UniProtKB - P08138 (TNR16_HUMAN)
Tumor necrosis factor receptor superfamily member 16
NGFR
Functioni
Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487).
Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity).
Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181).
Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity).
Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).
By similarity5 PublicationsGO - Molecular functioni
- amyloid-beta binding Source: ARUK-UCL
- calmodulin binding Source: UniProtKB
- coreceptor activity Source: UniProtKB
- death receptor activity Source: ARUK-UCL
- nerve growth factor binding Source: UniProtKB
- neurotrophin binding Source: UniProtKB
- signaling receptor activity Source: ProtInc
- small GTPase binding Source: UniProtKB
- transmembrane signaling receptor activity Source: ProtInc
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: BHF-UCL
- axon guidance Source: Ensembl
- cellular glucose homeostasis Source: UniProtKB
- cellular response to amyloid-beta Source: ARUK-UCL
- central nervous system development Source: Ensembl
- circadian regulation of gene expression Source: UniProtKB
- detection of temperature stimulus Source: Ensembl
- dorsal aorta development Source: Ensembl
- glucose homeostasis Source: UniProtKB
- hair follicle morphogenesis Source: Ensembl
- intracellular protein transport Source: UniProtKB
- negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: BHF-UCL
- negative regulation of cell migration Source: ARUK-UCL
- negative regulation of fibroblast growth factor receptor signaling pathway Source: Ensembl
- negative regulation of hair follicle development Source: Ensembl
- nerve development Source: Ensembl
- neuron apoptotic process Source: ARUK-UCL
- positive regulation of apoptotic signaling pathway Source: Ensembl
- positive regulation of fibroblast proliferation Source: Ensembl
- positive regulation of miRNA transcription Source: BHF-UCL
- positive regulation of odontogenesis of dentin-containing tooth Source: Ensembl
- positive regulation of protein localization to nucleus Source: BHF-UCL
- Rho protein signal transduction Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Receptor |
Biological process | Apoptosis, Biological rhythms, Differentiation, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | P08138 |
Reactomei | R-HSA-193634, Axonal growth inhibition (RHOA activation) R-HSA-193648, NRAGE signals death through JNK R-HSA-193670, p75NTR negatively regulates cell cycle via SC1 R-HSA-193681, Ceramide signalling R-HSA-193692, Regulated proteolysis of p75NTR R-HSA-205017, NFG and proNGF binds to p75NTR R-HSA-205025, NADE modulates death signalling R-HSA-205043, NRIF signals cell death from the nucleus R-HSA-209543, p75NTR recruits signalling complexes R-HSA-209560, NF-kB is activated and signals survival R-HSA-209563, Axonal growth stimulation |
SignaLinki | P08138 |
SIGNORi | P08138 |
Protein family/group databases
TCDBi | 9.B.87.4.1, the selenoprotein p receptor (selp-receptor) family |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factor receptor superfamily member 16Alternative name(s): Gp80-LNGFR Low affinity neurotrophin receptor p75NTR Low-affinity nerve growth factor receptor Short name: NGF receptor1 Publication p75 ICD CD_antigen: CD271 |
Gene namesi | Name:NGFR Synonyms:TNFRSF16 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7809, NGFR |
MIMi | 162010, gene |
neXtProti | NX_P08138 |
VEuPathDBi | HostDB:ENSG00000064300 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Curated
Other locations
- Perikaryon By similarity
- growth cone By similarity
- dendritic spine By similarity
Cytosol
- cytosol Source: Reactome
Endosome
- endosome Source: Reactome
Extracellular region or secreted
- extracellular region Source: Reactome
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: BHF-UCL
- cell-cell junction Source: Ensembl
- dendritic spine Source: UniProtKB-SubCell
- growth cone Source: UniProtKB-SubCell
- integral component of membrane Source: ARUK-UCL
- perikaryon Source: UniProtKB-SubCell
- postsynaptic density Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 29 – 250 | ExtracellularSequence analysisAdd BLAST | 222 | |
Transmembranei | 251 – 272 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 273 – 427 | CytoplasmicSequence analysisAdd BLAST | 155 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Membrane, SynapsePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 343 | K → A: Decreased interaction with ARHGDIA. 1 Publication | 1 | |
Mutagenesisi | 412 | D → A: Decreased interaction with ARHGDIA. 1 Publication | 1 | |
Mutagenesisi | 420 | E → A: Decreased interaction with ARHGDIA. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 4804 |
OpenTargetsi | ENSG00000064300 |
PharmGKBi | PA31615 |
Miscellaneous databases
Pharosi | P08138, Tclin |
Chemistry databases
ChEMBLi | CHEMBL4762 |
DrugCentrali | P08138 |
GuidetoPHARMACOLOGYi | 1888 |
Genetic variation databases
BioMutai | NGFR |
DMDMi | 128156 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | Add BLAST | 28 | |
ChainiPRO_0000034591 | 29 – 427 | Tumor necrosis factor receptor superfamily member 16Add BLAST | 399 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 32 ↔ 43 | PROSITE-ProRule annotation | ||
Disulfide bondi | 44 ↔ 57 | PROSITE-ProRule annotation | ||
Disulfide bondi | 47 ↔ 64 | PROSITE-ProRule annotation | ||
GlycosylationiCAR_000231 | 60 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Disulfide bondi | 67 ↔ 83 | PROSITE-ProRule annotation | ||
Disulfide bondi | 86 ↔ 99 | PROSITE-ProRule annotation | ||
Disulfide bondi | 89 ↔ 107 | PROSITE-ProRule annotation | ||
Disulfide bondi | 109 ↔ 122 | PROSITE-ProRule annotation | ||
Disulfide bondi | 125 ↔ 138 | PROSITE-ProRule annotation | ||
Disulfide bondi | 128 ↔ 146 | PROSITE-ProRule annotation | ||
Disulfide bondi | 149 ↔ 164 | PROSITE-ProRule annotation | ||
Disulfide bondi | 167 ↔ 180 | PROSITE-ProRule annotation | ||
Disulfide bondi | 170 ↔ 188 | PROSITE-ProRule annotation | ||
Modified residuei | 311 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P08138 |
jPOSTi | P08138 |
MassIVEi | P08138 |
MaxQBi | P08138 |
PaxDbi | P08138 |
PeptideAtlasi | P08138 |
PRIDEi | P08138 |
ProteomicsDBi | 52073 [P08138-1] 5660 |
PTM databases
GlyConnecti | 611, 3 N-Linked glycans (1 site), 2 O-Linked glycans |
GlyGeni | P08138, 2 sites, 6 N-linked glycans (1 site), 4 O-linked glycans (1 site) |
iPTMneti | P08138 |
PhosphoSitePlusi | P08138 |
Expressioni
Gene expression databases
Bgeei | ENSG00000064300, Expressed in tibial nerve and 167 other tissues |
Genevisiblei | P08138, HS |
Organism-specific databases
HPAi | ENSG00000064300, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer; disulfide-linked (By similarity). Heterodimer with SORCS2. The extracellular domains of the heterodimer bind NGF (PubMed:22155786, PubMed:24908487). The cytoplasmic region of the heterodimer binds TRIO. NGF binding mediates dissociation of TRIO from the receptor complex (PubMed:22155786).
Interacts with RTN4R (PubMed:19052207).
Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9 (PubMed:10514511, PubMed:9915784, PubMed:10544233, PubMed:12963025).
Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1 (PubMed:11244088).
Interacts with BEX1 (By similarity).
Interacts with BEX3 (By similarity).
Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1.
Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor (By similarity).
Interacts (via death domain) with RAB31 (By similarity).
Interacts with LINGO1 (PubMed:14966521).
Interacts with NRADD (By similarity).
Interacts with MAGED1; the interaction antagonizes the association NGFR:NTRK1 (By similarity).
Interacts (via death domain) with ARHGDIA and RIPK2 (PubMed:26646181).
By similarity10 PublicationsBinary interactionsi
P08138
GO - Molecular functioni
- calmodulin binding Source: UniProtKB
- nerve growth factor binding Source: UniProtKB
- neurotrophin binding Source: UniProtKB
- small GTPase binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 110870, 55 interactors |
CORUMi | P08138 |
DIPi | DIP-406N |
IntActi | P08138, 25 interactors |
MINTi | P08138 |
STRINGi | 9606.ENSP00000172229 |
Chemistry databases
BindingDBi | P08138 |
Miscellaneous databases
RNActi | P08138, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P08138 |
BMRBi | P08138 |
SMRi | P08138 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08138 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 31 – 64 | TNFR-Cys 1Add BLAST | 34 | |
Repeati | 66 – 107 | TNFR-Cys 2Add BLAST | 42 | |
Repeati | 108 – 146 | TNFR-Cys 3Add BLAST | 39 | |
Repeati | 148 – 188 | TNFR-Cys 4Add BLAST | 41 | |
Domaini | 344 – 421 | DeathPROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 194 – 219 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 281 – 338 | DisorderedSequence analysisAdd BLAST | 58 | |
Regioni | 326 – 341 | Mediates interaction with KIDINS220By similarityAdd BLAST | 16 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 200 – 215 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 305 – 328 | Polar residuesSequence analysisAdd BLAST | 24 |
Domaini
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWPN, Eukaryota |
GeneTreei | ENSGT00730000110974 |
HOGENOMi | CLU_052667_0_1_1 |
InParanoidi | P08138 |
OMAi | GECCMEC |
OrthoDBi | 757160at2759 |
PhylomeDBi | P08138 |
TreeFami | TF106466 |
Family and domain databases
CDDi | cd13416, TNFRSF16, 1 hit |
Gene3Di | 1.10.533.10, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR001368, TNFR/NGFR_Cys_rich_reg IPR041448, TNFR16_TM IPR022325, TNFR_16 IPR034046, TNFRSF16_N |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF18422, TNFR_16_TM, 1 hit PF00020, TNFR_c6, 2 hits |
PRINTSi | PR01966, TNFACTORR16 |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00208, TNFR, 4 hits |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS00652, TNFR_NGFR_1, 3 hits PS50050, TNFR_NGFR_2, 4 hits |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGAGATGRAM DGPRLLLLLL LGVSLGGAKE ACPTGLYTHS GECCKACNLG
60 70 80 90 100
EGVAQPCGAN QTVCEPCLDS VTFSDVVSAT EPCKPCTECV GLQSMSAPCV
110 120 130 140 150
EADDAVCRCA YGYYQDETTG RCEACRVCEA GSGLVFSCQD KQNTVCEECP
160 170 180 190 200
DGTYSDEANH VDPCLPCTVC EDTERQLREC TRWADAECEE IPGRWITRST
210 220 230 240 250
PPEGSDSTAP STQEPEAPPE QDLIASTVAG VVTTVMGSSQ PVVTRGTTDN
260 270 280 290 300
LIPVYCSILA AVVVGLVAYI AFKRWNSCKQ NKQGANSRPV NQTPPPEGEK
310 320 330 340 350
LHSDSGISVD SQSLHDQQPH TQTASGQALK GDGGLYSSLP PAKREEVEKL
360 370 380 390 400
LNGSAGDTWR HLAGELGYQP EHIDSFTHEA CPVRALLASW ATQDSATLDA
410 420
LLAALRRIQR ADLVESLCSE STATSPV
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020010 | 205 | S → L. Corresponds to variant dbSNP:rs2072446Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056850 | 1 – 94 | Missing in isoform 2. 1 PublicationAdd BLAST | 94 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14764 mRNA Translation: AAB59544.1 AK303278 mRNA Translation: BAG64358.1 AK313654 mRNA Translation: BAG36408.1 AC006487 Genomic DNA No translation available. AC015656 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94677.1 BC050309 mRNA Translation: AAH50309.1 M21621 Genomic DNA Translation: AAA36363.1 |
CCDSi | CCDS11549.1 [P08138-1] |
PIRi | A25218, GQHUN |
RefSeqi | NP_002498.1, NM_002507.3 [P08138-1] |
Genome annotation databases
Ensembli | ENST00000172229.8; ENSP00000172229.3; ENSG00000064300.9 ENST00000504201.1; ENSP00000421731.1; ENSG00000064300.9 [P08138-2] |
GeneIDi | 4804 |
KEGGi | hsa:4804 |
MANE-Selecti | ENST00000172229.8; ENSP00000172229.3; NM_002507.4; NP_002498.1 |
UCSCi | uc002ioz.5, human [P08138-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14764 mRNA Translation: AAB59544.1 AK303278 mRNA Translation: BAG64358.1 AK313654 mRNA Translation: BAG36408.1 AC006487 Genomic DNA No translation available. AC015656 Genomic DNA No translation available. CH471109 Genomic DNA Translation: EAW94677.1 BC050309 mRNA Translation: AAH50309.1 M21621 Genomic DNA Translation: AAA36363.1 |
CCDSi | CCDS11549.1 [P08138-1] |
PIRi | A25218, GQHUN |
RefSeqi | NP_002498.1, NM_002507.3 [P08138-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2N80 | NMR | - | A | 334-427 | [»] | |
2N83 | NMR | - | A | 330-427 | [»] | |
2N97 | NMR | - | A/B | 330-427 | [»] | |
3EWV | X-ray | 2.60 | E | 396-412 | [»] | |
5ZGG | NMR | - | A/B | 244-277 | [»] | |
7CSQ | NMR | - | A | 330-427 | [»] | |
AlphaFoldDBi | P08138 | |||||
BMRBi | P08138 | |||||
SMRi | P08138 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110870, 55 interactors |
CORUMi | P08138 |
DIPi | DIP-406N |
IntActi | P08138, 25 interactors |
MINTi | P08138 |
STRINGi | 9606.ENSP00000172229 |
Chemistry databases
BindingDBi | P08138 |
ChEMBLi | CHEMBL4762 |
DrugCentrali | P08138 |
GuidetoPHARMACOLOGYi | 1888 |
Protein family/group databases
TCDBi | 9.B.87.4.1, the selenoprotein p receptor (selp-receptor) family |
PTM databases
GlyConnecti | 611, 3 N-Linked glycans (1 site), 2 O-Linked glycans |
GlyGeni | P08138, 2 sites, 6 N-linked glycans (1 site), 4 O-linked glycans (1 site) |
iPTMneti | P08138 |
PhosphoSitePlusi | P08138 |
Genetic variation databases
BioMutai | NGFR |
DMDMi | 128156 |
Proteomic databases
EPDi | P08138 |
jPOSTi | P08138 |
MassIVEi | P08138 |
MaxQBi | P08138 |
PaxDbi | P08138 |
PeptideAtlasi | P08138 |
PRIDEi | P08138 |
ProteomicsDBi | 52073 [P08138-1] 5660 |
Protocols and materials databases
Antibodypediai | 1461, 1588 antibodies from 49 providers |
DNASUi | 4804 |
Genome annotation databases
Ensembli | ENST00000172229.8; ENSP00000172229.3; ENSG00000064300.9 ENST00000504201.1; ENSP00000421731.1; ENSG00000064300.9 [P08138-2] |
GeneIDi | 4804 |
KEGGi | hsa:4804 |
MANE-Selecti | ENST00000172229.8; ENSP00000172229.3; NM_002507.4; NP_002498.1 |
UCSCi | uc002ioz.5, human [P08138-1] |
Organism-specific databases
CTDi | 4804 |
DisGeNETi | 4804 |
GeneCardsi | NGFR |
HGNCi | HGNC:7809, NGFR |
HPAi | ENSG00000064300, Low tissue specificity |
MIMi | 162010, gene |
neXtProti | NX_P08138 |
OpenTargetsi | ENSG00000064300 |
PharmGKBi | PA31615 |
VEuPathDBi | HostDB:ENSG00000064300 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWPN, Eukaryota |
GeneTreei | ENSGT00730000110974 |
HOGENOMi | CLU_052667_0_1_1 |
InParanoidi | P08138 |
OMAi | GECCMEC |
OrthoDBi | 757160at2759 |
PhylomeDBi | P08138 |
TreeFami | TF106466 |
Enzyme and pathway databases
PathwayCommonsi | P08138 |
Reactomei | R-HSA-193634, Axonal growth inhibition (RHOA activation) R-HSA-193648, NRAGE signals death through JNK R-HSA-193670, p75NTR negatively regulates cell cycle via SC1 R-HSA-193681, Ceramide signalling R-HSA-193692, Regulated proteolysis of p75NTR R-HSA-205017, NFG and proNGF binds to p75NTR R-HSA-205025, NADE modulates death signalling R-HSA-205043, NRIF signals cell death from the nucleus R-HSA-209543, p75NTR recruits signalling complexes R-HSA-209560, NF-kB is activated and signals survival R-HSA-209563, Axonal growth stimulation |
SignaLinki | P08138 |
SIGNORi | P08138 |
Miscellaneous databases
BioGRID-ORCSi | 4804, 13 hits in 1073 CRISPR screens |
ChiTaRSi | NGFR, human |
EvolutionaryTracei | P08138 |
GeneWikii | Low-affinity_nerve_growth_factor_receptor |
GenomeRNAii | 4804 |
Pharosi | P08138, Tclin |
PROi | PR:P08138 |
RNActi | P08138, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000064300, Expressed in tibial nerve and 167 other tissues |
Genevisiblei | P08138, HS |
Family and domain databases
CDDi | cd13416, TNFRSF16, 1 hit |
Gene3Di | 1.10.533.10, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR001368, TNFR/NGFR_Cys_rich_reg IPR041448, TNFR16_TM IPR022325, TNFR_16 IPR034046, TNFRSF16_N |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF18422, TNFR_16_TM, 1 hit PF00020, TNFR_c6, 2 hits |
PRINTSi | PR01966, TNFACTORR16 |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00208, TNFR, 4 hits |
SUPFAMi | SSF47986, SSF47986, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS00652, TNFR_NGFR_1, 3 hits PS50050, TNFR_NGFR_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TNR16_HUMAN | |
Accessioni | P08138Primary (citable) accession number: P08138 Secondary accession number(s): B2R961, B4E096 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | August 1, 1988 | |
Last modified: | May 25, 2022 | |
This is version 223 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references