1 | |
Natural variantiVAR_015116 | 1100 | E → Q2 PublicationsCorresponds to variant dbSNP:rs2228226Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054829 | 1 – 128 | Missing in isoform 3. CuratedAdd BLAST | 128 | |
Alternative sequenceiVSP_042215 | 34 – 74 | Missing in isoform 2. 1 PublicationAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X07384 mRNA Translation: CAA30297.1 AF316573 Genomic DNA Translation: AAM13391.1 GQ890670 mRNA Translation: ACX35434.1 AC022506 Genomic DNA No translation available. BC013000 mRNA Translation: AAH13000.1 |
CCDSi | CCDS53806.1 [P08151-2] CCDS53807.1 [P08151-3] CCDS8940.1 [P08151-1] |
PIRi | S00672, TVHUGL |
RefSeqi | NP_001153517.1, NM_001160045.1 [P08151-3] NP_001161081.1, NM_001167609.1 [P08151-2] NP_005260.1, NM_005269.2 [P08151-1] XP_011536491.1, XM_011538189.2 [P08151-1] |
Genome annotation databases
Ensembli | ENST00000228682; ENSP00000228682; ENSG00000111087 [P08151-1] ENST00000528467; ENSP00000434408; ENSG00000111087 [P08151-2] ENST00000543426; ENSP00000437607; ENSG00000111087 [P08151-3] ENST00000546141; ENSP00000441006; ENSG00000111087 [P08151-2] |
GeneIDi | 2735 |
KEGGi | hsa:2735 |
UCSCi | uc001snx.4, human [P08151-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X07384 mRNA Translation: CAA30297.1 AF316573 Genomic DNA Translation: AAM13391.1 GQ890670 mRNA Translation: ACX35434.1 AC022506 Genomic DNA No translation available. BC013000 mRNA Translation: AAH13000.1 |
CCDSi | CCDS53806.1 [P08151-2] CCDS53807.1 [P08151-3] CCDS8940.1 [P08151-1] |
PIRi | S00672, TVHUGL |
RefSeqi | NP_001153517.1, NM_001160045.1 [P08151-3] NP_001161081.1, NM_001167609.1 [P08151-2] NP_005260.1, NM_005269.2 [P08151-1] XP_011536491.1, XM_011538189.2 [P08151-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2GLI | X-ray | 2.60 | A | 234-388 | [»] | |
4BLB | X-ray | 2.80 | E/F/G/H | 115-131 | [»] | |
4KMD | X-ray | 1.70 | B | 112-128 | [»] | |
5OM0 | X-ray | 3.20 | A/B | 637-645 | [»] | |
SMRi | P08151 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108997, 88 interactors |
ComplexPortali | CPX-56, GLI1-SUFU complex |
DIPi | DIP-32536N |
ELMi | P08151 |
IntActi | P08151, 41 interactors |
MINTi | P08151 |
STRINGi | 9606.ENSP00000228682 |
Chemistry databases
BindingDBi | P08151 |
ChEMBLi | CHEMBL5461 |
PTM databases
iPTMneti | P08151 |
PhosphoSitePlusi | P08151 |
Genetic variation databases
BioMutai | GLI1 |
DMDMi | 121323 |
Proteomic databases
EPDi | P08151 |
jPOSTi | P08151 |
MassIVEi | P08151 |
MaxQBi | P08151 |
PaxDbi | P08151 |
PeptideAtlasi | P08151 |
PRIDEi | P08151 |
ProteomicsDBi | 27194 52074 [P08151-1] 52075 [P08151-2] |
Protocols and materials databases
Antibodypediai | 4004, 790 antibodies |
Genome annotation databases
Ensembli | ENST00000228682; ENSP00000228682; ENSG00000111087 [P08151-1] ENST00000528467; ENSP00000434408; ENSG00000111087 [P08151-2] ENST00000543426; ENSP00000437607; ENSG00000111087 [P08151-3] ENST00000546141; ENSP00000441006; ENSG00000111087 [P08151-2] |
GeneIDi | 2735 |
KEGGi | hsa:2735 |
UCSCi | uc001snx.4, human [P08151-1] |
Organism-specific databases
CTDi | 2735 |
DisGeNETi | 2735 |
GeneCardsi | GLI1 |
HGNCi | HGNC:4317, GLI1 |
HPAi | ENSG00000111087, Low tissue specificity |
MalaCardsi | GLI1 |
MIMi | 165220, gene 174400, phenotype 618123, phenotype |
neXtProti | NX_P08151 |
OpenTargetsi | ENSG00000111087 |
Orphaneti | 289, Ellis Van Creveld syndrome 93339, Polydactyly of a biphalangeal thumb 93334, Postaxial polydactyly type A 93335, Postaxial polydactyly type B |
PharmGKBi | PA28720 |
VEuPathDBi | HostDB:ENSG00000111087.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160235 |
HOGENOMi | CLU_003666_0_0_1 |
InParanoidi | P08151 |
OMAi | CPQQVSY |
OrthoDBi | 135929at2759 |
PhylomeDBi | P08151 |
TreeFami | TF350216 |
Enzyme and pathway databases
PathwayCommonsi | P08151 |
Reactomei | R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610787, Hedgehog 'off' state R-HSA-5632684, Hedgehog 'on' state R-HSA-5635851, GLI proteins bind promoters of Hh responsive genes to promote transcription |
SignaLinki | P08151 |
SIGNORi | P08151 |
Miscellaneous databases
BioGRID-ORCSi | 2735, 25 hits in 1009 CRISPR screens |
EvolutionaryTracei | P08151 |
GeneWikii | GLI1 |
GenomeRNAii | 2735 |
Pharosi | P08151, Tchem |
PROi | PR:P08151 |
RNActi | P08151, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000111087, Expressed in tibial nerve and 163 other tissues |
ExpressionAtlasi | P08151, baseline and differential |
Genevisiblei | P08151, HS |
Family and domain databases
InterProi | View protein in InterPro IPR043359, GLI-like IPR032850, GLI1 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45718, PTHR45718, 2 hits PTHR45718:SF2, PTHR45718:SF2, 2 hits |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLI1_HUMAN | |
Accessioni | P08151Primary (citable) accession number: P08151 Secondary accession number(s): D0EUY3 Q8TDN9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | August 1, 1988 | |
Last modified: | April 7, 2021 | |
This is version 226 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families