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Protein

Beta-microseminoprotein

Gene

MSMB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Specific receptors for this protein are found on spermatozoa and in the prostate.

Caution

Was originally thought to inhibit the secretion of FSH by pituitary cells.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-microseminoprotein
Alternative name(s):
Immunoglobulin-binding factor
Short name:
IGBF
PN44
Prostate secreted seminal plasma protein
Prostate secretory protein of 94 amino acids
Short name:
PSP-94
Short name:
PSP94
Seminal plasma beta-inhibin
Gene namesi
Name:MSMB
Synonyms:PRSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000263639.5
HGNCiHGNC:7372 MSMB
MIMi157145 gene
neXtProtiNX_P08118

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Prostate cancer, hereditary, 13 (HPC13)
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
See also OMIM:611928

Organism-specific databases

DisGeNETi4477
MalaCardsiMSMB
MIMi611928 phenotype
OpenTargetsiENSG00000263639
Orphaneti1331 Familial prostate cancer
PharmGKBiPA31177

Polymorphism and mutation databases

BioMutaiMSMB
DMDMi131436

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 205 PublicationsAdd BLAST20
ChainiPRO_000001926821 – 114Beta-microseminoproteinAdd BLAST94

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 70
Disulfide bondi38 ↔ 62
Disulfide bondi57 ↔ 93
Disulfide bondi60 ↔ 69
Disulfide bondi84 ↔ 107

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP08118
PeptideAtlasiP08118
PRIDEiP08118
ProteomicsDBi52068
52069 [P08118-2]

PTM databases

iPTMnetiP08118
PhosphoSitePlusiP08118

Expressioni

Tissue specificityi

Strongly expressed in prostate, liver, kidney, breast and penis. Also expressed in pancreas, esophagus, stomach, deodenum, colon, trachea, lung, salivary glands and fallopian tube. PSP94 is expressed in lung and breast, whereas PSP57 is found in kidney and bladder.2 Publications

Gene expression databases

BgeeiENSG00000263639 Expressed in 109 organ(s), highest expression level in prostate gland
CleanExiHS_MSMB
GenevisibleiP08118 HS

Organism-specific databases

HPAiCAB026357
HPA051257

Interactioni

Subunit structurei

Homodimer; Interacts with PI16.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SGTAO437653EBI-10195681,EBI-347996

Protein-protein interaction databases

BioGridi110583, 2 interactors
IntActiP08118, 1 interactor
STRINGi9606.ENSP00000351363

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP08118
SMRiP08118
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08118

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-microseminoprotein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3M2 Eukaryota
ENOG410Y4MW LUCA
GeneTreeiENSGT00390000010587
HOGENOMiHOG000113668
HOVERGENiHBG031716
InParanoidiP08118
OMAiCKYIVVE
OrthoDBiEOG091G0YU5
PhylomeDBiP08118
TreeFamiTF338336

Family and domain databases

InterProiView protein in InterPro
IPR008735 PSP94
PANTHERiPTHR10500 PTHR10500, 1 hit
PfamiView protein in Pfam
PF05825 PSP94, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform PSP94 (identifier: P08118-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNVLLGSVVI FATFVTLCNA SCYFIPNEGV PGDSTRKCMD LKGNKHPINS
60 70 80 90 100
EWQTDNCETC TCYETEISCC TLVSTPVGYD KDNCQRIFKK EDCKYIVVEK
110
KDPKKTCSVS EWII
Length:114
Mass (Da):12,865
Last modified:August 1, 1988 - v1
Checksum:iD0B13E436D70BB1D
GO
Isoform PSP57 (identifier: P08118-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     37-77: KCMDLKGNKH...SCCTLVSTPV → MFLHLWVMTK...QKRPVLSVNG
     78-114: Missing.

Show »
Length:77
Mass (Da):8,778
Checksum:iADF30AB8D7A63C9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113I → G AA sequence (PubMed:6434350).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01193517L → S. Corresponds to variant dbSNP:rs1804776Ensembl.1
Natural variantiVAR_01193625I → M. Corresponds to variant dbSNP:rs1804778Ensembl.1
Natural variantiVAR_01193752W → R. Corresponds to variant dbSNP:rs1804780Ensembl.1
Natural variantiVAR_01193853Q → R. Corresponds to variant dbSNP:rs1804468Ensembl.1
Natural variantiVAR_01193980D → A. Corresponds to variant dbSNP:rs1802774Ensembl.1
Natural variantiVAR_01194087I → T. Corresponds to variant dbSNP:rs1802771Ensembl.1
Natural variantiVAR_01194191E → G. Corresponds to variant dbSNP:rs1804469Ensembl.1
Natural variantiVAR_01194292D → G. Corresponds to variant dbSNP:rs1804461Ensembl.1
Natural variantiVAR_01194398V → L. Corresponds to variant dbSNP:rs1804464Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00327537 – 77KCMDL…VSTPV → MFLHLWVMTKTTAKESSRRR TASISWWRRRTQKRPVLSVN G in isoform PSP57. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_00327678 – 114Missing in isoform PSP57. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15885 mRNA Translation: AAA36635.1
M34376
, M34373, M34374, M34375 Genomic DNA Translation: AAA59871.1
X57928
, X57929, X57930, X57931 Genomic DNA Translation: CAA41002.1
S67815 mRNA Translation: AAB29732.1
U22178 mRNA Translation: AAA83556.1
U78976 mRNA Translation: AAB37355.1
BT006816 mRNA Translation: AAP35462.1
CR457015 mRNA Translation: CAG33296.1
AL450342 Genomic DNA No translation available.
BC005257 mRNA Translation: AAH05257.1
AJ133356 Genomic DNA Translation: CAB39325.1
CCDSiCCDS73095.1 [P08118-2]
CCDS73096.1 [P08118-1]
PIRiA34567
G01730
RefSeqiNP_002434.1, NM_002443.3 [P08118-1]
NP_619540.1, NM_138634.2 [P08118-2]
UniGeneiHs.255462

Genome annotation databases

EnsembliENST00000581478; ENSP00000462641; ENSG00000263639 [P08118-2]
ENST00000582163; ENSP00000463092; ENSG00000263639 [P08118-1]
GeneIDi4477
KEGGihsa:4477
UCSCiuc001jiq.5 human [P08118-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15885 mRNA Translation: AAA36635.1
M34376
, M34373, M34374, M34375 Genomic DNA Translation: AAA59871.1
X57928
, X57929, X57930, X57931 Genomic DNA Translation: CAA41002.1
S67815 mRNA Translation: AAB29732.1
U22178 mRNA Translation: AAA83556.1
U78976 mRNA Translation: AAB37355.1
BT006816 mRNA Translation: AAP35462.1
CR457015 mRNA Translation: CAG33296.1
AL450342 Genomic DNA No translation available.
BC005257 mRNA Translation: AAH05257.1
AJ133356 Genomic DNA Translation: CAB39325.1
CCDSiCCDS73095.1 [P08118-2]
CCDS73096.1 [P08118-1]
PIRiA34567
G01730
RefSeqiNP_002434.1, NM_002443.3 [P08118-1]
NP_619540.1, NM_138634.2 [P08118-2]
UniGeneiHs.255462

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IZ3NMR-A21-114[»]
3IX0X-ray2.30A/B/C/D21-114[»]
ProteinModelPortaliP08118
SMRiP08118
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110583, 2 interactors
IntActiP08118, 1 interactor
STRINGi9606.ENSP00000351363

PTM databases

iPTMnetiP08118
PhosphoSitePlusiP08118

Polymorphism and mutation databases

BioMutaiMSMB
DMDMi131436

Proteomic databases

PaxDbiP08118
PeptideAtlasiP08118
PRIDEiP08118
ProteomicsDBi52068
52069 [P08118-2]

Protocols and materials databases

DNASUi4477
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000581478; ENSP00000462641; ENSG00000263639 [P08118-2]
ENST00000582163; ENSP00000463092; ENSG00000263639 [P08118-1]
GeneIDi4477
KEGGihsa:4477
UCSCiuc001jiq.5 human [P08118-1]

Organism-specific databases

CTDi4477
DisGeNETi4477
EuPathDBiHostDB:ENSG00000263639.5
GeneCardsiMSMB
HGNCiHGNC:7372 MSMB
HPAiCAB026357
HPA051257
MalaCardsiMSMB
MIMi157145 gene
611928 phenotype
neXtProtiNX_P08118
OpenTargetsiENSG00000263639
Orphaneti1331 Familial prostate cancer
PharmGKBiPA31177
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3M2 Eukaryota
ENOG410Y4MW LUCA
GeneTreeiENSGT00390000010587
HOGENOMiHOG000113668
HOVERGENiHBG031716
InParanoidiP08118
OMAiCKYIVVE
OrthoDBiEOG091G0YU5
PhylomeDBiP08118
TreeFamiTF338336

Miscellaneous databases

EvolutionaryTraceiP08118
GeneWikiiMSMB
GenomeRNAii4477
PROiPR:P08118
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000263639 Expressed in 109 organ(s), highest expression level in prostate gland
CleanExiHS_MSMB
GenevisibleiP08118 HS

Family and domain databases

InterProiView protein in InterPro
IPR008735 PSP94
PANTHERiPTHR10500 PTHR10500, 1 hit
PfamiView protein in Pfam
PF05825 PSP94, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMSMB_HUMAN
AccessioniPrimary (citable) accession number: P08118
Secondary accession number(s): B1API6
, P11999, Q13125, Q6IAY9, Q9UC59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: September 12, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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