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Entry version 201 (26 Feb 2020)
Sequence version 2 (01 Feb 1995)
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Protein

Lethal(2) giant larvae protein

Gene

l(2)gl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for the development of polarized epithelia, for cell polarity associated with asymmetric cell division of neuroblasts during development, and for oocyte polarity formation. Promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of par-1 which is required for oocyte polarization. Regulates the localization of axis-specifying morphogens such as stau and grk.
Has an essential role in control of cell proliferation and differentiation during development and could act as a tumor suppressor.
Has an accessory function in control of cell proliferation and differentiation during development.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell cycle, Exocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lethal(2) giant larvae protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:l(2)gl
ORF Names:CG2671
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002121 l(2)gl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Extracellular matrix, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000843451 – 1161Lethal(2) giant larvae proteinAdd BLAST1161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei473Phosphoserine1 Publication1
Modified residuei484Phosphoserine1 Publication1
Modified residuei679Phosphoserine1 Publication1
Modified residuei808Phosphoserine1 Publication1
Modified residuei869Phosphoserine1 Publication1
Modified residuei876Phosphoserine1 Publication1
Modified residuei887Phosphoserine1 Publication1
Modified residuei889Phosphoserine1 Publication1
Modified residuei893Phosphoserine1 Publication1
Modified residuei1013Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by aPKC which restricts l2gl activity to the oocyte posterior and is required for oocyte polarity formation.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P08111

PRoteomics IDEntifications database

More...
PRIDEi
P08111

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P08111

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the epithelial cells of the digestive tract and in gonads.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed abundantly in early embryogenesis. Moderate expression is found in larval and adult stages.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0002121 Expressed in wing disc (Drosophila) and 31 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P08111 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P08111 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form multimeric complexes.

Interacts with mahj.

Interacts with aPKC; the interaction results in phosphorylation of l2gl.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
59421, 34 interactors

Database of interacting proteins

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DIPi
DIP-22687N

Protein interaction database and analysis system

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IntActi
P08111, 6 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0297544

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P08111

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati39 – 72WD 1Add BLAST34
Repeati82 – 128WD 2Add BLAST47
Repeati131 – 167WD 3Add BLAST37
Repeati189 – 223WD 4Add BLAST35
Repeati231 – 263WD 5Add BLAST33
Repeati278 – 320WD 6Add BLAST43
Repeati328 – 358WD 7Add BLAST31
Repeati380 – 464WD 8Add BLAST85
Repeati513 – 594WD 9Add BLAST82
Repeati603 – 664WD 10Add BLAST62
Repeati708 – 778WD 11Add BLAST71
Repeati787 – 832WD 12Add BLAST46
Repeati837 – 927WD 13Add BLAST91
Repeati941 – 964WD 14Add BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat L(2)GL family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1983 Eukaryota
ENOG410XS6Z LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000182906

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P08111

KEGG Orthology (KO)

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KOi
K06094

Database for complete collections of gene phylogenies

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PhylomeDBi
P08111

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000664 Lethal2_giant
IPR013905 Lgl_C_dom
IPR013577 LLGL2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08596 Lgl_C, 1 hit
PF08366 LLGL, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00962 LETHAL2GIANT

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50978 SSF50978, 2 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform p127 (identifier: P08111-1) [UniParc]FASTAAdd to basket
Also known as: A, C

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLKFIRGKGQ QPSADRHRLQ KDLFAYRKTA QHGFPHKPSA LAYDPVLKLM
60 70 80 90 100
AIGTQTGALK VFGQPGVELY GQHTLLNNSA SELNVQLLEW VYGTGRILSL
110 120 130 140 150
TAANQLILWE PVGATLLPIK TLPFDGKLKK VSSLCCSLSK DLLWIGTEGG
160 170 180 190 200
NIYQLDLHTF TIKEPVIYHD VVLEQVPPAY KLNPGAIESI RQLPNSPSKL
210 220 230 240 250
LVAYNRGLCV LWDFESASVQ RAYIAPGHGQ SVGLTVNFEG SEFTWYHADG
260 270 280 290 300
SYATWSIDNP EPPSNVNYVP YGPDPCKSIN RLYKGKRRSN DVIVFSGGMP
310 320 330 340 350
RSAYGDHNCV SVHASDGHKV CLDFTSKVID FFVTFENNRD VAEVLVVLLE
360 370 380 390 400
EELCAYDLTD PNICAIKAPY LHSVHASAVT CNYLASEVVQ SVYESILRAG
410 420 430 440 450
DEQDIDYSNI SWPITGGTLP DNLEESVEED ATKLYEILLT GHEDGSVKFW
460 470 480 490 500
DCTGVLLKPI YNFKTSSIFG SESDFRDDAA ADMSAEQVDE GEPPFRKSGL
510 520 530 540 550
FDPYSDDPRL AVKKIAFCPK TGQLIVGGTA GQIVIADFID LPEKVSLKYI
560 570 580 590 600
SMNLVSDRDG FVWKGHDQLN VRSNLLDGEA IPTTERGVNI SGVLQVLPPA
610 620 630 640 650
SITCMALEAS WGLVSGGTAH GLVLFDFKNF VPVFHRCTLN PNDLTGAGEQ
660 670 680 690 700
LSRRKSFKKS LRESFRKLRK GRSTRTNQSN QVPTTLEARP VERQIEARCA
710 720 730 740 750
DDGLGSMVRC LLFAKTYVTN VNITSPTLWS ATNASTVSVF LLHLPPAQTA
760 770 780 790 800
ATAVPSASGN APPHMPRRIS AQLAKEIQLK HRAPVVGISI FDQAGSPVDQ
810 820 830 840 850
LNAGENGSPP HRVLIASEEQ FKVFSLPQLK PINKYKLTAN EGARIRRIHF
860 870 880 890 900
GSFSCRISPE TLQSMHGCSP TKSTRSHGDG EADPNISGSL AVSRGDVYNE
910 920 930 940 950
TALICLTNMG DIMVLSVPEL KRQLNAAAVR REDINGVSSL CFTNSGEALY
960 970 980 990 1000
MMSSSELQRI ALATSRVVQP TGVVPVEPLE NEESVLEEND AENNKETYAC
1010 1020 1030 1040 1050
DEVVNTYEIK NPSGISICTR PAEENVGRNS VQQVNGVNIS NSPNQANETI
1060 1070 1080 1090 1100
SSSIGDITVD SVRDHLNMTT TTLCSINTEE TIGRLSVLST QTNKASTTVN
1110 1120 1130 1140 1150
MSEIPNINIS NLEDLESKRN TTETSTSSVV IKSIITNISH EKTNGDNKIG
1160
TPKTAPEESQ F
Length:1,161
Mass (Da):126,892
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i979F73A01DA62A1A
GO
Isoform p78 (identifier: P08111-2) [UniParc]FASTAAdd to basket
Also known as: EC371

The sequence of this isoform differs from the canonical sequence as follows:
     708-708: V → F
     709-1161: Missing.

Show »
Length:708
Mass (Da):78,112
Checksum:i830226D7396A8CC5
GO
Isoform B (identifier: P08111-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     17-28: HRLQKDLFAYRK → QRYI

Show »
Length:1,153
Mass (Da):125,896
Checksum:i577E34DFAE48539C
GO
Isoform D (identifier: P08111-4) [UniParc]FASTAAdd to basket
Also known as: E, F

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Show »
Length:1,112
Mass (Da):121,249
Checksum:i524F615010E8B775
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9NCX1M9NCX1_DROME
Lethal (2) giant larvae, isoform G
l(2)gl D-LGL, dlgl, Dmel\CG2671, gl, l(2)
1,161Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PBJ2M9PBJ2_DROME
Lethal (2) giant larvae, isoform K
l(2)gl D-LGL, dlgl, Dmel\CG2671, gl, l(2)
1,093Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2L → F in AAA28671 (PubMed:3036370).Curated1
Sequence conflicti2L → F in AAA28672 (PubMed:3036370).Curated1
Sequence conflicti37 – 38KP → A in CAA29007 (PubMed:16453778).Curated2
Sequence conflicti58A → V in ACY56896 (Ref. 6) Curated1
Sequence conflicti185G → S in CAA29007 (PubMed:16453778).Curated1
Sequence conflicti227G → R in CAA29007 (PubMed:16453778).Curated1
Sequence conflicti243 – 245FTW → RYL in CAA29007 (PubMed:16453778).Curated3
Sequence conflicti304Y → N in CAA29007 (PubMed:16453778).Curated1
Sequence conflicti331F → I in CAA29007 (PubMed:16453778).Curated1
Sequence conflicti338N → S in CAA29007 (PubMed:16453778).Curated1
Sequence conflicti366I → T in CAA29007 (PubMed:16453778).Curated1
Sequence conflicti388V → L in CAA29007 (PubMed:16453778).Curated1
Sequence conflicti512 – 515VKKI → SEEN in CAA29007 (PubMed:16453778).Curated4
Sequence conflicti667 – 675KLRKGRSTR → SFARVDQTK in CAA29007 (PubMed:16453778).Curated9
Sequence conflicti727T → S in CAA29007 (PubMed:16453778).Curated1
Sequence conflicti857I → V in ACY56896 (Ref. 6) Curated1
Sequence conflicti959R → G in AAA28671 (PubMed:3036370).Curated1
Sequence conflicti1095A → G in CAA29007 (PubMed:16453778).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0217931 – 49Missing in isoform D. CuratedAdd BLAST49
Alternative sequenceiVSP_02179417 – 28HRLQK…FAYRK → QRYI in isoform B. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_004299708V → F in isoform p78. Curated1
Alternative sequenceiVSP_004300709 – 1161Missing in isoform p78. CuratedAdd BLAST453

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X05426 mRNA Translation: CAA29007.1
M17022 Genomic DNA Translation: AAA28671.1
M17022 Genomic DNA Translation: AAA28672.1
AE014134 Genomic DNA Translation: AAG22255.1
AE014134 Genomic DNA Translation: AAG22256.2
AE014134 Genomic DNA Translation: AAN10501.1
AE014134 Genomic DNA Translation: AAN10502.1
AE014134 Genomic DNA Translation: AAN10503.1
AY051654 mRNA Translation: AAK93078.1
BT100129 mRNA Translation: ACX85650.1
BT100228 mRNA Translation: ACY56896.1

Protein sequence database of the Protein Information Resource

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PIRi
A27069
A27868

NCBI Reference Sequences

More...
RefSeqi
NP_001245801.1, NM_001258872.2 [P08111-1]
NP_001245802.1, NM_001258873.2 [P08111-1]
NP_001245803.1, NM_001258874.2 [P08111-1]
NP_001245804.1, NM_001258875.2 [P08111-1]
NP_523439.2, NM_078715.4 [P08111-1]
NP_722583.1, NM_164348.3 [P08111-3]
NP_722584.1, NM_164349.3 [P08111-1]
NP_722585.1, NM_164350.3 [P08111-4]
NP_722586.1, NM_164351.3 [P08111-4]
NP_722587.1, NM_164352.3 [P08111-4]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0078166; FBpp0077824; FBgn0002121 [P08111-3]
FBtr0078167; FBpp0077825; FBgn0002121 [P08111-4]
FBtr0078168; FBpp0077826; FBgn0002121 [P08111-4]
FBtr0078169; FBpp0077827; FBgn0002121 [P08111-4]
FBtr0078170; FBpp0077828; FBgn0002121 [P08111-1]
FBtr0078171; FBpp0077829; FBgn0002121 [P08111-1]
FBtr0306589; FBpp0297544; FBgn0002121 [P08111-1]
FBtr0306590; FBpp0297545; FBgn0002121 [P08111-1]
FBtr0306591; FBpp0297546; FBgn0002121 [P08111-1]
FBtr0306592; FBpp0297547; FBgn0002121 [P08111-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
33156

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG2671

UCSC genome browser

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UCSCi
CG2671-RE d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05426 mRNA Translation: CAA29007.1
M17022 Genomic DNA Translation: AAA28671.1
M17022 Genomic DNA Translation: AAA28672.1
AE014134 Genomic DNA Translation: AAG22255.1
AE014134 Genomic DNA Translation: AAG22256.2
AE014134 Genomic DNA Translation: AAN10501.1
AE014134 Genomic DNA Translation: AAN10502.1
AE014134 Genomic DNA Translation: AAN10503.1
AY051654 mRNA Translation: AAK93078.1
BT100129 mRNA Translation: ACX85650.1
BT100228 mRNA Translation: ACY56896.1
PIRiA27069
A27868
RefSeqiNP_001245801.1, NM_001258872.2 [P08111-1]
NP_001245802.1, NM_001258873.2 [P08111-1]
NP_001245803.1, NM_001258874.2 [P08111-1]
NP_001245804.1, NM_001258875.2 [P08111-1]
NP_523439.2, NM_078715.4 [P08111-1]
NP_722583.1, NM_164348.3 [P08111-3]
NP_722584.1, NM_164349.3 [P08111-1]
NP_722585.1, NM_164350.3 [P08111-4]
NP_722586.1, NM_164351.3 [P08111-4]
NP_722587.1, NM_164352.3 [P08111-4]

3D structure databases

SMRiP08111
ModBaseiSearch...

Protein-protein interaction databases

BioGridi59421, 34 interactors
DIPiDIP-22687N
IntActiP08111, 6 interactors
STRINGi7227.FBpp0297544

PTM databases

iPTMnetiP08111

Proteomic databases

PaxDbiP08111
PRIDEiP08111

Genome annotation databases

EnsemblMetazoaiFBtr0078166; FBpp0077824; FBgn0002121 [P08111-3]
FBtr0078167; FBpp0077825; FBgn0002121 [P08111-4]
FBtr0078168; FBpp0077826; FBgn0002121 [P08111-4]
FBtr0078169; FBpp0077827; FBgn0002121 [P08111-4]
FBtr0078170; FBpp0077828; FBgn0002121 [P08111-1]
FBtr0078171; FBpp0077829; FBgn0002121 [P08111-1]
FBtr0306589; FBpp0297544; FBgn0002121 [P08111-1]
FBtr0306590; FBpp0297545; FBgn0002121 [P08111-1]
FBtr0306591; FBpp0297546; FBgn0002121 [P08111-1]
FBtr0306592; FBpp0297547; FBgn0002121 [P08111-1]
GeneIDi33156
KEGGidme:Dmel_CG2671
UCSCiCG2671-RE d. melanogaster

Organism-specific databases

FlyBaseiFBgn0002121 l(2)gl

Phylogenomic databases

eggNOGiKOG1983 Eukaryota
ENOG410XS6Z LUCA
GeneTreeiENSGT00950000182906
InParanoidiP08111
KOiK06094
PhylomeDBiP08111

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
l(2)gl fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
33156

Protein Ontology

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PROi
PR:P08111

Gene expression databases

BgeeiFBgn0002121 Expressed in wing disc (Drosophila) and 31 other tissues
ExpressionAtlasiP08111 differential
GenevisibleiP08111 DM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR000664 Lethal2_giant
IPR013905 Lgl_C_dom
IPR013577 LLGL2
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08596 Lgl_C, 1 hit
PF08366 LLGL, 1 hit
PRINTSiPR00962 LETHAL2GIANT
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL2GL_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P08111
Secondary accession number(s): A4UZW0
, D0IQ91, D0IQJ0, Q0E8V5, Q24377, Q8IPV4, Q8IPV5, Q9VPI1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 1, 1995
Last modified: February 26, 2020
This is version 201 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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