UniProtKB - P08133 (ANXA6_HUMAN)
Protein
Annexin A6
Gene
ANXA6
Organism
Homo sapiens (Human)
Status
Functioni
May associate with CD21. May regulate the release of Ca2+ from intracellular stores.
Miscellaneous
Seems to bind one calcium ion with high affinity.
GO - Molecular functioni
- actin filament binding Source: GO_Central
- calcium channel activity Source: GO_Central
- calcium-dependent phospholipid binding Source: UniProtKB
- calcium-dependent protein binding Source: AgBase
- calcium ion binding Source: InterPro
- cholesterol binding Source: UniProtKB
- chondroitin sulfate binding Source: GO_Central
- GTP binding Source: UniProtKB
- ligand-gated ion channel activity Source: UniProtKB
- lipid binding Source: UniProtKB
- phosphatidylserine binding Source: GO_Central
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- apoptotic signaling pathway Source: GO_Central
- growth plate cartilage chondrocyte differentiation Source: GO_Central
- ion transmembrane transport Source: UniProtKB
- mitochondrial calcium ion homeostasis Source: GO_Central
- negative regulation of sequestering of calcium ion Source: GO_Central
- plasma membrane repair Source: GO_Central
- protein homooligomerization Source: UniProtKB
- regulation of muscle contraction Source: GO_Central
Keywordsi
Ligand | Calcium, Calcium/phospholipid-binding |
Enzyme and pathway databases
Reactomei | R-HSA-445355 Smooth Muscle Contraction |
Protein family/group databases
TCDBi | 1.A.31.1.2 the annexin (annexin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Annexin A6Alternative name(s): 67 kDa calelectrin Annexin VI Annexin-6 Calphobindin-II Short name: CPB-II Chromobindin-20 Lipocortin VI Protein III p68 p70 |
Gene namesi | Name:ANXA6 Synonyms:ANX6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:544 ANXA6 |
MIMi | 114070 gene |
neXtProti | NX_P08133 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
- Melanosome 1 Publication
Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Endosome
- late endosome membrane Source: UniProtKB
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular exosome Source: UniProtKB
Lysosome
- lysosomal membrane Source: UniProtKB
Mitochondrion
- mitochondrion Source: GOC
Other locations
- focal adhesion Source: UniProtKB
- melanosome Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- perinuclear region of cytoplasm Source: Ensembl
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 309 |
OpenTargetsi | ENSG00000197043 |
PharmGKBi | PA24834 |
Miscellaneous databases
Pharosi | P08133 |
Polymorphism and mutation databases
BioMutai | ANXA6 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000067494 | 2 – 673 | Annexin A6Add BLAST | 672 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 13 | PhosphoserineCombined sources | 1 | |
Modified residuei | 30 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 63 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 68 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 75 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 81 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 201 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 306 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 370 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 418 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 422 | PhosphoserineBy similarity | 1 | |
Modified residuei | 483 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 537 | PhosphoserineCombined sources | 1 | |
Modified residuei | 620 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Phosphorylated in response to growth factor stimulation.
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-313 CPTAC-314 |
EPDi | P08133 |
jPOSTi | P08133 |
MassIVEi | P08133 |
MaxQBi | P08133 |
PaxDbi | P08133 |
PeptideAtlasi | P08133 |
PRIDEi | P08133 |
ProteomicsDBi | 20335 52071 [P08133-1] |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00221226 |
UCD-2DPAGEi | P08133 |
PTM databases
iPTMneti | P08133 |
PhosphoSitePlusi | P08133 |
SwissPalmi | P08133 |
Expressioni
Inductioni
By Epstein-Barr virus (EBV).
Gene expression databases
Bgeei | ENSG00000197043 Expressed in 231 organ(s), highest expression level in fundus of stomach |
ExpressionAtlasi | P08133 baseline and differential |
Genevisiblei | P08133 HS |
Organism-specific databases
HPAi | CAB005077 HPA002462 HPA009650 |
Interactioni
Binary interactionsi
With | Entry | #Exp. | IntAct | Notes |
---|---|---|---|---|
P10636-8 | 2 | EBI-352541,EBI-366233 |
GO - Molecular functioni
- actin filament binding Source: GO_Central
- calcium-dependent protein binding Source: AgBase
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGridi | 106806, 47 interactors |
CORUMi | P08133 |
IntActi | P08133, 23 interactors |
MINTi | P08133 |
STRINGi | 9606.ENSP00000346550 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P08133 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P08133 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 20 – 91 | Annexin 1PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 92 – 163 | Annexin 2PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 175 – 247 | Annexin 3PROSITE-ProRule annotationAdd BLAST | 73 | |
Repeati | 251 – 322 | Annexin 4PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 363 – 434 | Annexin 5PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 435 – 506 | Annexin 6PROSITE-ProRule annotationAdd BLAST | 72 | |
Repeati | 521 – 595 | Annexin 7PROSITE-ProRule annotationAdd BLAST | 75 | |
Repeati | 599 – 670 | Annexin 8PROSITE-ProRule annotationAdd BLAST | 72 |
Domaini
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Sequence similaritiesi
Keywords - Domaini
Annexin, RepeatPhylogenomic databases
eggNOGi | KOG0819 Eukaryota ENOG410XPUN LUCA |
GeneTreei | ENSGT00940000158770 |
HOGENOMi | HOG000158803 |
InParanoidi | P08133 |
KOi | K17094 |
OMAi | VEICQAY |
OrthoDBi | 856254at2759 |
PhylomeDBi | P08133 |
TreeFami | TF105452 |
Family and domain databases
Gene3Di | 1.10.220.10, 8 hits |
InterProi | View protein in InterPro IPR001464 Annexin IPR018502 Annexin_repeat IPR018252 Annexin_repeat_CS IPR037104 Annexin_sf IPR002393 ANX6 |
Pfami | View protein in Pfam PF00191 Annexin, 8 hits |
PRINTSi | PR00196 ANNEXIN PR00202 ANNEXINVI |
SMARTi | View protein in SMART SM00335 ANX, 8 hits |
SUPFAMi | SSF47874 SSF47874, 2 hits |
PROSITEi | View protein in PROSITE PS00223 ANNEXIN_1, 8 hits PS51897 ANNEXIN_2, 8 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P08133-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAKPAQGAKY RGSIHDFPGF DPNQDAEALY TAMKGFGSDK EAILDIITSR
60 70 80 90 100
SNRQRQEVCQ SYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYCDAKE
110 120 130 140 150
IKDAISGIGT DEKCLIEILA SRTNEQMHQL VAAYKDAYER DLEADIIGDT
160 170 180 190 200
SGHFQKMLVV LLQGTREEDD VVSEDLVQQD VQDLYEAGEL KWGTDEAQFI
210 220 230 240 250
YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK LMLAVVKCIR
260 270 280 290 300
STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS
310 320 330 340 350
LYSMIKNDTS GEYKKTLLKL SGGDDDAAGQ FFPEAAQVAY QMWELSAVAR
360 370 380 390 400
VELKGTVRPA NDFNPDADAK ALRKAMKGLG TDEDTIIDII THRSNVQRQQ
410 420 430 440 450
IRQTFKSHFG RDLMTDLKSE ISGDLARLIL GLMMPPAHYD AKQLKKAMEG
460 470 480 490 500
AGTDEKALIE ILATRTNAEI RAINEAYKED YHKSLEDALS SDTSGHFRRI
510 520 530 540 550
LISLATGHRE EGGENLDQAR EDAQVAAEIL EIADTPSGDK TSLETRFMTI
560 570 580 590 600
LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDAF VAIVQSVKNK
610 620 630 640 650
PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH
660 670
QAIEGDTSGD FLKALLALCG GED
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RI05 | E5RI05_HUMAN | Annexin | ANXA6 | 129 | Annotation score: | ||
E5RK63 | E5RK63_HUMAN | Annexin | ANXA6 | 150 | Annotation score: | ||
E5RJF5 | E5RJF5_HUMAN | Annexin | ANXA6 | 129 | Annotation score: | ||
E5RJR0 | E5RJR0_HUMAN | Annexin | ANXA6 | 110 | Annotation score: | ||
E5RK69 | E5RK69_HUMAN | Annexin | ANXA6 | 460 | Annotation score: | ||
E7EMC6 | E7EMC6_HUMAN | Annexin | ANXA6 | 330 | Annotation score: | ||
H0YC77 | H0YC77_HUMAN | Annexin | ANXA6 | 91 | Annotation score: | ||
E5RIU8 | E5RIU8_HUMAN | Annexin A6 | ANXA6 | 95 | Annotation score: | ||
E5RFF0 | E5RFF0_HUMAN | Annexin A6 | ANXA6 | 156 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 221 | T → A in BAH13893 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 226 – 227 | IE → MK in AAA35656 (PubMed:2963335).Curated | 2 | |
Sequence conflicti | 248 | C → R in BAC86715 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 555 | S → T in AAA35656 (PubMed:2963335).Curated | 1 | |
Sequence conflicti | 619 | E → D in CAA68286 (PubMed:3258820).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045480 | 1 – 32 | Missing in isoform 2. 1 PublicationAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00097 mRNA Translation: CAA68286.1 J03578 mRNA Translation: AAA35656.1 D00510 mRNA Translation: BAA00400.1 AK126836 mRNA Translation: BAC86715.1 Sequence problems. AK303078 mRNA Translation: BAH13893.1 AC008641 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61684.1 CH471062 Genomic DNA Translation: EAW61686.1 BC017046 mRNA Translation: AAH17046.1 |
CCDSi | CCDS47315.1 [P08133-1] CCDS54941.1 [P08133-2] |
PIRi | JU0032 AQHU68 |
RefSeqi | NP_001146.2, NM_001155.4 [P08133-1] NP_001180473.1, NM_001193544.1 [P08133-2] |
Genome annotation databases
Ensembli | ENST00000354546; ENSP00000346550; ENSG00000197043 [P08133-1] ENST00000523714; ENSP00000430517; ENSG00000197043 [P08133-2] |
GeneIDi | 309 |
KEGGi | hsa:309 |
UCSCi | uc003ltl.3 human [P08133-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y00097 mRNA Translation: CAA68286.1 J03578 mRNA Translation: AAA35656.1 D00510 mRNA Translation: BAA00400.1 AK126836 mRNA Translation: BAC86715.1 Sequence problems. AK303078 mRNA Translation: BAH13893.1 AC008641 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW61684.1 CH471062 Genomic DNA Translation: EAW61686.1 BC017046 mRNA Translation: AAH17046.1 |
CCDSi | CCDS47315.1 [P08133-1] CCDS54941.1 [P08133-2] |
PIRi | JU0032 AQHU68 |
RefSeqi | NP_001146.2, NM_001155.4 [P08133-1] NP_001180473.1, NM_001193544.1 [P08133-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1M9I | X-ray | 2.65 | A | 2-673 | [»] | |
SMRi | P08133 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 106806, 47 interactors |
CORUMi | P08133 |
IntActi | P08133, 23 interactors |
MINTi | P08133 |
STRINGi | 9606.ENSP00000346550 |
Protein family/group databases
TCDBi | 1.A.31.1.2 the annexin (annexin) family |
PTM databases
iPTMneti | P08133 |
PhosphoSitePlusi | P08133 |
SwissPalmi | P08133 |
Polymorphism and mutation databases
BioMutai | ANXA6 |
2D gel databases
REPRODUCTION-2DPAGEi | IPI00221226 |
UCD-2DPAGEi | P08133 |
Proteomic databases
CPTACi | CPTAC-313 CPTAC-314 |
EPDi | P08133 |
jPOSTi | P08133 |
MassIVEi | P08133 |
MaxQBi | P08133 |
PaxDbi | P08133 |
PeptideAtlasi | P08133 |
PRIDEi | P08133 |
ProteomicsDBi | 20335 52071 [P08133-1] |
Protocols and materials databases
DNASUi | 309 |
Genome annotation databases
Ensembli | ENST00000354546; ENSP00000346550; ENSG00000197043 [P08133-1] ENST00000523714; ENSP00000430517; ENSG00000197043 [P08133-2] |
GeneIDi | 309 |
KEGGi | hsa:309 |
UCSCi | uc003ltl.3 human [P08133-1] |
Organism-specific databases
CTDi | 309 |
DisGeNETi | 309 |
GeneCardsi | ANXA6 |
HGNCi | HGNC:544 ANXA6 |
HPAi | CAB005077 HPA002462 HPA009650 |
MIMi | 114070 gene |
neXtProti | NX_P08133 |
OpenTargetsi | ENSG00000197043 |
PharmGKBi | PA24834 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0819 Eukaryota ENOG410XPUN LUCA |
GeneTreei | ENSGT00940000158770 |
HOGENOMi | HOG000158803 |
InParanoidi | P08133 |
KOi | K17094 |
OMAi | VEICQAY |
OrthoDBi | 856254at2759 |
PhylomeDBi | P08133 |
TreeFami | TF105452 |
Enzyme and pathway databases
Reactomei | R-HSA-445355 Smooth Muscle Contraction |
Miscellaneous databases
ChiTaRSi | ANXA6 human |
EvolutionaryTracei | P08133 |
GeneWikii | ANXA6 |
GenomeRNAii | 309 |
Pharosi | P08133 |
PROi | PR:P08133 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197043 Expressed in 231 organ(s), highest expression level in fundus of stomach |
ExpressionAtlasi | P08133 baseline and differential |
Genevisiblei | P08133 HS |
Family and domain databases
Gene3Di | 1.10.220.10, 8 hits |
InterProi | View protein in InterPro IPR001464 Annexin IPR018502 Annexin_repeat IPR018252 Annexin_repeat_CS IPR037104 Annexin_sf IPR002393 ANX6 |
Pfami | View protein in Pfam PF00191 Annexin, 8 hits |
PRINTSi | PR00196 ANNEXIN PR00202 ANNEXINVI |
SMARTi | View protein in SMART SM00335 ANX, 8 hits |
SUPFAMi | SSF47874 SSF47874, 2 hits |
PROSITEi | View protein in PROSITE PS00223 ANNEXIN_1, 8 hits PS51897 ANNEXIN_2, 8 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANXA6_HUMAN | |
Accessioni | P08133Primary (citable) accession number: P08133 Secondary accession number(s): B7Z8A7 Q6ZT79 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | November 13, 2019 | |
This is version 210 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references