UniProtKB - P08133 (ANXA6_HUMAN)

BLAST

>sp|P08133|ANXA6_HUMAN Annexin A6 OS=Homo sapiens OX=9606 GN=ANXA6 PE=1 SV=3
MAKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQ
SYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILA
SRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQD
VQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEK
LMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKS
LYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPA
NDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSE
ISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKED
YHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDK
TSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNK
PLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGD
FLKALLALCGGED

Align

Format
Add to basket Added to basket
History
Entry version 200 (07 Nov 2018)
Sequence version 3 (23 Jan 2007)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Annexin A6

Gene

ANXA6

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May associate with CD21. May regulate the release of Ca²⁺ from intracellular stores.

Miscellaneous

Seems to bind one calcium ion with high affinity.

GO - Molecular functionⁱ

actin filament binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
calcium channel activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
calcium-dependent phospholipid binding
Source: UniProtKB
Inferred from direct assayⁱ
- 2138016
calcium-dependent protein binding
Source: AgBase
Inferred from physical interactionⁱ
- 15226301
calcium ion binding Source: InterPro
cholesterol binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23360953
chondroitin sulfate binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
enzyme binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
GTP binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16605264
heparin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ligand-gated ion channel activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16605264
lipid binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16605264
phosphatidylserine binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein-containing complex binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homodimerization activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16605264
signaling receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
biomineral tissue development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
calcium ion import
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
growth plate cartilage chondrocyte differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ion transmembrane transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16605264
mitochondrial calcium ion homeostasis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of sequestering of calcium ion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neural crest cell migration
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homooligomerization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16605264
regulation of muscle contraction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium, Calcium/phospholipid-binding

Ligand

Calcium, Calcium/phospholipid-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-445355 Smooth Muscle Contraction

Reactomeⁱ

R-HSA-445355 Smooth Muscle Contraction

Protein family/group databases

TCDBⁱ	1.A.31.1.2 the annexin (annexin) family

TCDBⁱ

1.A.31.1.2 the annexin (annexin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Annexin A6 Alternative name(s): 67 kDa calelectrin Annexin VI Annexin-6 Calphobindin-II Short name: CPB-II Chromobindin-20 Lipocortin VI Protein III p68 p70
Gene namesⁱ	Name:ANXA6 Synonyms:ANX6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197043.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:544 ANXA6
MIMⁱ	114070 gene
neXtProtⁱ	NX_P08133

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	309
Open Targets More...OpenTargetsⁱ	ENSG00000197043
PharmGKBⁱ	PA24834

Polymorphism and mutation databases

BioMutaⁱ	ANXA6

BioMutaⁱ

ANXA6

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000067494	2 – 673	Annexin A6Add BLAST		672

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	13	PhosphoserineCombined sources	1
Modified residueⁱ	30	PhosphotyrosineCombined sources	1
Modified residueⁱ	63	N6-acetyllysineCombined sources	1
Modified residueⁱ	68	N6-acetyllysineCombined sources	1
Modified residueⁱ	75	N6-acetyllysineCombined sources	1
Modified residueⁱ	81	N6-acetyllysineCombined sources	1
Modified residueⁱ	201	PhosphotyrosineBy similarity	1
Modified residueⁱ	306	N6-acetyllysineCombined sources	1
Modified residueⁱ	370	N6-acetyllysineCombined sources	1
Modified residueⁱ	418	N6-acetyllysineCombined sources	1
Modified residueⁱ	422	PhosphoserineBy similarity	1
Modified residueⁱ	483	N6-acetyllysineCombined sources	1
Modified residueⁱ	537	PhosphoserineCombined sources	1
Modified residueⁱ	620	N6-acetyllysineCombined sources	1

Post-translational modificationⁱ

Phosphorylated in response to growth factor stimulation.

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P08133
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P08133
PaxDbⁱ	P08133
PeptideAtlas More...PeptideAtlasⁱ	P08133
PRIDEⁱ	P08133
ProteomicsDBⁱ	52071

2D gel databases

REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00221226
UCD-2DPAGEⁱ	P08133

PTM databases

iPTMnetⁱ	P08133
PhosphoSitePlusⁱ	P08133
SwissPalmⁱ	P08133

Expressionⁱ

Inductionⁱ

By Epstein-Barr virus (EBV).

Gene expression databases

Bgeeⁱ	ENSG00000197043 Expressed in 231 organ(s), highest expression level in fundus of stomach
CleanExⁱ	HS_ANXA6
ExpressionAtlasⁱ	P08133 baseline and differential
Genevisibleⁱ	P08133 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB005077 HPA002462 HPA009650

HPAⁱ

CAB005077
HPA002462
HPA009650

Interactionⁱ

GO - Molecular functionⁱ

actin filament binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
calcium-dependent protein binding
Source: AgBase
Inferred from physical interactionⁱ
- 15226301
enzyme binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein homodimerization activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16605264

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106806, 44 interactors
CORUMⁱ	P08133
IntActⁱ	P08133, 14 interactors
Molecular INTeraction database More...MINTⁱ	P08133
STRINGⁱ	9606.ENSP00000346550

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	22 – 32	Combined sources	11
Beta strandⁱ	34 – 37	Combined sources	4
Helixⁱ	40 – 47	Combined sources	8
Helixⁱ	52 – 66	Combined sources	15
Helixⁱ	70 – 77	Combined sources	8
Helixⁱ	80 – 90	Combined sources	11
Helixⁱ	93 – 105	Combined sources	13
Beta strandⁱ	106 – 109	Combined sources	4
Helixⁱ	112 – 121	Combined sources	10
Helixⁱ	124 – 137	Combined sources	14
Helixⁱ	142 – 149	Combined sources	8
Helixⁱ	152 – 163	Combined sources	12
Helixⁱ	174 – 187	Combined sources	14
Turnⁱ	188 – 190	Combined sources	3
Beta strandⁱ	191 – 193	Combined sources	3
Helixⁱ	196 – 205	Combined sources	10
Helixⁱ	208 – 221	Combined sources	14
Beta strandⁱ	222 – 224	Combined sources	3
Helixⁱ	226 – 230	Combined sources	5
Turnⁱ	231 – 233	Combined sources	3
Helixⁱ	236 – 262	Combined sources	27
Beta strandⁱ	264 – 268	Combined sources	5
Helixⁱ	271 – 280	Combined sources	10
Turnⁱ	281 – 285	Combined sources	5
Helixⁱ	286 – 296	Combined sources	11
Beta strandⁱ	297 – 299	Combined sources	3
Helixⁱ	301 – 306	Combined sources	6
Helixⁱ	311 – 321	Combined sources	11
Helixⁱ	333 – 348	Combined sources	16
Helixⁱ	365 – 376	Combined sources	12
Beta strandⁱ	377 – 380	Combined sources	4
Helixⁱ	383 – 391	Combined sources	9
Helixⁱ	395 – 409	Combined sources	15
Helixⁱ	413 – 420	Combined sources	8
Helixⁱ	424 – 433	Combined sources	10
Helixⁱ	436 – 448	Combined sources	13
Beta strandⁱ	449 – 452	Combined sources	4
Helixⁱ	455 – 464	Combined sources	10
Helixⁱ	467 – 481	Combined sources	15
Helixⁱ	485 – 492	Combined sources	8
Helixⁱ	495 – 504	Combined sources	10
Helixⁱ	516 – 530	Combined sources	15
Helixⁱ	535 – 537	Combined sources	3
Helixⁱ	546 – 553	Combined sources	8
Helixⁱ	556 – 568	Combined sources	13
Beta strandⁱ	569 – 572	Combined sources	4
Helixⁱ	574 – 581	Combined sources	8
Helixⁱ	584 – 611	Combined sources	28
Beta strandⁱ	613 – 616	Combined sources	4
Helixⁱ	619 – 628	Combined sources	10
Turnⁱ	630 – 633	Combined sources	4
Helixⁱ	634 – 645	Combined sources	12
Helixⁱ	649 – 656	Combined sources	8
Helixⁱ	659 – 668	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	P08133
SMRⁱ	P08133
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P08133

EvolutionaryTraceⁱ

P08133

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	29 – 89	Annexin 1Add BLAST	61
Repeatⁱ	101 – 161	Annexin 2Add BLAST	61
Repeatⁱ	185 – 245	Annexin 3Add BLAST	61
Repeatⁱ	260 – 320	Annexin 4Add BLAST	61
Repeatⁱ	372 – 432	Annexin 5Add BLAST	61
Repeatⁱ	444 – 504	Annexin 6Add BLAST	61
Repeatⁱ	533 – 593	Annexin 7Add BLAST	61
Repeatⁱ	608 – 668	Annexin 8Add BLAST	61

Domainⁱ

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesⁱ

Belongs to the annexin family.Curated

Keywords - Domainⁱ

Annexin, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0819 Eukaryota ENOG410XPUN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118972
HOGENOMⁱ	HOG000158803
HOVERGENⁱ	HBG061815
InParanoidⁱ	P08133
KEGG Orthology (KO) More...KOⁱ	K17094
OMAⁱ	TLIRIMI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0H6H
PhylomeDBⁱ	P08133
TreeFamⁱ	TF105452

Family and domain databases

Gene3Dⁱ	1.10.220.10, 8 hits
InterProⁱ	View protein in InterPro IPR001464 Annexin IPR018502 Annexin_repeat IPR018252 Annexin_repeat_CS IPR037104 Annexin_sf IPR002393 ANX6
PANTHERⁱ	PTHR10502:SF19 PTHR10502:SF19, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00191 Annexin, 8 hits
PRINTSⁱ	PR00196 ANNEXIN PR00202 ANNEXINVI
SMARTⁱ	View protein in SMART SM00335 ANX, 8 hits
PROSITEⁱ	View protein in PROSITE PS00223 ANNEXIN, 8 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P08133-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKPAQGAKY RGSIHDFPGF DPNQDAEALY TAMKGFGSDK EAILDIITSR 
        60         70         80         90        100
SNRQRQEVCQ SYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYCDAKE 
       110        120        130        140        150
IKDAISGIGT DEKCLIEILA SRTNEQMHQL VAAYKDAYER DLEADIIGDT 
       160        170        180        190        200
SGHFQKMLVV LLQGTREEDD VVSEDLVQQD VQDLYEAGEL KWGTDEAQFI 
       210        220        230        240        250
YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK LMLAVVKCIR 
       260        270        280        290        300
STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS 
       310        320        330        340        350
LYSMIKNDTS GEYKKTLLKL SGGDDDAAGQ FFPEAAQVAY QMWELSAVAR 
       360        370        380        390        400
VELKGTVRPA NDFNPDADAK ALRKAMKGLG TDEDTIIDII THRSNVQRQQ 
       410        420        430        440        450
IRQTFKSHFG RDLMTDLKSE ISGDLARLIL GLMMPPAHYD AKQLKKAMEG 
       460        470        480        490        500
AGTDEKALIE ILATRTNAEI RAINEAYKED YHKSLEDALS SDTSGHFRRI 
       510        520        530        540        550
LISLATGHRE EGGENLDQAR EDAQVAAEIL EIADTPSGDK TSLETRFMTI 
       560        570        580        590        600
LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDAF VAIVQSVKNK 
       610        620        630        640        650
PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH 
       660        670 
QAIEGDTSGD FLKALLALCG GED

Length:673

Mass (Da):75,873

Last modified:January 23, 2007 - v3

Checksum:ⁱ90F47474F7F6D7B6

Isoform 2 (identifier: P08133-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-32: Missing.

« Hide

        10         20         30         40         50
MKGFGSDKEA ILDIITSRSN RQRQEVCQSY KSLYGKDLIA DLKYELTGKF 
        60         70         80         90        100
ERLIVGLMRP PAYCDAKEIK DAISGIGTDE KCLIEILASR TNEQMHQLVA 
       110        120        130        140        150
AYKDAYERDL EADIIGDTSG HFQKMLVVLL QGTREEDDVV SEDLVQQDVQ 
       160        170        180        190        200
DLYEAGELKW GTDEAQFIYI LGNRSKQHLR LVFDEYLKTT GKPIEASIRG 
       210        220        230        240        250
ELSGDFEKLM LAVVKCIRST PEYFAERLFK AMKGLGTRDN TLIRIMVSRS 
       260        270        280        290        300
ELDMLDIREI FRTKYEKSLY SMIKNDTSGE YKKTLLKLSG GDDDAAGQFF 
       310        320        330        340        350
PEAAQVAYQM WELSAVARVE LKGTVRPAND FNPDADAKAL RKAMKGLGTD 
       360        370        380        390        400
EDTIIDIITH RSNVQRQQIR QTFKSHFGRD LMTDLKSEIS GDLARLILGL 
       410        420        430        440        450
MMPPAHYDAK QLKKAMEGAG TDEKALIEIL ATRTNAEIRA INEAYKEDYH 
       460        470        480        490        500
KSLEDALSSD TSGHFRRILI SLATGHREEG GENLDQARED AQVAAEILEI 
       510        520        530        540        550
ADTPSGDKTS LETRFMTILC TRSYPHLRRV FQEFIKMTNY DVEHTIKKEM 
       560        570        580        590        600
SGDVRDAFVA IVQSVKNKPL FFADKLYKSM KGAGTDEKTL TRIMVSRSEI 
       610        620        630        640 
DLLNIRREFI EKYDKSLHQA IEGDTSGDFL KALLALCGGE D

Note: No experimental confirmation available.

Show »

Length:641

Mass (Da):72,423

Checksum:ⁱ61E3E5CAF66A51E3

Computationally mapped potential isoform sequencesⁱ

There are 9 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E5RJR0	E5RJR0_HUMAN	Annexin Annexin	ANXA6	110	Annotation score:
E5RK63	E5RK63_HUMAN	Annexin Annexin	ANXA6	150	Annotation score:
E5RK69	E5RK69_HUMAN	Annexin Annexin	ANXA6	460	Annotation score:
E5RI05	E5RI05_HUMAN	Annexin Annexin	ANXA6	129	Annotation score:
E7EMC6	E7EMC6_HUMAN	Annexin Annexin	ANXA6	330	Annotation score:
E5RJF5	E5RJF5_HUMAN	Annexin Annexin	ANXA6	129	Annotation score:
H0YC77	H0YC77_HUMAN	Annexin Annexin	ANXA6	91	Annotation score:
E5RFF0	E5RFF0_HUMAN	Annexin A6 Annexin A6	ANXA6	156	Annotation score:
E5RIU8	E5RIU8_HUMAN	Annexin A6 Annexin A6	ANXA6	95	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	221	T → A in BAH13893 (PubMed:14702039).Curated	1
Sequence conflictⁱ	226 – 227	IE → MK in AAA35656 (PubMed:2963335).Curated	2
Sequence conflictⁱ	248	C → R in BAC86715 (PubMed:14702039).Curated	1
Sequence conflictⁱ	555	S → T in AAA35656 (PubMed:2963335).Curated	1
Sequence conflictⁱ	619	E → D in CAA68286 (PubMed:3258820).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045480	1 – 32	Missing in isoform 2. 1 PublicationAdd BLAST		32

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00097 mRNA Translation: CAA68286.1 J03578 mRNA Translation: AAA35656.1 D00510 mRNA Translation: BAA00400.1 AK126836 mRNA Translation: BAC86715.1 Sequence problems. AK303078 mRNA Translation: BAH13893.1 AC008641 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61684.1 CH471062 Genomic DNA Translation: EAW61686.1 BC017046 mRNA Translation: AAH17046.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47315.1 [P08133-1] CCDS54941.1 [P08133-2]
PIRⁱ	JU0032 AQHU68
NCBI Reference Sequences More...RefSeqⁱ	NP_001146.2, NM_001155.4 [P08133-1] NP_001180473.1, NM_001193544.1 [P08133-2]
UniGeneⁱ	Hs.412117

Genome annotation databases

Ensemblⁱ	ENST00000354546; ENSP00000346550; ENSG00000197043 [P08133-1] ENST00000523714; ENSP00000430517; ENSG00000197043 [P08133-2]
GeneIDⁱ	309
KEGGⁱ	hsa:309
UCSC genome browser More...UCSCⁱ	uc003ltl.3 human [P08133-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P08133	Annexin (Fragment)		HUMAN		673	UniRef100_P08133
Annexin (Fragment)		PONAB		130
Isoform 2 of Annexin A6		HUMAN		641
Annexin		HUMAN		547
Annexin (Fragment)		HUMAN		150
+2

Protein	Similar proteins		Species	Score	Length	Source
P08133	Annexin A6	)	BOVIN		673	UniRef90_P79134
Annexin A6		RAT		673
Annexin A6		MOUSE		673
Annexin		MYOBR		833
Annexin		CHLSB		676
+213

Protein	Similar proteins		Species	Score	Length	Source
P08133	Annexin A6	)	BOVIN		673	UniRef50_P79134
Annexin A6		MOUSE		673
Annexin A6		RAT		673
Annexin A6		CHICK		671
Annexin		MYOBR		833
+439

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y00097 mRNA Translation: CAA68286.1 J03578 mRNA Translation: AAA35656.1 D00510 mRNA Translation: BAA00400.1 AK126836 mRNA Translation: BAC86715.1 Sequence problems. AK303078 mRNA Translation: BAH13893.1 AC008641 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61684.1 CH471062 Genomic DNA Translation: EAW61686.1 BC017046 mRNA Translation: AAH17046.1
CCDSⁱ	CCDS47315.1 [P08133-1] CCDS54941.1 [P08133-2]
PIRⁱ	JU0032 AQHU68
RefSeqⁱ	NP_001146.2, NM_001155.4 [P08133-1] NP_001180473.1, NM_001193544.1 [P08133-2]
UniGeneⁱ	Hs.412117

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1M9I	X-ray	2.65	A	2-673	[»]
ProteinModelPortalⁱ	P08133
SMRⁱ	P08133
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106806, 44 interactors
CORUMⁱ	P08133
IntActⁱ	P08133, 14 interactors
MINTⁱ	P08133
STRINGⁱ	9606.ENSP00000346550

Protein family/group databases

TCDBⁱ	1.A.31.1.2 the annexin (annexin) family

TCDBⁱ

1.A.31.1.2 the annexin (annexin) family

PTM databases

iPTMnetⁱ	P08133
PhosphoSitePlusⁱ	P08133
SwissPalmⁱ	P08133

Polymorphism and mutation databases

BioMutaⁱ	ANXA6

BioMutaⁱ

ANXA6

2D gel databases

REPRODUCTION-2DPAGEⁱ	IPI00221226
UCD-2DPAGEⁱ	P08133

Proteomic databases

EPDⁱ	P08133
MaxQBⁱ	P08133
PaxDbⁱ	P08133
PeptideAtlasⁱ	P08133
PRIDEⁱ	P08133
ProteomicsDBⁱ	52071

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	309
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000354546; ENSP00000346550; ENSG00000197043 [P08133-1] ENST00000523714; ENSP00000430517; ENSG00000197043 [P08133-2]
GeneIDⁱ	309
KEGGⁱ	hsa:309
UCSCⁱ	uc003ltl.3 human [P08133-1]

Organism-specific databases

CTDⁱ	309
DisGeNETⁱ	309
EuPathDBⁱ	HostDB:ENSG00000197043.13
GeneCardsⁱ	ANXA6
HGNCⁱ	HGNC:544 ANXA6
HPAⁱ	CAB005077 HPA002462 HPA009650
MIMⁱ	114070 gene
neXtProtⁱ	NX_P08133
OpenTargetsⁱ	ENSG00000197043
PharmGKBⁱ	PA24834
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0819 Eukaryota ENOG410XPUN LUCA
GeneTreeⁱ	ENSGT00760000118972
HOGENOMⁱ	HOG000158803
HOVERGENⁱ	HBG061815
InParanoidⁱ	P08133
KOⁱ	K17094
OMAⁱ	TLIRIMI
OrthoDBⁱ	EOG091G0H6H
PhylomeDBⁱ	P08133
TreeFamⁱ	TF105452

Enzyme and pathway databases

Reactomeⁱ	R-HSA-445355 Smooth Muscle Contraction

Reactomeⁱ

R-HSA-445355 Smooth Muscle Contraction

Miscellaneous databases

ChiTaRSⁱ	ANXA6 human
EvolutionaryTraceⁱ	P08133
GeneWikiⁱ	ANXA6
GenomeRNAiⁱ	309
Protein Ontology More...PROⁱ	PR:P08133
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000197043 Expressed in 231 organ(s), highest expression level in fundus of stomach
CleanExⁱ	HS_ANXA6
ExpressionAtlasⁱ	P08133 baseline and differential
Genevisibleⁱ	P08133 HS

Family and domain databases

Gene3Dⁱ	1.10.220.10, 8 hits
InterProⁱ	View protein in InterPro IPR001464 Annexin IPR018502 Annexin_repeat IPR018252 Annexin_repeat_CS IPR037104 Annexin_sf IPR002393 ANX6
PANTHERⁱ	PTHR10502:SF19 PTHR10502:SF19, 2 hits
Pfamⁱ	View protein in Pfam PF00191 Annexin, 8 hits
PRINTSⁱ	PR00196 ANNEXIN PR00202 ANNEXINVI
SMARTⁱ	View protein in SMART SM00335 ANX, 8 hits
PROSITEⁱ	View protein in PROSITE PS00223 ANNEXIN, 8 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ANXA6_HUMAN
Accessionⁱ	P08133Primary (citable) accession number: P08133 Secondary accession number(s): B7Z8A7 , D3DQH4, E9PGK1, Q6ZT79
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 200 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P08133 (ANXA6_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Annexin A6

ANXA6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Endosome

Extracellular region or secreted

Lysosome

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ