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Protein

Clathrin light chain A

Gene

Clta

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (By similarity).By similarity

GO - Molecular functioni

  • clathrin heavy chain binding Source: GO_Central
  • GTPase binding Source: CAFA
  • peptide binding Source: RGD
  • protein-containing complex binding Source: RGD
  • structural molecule activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis
LigandCalcium

Enzyme and pathway databases

ReactomeiR-RNO-177504 Retrograde neurotrophin signalling
R-RNO-190873 Gap junction degradation
R-RNO-196025 Formation of annular gap junctions
R-RNO-2132295 MHC class II antigen presentation
R-RNO-432720 Lysosome Vesicle Biogenesis
R-RNO-432722 Golgi Associated Vesicle Biogenesis
R-RNO-437239 Recycling pathway of L1
R-RNO-5099900 WNT5A-dependent internalization of FZD4
R-RNO-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2
R-RNO-8856825 Cargo recognition for clathrin-mediated endocytosis
R-RNO-8856828 Clathrin-mediated endocytosis
R-RNO-8866427 VLDLR internalisation and degradation
R-RNO-8964038 LDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Clathrin light chain A
Short name:
Lca
Gene namesi
Name:Clta
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi70919 Clta

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057691 – 248Clathrin light chain AAdd BLAST248

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105PhosphoserineBy similarity1
Modified residuei206PhosphoserineBy similarity1
Modified residuei223N6-acetyllysineBy similarity1
Modified residuei236PhosphoserineBy similarity1
Modified residuei242N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP08081
PRIDEiP08081

PTM databases

iPTMnetiP08081
PhosphoSitePlusiP08081
SwissPalmiP08081

Expressioni

Gene expression databases

BgeeiENSRNOG00000014635
ExpressionAtlasiP08081 baseline and differential
GenevisibleiP08081 RN

Interactioni

Subunit structurei

Clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains. Interacts with CALY; the interaction stimulates clathrin self-assembly and clathrin-mediated endocytosis (By similarity). Interacts with CKAP5 and TACC3 forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; the complex implicates clathrin triskelions (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • clathrin heavy chain binding Source: GO_Central
  • GTPase binding Source: CAFA

Protein-protein interaction databases

BioGridi249837, 10 interactors
CORUMiP08081
DIPiDIP-36947N
IntActiP08081, 8 interactors
MINTiP08081
STRINGi10116.ENSRNOP00000019737

Structurei

3D structure databases

SMRiP08081
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni100 – 162Involved in binding clathrin heavy chainAdd BLAST63

Sequence similaritiesi

Belongs to the clathrin light chain family.Curated

Phylogenomic databases

eggNOGiKOG4031 Eukaryota
ENOG4111J5K LUCA
GeneTreeiENSGT00390000010441
HOGENOMiHOG000008147
HOVERGENiHBG003386
InParanoidiP08081
KOiK04644
OMAiINHPCYR
OrthoDBiEOG091G0WEF
PhylomeDBiP08081
TreeFamiTF313162

Family and domain databases

InterProiView protein in InterPro
IPR000996 Clathrin_L-chain
PANTHERiPTHR10639 PTHR10639, 1 hit
PfamiView protein in Pfam
PF01086 Clathrin_lg_ch, 1 hit
PROSITEiView protein in PROSITE
PS00224 CLATHRIN_LIGHT_CHN_1, 1 hit
PS00581 CLATHRIN_LIGHT_CHN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Brain (identifier: P08081-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAELDPFGAP AGAPGGPALG NGVAGAGEED PAAAFLAQQE SEIAGIENDE
60 70 80 90 100
AFAILDGGAP GPQAHGEPPG GPDAVDGVMN GEYYQESNGP TDSYAAISEV
110 120 130 140 150
DRLQSEPESI RKWREEQTER LEALDANSRK QEAEWKEKAV KELEEWYARQ
160 170 180 190 200
DEQLQKTKAS NRVADEAFYK QPFADVIGYV TNINHPCYSL EQAAEEAFVN
210 220 230 240
DIDESSPGTE WERVARLCDF NPKSSKQAKD VSRMRSVLIS LKQAPLVH
Length:248
Mass (Da):26,981
Last modified:August 1, 1988 - v1
Checksum:iC939E85B0FD2E124
GO
Isoform Non-brain (identifier: P08081-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-192: Missing.

Show »
Length:218
Mass (Da):23,566
Checksum:iFEFE0F820F074C7B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001096163 – 192Missing in isoform Non-brain. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15882 mRNA Translation: AAA40868.1
M19261 mRNA Translation: AAA40870.1
M19260 mRNA Translation: AAA40869.1
PIRiA25994 LRRTA1
RefSeqiNP_114180.1, NM_031974.1 [P08081-1]
XP_006238166.1, XM_006238104.2
XP_006238168.1, XM_006238106.2 [P08081-2]
UniGeneiRn.112599

Genome annotation databases

EnsembliENSRNOT00000019737; ENSRNOP00000019737; ENSRNOG00000014635 [P08081-1]
ENSRNOT00000036366; ENSRNOP00000035138; ENSRNOG00000014635 [P08081-2]
GeneIDi83800
KEGGirno:83800
UCSCiRGD:70919 rat [P08081-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCLCA_RAT
AccessioniPrimary (citable) accession number: P08081
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: July 18, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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