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Protein

Annexin A6

Gene

ANXA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May associate with CD21. May regulate the release of Ca2+ from intracellular stores.

Miscellaneous

Seems to bind one calcium ion with high affinity.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • calcium channel activity Source: GO_Central
  • calcium-dependent phospholipid binding Source: UniProtKB
  • calcium-dependent protein binding Source: AgBase
  • calcium ion binding Source: InterPro
  • cholesterol binding Source: UniProtKB
  • chondroitin sulfate binding Source: GO_Central
  • enzyme binding Source: GO_Central
  • GTP binding Source: UniProtKB
  • heparin binding Source: GO_Central
  • ligand-gated ion channel activity Source: UniProtKB
  • lipid binding Source: UniProtKB
  • phosphatidylserine binding Source: GO_Central
  • protein-containing complex binding Source: GO_Central
  • protein homodimerization activity Source: UniProtKB
  • signaling receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Calcium/phospholipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-445355 Smooth Muscle Contraction

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.31.1.2 the annexin (annexin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Annexin A6
Alternative name(s):
67 kDa calelectrin
Annexin VI
Annexin-6
Calphobindin-II
Short name:
CPB-II
Chromobindin-20
Lipocortin VI
Protein III
p68
p70
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANXA6
Synonyms:ANX6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197043.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:544 ANXA6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
114070 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P08133

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
309

Open Targets

More...
OpenTargetsi
ENSG00000197043

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24834

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANXA6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000674942 – 673Annexin A6Add BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei30PhosphotyrosineCombined sources1
Modified residuei63N6-acetyllysineCombined sources1
Modified residuei68N6-acetyllysineCombined sources1
Modified residuei75N6-acetyllysineCombined sources1
Modified residuei81N6-acetyllysineCombined sources1
Modified residuei201PhosphotyrosineBy similarity1
Modified residuei306N6-acetyllysineCombined sources1
Modified residuei370N6-acetyllysineCombined sources1
Modified residuei418N6-acetyllysineCombined sources1
Modified residuei422PhosphoserineBy similarity1
Modified residuei483N6-acetyllysineCombined sources1
Modified residuei537PhosphoserineCombined sources1
Modified residuei620N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated in response to growth factor stimulation.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P08133

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P08133

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P08133

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08133

PeptideAtlas

More...
PeptideAtlasi
P08133

PRoteomics IDEntifications database

More...
PRIDEi
P08133

ProteomicsDB human proteome resource

More...
ProteomicsDBi
52071

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00221226

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P08133

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08133

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P08133

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P08133

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By Epstein-Barr virus (EBV).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197043 Expressed in 231 organ(s), highest expression level in fundus of stomach

CleanEx database of gene expression profiles

More...
CleanExi
HS_ANXA6

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P08133 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P08133 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005077
HPA002462
HPA009650

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106806, 44 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P08133

Protein interaction database and analysis system

More...
IntActi
P08133, 15 interactors

Molecular INTeraction database

More...
MINTi
P08133

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346550

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M9IX-ray2.65A2-673[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P08133

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P08133

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P08133

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati29 – 89Annexin 1Add BLAST61
Repeati101 – 161Annexin 2Add BLAST61
Repeati185 – 245Annexin 3Add BLAST61
Repeati260 – 320Annexin 4Add BLAST61
Repeati372 – 432Annexin 5Add BLAST61
Repeati444 – 504Annexin 6Add BLAST61
Repeati533 – 593Annexin 7Add BLAST61
Repeati608 – 668Annexin 8Add BLAST61

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0819 Eukaryota
ENOG410XPUN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158770

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000158803

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG061815

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08133

KEGG Orthology (KO)

More...
KOi
K17094

Identification of Orthologs from Complete Genome Data

More...
OMAi
TLIRIMI

Database of Orthologous Groups

More...
OrthoDBi
856254at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P08133

TreeFam database of animal gene trees

More...
TreeFami
TF105452

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.220.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002393 ANX6

The PANTHER Classification System

More...
PANTHERi
PTHR10502:SF19 PTHR10502:SF19, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00191 Annexin, 8 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00196 ANNEXIN
PR00202 ANNEXINVI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00335 ANX, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00223 ANNEXIN, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P08133-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKPAQGAKY RGSIHDFPGF DPNQDAEALY TAMKGFGSDK EAILDIITSR
60 70 80 90 100
SNRQRQEVCQ SYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYCDAKE
110 120 130 140 150
IKDAISGIGT DEKCLIEILA SRTNEQMHQL VAAYKDAYER DLEADIIGDT
160 170 180 190 200
SGHFQKMLVV LLQGTREEDD VVSEDLVQQD VQDLYEAGEL KWGTDEAQFI
210 220 230 240 250
YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK LMLAVVKCIR
260 270 280 290 300
STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS
310 320 330 340 350
LYSMIKNDTS GEYKKTLLKL SGGDDDAAGQ FFPEAAQVAY QMWELSAVAR
360 370 380 390 400
VELKGTVRPA NDFNPDADAK ALRKAMKGLG TDEDTIIDII THRSNVQRQQ
410 420 430 440 450
IRQTFKSHFG RDLMTDLKSE ISGDLARLIL GLMMPPAHYD AKQLKKAMEG
460 470 480 490 500
AGTDEKALIE ILATRTNAEI RAINEAYKED YHKSLEDALS SDTSGHFRRI
510 520 530 540 550
LISLATGHRE EGGENLDQAR EDAQVAAEIL EIADTPSGDK TSLETRFMTI
560 570 580 590 600
LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDAF VAIVQSVKNK
610 620 630 640 650
PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH
660 670
QAIEGDTSGD FLKALLALCG GED
Length:673
Mass (Da):75,873
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90F47474F7F6D7B6
GO
Isoform 2 (identifier: P08133-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.
Show »
Length:641
Mass (Da):72,423
Checksum:i61E3E5CAF66A51E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RJR0E5RJR0_HUMAN
Annexin
ANXA6
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK63E5RK63_HUMAN
Annexin
ANXA6
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK69E5RK69_HUMAN
Annexin
ANXA6
460Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI05E5RI05_HUMAN
Annexin
ANXA6
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC77H0YC77_HUMAN
Annexin
ANXA6
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJF5E5RJF5_HUMAN
Annexin
ANXA6
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMC6E7EMC6_HUMAN
Annexin
ANXA6
330Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFF0E5RFF0_HUMAN
Annexin A6
ANXA6
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIU8E5RIU8_HUMAN
Annexin A6
ANXA6
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti221T → A in BAH13893 (PubMed:14702039).Curated1
Sequence conflicti226 – 227IE → MK in AAA35656 (PubMed:2963335).Curated2
Sequence conflicti248C → R in BAC86715 (PubMed:14702039).Curated1
Sequence conflicti555S → T in AAA35656 (PubMed:2963335).Curated1
Sequence conflicti619E → D in CAA68286 (PubMed:3258820).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0454801 – 32Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Y00097 mRNA Translation: CAA68286.1
J03578 mRNA Translation: AAA35656.1
D00510 mRNA Translation: BAA00400.1
AK126836 mRNA Translation: BAC86715.1 Sequence problems.
AK303078 mRNA Translation: BAH13893.1
AC008641 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61684.1
CH471062 Genomic DNA Translation: EAW61686.1
BC017046 mRNA Translation: AAH17046.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS47315.1 [P08133-1]
CCDS54941.1 [P08133-2]

Protein sequence database of the Protein Information Resource

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PIRi
JU0032 AQHU68

NCBI Reference Sequences

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RefSeqi
NP_001146.2, NM_001155.4 [P08133-1]
NP_001180473.1, NM_001193544.1 [P08133-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.412117

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000354546; ENSP00000346550; ENSG00000197043 [P08133-1]
ENST00000523714; ENSP00000430517; ENSG00000197043 [P08133-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
309

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:309

UCSC genome browser

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UCSCi
uc003ltl.3 human [P08133-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00097 mRNA Translation: CAA68286.1
J03578 mRNA Translation: AAA35656.1
D00510 mRNA Translation: BAA00400.1
AK126836 mRNA Translation: BAC86715.1 Sequence problems.
AK303078 mRNA Translation: BAH13893.1
AC008641 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61684.1
CH471062 Genomic DNA Translation: EAW61686.1
BC017046 mRNA Translation: AAH17046.1
CCDSiCCDS47315.1 [P08133-1]
CCDS54941.1 [P08133-2]
PIRiJU0032 AQHU68
RefSeqiNP_001146.2, NM_001155.4 [P08133-1]
NP_001180473.1, NM_001193544.1 [P08133-2]
UniGeneiHs.412117

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M9IX-ray2.65A2-673[»]
ProteinModelPortaliP08133
SMRiP08133
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106806, 44 interactors
CORUMiP08133
IntActiP08133, 15 interactors
MINTiP08133
STRINGi9606.ENSP00000346550

Protein family/group databases

TCDBi1.A.31.1.2 the annexin (annexin) family

PTM databases

iPTMnetiP08133
PhosphoSitePlusiP08133
SwissPalmiP08133

Polymorphism and mutation databases

BioMutaiANXA6

2D gel databases

REPRODUCTION-2DPAGEiIPI00221226
UCD-2DPAGEiP08133

Proteomic databases

EPDiP08133
jPOSTiP08133
MaxQBiP08133
PaxDbiP08133
PeptideAtlasiP08133
PRIDEiP08133
ProteomicsDBi52071

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
309
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354546; ENSP00000346550; ENSG00000197043 [P08133-1]
ENST00000523714; ENSP00000430517; ENSG00000197043 [P08133-2]
GeneIDi309
KEGGihsa:309
UCSCiuc003ltl.3 human [P08133-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
309
DisGeNETi309
EuPathDBiHostDB:ENSG00000197043.13

GeneCards: human genes, protein and diseases

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GeneCardsi
ANXA6
HGNCiHGNC:544 ANXA6
HPAiCAB005077
HPA002462
HPA009650
MIMi114070 gene
neXtProtiNX_P08133
OpenTargetsiENSG00000197043
PharmGKBiPA24834

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00940000158770
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP08133
KOiK17094
OMAiTLIRIMI
OrthoDBi856254at2759
PhylomeDBiP08133
TreeFamiTF105452

Enzyme and pathway databases

ReactomeiR-HSA-445355 Smooth Muscle Contraction

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANXA6 human
EvolutionaryTraceiP08133

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ANXA6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
309

Protein Ontology

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PROi
PR:P08133

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197043 Expressed in 231 organ(s), highest expression level in fundus of stomach
CleanExiHS_ANXA6
ExpressionAtlasiP08133 baseline and differential
GenevisibleiP08133 HS

Family and domain databases

Gene3Di1.10.220.10, 8 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002393 ANX6
PANTHERiPTHR10502:SF19 PTHR10502:SF19, 2 hits
PfamiView protein in Pfam
PF00191 Annexin, 8 hits
PRINTSiPR00196 ANNEXIN
PR00202 ANNEXINVI
SMARTiView protein in SMART
SM00335 ANX, 8 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANXA6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08133
Secondary accession number(s): B7Z8A7
, D3DQH4, E9PGK1, Q6ZT79
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 202 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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