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Protein

Rho-related GTP-binding protein RhoC

Gene

RHOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19GTPBy similarity8
Nucleotide bindingi59 – 63GTPBy similarity5
Nucleotide bindingi117 – 120GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: GO_Central
  • protein kinase binding Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins
SignaLinkiP08134
SIGNORiP08134

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoC
Alternative name(s):
Rho cDNA clone 9
Short name:
h9
Gene namesi
Name:RHOC
Synonyms:ARH9, ARHC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000155366.16
HGNCiHGNC:669 RHOC
MIMi165380 gene
neXtProtiNX_P08134

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi389
OpenTargetsiENSG00000155366
PharmGKBiPA24951

Chemistry databases

ChEMBLiCHEMBL3883318

Polymorphism and mutation databases

BioMutaiRHOC
DMDMi132543

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000420221 – 190Rho-related GTP-binding protein RhoCAdd BLAST190
PropeptideiPRO_0000042023191 – 193Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_022301 Publication1
Modified residuei41ADP-ribosylasparagine; by botulinum toxinBy similarity1
Modified residuei190Cysteine methyl esterBy similarity1
Lipidationi190S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

(Microbial infection) Glycosylated at Tyr-34 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rho and leads to actin disassembly.1 Publication

Keywords - PTMi

ADP-ribosylation, Glycoprotein, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiP08134
MaxQBiP08134
PaxDbiP08134
PeptideAtlasiP08134
PRIDEiP08134
ProteomicsDBi52072
TopDownProteomicsiP08134

PTM databases

iPTMnetiP08134
PhosphoSitePlusiP08134
SwissPalmiP08134

Expressioni

Gene expression databases

BgeeiENSG00000155366 Expressed in 226 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_RHOC
ExpressionAtlasiP08134 baseline and differential
GenevisibleiP08134 HS

Interactioni

Subunit structurei

Interacts with RTKN (By similarity). Interacts with AKAP13 (PubMed:11546812). Interacts with DIAPH1 (PubMed:15864301). Interacts with PKN2 (PubMed:20974804). Interacts with ROCK1 and ROCK2 (PubMed:8816443). Interacts with ARHGDIA (PubMed:20400958). Interacts with RIPOR1 (PubMed:27807006).By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RIPOR2Q9Y4F95EBI-747589,EBI-2798942

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106882, 31 interactors
IntActiP08134, 12 interactors
MINTiP08134
STRINGi9606.ENSP00000285735

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08134
SMRiP08134
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08134

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 42Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiP08134
KOiK07857
OMAiWISEVVH
PhylomeDBiP08134
TreeFamiTF300837

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

P08134-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYIADIEVDG
60 70 80 90 100
KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT
110 120 130 140 150
PEVKHFCPNV PIILVGNKKD LRQDEHTRRE LAKMKQEPVR SEEGRDMANR
160 170 180 190
ISAFGYLECS AKTKEGVREV FEMATRAGLQ VRKNKRRRGC PIL
Length:193
Mass (Da):22,006
Last modified:August 1, 1988 - v1
Checksum:iA193DA581560F131
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JR08Q5JR08_HUMAN
Rho-related GTP-binding protein Rho...
RHOC
188Annotation score:
Q5JR05Q5JR05_HUMAN
Rho-related GTP-binding protein Rho...
RHOC
199Annotation score:
Q5JR07Q5JR07_HUMAN
Rho-related GTP-binding protein Rho...
RHOC
127Annotation score:
E9PN11E9PN11_HUMAN
Rho-related GTP-binding protein Rho...
RHOC
129Annotation score:
E9PQH6E9PQH6_HUMAN
Rho-related GTP-binding protein Rho...
RHOC
169Annotation score:
Q5JR06Q5JR06_HUMAN
Rho-related GTP-binding protein Rho...
RHOC
91Annotation score:
E9PLA2E9PLA2_HUMAN
Rho-related GTP-binding protein Rho...
RHOC
66Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051974120D → H. Corresponds to variant dbSNP:rs11538959Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06821 mRNA Translation: CAA29969.1
L25081 mRNA Translation: AAC33179.1
AF498972 mRNA Translation: AAM21119.1
CR450360 mRNA Translation: CAG29356.1
BT019448 mRNA Translation: AAV38255.1
AK094474 mRNA Translation: BAG52873.1
AL603832 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56534.1
BC007245 mRNA Translation: AAH07245.1
BC009177 mRNA Translation: AAH09177.1
BC052808 mRNA Translation: AAH52808.1
CCDSiCCDS854.1
PIRiS01029 TVHURC
RefSeqiNP_001036143.1, NM_001042678.1
NP_001036144.1, NM_001042679.1
NP_786886.1, NM_175744.4
UniGeneiHs.502659
Hs.658289

Genome annotation databases

EnsembliENST00000285735; ENSP00000285735; ENSG00000155366
ENST00000339083; ENSP00000345236; ENSG00000155366
ENST00000369632; ENSP00000358646; ENSG00000155366
ENST00000369633; ENSP00000358647; ENSG00000155366
ENST00000369637; ENSP00000358651; ENSG00000155366
ENST00000369638; ENSP00000358652; ENSG00000155366
ENST00000369642; ENSP00000358656; ENSG00000155366
GeneIDi389
KEGGihsa:389
UCSCiuc001ecp.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06821 mRNA Translation: CAA29969.1
L25081 mRNA Translation: AAC33179.1
AF498972 mRNA Translation: AAM21119.1
CR450360 mRNA Translation: CAG29356.1
BT019448 mRNA Translation: AAV38255.1
AK094474 mRNA Translation: BAG52873.1
AL603832 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56534.1
BC007245 mRNA Translation: AAH07245.1
BC009177 mRNA Translation: AAH09177.1
BC052808 mRNA Translation: AAH52808.1
CCDSiCCDS854.1
PIRiS01029 TVHURC
RefSeqiNP_001036143.1, NM_001042678.1
NP_001036144.1, NM_001042679.1
NP_786886.1, NM_175744.4
UniGeneiHs.502659
Hs.658289

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z2CX-ray3.00A/C1-193[»]
2GCNX-ray1.85A1-181[»]
2GCOX-ray1.40A/B1-181[»]
2GCPX-ray2.15A1-181[»]
ProteinModelPortaliP08134
SMRiP08134
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106882, 31 interactors
IntActiP08134, 12 interactors
MINTiP08134
STRINGi9606.ENSP00000285735

Chemistry databases

ChEMBLiCHEMBL3883318

PTM databases

iPTMnetiP08134
PhosphoSitePlusiP08134
SwissPalmiP08134

Polymorphism and mutation databases

BioMutaiRHOC
DMDMi132543

Proteomic databases

EPDiP08134
MaxQBiP08134
PaxDbiP08134
PeptideAtlasiP08134
PRIDEiP08134
ProteomicsDBi52072
TopDownProteomicsiP08134

Protocols and materials databases

DNASUi389
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285735; ENSP00000285735; ENSG00000155366
ENST00000339083; ENSP00000345236; ENSG00000155366
ENST00000369632; ENSP00000358646; ENSG00000155366
ENST00000369633; ENSP00000358647; ENSG00000155366
ENST00000369637; ENSP00000358651; ENSG00000155366
ENST00000369638; ENSP00000358652; ENSG00000155366
ENST00000369642; ENSP00000358656; ENSG00000155366
GeneIDi389
KEGGihsa:389
UCSCiuc001ecp.1 human

Organism-specific databases

CTDi389
DisGeNETi389
EuPathDBiHostDB:ENSG00000155366.16
GeneCardsiRHOC
HGNCiHGNC:669 RHOC
MIMi165380 gene
neXtProtiNX_P08134
OpenTargetsiENSG00000155366
PharmGKBiPA24951
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiP08134
KOiK07857
OMAiWISEVVH
PhylomeDBiP08134
TreeFamiTF300837

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
R-HSA-416482 G alpha (12/13) signalling events
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5625900 RHO GTPases activate CIT
R-HSA-5627117 RHO GTPases Activate ROCKs
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins
SignaLinkiP08134
SIGNORiP08134

Miscellaneous databases

ChiTaRSiRHOC human
EvolutionaryTraceiP08134
GeneWikiiRhoC
GenomeRNAii389
PROiPR:P08134
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155366 Expressed in 226 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_RHOC
ExpressionAtlasiP08134 baseline and differential
GenevisibleiP08134 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHOC_HUMAN
AccessioniPrimary (citable) accession number: P08134
Secondary accession number(s): B3KSW1, Q6ICN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 7, 2018
This is version 207 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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