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Protein

Annexin A6

Gene

ANXA6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May associate with CD21. May regulate the release of Ca2+ from intracellular stores.

Miscellaneous

Seems to bind one calcium ion with high affinity.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB
  • calcium-dependent protein binding Source: AgBase
  • calcium ion binding Source: InterPro
  • cholesterol binding Source: UniProtKB
  • GTP binding Source: UniProtKB
  • ligand-gated ion channel activity Source: UniProtKB
  • lipid binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCalcium, Calcium/phospholipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-445355 Smooth Muscle Contraction

Protein family/group databases

TCDBi1.A.31.1.2 the annexin (annexin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A6
Alternative name(s):
67 kDa calelectrin
Annexin VI
Annexin-6
Calphobindin-II
Short name:
CPB-II
Chromobindin-20
Lipocortin VI
Protein III
p68
p70
Gene namesi
Name:ANXA6
Synonyms:ANX6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000197043.13
HGNCiHGNC:544 ANXA6
MIMi114070 gene
neXtProtiNX_P08133

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi309
OpenTargetsiENSG00000197043
PharmGKBiPA24834

Polymorphism and mutation databases

BioMutaiANXA6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00000674942 – 673Annexin A6Add BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei30PhosphotyrosineCombined sources1
Modified residuei63N6-acetyllysineCombined sources1
Modified residuei68N6-acetyllysineCombined sources1
Modified residuei75N6-acetyllysineCombined sources1
Modified residuei81N6-acetyllysineCombined sources1
Modified residuei201PhosphotyrosineBy similarity1
Modified residuei306N6-acetyllysineCombined sources1
Modified residuei370N6-acetyllysineCombined sources1
Modified residuei418N6-acetyllysineCombined sources1
Modified residuei422PhosphoserineBy similarity1
Modified residuei483N6-acetyllysineCombined sources1
Modified residuei537PhosphoserineCombined sources1
Modified residuei620N6-acetyllysineCombined sources1

Post-translational modificationi

Phosphorylated in response to growth factor stimulation.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP08133
MaxQBiP08133
PaxDbiP08133
PeptideAtlasiP08133
PRIDEiP08133
ProteomicsDBi52071

2D gel databases

REPRODUCTION-2DPAGEiIPI00221226
UCD-2DPAGEiP08133

PTM databases

iPTMnetiP08133
PhosphoSitePlusiP08133
SwissPalmiP08133

Expressioni

Inductioni

By Epstein-Barr virus (EBV).

Gene expression databases

BgeeiENSG00000197043 Expressed in 231 organ(s), highest expression level in fundus of stomach
CleanExiHS_ANXA6
ExpressionAtlasiP08133 baseline and differential
GenevisibleiP08133 HS

Organism-specific databases

HPAiCAB005077
HPA002462
HPA009650

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106806, 44 interactors
CORUMiP08133
IntActiP08133, 14 interactors
MINTiP08133
STRINGi9606.ENSP00000346550

Structurei

Secondary structure

1673
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08133
SMRiP08133
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08133

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 89Annexin 1Add BLAST61
Repeati101 – 161Annexin 2Add BLAST61
Repeati185 – 245Annexin 3Add BLAST61
Repeati260 – 320Annexin 4Add BLAST61
Repeati372 – 432Annexin 5Add BLAST61
Repeati444 – 504Annexin 6Add BLAST61
Repeati533 – 593Annexin 7Add BLAST61
Repeati608 – 668Annexin 8Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP08133
KOiK17094
OMAiLGTRDNT
OrthoDBiEOG091G0H6H
PhylomeDBiP08133
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 8 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002393 ANX6
PANTHERiPTHR10502:SF19 PTHR10502:SF19, 2 hits
PfamiView protein in Pfam
PF00191 Annexin, 8 hits
PRINTSiPR00196 ANNEXIN
PR00202 ANNEXINVI
SMARTiView protein in SMART
SM00335 ANX, 8 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 8 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P08133-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKPAQGAKY RGSIHDFPGF DPNQDAEALY TAMKGFGSDK EAILDIITSR
60 70 80 90 100
SNRQRQEVCQ SYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYCDAKE
110 120 130 140 150
IKDAISGIGT DEKCLIEILA SRTNEQMHQL VAAYKDAYER DLEADIIGDT
160 170 180 190 200
SGHFQKMLVV LLQGTREEDD VVSEDLVQQD VQDLYEAGEL KWGTDEAQFI
210 220 230 240 250
YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK LMLAVVKCIR
260 270 280 290 300
STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS
310 320 330 340 350
LYSMIKNDTS GEYKKTLLKL SGGDDDAAGQ FFPEAAQVAY QMWELSAVAR
360 370 380 390 400
VELKGTVRPA NDFNPDADAK ALRKAMKGLG TDEDTIIDII THRSNVQRQQ
410 420 430 440 450
IRQTFKSHFG RDLMTDLKSE ISGDLARLIL GLMMPPAHYD AKQLKKAMEG
460 470 480 490 500
AGTDEKALIE ILATRTNAEI RAINEAYKED YHKSLEDALS SDTSGHFRRI
510 520 530 540 550
LISLATGHRE EGGENLDQAR EDAQVAAEIL EIADTPSGDK TSLETRFMTI
560 570 580 590 600
LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDAF VAIVQSVKNK
610 620 630 640 650
PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH
660 670
QAIEGDTSGD FLKALLALCG GED
Length:673
Mass (Da):75,873
Last modified:January 23, 2007 - v3
Checksum:i90F47474F7F6D7B6
GO
Isoform 2 (identifier: P08133-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.
Show »
Length:641
Mass (Da):72,423
Checksum:i61E3E5CAF66A51E3
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RK63E5RK63_HUMAN
Annexin
ANXA6
150Annotation score:
E5RI05E5RI05_HUMAN
Annexin
ANXA6
129Annotation score:
E5RK69E5RK69_HUMAN
Annexin
ANXA6
460Annotation score:
E5RJR0E5RJR0_HUMAN
Annexin
ANXA6
110Annotation score:
H0YC77H0YC77_HUMAN
Annexin
ANXA6
91Annotation score:
E7EMC6E7EMC6_HUMAN
Annexin
ANXA6
330Annotation score:
E5RJF5E5RJF5_HUMAN
Annexin
ANXA6
129Annotation score:
E5RFF0E5RFF0_HUMAN
Annexin A6
ANXA6
156Annotation score:
E5RIU8E5RIU8_HUMAN
Annexin A6
ANXA6
95Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221T → A in BAH13893 (PubMed:14702039).Curated1
Sequence conflicti226 – 227IE → MK in AAA35656 (PubMed:2963335).Curated2
Sequence conflicti248C → R in BAC86715 (PubMed:14702039).Curated1
Sequence conflicti555S → T in AAA35656 (PubMed:2963335).Curated1
Sequence conflicti619E → D in CAA68286 (PubMed:3258820).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0454801 – 32Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00097 mRNA Translation: CAA68286.1
J03578 mRNA Translation: AAA35656.1
D00510 mRNA Translation: BAA00400.1
AK126836 mRNA Translation: BAC86715.1 Sequence problems.
AK303078 mRNA Translation: BAH13893.1
AC008641 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61684.1
CH471062 Genomic DNA Translation: EAW61686.1
BC017046 mRNA Translation: AAH17046.1
CCDSiCCDS47315.1 [P08133-1]
CCDS54941.1 [P08133-2]
PIRiJU0032 AQHU68
RefSeqiNP_001146.2, NM_001155.4 [P08133-1]
NP_001180473.1, NM_001193544.1 [P08133-2]
UniGeneiHs.412117

Genome annotation databases

EnsembliENST00000354546; ENSP00000346550; ENSG00000197043 [P08133-1]
ENST00000523714; ENSP00000430517; ENSG00000197043 [P08133-2]
GeneIDi309
KEGGihsa:309
UCSCiuc003ltl.3 human [P08133-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00097 mRNA Translation: CAA68286.1
J03578 mRNA Translation: AAA35656.1
D00510 mRNA Translation: BAA00400.1
AK126836 mRNA Translation: BAC86715.1 Sequence problems.
AK303078 mRNA Translation: BAH13893.1
AC008641 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61684.1
CH471062 Genomic DNA Translation: EAW61686.1
BC017046 mRNA Translation: AAH17046.1
CCDSiCCDS47315.1 [P08133-1]
CCDS54941.1 [P08133-2]
PIRiJU0032 AQHU68
RefSeqiNP_001146.2, NM_001155.4 [P08133-1]
NP_001180473.1, NM_001193544.1 [P08133-2]
UniGeneiHs.412117

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M9IX-ray2.65A2-673[»]
ProteinModelPortaliP08133
SMRiP08133
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106806, 44 interactors
CORUMiP08133
IntActiP08133, 14 interactors
MINTiP08133
STRINGi9606.ENSP00000346550

Protein family/group databases

TCDBi1.A.31.1.2 the annexin (annexin) family

PTM databases

iPTMnetiP08133
PhosphoSitePlusiP08133
SwissPalmiP08133

Polymorphism and mutation databases

BioMutaiANXA6

2D gel databases

REPRODUCTION-2DPAGEiIPI00221226
UCD-2DPAGEiP08133

Proteomic databases

EPDiP08133
MaxQBiP08133
PaxDbiP08133
PeptideAtlasiP08133
PRIDEiP08133
ProteomicsDBi52071

Protocols and materials databases

DNASUi309
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354546; ENSP00000346550; ENSG00000197043 [P08133-1]
ENST00000523714; ENSP00000430517; ENSG00000197043 [P08133-2]
GeneIDi309
KEGGihsa:309
UCSCiuc003ltl.3 human [P08133-1]

Organism-specific databases

CTDi309
DisGeNETi309
EuPathDBiHostDB:ENSG00000197043.13
GeneCardsiANXA6
HGNCiHGNC:544 ANXA6
HPAiCAB005077
HPA002462
HPA009650
MIMi114070 gene
neXtProtiNX_P08133
OpenTargetsiENSG00000197043
PharmGKBiPA24834
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP08133
KOiK17094
OMAiLGTRDNT
OrthoDBiEOG091G0H6H
PhylomeDBiP08133
TreeFamiTF105452

Enzyme and pathway databases

ReactomeiR-HSA-445355 Smooth Muscle Contraction

Miscellaneous databases

ChiTaRSiANXA6 human
EvolutionaryTraceiP08133
GeneWikiiANXA6
GenomeRNAii309
PROiPR:P08133
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197043 Expressed in 231 organ(s), highest expression level in fundus of stomach
CleanExiHS_ANXA6
ExpressionAtlasiP08133 baseline and differential
GenevisibleiP08133 HS

Family and domain databases

Gene3Di1.10.220.10, 8 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002393 ANX6
PANTHERiPTHR10502:SF19 PTHR10502:SF19, 2 hits
PfamiView protein in Pfam
PF00191 Annexin, 8 hits
PRINTSiPR00196 ANNEXIN
PR00202 ANNEXINVI
SMARTiView protein in SMART
SM00335 ANX, 8 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANXA6_HUMAN
AccessioniPrimary (citable) accession number: P08133
Secondary accession number(s): B7Z8A7
, D3DQH4, E9PGK1, Q6ZT79
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 199 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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