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UniProtKB - P08138 (TNR16_HUMAN)

Entry version 219 (07 Apr 2021)
Sequence version 1 (01 Aug 1988)
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Protein

Tumor necrosis factor receptor superfamily member 16

Gene

NGFR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).By similarity5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processApoptosis, Biological rhythms, Differentiation, Neurogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P08138

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-193634, Axonal growth inhibition (RHOA activation)
R-HSA-193648, NRAGE signals death through JNK
R-HSA-193670, p75NTR negatively regulates cell cycle via SC1
R-HSA-193681, Ceramide signalling
R-HSA-193692, Regulated proteolysis of p75NTR
R-HSA-205017, NFG and proNGF binds to p75NTR
R-HSA-205025, NADE modulates death signalling
R-HSA-205043, NRIF signals cell death from the nucleus
R-HSA-209543, p75NTR recruits signalling complexes
R-HSA-209560, NF-kB is activated and signals survival
R-HSA-209563, Axonal growth stimulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P08138

SIGNOR Signaling Network Open Resource

More...SIGNORi		P08138

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 16
Alternative name(s):
Gp80-LNGFR
Low affinity neurotrophin receptor p75NTR
Low-affinity nerve growth factor receptor
Short name:
NGF receptor1 Publication
p75 ICD
CD_antigen: CD271
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NGFR
Synonyms:TNFRSF16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7809, NGFR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		162010, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P08138

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000064300.8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 250ExtracellularSequence analysisAdd BLAST222
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei251 – 272HelicalSequence analysisAdd BLAST22
Topological domaini273 – 427CytoplasmicSequence analysisAdd BLAST155

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi343K → A: Decreased interaction with ARHGDIA. 1 Publication1
Mutagenesisi412D → A: Decreased interaction with ARHGDIA. 1 Publication1
Mutagenesisi420E → A: Decreased interaction with ARHGDIA. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		4804

Open Targets

More...OpenTargetsi		ENSG00000064300

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31615

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P08138, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4762

DrugCentral

More...DrugCentrali		P08138

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1888

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NGFR

Domain mapping of disease mutations (DMDM)

More...DMDMi		128156

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Add BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003459129 – 427Tumor necrosis factor receptor superfamily member 16Add BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi32 ↔ 43PROSITE-ProRule annotation
Disulfide bondi44 ↔ 57PROSITE-ProRule annotation
Disulfide bondi47 ↔ 64PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>GlycosylationiCAR_00023160N-linked (GlcNAc...) asparagineCurated1
Disulfide bondi67 ↔ 83PROSITE-ProRule annotation
Disulfide bondi86 ↔ 99PROSITE-ProRule annotation
Disulfide bondi89 ↔ 107PROSITE-ProRule annotation
Disulfide bondi109 ↔ 122PROSITE-ProRule annotation
Disulfide bondi125 ↔ 138PROSITE-ProRule annotation
Disulfide bondi128 ↔ 146PROSITE-ProRule annotation
Disulfide bondi149 ↔ 164PROSITE-ProRule annotation
Disulfide bondi167 ↔ 180PROSITE-ProRule annotation
Disulfide bondi170 ↔ 188PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei311PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated.
O-linked glycans consist of Gal1-3GalNAc core elongated by 1 or 2 NeuNAc.
Phosphorylated on serine residues.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P08138

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P08138

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P08138

MaxQB - The MaxQuant DataBase

More...MaxQBi		P08138

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P08138

PeptideAtlas

More...PeptideAtlasi		P08138

PRoteomics IDEntifications database

More...PRIDEi		P08138

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52073 [P08138-1]
5660

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		611, 3 N-Linked glycans (1 site), 2 O-Linked glycans

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P08138, 1 site, 3 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P08138

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P08138

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000064300, Expressed in tibial nerve and 166 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P08138, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000064300, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked (By similarity). Heterodimer with SORCS2. The extracellular domains of the heterodimer bind NGF (PubMed:22155786, PubMed:24908487). The cytoplasmic region of the heterodimer binds TRIO. NGF binding mediates dissociation of TRIO from the receptor complex (PubMed:22155786).

Interacts with RTN4R (PubMed:19052207).

Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9 (PubMed:10514511, PubMed:9915784, PubMed:10544233, PubMed:12963025).

Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1 (PubMed:11244088).

Interacts with BEX1 (By similarity).

Interacts with BEX3 (By similarity).

Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1.

Interacts with NTRK2; may regulate the ligand specificity of the NTRK2 receptor (By similarity).

Interacts (via death domain) with RAB31 (By similarity).

Interacts with LINGO1 (PubMed:14966521).

Interacts with NRADD (By similarity).

Interacts with MAGED1; the interaction antagonizes the association NGFR:NTRK1 (By similarity).

Interacts (via death domain) with ARHGDIA and RIPK2 (PubMed:26646181).

By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110870, 50 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P08138

Database of interacting proteins

More...DIPi		DIP-406N

Protein interaction database and analysis system

More...IntActi		P08138, 25 interactors

Molecular INTeraction database

More...MINTi		P08138

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000172229

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P08138

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P08138, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1427
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P08138

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P08138

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P08138

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati31 – 64TNFR-Cys 1Add BLAST34
Repeati66 – 107TNFR-Cys 2Add BLAST42
Repeati108 – 146TNFR-Cys 3Add BLAST39
Repeati148 – 188TNFR-Cys 4Add BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini344 – 421DeathPROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni326 – 341Mediates interaction with KIDINS220By similarityAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi197 – 248Ser/Thr-richAdd BLAST52

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The death domain mediates interaction with RANBP9 (By similarity). It also mediates interaction with ARHGDIA and RIPK2 (PubMed:26646181).By similarity1 Publication
The extracellular domain is responsible for interaction with NTRK1.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWPN, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00730000110974

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_052667_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P08138

Identification of Orthologs from Complete Genome Data

More...OMAi		LRMETPC

Database of Orthologous Groups

More...OrthoDBi		757160at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P08138

TreeFam database of animal gene trees

More...TreeFami		TF106466

Family and domain databases

Conserved Domains Database

More...CDDi		cd13416, TNFRSF16, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR001368, TNFR/NGFR_Cys_rich_reg
IPR041448, TNFR16_TM
IPR022325, TNFR_16
IPR034046, TNFRSF16_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00531, Death, 1 hit
PF18422, TNFR_16_TM, 1 hit
PF00020, TNFR_c6, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01966, TNFACTORR16

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00005, DEATH, 1 hit
SM00208, TNFR, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50017, DEATH_DOMAIN, 1 hit
PS00652, TNFR_NGFR_1, 3 hits
PS50050, TNFR_NGFR_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P08138-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGAGATGRAM DGPRLLLLLL LGVSLGGAKE ACPTGLYTHS GECCKACNLG 
        60         70         80         90        100
EGVAQPCGAN QTVCEPCLDS VTFSDVVSAT EPCKPCTECV GLQSMSAPCV 
       110        120        130        140        150
EADDAVCRCA YGYYQDETTG RCEACRVCEA GSGLVFSCQD KQNTVCEECP 
       160        170        180        190        200
DGTYSDEANH VDPCLPCTVC EDTERQLREC TRWADAECEE IPGRWITRST 
       210        220        230        240        250
PPEGSDSTAP STQEPEAPPE QDLIASTVAG VVTTVMGSSQ PVVTRGTTDN 
       260        270        280        290        300
LIPVYCSILA AVVVGLVAYI AFKRWNSCKQ NKQGANSRPV NQTPPPEGEK 
       310        320        330        340        350
LHSDSGISVD SQSLHDQQPH TQTASGQALK GDGGLYSSLP PAKREEVEKL 
       360        370        380        390        400
LNGSAGDTWR HLAGELGYQP EHIDSFTHEA CPVRALLASW ATQDSATLDA 
       410        420 
LLAALRRIQR ADLVESLCSE STATSPV
Length:427
Mass (Da):45,183
Last modified:August 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB09FA143FB3D625B
GO
Isoform 2 (identifier: P08138-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Show »
Length:333
Mass (Da):35,767
Checksum:iFC38A7379D84CB28
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_020010205S → L. Corresponds to variant dbSNP:rs2072446Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0568501 – 94Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M14764 mRNA Translation: AAB59544.1
AK303278 mRNA Translation: BAG64358.1
AK313654 mRNA Translation: BAG36408.1
AC006487 Genomic DNA No translation available.
AC015656 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94677.1
BC050309 mRNA Translation: AAH50309.1
M21621 Genomic DNA Translation: AAA36363.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11549.1 [P08138-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A25218, GQHUN

NCBI Reference Sequences

More...RefSeqi		NP_002498.1, NM_002507.3 [P08138-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000172229; ENSP00000172229; ENSG00000064300 [P08138-1]
ENST00000504201; ENSP00000421731; ENSG00000064300 [P08138-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4804

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4804

UCSC genome browser

More...UCSCi		uc002ioz.5, human [P08138-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14764 mRNA Translation: AAB59544.1
AK303278 mRNA Translation: BAG64358.1
AK313654 mRNA Translation: BAG36408.1
AC006487 Genomic DNA No translation available.
AC015656 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94677.1
BC050309 mRNA Translation: AAH50309.1
M21621 Genomic DNA Translation: AAA36363.1
CCDSiCCDS11549.1 [P08138-1]
PIRiA25218, GQHUN
RefSeqiNP_002498.1, NM_002507.3 [P08138-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N80NMR-A334-427[»]
2N83NMR-A330-427[»]
2N97NMR-A/B330-427[»]
3EWVX-ray2.60E396-412[»]
5ZGGNMR-A/B244-277[»]
BMRBiP08138
SMRiP08138
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110870, 50 interactors
CORUMiP08138
DIPiDIP-406N
IntActiP08138, 25 interactors
MINTiP08138
STRINGi9606.ENSP00000172229

Chemistry databases

BindingDBiP08138
ChEMBLiCHEMBL4762
DrugCentraliP08138
GuidetoPHARMACOLOGYi1888

PTM databases

GlyConnecti611, 3 N-Linked glycans (1 site), 2 O-Linked glycans
GlyGeniP08138, 1 site, 3 N-linked glycans (1 site)
iPTMnetiP08138
PhosphoSitePlusiP08138

Genetic variation databases

BioMutaiNGFR
DMDMi128156

Proteomic databases

EPDiP08138
jPOSTiP08138
MassIVEiP08138
MaxQBiP08138
PaxDbiP08138
PeptideAtlasiP08138
PRIDEiP08138
ProteomicsDBi52073 [P08138-1]
5660

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1461, 1560 antibodies

The DNASU plasmid repository

More...DNASUi		4804

Genome annotation databases

EnsembliENST00000172229; ENSP00000172229; ENSG00000064300 [P08138-1]
ENST00000504201; ENSP00000421731; ENSG00000064300 [P08138-2]
GeneIDi4804
KEGGihsa:4804
UCSCiuc002ioz.5, human [P08138-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4804
DisGeNETi4804

GeneCards: human genes, protein and diseases

More...GeneCardsi		NGFR
HGNCiHGNC:7809, NGFR
HPAiENSG00000064300, Low tissue specificity
MIMi162010, gene
neXtProtiNX_P08138
OpenTargetsiENSG00000064300
PharmGKBiPA31615
VEuPathDBiHostDB:ENSG00000064300.8

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QWPN, Eukaryota
GeneTreeiENSGT00730000110974
HOGENOMiCLU_052667_0_1_1
InParanoidiP08138
OMAiLRMETPC
OrthoDBi757160at2759
PhylomeDBiP08138
TreeFamiTF106466

Enzyme and pathway databases

PathwayCommonsiP08138
ReactomeiR-HSA-193634, Axonal growth inhibition (RHOA activation)
R-HSA-193648, NRAGE signals death through JNK
R-HSA-193670, p75NTR negatively regulates cell cycle via SC1
R-HSA-193681, Ceramide signalling
R-HSA-193692, Regulated proteolysis of p75NTR
R-HSA-205017, NFG and proNGF binds to p75NTR
R-HSA-205025, NADE modulates death signalling
R-HSA-205043, NRIF signals cell death from the nucleus
R-HSA-209543, p75NTR recruits signalling complexes
R-HSA-209560, NF-kB is activated and signals survival
R-HSA-209563, Axonal growth stimulation
SignaLinkiP08138
SIGNORiP08138

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4804, 9 hits in 990 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NGFR, human
EvolutionaryTraceiP08138

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Low-affinity_nerve_growth_factor_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4804
PharosiP08138, Tclin

Protein Ontology

More...PROi		PR:P08138
RNActiP08138, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000064300, Expressed in tibial nerve and 166 other tissues
GenevisibleiP08138, HS

Family and domain databases

CDDicd13416, TNFRSF16, 1 hit
InterProiView protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR001368, TNFR/NGFR_Cys_rich_reg
IPR041448, TNFR16_TM
IPR022325, TNFR_16
IPR034046, TNFRSF16_N
PfamiView protein in Pfam
PF00531, Death, 1 hit
PF18422, TNFR_16_TM, 1 hit
PF00020, TNFR_c6, 2 hits
PRINTSiPR01966, TNFACTORR16
SMARTiView protein in SMART
SM00005, DEATH, 1 hit
SM00208, TNFR, 4 hits
SUPFAMiSSF47986, SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017, DEATH_DOMAIN, 1 hit
PS00652, TNFR_NGFR_1, 3 hits
PS50050, TNFR_NGFR_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNR16_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08138
Secondary accession number(s): B2R961, B4E096
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 7, 2021
This is version 219 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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