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Protein

Collagen alpha-1(III) chain

Gene

Col3a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi1278CalciumBy similarity1
Metal bindingi1280CalciumBy similarity1
Metal bindingi1281Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1283Calcium; via carbonyl oxygenBy similarity1
Metal bindingi1286CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1474244 Extracellular matrix organization
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-186797 Signaling by PDGF
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-419037 NCAM1 interactions
R-MMU-8874081 MET activates PTK2 signaling
R-MMU-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(III) chain
Gene namesi
Name:Col3a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88453 Col3a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Disruption phenotypei

Neuronal ectopias and abnormal cortical lamination.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
PropeptideiPRO_000000574324 – 154N-terminal propeptideAdd BLAST131
ChainiPRO_0000005744155 – 1219Collagen alpha-1(III) chainAdd BLAST1065
PropeptideiPRO_00000057451220 – 1464C-terminal propeptideAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2625-hydroxylysine; alternateBy similarity1
Glycosylationi262O-linked (Gal...) hydroxylysine; alternateBy similarity1
Modified residuei2835-hydroxylysineBy similarity1
Modified residuei8595-hydroxylysineBy similarity1
Modified residuei9765-hydroxylysineBy similarity1
Modified residuei10935-hydroxylysineBy similarity1
Modified residuei11055-hydroxylysineBy similarity1
Disulfide bondi1195InterchainPROSITE-ProRule annotation
Disulfide bondi1196InterchainPROSITE-ProRule annotation
Disulfide bondi1260 ↔ 1292PROSITE-ProRule annotation
Disulfide bondi1266Interchain (with C-1283)PROSITE-ProRule annotation
Disulfide bondi1283Interchain (with C-1266)PROSITE-ProRule annotation
Disulfide bondi1300 ↔ 1462PROSITE-ProRule annotation
Disulfide bondi1370 ↔ 1415PROSITE-ProRule annotation

Post-translational modificationi

Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiP08121
PeptideAtlasiP08121
PRIDEiP08121

PTM databases

iPTMnetiP08121
PhosphoSitePlusiP08121

Expressioni

Tissue specificityi

Expressed in embryonic brain, specifically in the meninges, pial basement membrane and blood vessels (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000026043 Expressed in 308 organ(s), highest expression level in dermis
CleanExiMM_COL3A1
ExpressionAtlasiP08121 baseline and differential
GenevisibleiP08121 MM

Interactioni

Subunit structurei

Trimers of identical alpha 1(III) chains. The chains are linked to each other by interchain disulfide bonds. Trimers are also cross-linked via hydroxylysines.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198815, 6 interactors
ComplexPortaliCPX-2958 Collagen type III trimer
IntActiP08121, 2 interactors
STRINGi10090.ENSMUSP00000085192

Structurei

3D structure databases

ProteinModelPortaliP08121
SMRiP08121
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 90VWFCPROSITE-ProRule annotationAdd BLAST60
Domaini1230 – 1464Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni155 – 169Nonhelical region (N-terminal)Add BLAST15
Regioni170 – 1195Triple-helical regionAdd BLAST1026

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140789
HOVERGENiHBG004933
InParanoidiP08121
KOiK19720
OMAiDFKINTD
OrthoDBiEOG091G03LV
TreeFamiTF344135

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C
IPR001007 VWF_dom
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 4 hits
PF00093 VWC, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00214 VWC, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P08121-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMSFVQSGTW FLLTLLHPTL ILAQQSNVDE LGCSHLGQSY ESRDVWKPEP
60 70 80 90 100
CQICVCDSGS VLCDDIICDE EPLDCPNPEI PFGECCAICP QPSTPAPVLP
110 120 130 140 150
DGHGPQGPKG DPGPPGIPGR NGDPGLPGQP GLPGPPGSPG ICESCPTGGQ
160 170 180 190 200
NYSPQFDSYD VKSGVGGMGG YPGPAGPPGP PGPPGSSGHP GSPGSPGYQG
210 220 230 240 250
PPGEPGQAGP AGPPGPPGAL GPAGPAGKDG ESGRPGRPGE RGLPGPPGIK
260 270 280 290 300
GPAGMPGFPG MKGHRGFDGR NGEKGETGAP GLKGENGLPG DNGAPGPMGP
310 320 330 340 350
RGAPGERGRP GLPGAAGARG NDGARGSDGQ PGPPGPPGTA GFPGSPGAKG
360 370 380 390 400
EVGPAGSPGS NGSPGQRGEP GPQGHAGAQG PPGPPGNNGS PGGKGEMGPA
410 420 430 440 450
GIPGAPGLIG ARGPPGPAGT NGIPGTRGPS GEPGKNGAKG EPGARGERGE
460 470 480 490 500
AGSPGIPGPK GEDGKDGSPG EPGANGLPGA AGERGPSGFR GPAGPNGIPG
510 520 530 540 550
EKGPPGERGG PGPAGPRGVA GEPGRDGTPG GPGIRGMPGS PGGPGNDGKP
560 570 580 590 600
GPPGSQGESG RPGPPGPSGP RGQPGVMGFP GPKGNDGAPG KNGERGGPGG
610 620 630 640 650
PGLPGPAGKN GETGPQGPPG PTGPAGDKGD SGPPGPQGLQ GIPGTGGPPG
660 670 680 690 700
ENGKPGEPGP KGEVGAPGAP GGKGDSGAPG ERGPPGTAGI PGARGGAGPP
710 720 730 740 750
GPEGGKGPAG PPGPPGASGS PGLQGMPGER GGPGSPGPKG EKGEPGGAGA
760 770 780 790 800
DGVPGKDGPR GPAGPIGPPG PAGQPGDKGE GGSPGLPGIA GPRGGPGERG
810 820 830 840 850
EHGPPGPAGF PGAPGQNGEP GAKGERGAPG EKGEGGPPGP AGPTGSSGPA
860 870 880 890 900
GPPGPQGVKG ERGSPGGPGT AGFPGGRGLP GPPGNNGNPG PPGPSGAPGK
910 920 930 940 950
DGPPGPAGNS GSPGNPGIAG PKGDAGQPGE KGPPGAQGPP GSPGPLGIAG
960 970 980 990 1000
LTGARGLAGP PGMPGPRGSP GPQGIKGESG KPGASGHNGE RGPPGPQGLP
1010 1020 1030 1040 1050
GQPGTAGEPG RDGNPGSDGQ PGRDGSPGGK GDRGENGSPG APGAPGHPGP
1060 1070 1080 1090 1100
PGPVGPSGKS GDRGETGPAG PSGAPGPAGA RGAPGPQGPR GDKGETGERG
1110 1120 1130 1140 1150
SNGIKGHRGF PGNPGPPGSP GAAGHQGAIG SPGPAGPRGP VGPHGPPGKD
1160 1170 1180 1190 1200
GTSGHPGPIG PPGPRGNRGE RGSEGSPGHP GQPGPPGPPG APGPCCGGGA
1210 1220 1230 1240 1250
AAIAGVGGEK SGGFSPYYGD DPMDFKINTE EIMSSLKSVN GQIESLISPD
1260 1270 1280 1290 1300
GSRKNPARNC RDLKFCHPEL KSGEYWVDPN QGCKMDAIKV FCNMETGETC
1310 1320 1330 1340 1350
INASPMTVPR KHWWTDSGAE KKHVWFGESM NGGFQFSYGP PDLPEDVVDV
1360 1370 1380 1390 1400
QLAFLRLLSS RASQNITYHC KNSIAYMDQA SGNVKKSLKL MGSNEGEFKA
1410 1420 1430 1440 1450
EGNSKFTYTV LEDGCTKHTG EWSKTVFEYQ TRKAMRLPII DIAPYDIGGP
1460
DQEFGVDIGP VCFL
Length:1,464
Mass (Da):138,943
Last modified:July 15, 1999 - v4
Checksum:i2104EC27A886090B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WPJ5A0A087WPJ5_MOUSE
Collagen alpha-1(III) chain
Col3a1
245Annotation score:
A0A087WPS3A0A087WPS3_MOUSE
Collagen alpha-1(III) chain
Col3a1
195Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52046 Genomic DNA Translation: CAA36279.1
BC043089 mRNA Translation: AAH43089.1
BC058724 mRNA Translation: AAH58724.1
M18933 mRNA Translation: AAA37338.1
K03037 Genomic DNA No translation available.
AK019448 mRNA Translation: BAB31724.1
X57983 Genomic DNA Translation: CAA41048.1
CCDSiCCDS35554.1
PIRiA27353
S59856
RefSeqiNP_034060.2, NM_009930.2
UniGeneiMm.249555

Genome annotation databases

EnsembliENSMUST00000087883; ENSMUSP00000085192; ENSMUSG00000026043
GeneIDi12825
KEGGimmu:12825
UCSCiuc007awq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52046 Genomic DNA Translation: CAA36279.1
BC043089 mRNA Translation: AAH43089.1
BC058724 mRNA Translation: AAH58724.1
M18933 mRNA Translation: AAA37338.1
K03037 Genomic DNA No translation available.
AK019448 mRNA Translation: BAB31724.1
X57983 Genomic DNA Translation: CAA41048.1
CCDSiCCDS35554.1
PIRiA27353
S59856
RefSeqiNP_034060.2, NM_009930.2
UniGeneiMm.249555

3D structure databases

ProteinModelPortaliP08121
SMRiP08121
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198815, 6 interactors
ComplexPortaliCPX-2958 Collagen type III trimer
IntActiP08121, 2 interactors
STRINGi10090.ENSMUSP00000085192

PTM databases

iPTMnetiP08121
PhosphoSitePlusiP08121

Proteomic databases

PaxDbiP08121
PeptideAtlasiP08121
PRIDEiP08121

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087883; ENSMUSP00000085192; ENSMUSG00000026043
GeneIDi12825
KEGGimmu:12825
UCSCiuc007awq.2 mouse

Organism-specific databases

CTDi1281
MGIiMGI:88453 Col3a1

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140789
HOVERGENiHBG004933
InParanoidiP08121
KOiK19720
OMAiDFKINTD
OrthoDBiEOG091G03LV
TreeFamiTF344135

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1474244 Extracellular matrix organization
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-186797 Signaling by PDGF
R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-2022090 Assembly of collagen fibrils and other multimeric structures
R-MMU-216083 Integrin cell surface interactions
R-MMU-3000171 Non-integrin membrane-ECM interactions
R-MMU-3000178 ECM proteoglycans
R-MMU-419037 NCAM1 interactions
R-MMU-8874081 MET activates PTK2 signaling
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

ChiTaRSiCol3a1 mouse
PROiPR:P08121
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026043 Expressed in 308 organ(s), highest expression level in dermis
CleanExiMM_COL3A1
ExpressionAtlasiP08121 baseline and differential
GenevisibleiP08121 MM

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR000885 Fib_collagen_C
IPR001007 VWF_dom
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 4 hits
PF00093 VWC, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00214 VWC, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCO3A1_MOUSE
AccessioniPrimary (citable) accession number: P08121
Secondary accession number(s): Q61429, Q9CRN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: July 15, 1999
Last modified: November 7, 2018
This is version 176 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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