Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Collagen alpha-2(IV) chain

Gene

Col4a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.1 Publication
Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1442490 Collagen degradation
R-MMU-1474244 Extracellular matrix organization
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-186797 Signaling by PDGF
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-2214320 Anchoring fibril formation
R-MMU-2243919 Crosslinking of collagen fibrils
R-MMU-3000157 Laminin interactions
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-419037 NCAM1 interactions
R-MMU-8948216 Collagen chain trimerization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Collagen alpha-2(IV) chain
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Col4a2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88455 Col4a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Add BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000000582626 – 183N-terminal propeptide (7S domain)Add BLAST158
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000005827184 – 1707Collagen alpha-2(IV) chainAdd BLAST1524
ChainiPRO_00003904871481 – 1707CanstatinAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1270N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1499 ↔ 1588PROSITE-ProRule annotation
Disulfide bondi1532 ↔ 1585PROSITE-ProRule annotation
Disulfide bondi1544 ↔ 1550PROSITE-ProRule annotation
Disulfide bondi1607 ↔ 1703PROSITE-ProRule annotation
Disulfide bondi1641 ↔ 1700PROSITE-ProRule annotation
Disulfide bondi1653 ↔ 1660PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
Type IV collagens contain numerous cysteine residues which are involved in inter- and intramolecular disulfide bonding. 12 of these, located in the NC1 domain, are conserved in all known type IV collagens.
Proteolytic processing produces the C-terminal NC1 peptide, canstatin.By similarity
The trimeric structure of the NC1 domains is stabilized by covalent bonds between Lys and Met residues.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P08122

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08122

PRoteomics IDEntifications database

More...
PRIDEi
P08122

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08122

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P08122

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P08122

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031503 Expressed in 300 organ(s), highest expression level in epithelium of lens

CleanEx database of gene expression profiles

More...
CleanExi
MM_COL4A2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P08122 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P08122 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198817, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2959 Collagen type IV trimer variant 1

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000033899

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P08122

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P08122

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1484 – 1707Collagen IV NC1PROSITE-ProRule annotationAdd BLAST224

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni184 – 1479Triple-helical regionAdd BLAST1296

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Alpha chains of type IV collagen have a non-collagenous domain (NC1) at their C-terminus, frequent interruptions of the G-X-Y repeats in the long central triple-helical domain (which may cause flexibility in the triple helix), and a short N-terminal triple-helical 7S domain.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type IV collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410XNMM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157234

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004933

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P08122

KEGG Orthology (KO)

More...
KOi
K06237

Identification of Orthologs from Complete Genome Data

More...
OMAi
NPGTKGW

Database of Orthologous Groups

More...
OrthoDBi
63831at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P08122

TreeFam database of animal gene trees

More...
TreeFami
TF344135

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 16 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00111 C4, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51403 NC1_IV, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P08122-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRVRFKASG PPLRGWLLLA TVTVGLLAQS VLGGVKKLDV PCGGRDCSGG
60 70 80 90 100
CQCYPEKGAR GQPGAVGPQG YNGPPGLQGF PGLQGRKGDK GERGVPGPTG
110 120 130 140 150
PKGDVGARGV SGFPGADGIP GHPGQGGPRG RPGYDGCNGT RGDAGPQGPS
160 170 180 190 200
GSGGFPGLPG PQGPKGQKGE PYALSKEDRD KYRGEPGEPG LVGYQGPPGR
210 220 230 240 250
PGPIGQMGPM GAPGRPGPPG PPGPKGQPGN RGLGFYGQKG EKGDIGQPGP
260 270 280 290 300
NGIPSDITLV GPTTSTIHPD LYKGEKGDEG EQGIPGVISK GEEGIMGFPG
310 320 330 340 350
IRGFPGLDGE KGVVGQKGSR GLDGFQGPSG PRGPKGERGE QGPPGPSVYS
360 370 380 390 400
PHPSLAKGAR GDPGFQGAHG EPGSRGEPGE PGTAGPPGPS VGDEDSMRGL
410 420 430 440 450
PGEMGPKGFS GEPGSPARYL GPPGADGRPG PQGVPGPAGP PGPDGFLFGL
460 470 480 490 500
KGSEGRVGYP GPSGFPGTRG QKGWKGEAGD CQCGQVIGGL PGLPGPKGFP
510 520 530 540 550
GVNGELGKKG DQGDPGLHGI PGFPGFKGAP GVAGAPGPKG IKGDSRTITT
560 570 580 590 600
KGERGQPGIP GVHGMKGDDG VPGRDGLDGF PGLPGPPGDG IKGPPGDAGL
610 620 630 640 650
PGVPGTKGFP GDIGPPGQGL PGPKGERGFP GDAGLPGPPG FPGPPGPPGT
660 670 680 690 700
PGQRDCDTGV KRPIGGGQQV VVQPGCIEGP TGSPGQPGPP GPTGAKGVRG
710 720 730 740 750
MPGFPGASGE QGLKGFPGDP GREGFPGPPG FMGPRGSKGT TGLPGPDGPP
760 770 780 790 800
GPIGLPGPAG PPGDRGIPGE VLGAQPGTRG DAGLPGQPGL KGLPGETGAP
810 820 830 840 850
GFRGSQGMPG MPGLKGQPGF PGPSGQPGQS GPPGQHGFPG TPGREGPLGQ
860 870 880 890 900
PGSPGLGGLP GDRGEPGDPG VPGPVGMKGL SGDRGDAGMS GERGHPGSPG
910 920 930 940 950
FKGMAGMPGI PGQKGDRGSP GMDGFQGMLG LKGRQGFPGT KGEAGFFGVP
960 970 980 990 1000
GLKGLPGEPG VKGNRGDRGP PGPPPLILPG MKDIKGEKGD EGPMGLKGYL
1010 1020 1030 1040 1050
GLKGIQGMPG VPGVSGFPGL PGRPGFIKGV KGDIGVPGTP GLPGFPGVSG
1060 1070 1080 1090 1100
PPGITGFPGF TGSRGEKGTP GVAGVFGETG PTGDFGDIGD TVDLPGSPGL
1110 1120 1130 1140 1150
KGERGITGIP GLKGFFGEKG AAGDIGFPGI TGMAGAQGSP GLKGQTGFPG
1160 1170 1180 1190 1200
LTGLQGPQGE PGRIGIPGDK GDFGWPGVPG LPGFPGIRGI SGLHGLPGTK
1210 1220 1230 1240 1250
GFPGSPGVDA HGDPGFPGPT GDRGDRGEAN TLPGPVGVPG QKGERGTPGE
1260 1270 1280 1290 1300
RGPAGSPGLQ GFPGISPPSN ISGSPGDVGA PGIFGLQGYQ GPPGPPGPNA
1310 1320 1330 1340 1350
LPGIKGDEGS SGAAGFPGQK GWVGDPGPQG QPGVLGLPGE KGPKGEQGFM
1360 1370 1380 1390 1400
GNTGPSGAVG DRGPKGPKGD QGFPGAPGSM GSPGIPGIPQ KIAVQPGTLG
1410 1420 1430 1440 1450
PQGRRGLPGA LGEIGPQGPP GDPGFRGAPG KAGPQGRGGV SAVPGFRGDQ
1460 1470 1480 1490 1500
GPMGHQGPVG QEGEPGRPGS PGLPGMPGRS VSIGYLLVKH SQTDQEPMCP
1510 1520 1530 1540 1550
VGMNKLWSGY SLLYFEGQEK AHNQDLGLAG SCLARFSTMP FLYCNPGDVC
1560 1570 1580 1590 1600
YYASRNDKSY WLSTTAPLPM MPVAEEEIKP YISRCSVCEA PAVAIAVHSQ
1610 1620 1630 1640 1650
DTSIPHCPAG WRSLWIGYSF LMHTAAGDEG GGQSLVSPGS CLEDFRATPF
1660 1670 1680 1690 1700
IECNGGRGTC HYFANKYSFW LTTIPEQNFQ STPSADTLKA GLIRTHISRC

QVCMKNL
Length:1,707
Mass (Da):167,325
Last modified:February 20, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i67CB3E3CB2A5B1F6
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH80789 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 277.Curated
The sequence AAI07686 differs from that shown. Contaminating sequence. Potential poly-A sequence starting in position 277.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti275E → K in AAH80789 (PubMed:15489334).Curated1
Sequence conflicti626E → R in AAA50293 (PubMed:2703491).Curated1
Sequence conflicti837G → A in AAA50293 (PubMed:2703491).Curated1
Sequence conflicti1051P → R in CAA27998 (PubMed:3758345).Curated1
Sequence conflicti1097S → G in CAA26655 (PubMed:3839908).Curated1
Sequence conflicti1171G → S in CAA27998 (PubMed:3758345).Curated1
Sequence conflicti1179P → R in CAA27998 (PubMed:3758345).Curated1
Sequence conflicti1241Q → E in CAA27998 (PubMed:3758345).Curated1
Sequence conflicti1328P → A in CAA27998 (PubMed:3758345).Curated1
Sequence conflicti1573V → L in CAA28308 (PubMed:3780963).Curated1
Sequence conflicti1583S → I in AAR89902 (PubMed:15592653).Curated1
Sequence conflicti1583S → I in AAQ83370 (PubMed:15592653).Curated1
Sequence conflicti1623H → Y in AAA50293 (PubMed:2703491).Curated1
Sequence conflicti1623H → Y in AAA37341 (PubMed:3597383).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J04695 mRNA Translation: AAA50293.1
AK053858 mRNA Translation: BAC35559.1
AK075619 mRNA Translation: BAC35863.1
AK164096 mRNA Translation: BAE37626.1
BC013560 mRNA Translation: AAH13560.2
BC080789 mRNA Translation: AAH80789.1 Sequence problems.
BC107685 mRNA Translation: AAI07686.1 Sequence problems.
M23334, M23333 Genomic DNA Translation: AAA51626.1
J04448 Genomic DNA Translation: AAA37438.1
X02896 mRNA Translation: CAA26655.1
X02897 Genomic DNA Translation: CAB51614.1
X02898 Genomic DNA Translation: CAA26657.1
X02899 Genomic DNA Translation: CAA26658.1
X04410 mRNA Translation: CAA27998.1
X04647 mRNA Translation: CAA28308.1
M15833 mRNA Translation: AAA37341.1
AY375463 mRNA Translation: AAQ83370.1
AY502946 mRNA Translation: AAR89901.1
AY502947 mRNA Translation: AAR89902.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40220.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A33526

NCBI Reference Sequences

More...
RefSeqi
NP_034062.3, NM_009932.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.181021

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000033899; ENSMUSP00000033899; ENSMUSG00000031503

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12827

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12827

UCSC genome browser

More...
UCSCi
uc009kvc.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04695 mRNA Translation: AAA50293.1
AK053858 mRNA Translation: BAC35559.1
AK075619 mRNA Translation: BAC35863.1
AK164096 mRNA Translation: BAE37626.1
BC013560 mRNA Translation: AAH13560.2
BC080789 mRNA Translation: AAH80789.1 Sequence problems.
BC107685 mRNA Translation: AAI07686.1 Sequence problems.
M23334, M23333 Genomic DNA Translation: AAA51626.1
J04448 Genomic DNA Translation: AAA37438.1
X02896 mRNA Translation: CAA26655.1
X02897 Genomic DNA Translation: CAB51614.1
X02898 Genomic DNA Translation: CAA26657.1
X02899 Genomic DNA Translation: CAA26658.1
X04410 mRNA Translation: CAA27998.1
X04647 mRNA Translation: CAA28308.1
M15833 mRNA Translation: AAA37341.1
AY375463 mRNA Translation: AAQ83370.1
AY502946 mRNA Translation: AAR89901.1
AY502947 mRNA Translation: AAR89902.1
CCDSiCCDS40220.1
PIRiA33526
RefSeqiNP_034062.3, NM_009932.4
UniGeneiMm.181021

3D structure databases

ProteinModelPortaliP08122
SMRiP08122
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198817, 1 interactor
ComplexPortaliCPX-2959 Collagen type IV trimer variant 1
STRINGi10090.ENSMUSP00000033899

PTM databases

iPTMnetiP08122
PhosphoSitePlusiP08122
SwissPalmiP08122

Proteomic databases

MaxQBiP08122
PaxDbiP08122
PRIDEiP08122

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033899; ENSMUSP00000033899; ENSMUSG00000031503
GeneIDi12827
KEGGimmu:12827
UCSCiuc009kvc.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1284
MGIiMGI:88455 Col4a2

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00940000157234
HOVERGENiHBG004933
InParanoidiP08122
KOiK06237
OMAiNPGTKGW
OrthoDBi63831at2759
PhylomeDBiP08122
TreeFamiTF344135

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1474244 Extracellular matrix organization
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-186797 Signaling by PDGF
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-2214320 Anchoring fibril formation
R-MMU-2243919 Crosslinking of collagen fibrils
R-MMU-3000157 Laminin interactions
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-419037 NCAM1 interactions
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Col4a2 mouse

Protein Ontology

More...
PROi
PR:P08122

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000031503 Expressed in 300 organ(s), highest expression level in epithelium of lens
CleanExiMM_COL4A2
ExpressionAtlasiP08122 baseline and differential
GenevisibleiP08122 MM

Family and domain databases

Gene3Di2.170.240.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 16 hits
SMARTiView protein in SMART
SM00111 C4, 2 hits
SUPFAMiSSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS51403 NC1_IV, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO4A2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08122
Secondary accession number(s): Q3B7C2
, Q3TPV9, Q61375, Q66JS5, Q6RCT6, Q6RCT7, Q6U9X1, Q8BPI9, Q8BPK3, Q91VI3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 20, 2007
Last modified: January 16, 2019
This is version 188 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again