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Protein

Lantibiotic epidermin

Gene

epiA

Organism
Staphylococcus epidermidis
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Bacteriocin, Lantibiotic

Protein family/group databases

TCDBi1.C.20.1.6 the nisin (nisin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Lantibiotic epidermin
Gene namesi
Name:epiA
Encoded oniPlasmid pTu 320 Publication
OrganismiStaphylococcus epidermidis
Taxonomic identifieri1282 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000171161 – 301 PublicationAdd BLAST30
PeptideiPRO_000001711731 – 52Lantibiotic epidermin1 PublicationAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki33 ↔ 37Lanthionine (Ser-Cys)1 Publication
Cross-linki38 ↔ 41Beta-methyllanthionine (Thr-Cys)1 Publication
Modified residuei44(Z)-2,3-didehydrobutyrine1 Publication1
Cross-linki46 ↔ 51Lanthionine (Ser-Cys)1 Publication
Cross-linki49 ↔ 52S-(2-aminovinyl)-D-cysteine (Ser-Cys)1 Publication

Post-translational modificationi

Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. The C-terminal lanthionine undergoes decarboxylation. This is followed by membrane translocation and cleavage of the modified precursor.
The 2,3-didehydrobutyrine is determined to be the Z-isomer.1 Publication

Keywords - PTMi

D-amino acid, Thioether bond

Miscellaneous databases

PMAP-CutDBiP08136

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiP08136
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08136

Family & Domainsi

Sequence similaritiesi

Belongs to the type A lantibiotic family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR006079 Lantibiotic_typ-A_Bacillales
PfamiView protein in Pfam
PF02052 Gallidermin, 1 hit
PRINTSiPR00323 GALLIDERMIN
TIGRFAMsiTIGR03731 lantibio_gallid, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAVKEKNDL FNLDVKVNAK ESNDSGAEPR IASKFICTPG CAKTGSFNSY

CC
Length:52
Mass (Da):5,632
Last modified:August 1, 1988 - v1
Checksum:i8B1AD2875BF16D6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07840 Genomic DNA Translation: CAA30689.1
X07840 Genomic DNA Translation: CAA30690.1
X62386 Genomic DNA Translation: CAA44252.1
PIRiS00768 EPSED

Similar proteinsi

Entry informationi

Entry nameiLANE_STAEP
AccessioniPrimary (citable) accession number: P08136
Secondary accession number(s): Q54093
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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